cizolirtine has been researched along with substance p in 5 studies
| Studies (cizolirtine) | Trials (cizolirtine) | Recent Studies (post-2010) (cizolirtine) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 22 | 5 | 2 | 17,289 | 277 | 2,010 |
| Protein | Taxonomy | cizolirtine (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aubel, B; Ballet, S; Bourgoin, AS; Cesselin, F; Farré, A; Hamon, M; Mauborgne, A; Poliénor, H | 1 |
| Bauer, R; May, F | 1 |
| Abadías, M; Arañó, P; Conejero, J; Martínez-García, R; Perales, L; Ruíz, JL; Sust, M | 1 |
| Encina, G; Fernández de Henestrosa, AR; Guzmán, A; Marín, AP; Tortajada, A; Vila, C | 1 |
| Encina, G; Guzmán, A; Marín, AP; Tortajada, A; Vila, C | 1 |
1 trial(s) available for cizolirtine and substance p
| Article | Year |
|---|---|
Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study.
Topics: Adult; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Middle Aged; Nausea; Pilot Projects; Pyrazoles; Substance P; Urinary Bladder, Overactive; Urinary Incontinence; Urodynamics; Vision Disorders; Vomiting; Young Adult | 2009 |
4 other study(ies) available for cizolirtine and substance p
| Article | Year |
|---|---|
The novel analgesic, cizolirtine, inhibits the spinal release of substance P and CGRP in rats.
Topics: Acetic Acid; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Aspirin; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Injections, Intraperitoneal; Injections, Spinal; Male; Pain; Potassium; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study.
Topics: Calcitonin Gene-Related Peptide; Female; Humans; Muscarinic Antagonists; Pyrazoles; Substance P; Urinary Bladder, Overactive; Urinary Incontinence | 2009 |
Twenty six-week repeat dose oral rat toxicity study of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator.
Topics: Analgesics; Animals; Body Weight; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drinking; Female; Hydrogen-Ion Concentration; Lipids; Liver; Male; Organ Size; Pyrazoles; Rats; Rats, Sprague-Dawley; Sex Factors; Substance P; Water-Electrolyte Balance | 2021 |
Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator.
Topics: Animals; Calcitonin Gene-Related Peptide; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Pyrazoles; Rats; Rats, Wistar; Rodentia; Substance P | 2022 |