Page last updated: 2024-09-02

cl 218872 and chlordiazepoxide

cl 218872 has been researched along with chlordiazepoxide in 11 studies

Compound Research Comparison

Studies
(cl 218872)
Trials
(cl 218872)
Recent Studies (post-2010)
(cl 218872)
Studies
(chlordiazepoxide)
Trials
(chlordiazepoxide)
Recent Studies (post-2010) (chlordiazepoxide)
158033,962385104

Protein Interaction Comparison

ProteinTaxonomycl 218872 (IC50)chlordiazepoxide (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.216
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.1
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.9967
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.216
Histamine H1 receptorHomo sapiens (human)1.795
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.216
GABA theta subunitRattus norvegicus (Norway rat)0.216
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.216

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199010 (90.91)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barone, D; Corsico, N; Gallico, L; Luzzani, F; Occelli, E; Tarzia, G; Toja, E1
Albright, JD; Beer, B; Collins, JB; Greenblatt, EN; Lippa, AS; Moran, DB; Wright, WB1
Gardner, CR1
File, SE; Pellow, S; Wilks, L1
Feldman, RS; Fleming, RL; McElroy, JF1
Feldman, RS; McElroy, JF; Meyer, JS1
McElroy, JF; Meyer, JS; Miller, JM1
Spealman, RD1
Gerhardt, S; Liebman, JM; Prowse, J1
Feldman, RS; McElroy, JF1
Mathiasen, LS; Mirza, NR; Rodgers, RJ1

Other Studies

11 other study(ies) available for cl 218872 and chlordiazepoxide

ArticleYear
6-(Alkylamino)-3-aryl-1,2,4-triazolo[3,4-a]phthalazines. A new class of benzodiazepine receptor ligands.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:6

    Topics: Aggression; Animals; Anticonvulsants; Conflict, Psychological; In Vitro Techniques; Ligands; Macaca; Male; Mice; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Species Specificity; Structure-Activity Relationship

1988
Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antihypertensive Agents; Binding, Competitive; Chemical Phenomena; Chemistry; Conflict, Psychological; Diazepam; Male; Pyridazines; Rats; Triazoles

1981
Discriminative stimulus properties of CL218872 and chlordiazepoxide in the rat.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Discrimination Learning; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1989
The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists.
    Psychopharmacology, 1985, Volume: 85, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Convulsants; Flumazenil; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pyrazoles; Pyridazines

1985
A comparison between chlordiazepoxide and CL 218,872--a synthetic nonbenzodiazepine ligand for benzodiazepine receptors on spontaneous locomotor activity in rats.
    Psychopharmacology, 1985, Volume: 85, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Drug Tolerance; Male; Motor Activity; Pyridazines; Rats

1985
A comparison between chlordiazepoxide and CL 218,872, a synthetic non-benzodiazepine ligand for benzodiazepine receptors, on serotonin and catecholamine turnover in brain.
    Psychopharmacology, 1986, Volume: 88, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Biotransformation; Brain; Catecholamines; Chlordiazepoxide; Dihydroxyphenylalanine; Hydrazines; Male; Pyridazines; Rats; Receptors, GABA-A; Serotonin

1986
Comparison of the effects of chlordiazepoxide and CL 218,872 on serum corticosterone concentrations in rats.
    Psychopharmacology, 1987, Volume: 91, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Corticosterone; Injections, Intraventricular; Male; Pyridazines; Rats; Stress, Psychological

1987
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine

1985
Anxiolytic drugs selectively increase preferred duration of rewarding brain stimulation in a shuttlebox test.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Apomorphine; Brain; Chlordiazepoxide; Diazepam; Male; Pentobarbital; Pyridazines; Rats; Rats, Inbred F344; Reaction Time; Reward; Self Stimulation

1982
Generalization between benzodiazepine- and triazolopyridazine-elicited discriminative cues.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:4

    Topics: Amphetamine; Animals; Benzodiazepines; Bicuculline; Chlordiazepoxide; Discrimination Learning; Drug Antagonism; Male; Pentylenetetrazole; Pyridazines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Reinforcement, Psychology; Strychnine

1982
Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Cues; Discrimination Learning; Fluorobenzenes; GABA Modulators; Generalization, Psychological; Male; Piperazines; Protein Subunits; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Triazoles; Zolpidem

2006