Page last updated: 2024-09-04

cl 246738 and acridines

cl 246738 has been researched along with acridines in 15 studies

Compound Research Comparison

Studies
(cl 246738)
Trials
(cl 246738)
Recent Studies (post-2010)
(cl 246738)
Studies
(acridines)
Trials
(acridines)
Recent Studies (post-2010) (acridines)
18016,987169856

Protein Interaction Comparison

ProteinTaxonomycl 246738 (IC50)acridines (IC50)
AcetylcholinesteraseHomo sapiens (human)6.84

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19908 (53.33)18.7374
1990's7 (46.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grave, S; Lüllmann, H; Lüllmann-Rauch, R; Osterkamp, G; Prokopek, M1
Borden, EC; Goodavish, CN; Grossberg, SE; Hong, R; Litton, GJ; Vechlekar, D1
Durr, FE; Lumanglas, AL; Ruszala-Mallon, V; Silva, J; Wang, BS1
Lüllmann-Rauch, R2
Baron, S; Coppenhaver, DH; Poast, J; Sarzotti, M; Singh, IP1
Baron, S; Coppenhaver, DH; Lucia, HL1
Dickinson, A; Halcrow, P; Hales, J; Harris, AL; Lawrence, GF; Lennard, TW; McDonald, M; Shenton, BK; Taylor, RM; Wolstencroft, R1
Gibbons, JJ; Lucas, J; Raventos-Suarez, C; Ruszala-Mallon, VM; Wang, BS1
Durr, FE; Lumanglas, AL; Ruszala-Mallon, M; Veronica, JS; Wang, BS1
Alvarez, JM; Guimaraes, L; Takehara, HA1
Durr, FE; Lumanglas, AL; Ruszala-Mallon, VM; Silva, J; Wang, BS1
Durr, FE; Lumanglas, AL; Ruszala-Mallon, VM; Wang, BS1
Kelly, KM; Kunder, SC; Morahan, PS1
Black, PL; McKinnon, KM; Ussery, MA; Wooden, SL1

Other Studies

15 other study(ies) available for cl 246738 and acridines

ArticleYear
Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives.
    Toxicology and applied pharmacology, 1992, Volume: 114, Issue:2

    Topics: Acridines; Adjuvants, Immunologic; Animals; Female; Glycosaminoglycans; Liver; Lysosomes; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Spleen; Tilorone

1992
Biological and clinical effects of the oral immunomodulator 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride in patients with malignancy.
    Journal of biological response modifiers, 1990, Volume: 9, Issue:1

    Topics: 2',5'-Oligoadenylate Synthetase; Acridines; Adjuvants, Immunologic; Administration, Oral; Antineoplastic Agents; beta 2-Microglobulin; Cell Division; Cytotoxicity Tests, Immunologic; Drug Evaluation; Female; Humans; In Vitro Techniques; Interferons; Male; Phenotype; T-Lymphocytes

1990
The mechanism of action of a synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738), in natural killer cell activation in animals.
    International journal of immunopharmacology, 1991, Volume: 13, Issue:7

    Topics: Acridines; Adjuvants, Immunologic; Aging; Animals; Interferons; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred C57BL; Mice, Nude; Spleen

1991
Mucopolysaccharidosis (MPS) in ocular tissues as induced by amphiphilic di-cationic drugs.
    Lens and eye toxicity research, 1990, Volume: 7, Issue:3-4

    Topics: Acridines; Animals; Conjunctiva; Cornea; Eye; Female; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Sclera; Tilorone; Uvea

1990
The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.
    Journal of interferon research, 1989, Volume: 9, Issue:3

    Topics: Acridines; Adjuvants, Immunologic; Administration, Oral; Animals; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Encephalitis; Female; Flavivirus; Interferon Inducers; Interferon Type I; Mice; Peritoneal Cavity; Semliki forest virus; Togaviridae Infections

1989
Arenavirus infection in the guinea pig model: antiviral therapy with recombinant interferon-alpha, the immunomodulator CL246,738 and ribavirin.
    Antiviral research, 1989, Volume: 12, Issue:5-6

    Topics: Acridines; Adjuvants, Immunologic; Animals; Antiviral Agents; Arenaviridae Infections; Disease Models, Animal; Female; Guinea Pigs; Interferon Type I; Male; Precipitin Tests; Recombinant Proteins; Ribavirin; Ribonucleosides

1989
A phase I study of immunostimulation and toxicity in patients with colorectal carcinoma using the immunomodulator 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246738).
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:11

    Topics: Acridines; Adenocarcinoma; Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged

1989
The effect of 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246, 738) on acute graft vs host reactions in mice.
    International journal of immunopharmacology, 1989, Volume: 11, Issue:7

    Topics: Acridines; Adjuvants, Immunologic; Animals; Antigens, Surface; G(M1) Ganglioside; Glycosphingolipids; Graft vs Host Reaction; Immune Tolerance; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA

1989
Activation of natural killer cells with 3,6-bis (2-piperidinoethoxy) acridine trihydrochloride (CL 246, 738).
    Chinese medical journal, 1987, Volume: 100, Issue:3

    Topics: Acridines; Adjuvants, Immunologic; Animals; Interferon Type I; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred C57BL

1987
Protective effects of 3,6-bis-(2-piperidinoethoxyl) acridine trihydrochloride (CL-246738) in experimental acute Trypanosoma cruzi infection.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:4

    Topics: Acridines; Adjuvants, Immunologic; Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice

1988
The mechanism of action of 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738) in the potentiation of natural killer cells.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Oct-15, Volume: 137, Issue:8

    Topics: Acridines; Animals; Antibodies; Antigen-Antibody Complex; Cell Line; Cytotoxicity, Immunologic; G(M1) Ganglioside; Glycosphingolipids; Immunosuppressive Agents; Killer Cells, Natural; Lymphocyte Activation; Lymphoma; Mice; Mice, Inbred C57BL

1986
Induction of tumor-inhibitory macrophages with a novel synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738).
    Journal of immunology (Baltimore, Md. : 1950), 1985, Volume: 135, Issue:1

    Topics: Acridines; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Ascitic Fluid; Cytotoxicity, Immunologic; Leukemia, Experimental; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA

1985
Biological response modifier-mediated resistance to herpesvirus infections requires induction of alpha/beta interferon.
    Antiviral research, 1993, Volume: 21, Issue:2

    Topics: Acridines; Animals; Carboxymethylcellulose Sodium; Cytomegalovirus Infections; Female; Herpes Simplex; Herpesviridae Infections; Immunity, Innate; Immunologic Factors; Interferon Inducers; Interferon-alpha; Interferon-beta; Interferons; Mice; Mice, Inbred Strains; Poly I-C; Polylysine; Specific Pathogen-Free Organisms; Survival Analysis

1993
Drug-induced intralysosomal storage of sulfated glycosaminoglycans (GAGs): a methodical pitfall occurring with acridine derivatives.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1994, Volume: 46, Issue:4-5

    Topics: Acridines; Adjuvants, Immunologic; Animals; Cells, Cultured; Fibroblasts; Glycosaminoglycans; Histocytochemistry; Liver; Lymph Nodes; Lysosomal Storage Diseases; Lysosomes; Microscopy, Electron; Microscopy, Fluorescence; Rats; Spleen; Tilorone; Tissue Fixation

1994
Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT.
    International journal of immunopharmacology, 1996, Volume: 18, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acridines; Animals; Antibodies; Antiviral Agents; Asialoglycoproteins; Disease Models, Animal; Drug Synergism; Female; G(M1) Ganglioside; Glucans; Guanosine; Immunologic Factors; In Vitro Techniques; Killer Cells, Natural; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Poly I-C; Poly U; Pyran Copolymer; Rabbits; Rauscher Virus; Specific Pathogen-Free Organisms; Viral Plaque Assay; Zidovudine

1996