cl 246738 has been researched along with acridines in 15 studies
| Studies (cl 246738) | Trials (cl 246738) | Recent Studies (post-2010) (cl 246738) | Studies (acridines) | Trials (acridines) | Recent Studies (post-2010) (acridines) |
|---|---|---|---|---|---|
| 18 | 0 | 1 | 6,987 | 169 | 856 |
| Protein | Taxonomy | cl 246738 (IC50) | acridines (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | 6.84 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grave, S; Lüllmann, H; Lüllmann-Rauch, R; Osterkamp, G; Prokopek, M | 1 |
| Borden, EC; Goodavish, CN; Grossberg, SE; Hong, R; Litton, GJ; Vechlekar, D | 1 |
| Durr, FE; Lumanglas, AL; Ruszala-Mallon, V; Silva, J; Wang, BS | 1 |
| Lüllmann-Rauch, R | 2 |
| Baron, S; Coppenhaver, DH; Poast, J; Sarzotti, M; Singh, IP | 1 |
| Baron, S; Coppenhaver, DH; Lucia, HL | 1 |
| Dickinson, A; Halcrow, P; Hales, J; Harris, AL; Lawrence, GF; Lennard, TW; McDonald, M; Shenton, BK; Taylor, RM; Wolstencroft, R | 1 |
| Gibbons, JJ; Lucas, J; Raventos-Suarez, C; Ruszala-Mallon, VM; Wang, BS | 1 |
| Durr, FE; Lumanglas, AL; Ruszala-Mallon, M; Veronica, JS; Wang, BS | 1 |
| Alvarez, JM; Guimaraes, L; Takehara, HA | 1 |
| Durr, FE; Lumanglas, AL; Ruszala-Mallon, VM; Silva, J; Wang, BS | 1 |
| Durr, FE; Lumanglas, AL; Ruszala-Mallon, VM; Wang, BS | 1 |
| Kelly, KM; Kunder, SC; Morahan, PS | 1 |
| Black, PL; McKinnon, KM; Ussery, MA; Wooden, SL | 1 |
15 other study(ies) available for cl 246738 and acridines
| Article | Year |
|---|---|
Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives.
Topics: Acridines; Adjuvants, Immunologic; Animals; Female; Glycosaminoglycans; Liver; Lysosomes; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Spleen; Tilorone | 1992 |
Biological and clinical effects of the oral immunomodulator 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride in patients with malignancy.
Topics: 2',5'-Oligoadenylate Synthetase; Acridines; Adjuvants, Immunologic; Administration, Oral; Antineoplastic Agents; beta 2-Microglobulin; Cell Division; Cytotoxicity Tests, Immunologic; Drug Evaluation; Female; Humans; In Vitro Techniques; Interferons; Male; Phenotype; T-Lymphocytes | 1990 |
The mechanism of action of a synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738), in natural killer cell activation in animals.
Topics: Acridines; Adjuvants, Immunologic; Aging; Animals; Interferons; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred C57BL; Mice, Nude; Spleen | 1991 |
Mucopolysaccharidosis (MPS) in ocular tissues as induced by amphiphilic di-cationic drugs.
Topics: Acridines; Animals; Conjunctiva; Cornea; Eye; Female; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Sclera; Tilorone; Uvea | 1990 |
The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.
Topics: Acridines; Adjuvants, Immunologic; Administration, Oral; Animals; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Encephalitis; Female; Flavivirus; Interferon Inducers; Interferon Type I; Mice; Peritoneal Cavity; Semliki forest virus; Togaviridae Infections | 1989 |
Arenavirus infection in the guinea pig model: antiviral therapy with recombinant interferon-alpha, the immunomodulator CL246,738 and ribavirin.
Topics: Acridines; Adjuvants, Immunologic; Animals; Antiviral Agents; Arenaviridae Infections; Disease Models, Animal; Female; Guinea Pigs; Interferon Type I; Male; Precipitin Tests; Recombinant Proteins; Ribavirin; Ribonucleosides | 1989 |
A phase I study of immunostimulation and toxicity in patients with colorectal carcinoma using the immunomodulator 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246738).
Topics: Acridines; Adenocarcinoma; Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged | 1989 |
The effect of 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246, 738) on acute graft vs host reactions in mice.
Topics: Acridines; Adjuvants, Immunologic; Animals; Antigens, Surface; G(M1) Ganglioside; Glycosphingolipids; Graft vs Host Reaction; Immune Tolerance; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1989 |
Activation of natural killer cells with 3,6-bis (2-piperidinoethoxy) acridine trihydrochloride (CL 246, 738).
Topics: Acridines; Adjuvants, Immunologic; Animals; Interferon Type I; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred C57BL | 1987 |
Protective effects of 3,6-bis-(2-piperidinoethoxyl) acridine trihydrochloride (CL-246738) in experimental acute Trypanosoma cruzi infection.
Topics: Acridines; Adjuvants, Immunologic; Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice | 1988 |
The mechanism of action of 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738) in the potentiation of natural killer cells.
Topics: Acridines; Animals; Antibodies; Antigen-Antibody Complex; Cell Line; Cytotoxicity, Immunologic; G(M1) Ganglioside; Glycosphingolipids; Immunosuppressive Agents; Killer Cells, Natural; Lymphocyte Activation; Lymphoma; Mice; Mice, Inbred C57BL | 1986 |
Induction of tumor-inhibitory macrophages with a novel synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738).
Topics: Acridines; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Ascitic Fluid; Cytotoxicity, Immunologic; Leukemia, Experimental; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1985 |
Biological response modifier-mediated resistance to herpesvirus infections requires induction of alpha/beta interferon.
Topics: Acridines; Animals; Carboxymethylcellulose Sodium; Cytomegalovirus Infections; Female; Herpes Simplex; Herpesviridae Infections; Immunity, Innate; Immunologic Factors; Interferon Inducers; Interferon-alpha; Interferon-beta; Interferons; Mice; Mice, Inbred Strains; Poly I-C; Polylysine; Specific Pathogen-Free Organisms; Survival Analysis | 1993 |
Drug-induced intralysosomal storage of sulfated glycosaminoglycans (GAGs): a methodical pitfall occurring with acridine derivatives.
Topics: Acridines; Adjuvants, Immunologic; Animals; Cells, Cultured; Fibroblasts; Glycosaminoglycans; Histocytochemistry; Liver; Lymph Nodes; Lysosomal Storage Diseases; Lysosomes; Microscopy, Electron; Microscopy, Fluorescence; Rats; Spleen; Tilorone; Tissue Fixation | 1994 |
Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT.
Topics: Acquired Immunodeficiency Syndrome; Acridines; Animals; Antibodies; Antiviral Agents; Asialoglycoproteins; Disease Models, Animal; Drug Synergism; Female; G(M1) Ganglioside; Glucans; Guanosine; Immunologic Factors; In Vitro Techniques; Killer Cells, Natural; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Poly I-C; Poly U; Pyran Copolymer; Rabbits; Rauscher Virus; Specific Pathogen-Free Organisms; Viral Plaque Assay; Zidovudine | 1996 |