Page last updated: 2024-09-03

cl 232468 and mitoxantrone

cl 232468 has been researched along with mitoxantrone in 7 studies

*Mitoxantrone: An anthracenedione-derived antineoplastic agent. [MeSH]

*Mitoxantrone: An anthracenedione-derived antineoplastic agent. [MeSH]

Compound Research Comparison

Studies
(cl 232468)
Trials
(cl 232468)
Recent Studies (post-2010)
(cl 232468)
Studies
(mitoxantrone)
Trials
(mitoxantrone)
Recent Studies (post-2010) (mitoxantrone)
8024,5551,0421,004

Protein Interaction Comparison

ProteinTaxonomycl 232468 (IC50)mitoxantrone (IC50)
Chain A, Probable serine/threonine-protein kinase pknBMycobacterium tuberculosis H37Rv0.8
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))2.049
rac GTPase-activating protein 1 isoform aHomo sapiens (human)14.46
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.5619
Epidermal growth factor receptorHomo sapiens (human)5.3859
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.0352
Tyrosine-protein kinase FynHomo sapiens (human)1.2579
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)4.9898
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.219
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.6441
ATP-dependent translocase ABCB1Homo sapiens (human)1.501
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)2.9987
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.7487
DNA topoisomerase 2-alphaHomo sapiens (human)5.3
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.7853
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)3.5849
Casein kinase II subunit alpha'Homo sapiens (human)0.66
Sodium-dependent noradrenaline transporter Homo sapiens (human)4.9898
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.5619
Multidrug resistance-associated protein 1 Homo sapiens (human)0.0081
Casein kinase II subunit betaHomo sapiens (human)0.66
Casein kinase II subunit alphaHomo sapiens (human)0.66
Tyrosine-protein kinase BTKHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.5849
TAR DNA-binding protein 43Homo sapiens (human)10
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)3.5849
Integrase Human immunodeficiency virus 15.9
Multidrug and toxin extrusion protein 2Homo sapiens (human)0.68
Casein kinase II subunit alpha 3Homo sapiens (human)0.66
Multidrug and toxin extrusion protein 1Homo sapiens (human)0.3733
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.39
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.9038

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19906 (85.71)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Collins, JG; Cutts, SM; Evison, BJ; Kelso, C; Konda, SK; Medan, J; Phillips, DR; Pumuye, PP; Sleebs, BE; Watson, K1
Cornacoff, JB; Dean, JH; House, RV; Pallardy, MJ; Thurmond, LM1
Dean, JH; House, RV2
Cornacoff, JB; Dean, JH; House, RV; Lauer, LD; Thurmond, LM1
Gherson, J; Levine, S1
Durr, FE; Lumanglas, AL; Ruszala-Mallon, VM; Wallace, RE; Wang, BS1

Other Studies

7 other study(ies) available for cl 232468 and mitoxantrone

ArticleYear
Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.
    Bioorganic & medicinal chemistry, 2020, 02-01, Volume: 28, Issue:3

    Topics: Animals; Cattle; DNA; Dose-Response Relationship, Drug; Formaldehyde; Mass Spectrometry; Mitoxantrone; Models, Molecular; Molecular Structure; Structure-Activity Relationship

2020
Suppression of cytolytic function in murine lymphocytes exposed to 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD): inhibition of proliferation by cytotoxic T-lymphocyte precursors.
    International journal of immunopharmacology, 1989, Volume: 11, Issue:3

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Immunologic; Female; Interleukin-5; Interleukins; Kinetics; Lymphocyte Activation; Mice; Mitoxantrone; RNA; Spleen; T-Lymphocytes, Cytotoxic

1989
Target cell specificity of immunosuppression in murine lymphocytes exposed to 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD).
    International journal of immunopharmacology, 1989, Volume: 11, Issue:1

    Topics: Animals; Antigens, Surface; Cytotoxicity, Immunologic; Female; Immunosuppression Therapy; Injections, Intraperitoneal; Interleukin-1; Interleukin-2; Mice; Mitoxantrone; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer

1989
Selective immunosuppression following exposure to a novel anthraquinone, 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD).
    International journal of immunopharmacology, 1989, Volume: 11, Issue:1

    Topics: Animals; Antibody Formation; Female; Immunosuppression Therapy; In Vitro Techniques; Injections, Intraperitoneal; Killer Cells, Natural; Mice; Mitoxantrone; Organ Size; T-Lymphocytes, Cytotoxic; Time Factors; Viral Plaque Assay

1989
Trypanosoma musculi: characterization of the T-lymphocyte dependency of immunity by selective immunomodulation of the mouse, Mus musculus.
    Experimental parasitology, 1988, Volume: 67, Issue:1

    Topics: Animals; Antibodies; Antibodies, Monoclonal; Cyclosporins; Female; Immunosuppressive Agents; Killer Cells, Natural; Kinetics; Mice; Mitoxantrone; T-Lymphocytes; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Trypanosomiasis

1988
Morphologic effects of mitoxantrone and a related anthracenedione on lymphoid tissues.
    International journal of immunopharmacology, 1986, Volume: 8, Issue:8

    Topics: Animals; Female; Lymph Nodes; Lymphocytes; Lymphoid Tissue; Macrophages; Male; Mice; Mitoxantrone; Rats; Rats, Inbred Lew; Spleen

1986
Induction of alloreactive immunosuppression by 1,4-bis [( 2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (CL 232,468).
    International journal of immunopharmacology, 1984, Volume: 6, Issue:5

    Topics: Animals; Anthraquinones; Bone and Bones; Cell Division; Cyclosporins; Immunity, Cellular; Immunosuppressive Agents; Isoantigens; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitoxantrone; Spleen; T-Lymphocytes, Cytotoxic; Time Factors

1984