Compounds > clarithromycin
Page last updated: 2024-08-25

clarithromycin and hmr 3647

clarithromycin has been researched along with hmr 3647 in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.82)18.2507
2000's20 (36.36)29.6817
2010's31 (56.36)24.3611
2020's3 (5.45)2.80

Authors

AuthorsStudies
Agouridas, C; Auger, JM; Benedetti, Y; Bonnefoy, A; Bretin, F; Chantot, JF; D'Ambrières, SG; Denis, A; Dussarat, A; Fromentin, C; Lachaud, S; Laurin, P; Le Martret, O; Loyau, V; Pejac, JM; Perron, S; Tessot, N1
Agouridas, C; Bonnefoy, A; Bonnet, A; Bretin, F; Denis, A; Fromentin, C; Piltan, G1
Alder, J; Brazzale, A; Cao, Z; Chu, DT; Clark, RF; Ewing, P; Flamm, R; Griesgraber, G; Li, L; Ma, Z; Meulbroek, J; Mitten, M; Nemoto, PA; Nilius, AM; Or, YS; Phan, LT; Plattner, JJ; Rupp, MJ; Shortridge, VD; Wang, S; Yong, H; Zhang, S; Zhang, X; Zhong, P1
Anderson, S; Barker, L; Burger, MT; Carroll, GL; Chu, DT; Desai, MC; Hiebert, C; Huh, K; Kidney, J; Langhorne, M; Lin, X; Plattner, JJ; Rico, AC; Seid, M; Shawar, R; Young, K1
Barker, L; Carroll, GL; Chu, DT; Desai, MC; Lin, X; Plattner, JJ; Rico, AC; Shawar, R1
Klugman, KP; Low, DE; Smith, AM; Wolter, N1
Aralar, P; Baimukanova, G; Bermudez, LE; Chee, C; Inderlied, C; Kolonoski, P; Motamedi, N; Phan, LT; Wang, G; Young, LS1
Baba, S; Billal, DS; Fujihara, K; Hotomi, M; Nishimura, T; Suzuki, K; Yamanaka, N1
Andricopulo, AD; Moda, TL; Montanari, CA1
Appelbaum, PC; Clark, CL; Ednie, LM; Kosowska-Shick, K1
Chiba, N; Hasegawa, K; Iwata, S; Matsubara, K; Morozumi, M; Nakayama, E; Sunakawa, K; Takayanagi, R; Ubukata, K1
Douthwaite, S; Farrell, DJ; Klugman, KP; Northwood, JB; Smith, AM; Wolter, N1
Bailey, M; Chettiath, T; Mankin, AS1
Lombardo, F; Obach, RS; Waters, NJ1
Brown-Elliott, BA; Nash, KA; Wallace, RJ1
Jiang, LJ; Or, YS; Wang, M1
Appelbaum, PC; Ednie, LM; Kosowska-Shick, K; McGhee, P1
Chen, XZ; Jin, ZP; Lei, PS; Li, Y; Liu, J; Liu, L; Wang, GQ; Xu, P1
Lemaire, S; Tulkens, PM; Van Bambeke, F1
Amaral, K; Dzink-Fox, J; Fischer, E; Goldovitz, J; Manni, K; Neckermann, G; Osborne, CS; Pecanka, R; Ryder, NS; Yu, D1
Buzon, RA; Chupak, L; Dougherty, TJ; Falcone, MJ; Farley, KA; Finegan, SM; Flanagan, ME; Girard, D; Granskog, K; Hagen, AE; Hardink, JR; Huband, MD; Kamicker, BJ; Kaneko, T; Knickerbocker, MJ; Li, B; Liras, JL; Magee, TV; Marra, A; Medina, I; Nguyen, TT; Noe, MC; O'Donnell, JP; Obach, RS; Penzien, JB; Reilly, UD; Ripp, SL; Schafer, JR; Shen, Y; Stone, GG; Strelevitz, TJ; Sun, J; Tait-Kamradt, A; Vaz, AD; Whipple, DA; Widlicka, DW; Wishka, DG; Wolkowski, JP1
Appelbaum, PC; Beachel, L; Clark, C; Dewasse, B; Kosowska-Shick, KM; McGhee, P; Nagai, K1
Furuie, H; Saisho, Y; Shimada, J; Yoshikawa, T1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Hakanen, AJ; Huovinen, P; Kotilainen, P; Lehtopolku, M; Nakari, UM; Siitonen, A1
Hammerschlag, MR; Kohlhoff, SA; Parker, C; Roblin, PM1
Castanheira, M; Jones, RN; Woosley, LN1
Shakya, T; Wright, GD1
Ajito, K; Fushimi, H; Kanemoto, K; Miura, T; Natsume, S; Shitara, E; Yoshida, T1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Biedenbach, DJ; Castanheira, M; Jones, RN1
Alihodzić, S; Andreotti, D; Berge, JM; Cipcić Paljetak, H; Derek, M; Dumić, M; Eraković Haber, V; Fajdetić, A; Holmes, DJ; Hutinec, A; Lazarevski, G; Lociuro, S; Marsić, N; Mutak, S; Spaventi, R; Stimac, V; Sunjić, V1
Biedenbach, DJ; Hammerschlag, MR; Jones, RN; Kohlhoff, SA; Roblin, PM1
Alihodzić, S; Antolović, R; Broskey, JP; Cipcić Paljetak, H; Eraković Haber, V; Holmes, DJ; Hunt, E; Jarvest, RL; Kapić, S1
Chen, XZ; Jin, ZP; Lei, PS; Liu, L; Xu, P1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, XZ; Lei, PS; Liu, L; Xu, P; Zheng, D1
Bhateja, P; Chakrabarti, A; Das, B; Dullu, J; Hajare, AK; Jadhav, JS; Kumar, R; Pandya, M; Ramkumar, G; Rathy, S; Surase, YB; Venkataramanan, R1
Sugimoto, T; Suzuki, K; Tanikawa, T; Yamasaki, Y1
Chen, X; Lei, P; Liu, L; Liu, Y; Xu, P; Xu, Y; Zhu, D1
An, K; Cushman, M; Li, XL; Liang, JH; Lv, W; Wang, H; Xu, YC1
Jiang, JW; Li, X; Nie, Y; Sun, HP; Sun, Y; You, QD; Zhang, XJ; Zhi, HJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, X; Jin, L; Lei, P; Liu, C; Liu, Y; Xu, Y; Zhao, Z; Zhu, D1
Chen, X; Lei, P; Liu, Y; Xu, Y; Zhao, Z; Zhu, D1
Cushman, M; Guo, SY; Han, X; Liang, JH; Lv, W1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kimmins, S; Mutak, S; Pavlović, D1
Cushman, M; Fan, BZ; Han, X; Li, YX; Liang, JH; Lv, W; Tian, JC; Wang, H1
Jin, LL; Lei, PS; Yang, S; Zhang, XX; Zhao, ZH1
Cushman, M; Fan, BZ; Han, X; Kong, FS; Li, YX; Liang, JH; Lv, W; Ma, CX; Tian, JC1
Cushman, M; Fan, BZ; Guo, SY; Kong, FS; Li, XM; Li, YX; Liang, JH; Lv, W; Zhang, J1
Bertrand, D; Fernandes, P; Pereira, D; Watkins, PB1
Aldrich, C; Brody, S; Cushman, M; Fan, BZ; Hiasa, H; Liang, JH; Lv, W; Yang, ZY1
Cushman, M; Ding, J; Li, Y; Liang, JH; Liu, LY; Liu, XP; Lv, W; Xue, F; Zhang, JR; Zhang, JZ; Zhao, F1

Reviews

1 review(s) available for clarithromycin and hmr 3647

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for clarithromycin and hmr 3647

ArticleYear
Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Macrolides; Male; Middle Aged; Treatment Outcome; Young Adult

2009
Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Asian People; Bridged-Ring Compounds; Bronchoalveolar Lavage; Chromatography, High Pressure Liquid; Humans; Macrolides; Macrophages, Alveolar; Male; Mass Spectrometry; Middle Aged; Pulmonary Alveoli; Young Adult

2010

Other Studies

52 other study(ies) available for clarithromycin and hmr 3647

ArticleYear
Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens.
    Bioorganic & medicinal chemistry letters, 1999, Nov-01, Volume: 9, Issue:21

    Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Erythromycin; Gram-Negative Bacteria; Gram-Positive Bacteria; Haemophilus influenzae; Ketolides; Macrolides; Mice; Microbial Sensitivity Tests; Molecular Structure

1999
Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides.
    Bioorganic & medicinal chemistry letters, 2000, Sep-04, Volume: 10, Issue:17

    Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Macrolides; Mice; Structure-Activity Relationship

2000
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
    Journal of medicinal chemistry, 2001, Nov-22, Volume: 44, Issue:24

    Topics: Animals; Anti-Bacterial Agents; Carbamates; Cell-Free System; Drug Resistance, Multiple; Erythromycin; Haemophilus influenzae; Ketolides; Lung; Mice; Models, Molecular; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Respiratory Tract Infections; Ribosomes; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Structure-Activity Relationship; Transcription, Genetic

2001
Synthesis and antibacterial activity of novel C12 vinyl ketolides.
    Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biological Availability; Drug Resistance, Bacterial; Enterococcus faecalis; Haemophilus Infections; Haemophilus influenzae; Half-Life; Ketolides; Lung Diseases; Male; Microbial Sensitivity Tests; Pneumococcal Infections; Rats; Rats, Sprague-Dawley; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Structure-Activity Relationship; Vinyl Compounds

2006
Synthesis and antibacterial activity of C12 des-methyl ketolides.
    Bioorganic & medicinal chemistry letters, 2006, Sep-01, Volume: 16, Issue:17

    Topics: Anti-Bacterial Agents; Carbon; Gram-Positive Cocci; Haemophilus influenzae; Ketolides; Methylation; Molecular Structure; Structure-Activity Relationship

2006
High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:3

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Culture Media; Drug Resistance, Bacterial; Genotype; Humans; Ketolides; Methyltransferases; Microbial Sensitivity Tests; Mutation; Phenotype; Pneumococcal Infections; Ribosomal Proteins; Streptococcus pneumoniae

2007
EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Female; Humans; Macrolides; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mycobacterium avium

2007
Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Adolescent; Adult; Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; beta-Lactamases; Child; Child, Preschool; Female; Gene Frequency; Genotype; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Japan; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Polymerase Chain Reaction; Respiratory Tract Infections

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Anti-Bacterial Agents; Aza Compounds; Azithromycin; Clarithromycin; Clavulanic Acid; Clindamycin; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Imipenem; Ketolides; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Streptococcus pneumoniae

2007
Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Community-Acquired Infections; Drug Resistance, Bacterial; Humans; Infant; Infant, Newborn; Macrolides; Microbial Sensitivity Tests; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; RNA, Ribosomal, 23S

2008
Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: 5' Untranslated Regions; Amino Acid Sequence; Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Ketolides; Methylation; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; RNA, Ribosomal; Sequence Deletion; Streptococcus pneumoniae

2008
Induction of erm(C) expression by noninducing antibiotics.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enzyme Induction; Escherichia coli; Gene Expression Regulation, Bacterial; Ketolides; Macrolides; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Protein Conformation; Protein Sorting Signals; Ribosomes; RNA, Messenger

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4

    Topics: Amino Acid Sequence; Clarithromycin; Drug Resistance, Bacterial; Humans; Macrolides; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Mycobacterium chelonae; Nontuberculous Mycobacteria; Polymerase Chain Reaction; RNA

2009
Comparative antipneumococcal activities of sulopenem and other drugs.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; Lactams; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Streptococcus pneumoniae

2009
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity.
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Anti-Bacterial Agents; Chemistry, Pharmaceutical; Clarithromycin; Drug Design; Drug Resistance, Multiple, Bacterial; Erythromycin; Humans; Imidazoles; Ketolides; Macrolides; Microbial Sensitivity Tests; Models, Chemical; Respiratory Tract Infections; Staphylococcus aureus; Streptococcus pneumoniae; Sulfides; Sulfur

2009
Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-Bacterial Agents; Cell Line; Humans; Ketolides; Legionella pneumophila; Listeria monocytogenes; Macrophages; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus

2009
In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Acetamides; Amidohydrolases; Animals; Anti-Infective Agents; Female; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Peptides; Pneumonia; Staphylococcus aureus; Streptococcus pneumoniae; Thigh

2009
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Animals; Azetidines; Bacteria; Community-Acquired Infections; Disease Susceptibility; Drug Discovery; Drug Resistance, Multiple; Drug-Related Side Effects and Adverse Reactions; Humans; Ketolides; Mice; Microbial Sensitivity Tests; Respiratory Tract Infections

2009
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Macrolides; Microbial Sensitivity Tests; Penicillin G; Streptococcus pneumoniae; Streptococcus pyogenes; Triazoles

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Anti-Bacterial Agents; Campylobacter coli; Campylobacter Infections; Campylobacter jejuni; Carbapenems; Drug Resistance, Multiple, Bacterial; Erythromycin; Feces; Finland; Humans; Macrolides; Microbial Sensitivity Tests; Minocycline; Tigecycline

2010
In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Child; Child, Preschool; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila Infections; Chlamydophila pneumoniae; Female; Humans; Infant; Macrolides; Microbial Sensitivity Tests; Pneumonia, Bacterial; Triazoles

2010
CEM-101 activity against Gram-positive organisms.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Clarithromycin; Drug Resistance, Bacterial; Drug Synergism; Erythromycin; Gentamicins; Gram-Positive Bacteria; Ketolides; Macrolides; Microbial Sensitivity Tests; Ofloxacin; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae; Streptococcus pyogenes; Triazoles; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin

2010
Nucleotide selectivity of antibiotic kinases.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Anti-Bacterial Agents; Bacteria; Binding, Competitive; Drug Resistance, Bacterial; Guanosine Triphosphate; Kanamycin Kinase; Models, Chemical; Nucleotides; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Substrate Specificity

2010
Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities.
    Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7

    Topics: Anti-Bacterial Agents; Aza Compounds; Bacterial Proteins; Drug Resistance, Bacterial; Gram-Positive Bacteria; Indicators and Reagents; Macrolides; Membrane Proteins; Microbial Sensitivity Tests; Streptococcus pneumoniae

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Ciprofloxacin; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Minocycline; Neisseria meningitidis; Penicillins; Rifampin; Sulfamethoxazole; Triazoles; Trimethoprim

2010
4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.
    Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17

    Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Bacterial; Erythromycin; Humans; Macrolides; Microbial Sensitivity Tests; Propionates

2010
Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Fusidic Acid; Neisseria gonorrhoeae

2010
6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile.
    Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17

    Topics: Anti-Bacterial Agents; Azithromycin; Clarithromycin; Humans; Macrolides; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship

2010
A new series of macrolide derivatives with 4''-O-saccharide substituents.
    Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Glycosylation; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Macrolides; Staphylococcus; Streptococcus

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Anti-Bacterial Agents; Bacteria; Ketolides; Microbial Sensitivity Tests; Sulfur

2011
Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Anti-Bacterial Agents; Chemistry, Pharmaceutical; Clarithromycin; Drug Design; Drug Resistance, Bacterial; Haemophilus influenzae; Humans; Ketolides; Microbial Sensitivity Tests; Models, Chemical; Nitrogen; Respiratory Tract Infections; Streptococcus pneumoniae

2012
Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'.
    Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Erythromycin; Humans; Macrolides; Pneumococcal Infections; Respiratory Tract Infections; Streptococcus pneumoniae; Structure-Activity Relationship

2012
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides.
    Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Ketolides; Microbial Sensitivity Tests; Molecular Conformation; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus Phages; Streptococcus pneumoniae; Structure-Activity Relationship

2012
Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Anti-Bacterial Agents; Clarithromycin; Erythromycin; Ether; Ketolides; Models, Molecular; Oximes; RNA, Bacterial; RNA, Ribosomal

2013
Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives.
    Bioorganic & medicinal chemistry letters, 2013, Jun-01, Volume: 23, Issue:11

    Topics: Anti-Bacterial Agents; Bacteria; Binding Sites; Clarithromycin; Crystallography, X-Ray; Drug Evaluation, Preclinical; Ketolides; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Conformation; Molecular Docking Simulation; Peptidyl Transferases; Protein Structure, Tertiary; Structure-Activity Relationship

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Ketolides; Methicillin; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Staphylococcus epidermidis; Structure-Activity Relationship

2013
Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities.
    Bioorganic & medicinal chemistry letters, 2013, Dec-01, Volume: 23, Issue:23

    Topics: Anti-Bacterial Agents; Clarithromycin; Glycosylation; Macrolides; Microbial Sensitivity Tests; Structure-Activity Relationship

2013
Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity.
    Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19

    Topics: Anti-Bacterial Agents; Binding Sites; Drug Resistance, Bacterial; Erythromycin; Haemophilus influenzae; Hydrogen Bonding; Ketolides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Docking Simulation; Oximes; Ribosome Subunits, Large, Bacterial; Staphylococcus aureus; Streptococcus pyogenes; Structure-Activity Relationship

2015
Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Animals; Anti-Bacterial Agents; Biological Availability; Drug Resistance, Bacterial; Erythromycin; Humans; Macrolides; Structure-Activity Relationship

2017
Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides.
    Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7

    Topics: Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Ketolides; Molecular Docking Simulation; Oximes; Ribosomes; Stereoisomerism; Structure-Activity Relationship

2017
Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains.
    Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14

    Topics: Anti-Bacterial Agents; Azithromycin; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Haemophilus influenzae; Ketolides; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Quinolines; Staphylococcus; Structure-Activity Relationship

2018
Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens.
    European journal of medicinal chemistry, 2019, May-01, Volume: 169

    Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Bacterial; Ketolides; Microbial Sensitivity Tests; Molecular Structure; Oximes; Quinolones; Streptococcus pneumoniae; Streptococcus pyogenes; Structure-Activity Relationship

2019
Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH.
    European journal of medicinal chemistry, 2019, Jun-01, Volume: 171

    Topics: Anti-Bacterial Agents; Bacteria; Clarithromycin; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship

2019
Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.
    Journal of medicinal chemistry, 2020, 06-25, Volume: 63, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Bacterial; Drug-Related Side Effects and Adverse Reactions; Humans; Ketolides; Macrolides

2020
Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides.
    European journal of medicinal chemistry, 2020, May-01, Volume: 193

    Topics: Anti-Bacterial Agents; Azithromycin; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Macrolides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Quinolines; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

2020
Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides.
    Bioorganic & medicinal chemistry letters, 2022, 07-15, Volume: 68

    Topics: Anti-Bacterial Agents; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Mycoplasma pneumoniae; Quinolones; Structure-Activity Relationship

2022