citrulline and sapropterin

citrulline has been researched along with sapropterin in 50 studies

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.00)	18.7374
1990's	25 (50.00)	18.2507
2000's	17 (34.00)	29.6817
2010's	6 (12.00)	24.3611
2020's	1 (2.00)	2.80

Authors

Authors	Studies
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA	1
Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B	1
Datto, GA; Wolff, DJ	1
Böhme, E; John, M; Mayer, B	1
Böhme, E; Heinzel, B; John, M; Mayer, B; Schultz, G; Wachter, H; Werner, ER	1
Förstermann, U; Mitchell, JA; Murad, F; Sheng, H	1
Marletta, MA; Tayeh, MA	1
Figueroa, JP; Massmann, GA	1
Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y	1
Chen, Y; Rosazza, JP	1
Lubeskie, A; Wolff, DJ	1
Hofmann, H; Schmidt, HH	1
Datto, GA; Samatovicz, RA; Wolff, DJ	1
Lincoln, J; Messersmith, WA	1
Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; List, BM; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER	1
Klatt, P; List, BM; Mayer, B; Schmidt, K; Werner, ER	1
Hertelendy, F; Kukor, Z; Mészáros, G; Tóth, M	1
Beasjours, S; Guo, Y; Hussain, SN; Mori, M; Ward, ME	1
Andrade, J; Bedoya, FJ; Conde, M; Ramírez, R; Sobrino, F	1
Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C	1
Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A	1
Hurshman, AR; Marletta, MA; Rusche, KM	1
Gräbner, R; Heller, R; Münscher-Paulig, F; Till, U	1
Ludwig, ML; Marletta, MA	1
Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Pritchard, KA; Vásquez-Vivar, J	1
Cosentino, F; Lüscher, TF	1
Adak, S; Stuehr, DJ; Wang, Q	1
Heller, R; Mayer, B; Schellenberg, B; Unbehaun, A; Werner, ER; Werner-Felmayer, G	1
Hurt, RD; Miller, VM; Severson, SR; Tonnessen, BH	1
Cioffi, FA; d'Ischia, M; Palumbo, A	1
Gräbner, R; Heller, R; Malle, E; Marsche, G; Nuszkowski, A; Unbehaun, A	1
Hecker, R; Maier, J; Ninnemann, H; Rockel, P	1
Conrad, KP; Davis, AK; Novak, J; Powers, RW	1
Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA	1
Marks, N; Wolff, DJ	1
Ishii, M; Kiuchi, Y; Miyasaka, Y; Mori, Y; Nishida, M; Shimizu, S; Shiota, K; Watabe, T; Yamamoto, S; Yamamoto, T	1
Dikshit, M; Raghavan, SA; Sharma, P	1
Cardounel, AJ; Xia, Y; Zweier, JL	1
Heller, R; Werner, ER; Werner-Felmayer, G	1
Abu-Soud, HM; Diamond, MP; Saed, GM; Zhao, M	1
Fekkes, D; Hoekstra, R; Loonen, AJ; Pepplinkhuizen, L; Tuinier, S; Verhoeven, WM	1
Datta, S; Kim, SW; Li, P; Li, X; Pond, WG; Wu, G	1
Boucher, JL; Fournet-Bourguignon, MP; Frapart, Y; Gosgnach, W; Lesage, L; Molez, S; Perrier, E; Reure, H; Royere, E; Vilaine, JP; Villeneuve, N	1
Deutz, NE; Engelen, MP; Luiking, YC	1
Boucher, JL; Mansuy, D; Salard-Arnaud, I; Stuehr, D	1
Cottin, Y; Guilland, JC; Lorin, J; Rochette, L; Vergely, C; Zeller, M	1
Chen, W; Harbeck, MC; He, D; Peng, H; Xie, L; Zhuang, Y	1
Baumgardt, SL; Bosnjak, ZJ; Fang, J; Ge, ZD; Kersten, JR; Leucker, TM; Paterson, M; Warltier, DC; Zhang, DX	1
Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C	1
Aschner, JL; Cunningham, G; Dikalova, A; Fike, CD; Kaplowitz, MR; Summar, M	1

Reviews

5 review(s) available for citrulline and sapropterin

Article	Year
Catalysis by nitric oxide synthase. Current opinion in chemical biology, 1998, Volume: 2, Issue:5 Topics: Antioxidants; Arginine; Biopterins; Catalysis; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Hydrogen Peroxide; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase	1998
A new decoration for nitric oxide synthase - a Zn(Cys)4 site. Structure (London, England : 1993), 1999, Apr-15, Volume: 7, Issue:4 Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Cysteine; Dimerization; Electron Transport; Macromolecular Substances; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Zinc	1999
Tetrahydrobiopterin and endothelial nitric oxide synthase activity. Cardiovascular research, 1999, Aug-01, Volume: 43, Issue:2 Topics: Antioxidants; Arginine; Biopterins; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Vascular Diseases	1999
Regulation of nitric oxide production in health and disease. Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:1 Topics: Animals; Arginase; Arginine; Ascorbic Acid; Biopterins; Citrulline; Diet; Dietary Fats; Endothelium; Humans; Hypertension; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Sepsis	2010
Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects. Molecular nutrition & food research, 2014, Volume: 58, Issue:1 Topics: Adipose Tissue; Arginine; Biological Transport; Biopterins; Cardiovascular Diseases; Cardiovascular System; Citrulline; Diet; Dietary Supplements; Humans; Nitric Oxide Synthase	2014

Other Studies

45 other study(ies) available for citrulline and sapropterin

Article	Year
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages. British journal of pharmacology, 1992, Volume: 107, Issue:4 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins	1992
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. The Biochemical journal, 1992, Feb-01, Volume: 281 ( Pt 3) Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding, Competitive; Biopterins; Brain; Calcium; Calmodulin; Citrulline; Hydrogen Peroxide; NADP; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Swine	1992
Identification and characterization of a calmodulin-dependent nitric oxide synthase from GH3 pituitary cells. The Biochemical journal, 1992, Jul-01, Volume: 285 ( Pt 1) Topics: Amino Acid Oxidoreductases; Animals; Arginine; Autoradiography; Biopterins; Blotting, Western; Brain; Calmodulin; Cattle; Cells, Cultured; Chromatography, DEAE-Cellulose; Citrulline; Enzyme Activation; Kinetics; NADH Dehydrogenase; Nitric Oxide Synthase; Nitroarginine; Nitroblue Tetrazolium; omega-N-Methylarginine; Pituitary Gland	1992
Purification of a Ca2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin. FEBS letters, 1990, Dec-17, Volume: 277, Issue:1-2 Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Calcium; Calmodulin; Cerebellum; Citrulline; Cyclic GMP; Guanylate Cyclase; Molecular Weight; Nitric Oxide Synthase; Swine	1990
Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS letters, 1991, Aug-19, Volume: 288, Issue:1-2 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Spectrophotometry; Swine	1991
Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. British journal of pharmacology, 1991, Volume: 104, Issue:2 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Citrulline; Endothelium, Vascular; In Vitro Techniques; Male; Muscles; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Inbred Strains; Vas Deferens	1991
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33 Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction	1989
Estrogen increases nitric oxide synthase activity in the uterus of nonpregnant sheep. American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:5 Topics: Animals; Biopterins; Calcium; Carbon Radioisotopes; Cell Membrane; Citrulline; Endometrium; Estradiol; Estrus; Female; Kinetics; Myometrium; Nitric Oxide Synthase; Ovariectomy; Radioisotope Dilution Technique; Reference Values; Reproducibility of Results; Sheep; Uterus; Vagina	1995
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. The Journal of biological chemistry, 1994, Aug-26, Volume: 269, Issue:34 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase	1994
A bacterial nitric oxide synthase from a Nocardia species. Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2 Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Calcium; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nocardia; Oxygen	1994
Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase. Archives of biochemistry and biophysics, 1995, Jan-10, Volume: 316, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Calcium; Cattle; Cells, Cultured; Citrulline; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Isoenzymes; Kinetics; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Pituitary Gland; Pulmonary Artery	1995
Thiol dependence of nitric oxide synthase. Biochemistry, 1995, Oct-17, Volume: 34, Issue:41 Topics: Animals; Arginine; Biopterins; Cerebellum; Citrulline; Kinetics; NADP; Nitric Oxide Synthase; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Swine	1995
The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. The Journal of biological chemistry, 1993, May-05, Volume: 268, Issue:13 Topics: Amino Acid Oxidoreductases; Animals; Antifungal Agents; Biopterins; Brain; Calmodulin; Cattle; Citrulline; Clotrimazole; Imidazoles; Ketoconazole; Kinetics; Miconazole; NADH Dehydrogenase; Nitric Oxide Synthase; Pituitary Neoplasms; Rats; Tumor Cells, Cultured	1993
Conditions required for the measurement of nitric oxide synthase activity in a myenteric plexus/smooth muscle preparation from the rat ileum. Journal of neuroscience methods, 1995, Volume: 59, Issue:2 Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Ileum; In Vitro Techniques; Muscle, Smooth; Myenteric Plexus; NADP; Nitric Oxide Synthase; Rats; Rats, Wistar	1995
Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. The Journal of biological chemistry, 1996, Mar-29, Volume: 271, Issue:13 Topics: Animals; Arginine; Binding Sites; Biopterins; Brain; Chromatography, Gel; Circular Dichroism; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Isoenzymes; Light; Macromolecular Substances; Neurons; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Protein Structure, Secondary; Rats; Scattering, Radiation; Thermodynamics	1996
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding. The Biochemical journal, 1996, Apr-01, Volume: 315 ( Pt 1) Topics: Animals; Arginine; Baculoviridae; Biopterins; Brain; Citrulline; Culture Media; Flavins; Heme; Kinetics; Neurons; Nitric Oxide Synthase; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Spodoptera; Tritium	1996
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta. Placenta, 1996, Volume: 17, Issue:1 Topics: Arginine; Biopterins; Calcium; Citrulline; Enzyme Activation; Female; Humans; NADP; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pregnancy	1996
Regulation of cerebellar nitric oxide production in response to prolonged in vivo hypoxia. Journal of neuroscience research, 1997, Jul-01, Volume: 49, Issue:1 Topics: Animals; Arginine; Argininosuccinate Lyase; Biopterins; Cerebellum; Citrulline; Endothelium, Vascular; Enzyme Induction; GTP Cyclohydrolase; Hypoxia, Brain; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger	1997
Nicotinamide inhibits inducible nitric oxide synthase enzyme activity in macrophages by allowing nitric oxide to inhibit its own formation. Life sciences, 1997, Volume: 61, Issue:18 Topics: Animals; Biopterins; Citrulline; Female; Hemoglobins; Macrophages, Peritoneal; Male; Mice; NADP; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; RNA, Messenger	1997
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (New York, N.Y.), 1998, Mar-27, Volume: 279, Issue:5359 Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Isoenzymes; Ligands; Macrophages; Mice; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Protein Folding; Protein Structure, Secondary; Thiourea	1998
Effects of pH on the structure and function of neuronal nitric oxide synthase. The Biochemical journal, 1998, May-01, Volume: 331 ( Pt 3) Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry	1998
L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. The Journal of biological chemistry, 1999, Mar-19, Volume: 274, Issue:12 Topics: Antioxidants; Ascorbic Acid; Biopterins; Calcium; Cells, Cultured; Citrulline; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Enzyme Induction; Free Radicals; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III	1999
Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. The Journal of biological chemistry, 1999, Sep-17, Volume: 274, Issue:38 Topics: Animals; Arginine; Biopterins; Cattle; Citrulline; Electron Spin Resonance Spectroscopy; Models, Chemical; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Superoxides	1999
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism. The Journal of biological chemistry, 2000, Oct-27, Volume: 275, Issue:43 Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction	2000
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1 Topics: Ascorbic Acid; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Humans; Hypoxanthines; Nitric Oxide; Nitric Oxide Synthase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; RNA, Messenger; Solutions; Umbilical Cord	2001
Modulation of nitric-oxide synthase by nicotine. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Citrulline; Dogs; Endothelium, Vascular; Flavin-Adenine Dinucleotide; Male; NADP; Nicotine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins	2000
2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS letters, 2000, Nov-24, Volume: 485, Issue:2-3 Topics: Animals; Antithyroid Agents; Arginine; Binding, Competitive; Biopterins; Cerebellum; Citrulline; Cytochrome c Group; Dimerization; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Thiouracil	2000
Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17 Topics: Antioxidants; Arginine; Biopterins; Blotting, Western; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Citrulline; Cyclic GMP; Cyclodextrins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Golgi Apparatus; Humans; Hypochlorous Acid; Immunoblotting; Immunohistochemistry; Ionomycin; Ionophores; Lipoproteins, LDL; Microscopy, Fluorescence; Myristic Acids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Palmitic Acids; Precipitin Tests; RNA, Messenger; Subcellular Fractions; Sucrose; Time Factors; Umbilical Veins	2001
Role of nitric oxide synthase in the light-induced development of sporangiophores in Phycomyces blakesleeanus. Plant physiology, 2001, Volume: 126, Issue:3 Topics: Biopterins; Citrulline; Culture Media; Enzyme Inhibitors; Light; Nitric Oxide; Nitric Oxide Synthase; Phycomyces; Signal Transduction; Spores, Fungal	2001
Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1 Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Carbon Radioisotopes; Chelating Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Citrulline; Egtazic Acid; Enzyme Inhibitors; Female; Guanidines; Humans; Kidney Cortex; Male; Mice; Mice, Inbred Strains; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Placenta; Rats; Rats, Long-Evans; Tritium	2002
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jan-08, Volume: 99, Issue:1 Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc	2002
The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform. Archives of biochemistry and biophysics, 2002, Nov-01, Volume: 407, Issue:1 Topics: Animals; Antithyroid Agents; Arginine; Biopterins; Calcium; Calmodulin; Carbon Monoxide; Carbon Radioisotopes; Citrulline; Enzyme Activation; Enzyme Inhibitors; Heme; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Neoplasms; Propylthiouracil; Rats; Thiouracil; Tumor Cells, Cultured	2002
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. Free radical biology & medicine, 2003, May-15, Volume: 34, Issue:10 Topics: Animals; Arginine; Biopterins; Blotting, Northern; Brain; Cells, Cultured; Citrulline; DNA Primers; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; GTP Cyclohydrolase; Hydrogen Peroxide; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidants; Reverse Transcriptase Polymerase Chain Reaction	2003
Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes. Biochemical and biophysical research communications, 2003, Sep-12, Volume: 309, Issue:1 Topics: Animals; Ascorbic Acid; Biopterins; Blood Platelets; Citrulline; Dehydroascorbic Acid; Flow Cytometry; Haplorhini; Humans; Iodoacetamide; Male; Neutrophils; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxygen; Rats; Rats, Sprague-Dawley	2003
Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9 Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cell Line; Citrulline; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Humans; Magnetics; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Rats; Spin Trapping; Superoxides; Time Factors; Transfection	2005
Alpha-Tocopherol and endothelial nitric oxide synthesis. Annals of the New York Academy of Sciences, 2004, Volume: 1031 Topics: alpha-Tocopherol; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Serine; Umbilical Veins	2004
Regulation of inducible nitric oxide synthase in post-operative adhesions. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:6 Topics: Animals; Arginine; Biopsy; Biopterins; Citrulline; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tissue Adhesions	2006
Nitric oxide and neopterin in bipolar affective disorder. Neuropsychobiology, 2006, Volume: 54, Issue:1 Topics: Adult; Arginine; Biopterins; Bipolar Disorder; Chi-Square Distribution; Citrulline; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neopterin; Nitric Oxide	2006
Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs. Nitric oxide : biology and chemistry, 2008, Volume: 19, Issue:3 Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Citrulline; Dietary Supplements; Docosahexaenoic Acids; GTP Cyclohydrolase; Liver; Muscle, Skeletal; NADP; Nitric Oxide; Nitric Oxide Synthase; Swine	2008
Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells. Cardiovascular research, 2009, Apr-01, Volume: 82, Issue:1 Topics: Animals; Arginine; Biopterins; Bradykinin; Calcium; Cells, Cultured; Cellular Senescence; Citrulline; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Homeostasis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxides; Swine; Time Factors	2009
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases. Journal of inorganic biochemistry, 2012, Volume: 106, Issue:1 Topics: Animals; Arginine; Bacillus subtilis; Bacteria; Bacterial Proteins; Binding Sites; Biocatalysis; Biopterins; Citrulline; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Peroxide; Imidazoles; Kinetics; Mammals; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Species Specificity; Spectrophotometry	2012
Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation. PloS one, 2015, Volume: 10, Issue:11 Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Cell Survival; Citrulline; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; HEK293 Cells; Humans; Mutation; NADP; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Reactive Oxygen Species; Recombinant Proteins; Serine; Spin Trapping; Superoxides; Vascular Endothelial Growth Factor A	2015
Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice. Circulation. Heart failure, 2016, Volume: 9, Issue:1 Topics: Age Factors; Animals; Biopterins; Cardiotonic Agents; Cells, Cultured; Citrulline; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Isolated Heart Preparation; Mice, Inbred C57BL; Mice, Obese; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Protein Multimerization; Pterins; Time Factors; Vasodilation; Ventricular Function, Left	2016
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling. Journal of inorganic biochemistry, 2018, Volume: 181 Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics	2018
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. American journal of physiology. Lung cellular and molecular physiology, 2020, 04-01, Volume: 318, Issue:4 Topics: Animals; Animals, Newborn; Arginine; Biopterins; Citrulline; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; Swine; Vascular Resistance	2020