citalopram has been researched along with imipramine in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (12.78) | 18.7374 |
| 1990's | 56 (31.11) | 18.2507 |
| 2000's | 53 (29.44) | 29.6817 |
| 2010's | 41 (22.78) | 24.3611 |
| 2020's | 7 (3.89) | 2.80 |
| Authors | Studies |
|---|---|
| Costanzo, MJ; Maryanoff, BE; McComsey, DF; Nortey, SO; Shank, RP; Vaught, JL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Keserü, GM | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Sen, S; Sinha, N | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Peters, JU | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bucki, A; Gryboś, A; Głuch-Lutwin, M; Jastrzębska-Więsek, M; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Pytka, K; Siwek, A; Śniecikowska, J; Wesołowska, A; Więckowski, K | 1 |
| Qin, W; Tian, S; Wold, EA; Xu, Q; Ye, N; Zhen, XC; Zhou, J | 1 |
| Bakshtanovskaia, IV; Kudriavtseva, NN; Madorskaia, IA; Marona-Lewicka, D; Popova, NK; Vetulani, I | 1 |
| Breese, GR; Duncan, GE; Kaldas, RS; Kirkman, JA; Little, KY; Stumpf, WE | 1 |
| Briley, M; Moret, C | 2 |
| Anestis, DK; Gruetter, CA; Lemke, SM; Szarek, JL; Valentovic, MA | 1 |
| Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 3 |
| Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J | 1 |
| Melzacka, M; Nocon, H | 1 |
| Mellerup, ET; Plenge, P | 2 |
| Laursen, H; Mellerup, ET; Plenge, P | 2 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Jaworska, L; Przegalinski, E | 1 |
| Christensen, AV; Geoffroy, M; Scheel-Krüger, J | 1 |
| Esnaud, H; Graham, D; Habert, E; Langer, SZ | 1 |
| Nowak, G | 1 |
| Baran, L; Przegaliński, E; Siwanowicz, J | 1 |
| Galzin, AM; Langer, SZ; Moret, C; Verzier, B | 1 |
| Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A | 1 |
| Bergström, M; Eriksson, K; Marcusson, JO; Ross, SB | 1 |
| Eriksson, K; Marcusson, J | 1 |
| Christensen, P | 1 |
| D'Amato, RJ; Largent, BL; Snowman, AM; Snyder, SH | 1 |
| Abbiati, GA; Angelico, P; Testa, R | 1 |
| D'Amato, RJ; Mayeux, R; Price, DL; Singer, HS; Snyder, SH; Wenk, GL; Whitehouse, PJ; Zweig, RM | 1 |
| Abbiati, G; Ibba, M; Schiavi, S; Testa, R | 1 |
| Lasoń, W; Majeed, NH; Przewłocka, B; Przewłocki, R | 1 |
| Lingjaerde, O | 1 |
| Górka, Z; Mazela, H; Nowak, G; Pawlowski, L | 1 |
| Antkiewicz-Michaluk, L; Rokosz-Pelc, A; Vetulani, J | 2 |
| Bozak, MM; Itil, KZ; Itil, TM; Menon, GN | 1 |
| Constantinidis, J; Dick, P; Tissot, R | 1 |
| Drew, R; Siddik, ZH | 1 |
| Erreboe, I; Mellerup, ET; Plenge, P | 1 |
| Betz, H; Schloss, P | 1 |
| Bastide, P; Coudert, P; Rubat, C; Tronche, P | 1 |
| Auerbach, SB; Hjorth, S; Lundberg, JF | 1 |
| Griebel, G; Jenck, F; Martin, JR; Misslin, R; Moreau, JL | 1 |
| Asou, T; Hayashida, M; Minami, H; Nakane, Y; Tateishi, T; Togita, M; Tsujimura, T | 1 |
| Falkowski, J; Horton, RW; Jacobson, RR; Lawrence, KM | 1 |
| Hietala, J; Kuoppamäki, M; Laakso, A; Pälvimäki, EP; Syvälahti, E | 1 |
| Abel, EL | 1 |
| Baker, GB; Coutts, RT; Su, P | 1 |
| Damsbo, N; Fuglum, E; Horsgård, S; Jacobsen, LV; Rosenberg, C | 1 |
| Layer, RT; Nowak, G; Paul, IA; Popik, P; Skolnick, P | 1 |
| Aaes-Jørgensen, T; Brøsen, K; Gram, LF; Hansen, MG; Overø, KF; Poulsen, JH; Sindrup, SH | 1 |
| Bolwig, TG; Dam, H; Mellerup, ET; Plenge, P | 1 |
| Moryl, E; Papp, M; Przegaliński, E | 1 |
| Descarries, L; Lafaille, F; Mrini, A; Soucy, JP; Tanguay, R | 1 |
| Djärv, L; Montgomery, SA | 1 |
| Artigas, F; Bel, N | 1 |
| Bech, P; Damsbo, N; Fuglum, E; Lauritzen, L; Rosenberg, C; Stage, K | 1 |
| Hietala, J; Kuoppamäki, M; Laakso, A; Majasuo, H; Pälvimäki, EP; Roth, BL; Syvälahti, E | 1 |
| Drujan, Y; Lima, L; Matus, P; Urbina, M | 1 |
| Hayashi-Kuwabara, Y; Ikeda, Y; Izumi, J; Kiuchi, Y; Oguchi, K; Tanaka, Y; Washizuka, M; Yoshinaga, K | 1 |
| DePierre, JW; Nässberger, L; Xia, Z | 1 |
| Bourin, M; Redrobe, JP | 1 |
| Appelkvist, EL; DePierre, JW; Nässberger, L; Xia, Z | 1 |
| Dziedzicka-Wasylewska, M; Klimek, V; Maj, J; Rogoz, R | 1 |
| Balant, L; Busquets, X; Escribá, PV; García-Sevilla, JA; Guimón, J; Walzer, C | 1 |
| Betz, H; Schloss, P; Sur, C | 2 |
| Leander, JD; Wolff, MC | 1 |
| Dziedzicka-Wasylewska, M; Maj, J; Rogoz, R; Rogóz, Z | 1 |
| Evenden, JL | 1 |
| Boyer, PA; Fossom, LH; Skolnick, P | 1 |
| Del Zompo, M; Morelli, M; Pinna, A; Ruiu, S | 1 |
| Nowak, G; Schlegel-Zawadzka, M | 2 |
| Dziedzicka-Wasylewska, M; Rogoz, R | 1 |
| Meyers, BS | 1 |
| Kristensen, AS; Mortensen, OV; Rudnick, G; Wiborg, O | 1 |
| Morelli, M; Pinna, A | 1 |
| Bergstrand, A; DePierre, JW; Nässberger, L; Xia, Z | 1 |
| Papp, M; Sánchez, C | 1 |
| Damberg, M; Ekblom, J; Oreland, L | 1 |
| Bergstrand, A; DePierre, JW; Lundgren, B; Nässberger, L; Xia, Z | 1 |
| Dlaboga, D; Dziedzicka-Wasylewska, M; Góralska, M; Margas, W; Rogóz, Z | 1 |
| Jeanningros, R; Mazzola-Pomietto, P; Moreau, X | 1 |
| Harvey, BH; Rosenberg, R; Volke, V; Wegener, G | 1 |
| DePierre, JW; Karlsson, H; Nässberger, L; Ying, G | 1 |
| Bobula, B; Hess, G; Tokarski, K; Zahorodna, A | 1 |
| Kozela, E; Krawczyk, M; Popik, P | 1 |
| Horschitz, S; Hummerich, R; Schloss, P | 1 |
| Bobula, B; Hess, G; Tokarski, K | 1 |
| Bourin, M; Dailly, E; David, DJ; Hascoët, M; Ripoll, N | 1 |
| Holoubek, G; Müller, WE | 1 |
| Chojnacka-Wójcik, E; Kłodzińska, A; Stachowicz, K; Tatarczyńska, E | 1 |
| Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G | 1 |
| Ehrlichmann, W; Heinz, A; Hummerich, R; Machulla, HJ; Reischl, G; Schloss, P | 1 |
| Janka, Z; Kálmán, J; Kitajka, K; Molnár, J; Pákáski, M; Palotás, A; Palotás, M; Penke, B; Puskás, LG | 1 |
| Calviño, MA; Iscla, IR; Szczupak, L | 1 |
| Feltenstein, MW; Sufka, KJ | 1 |
| Bryan-Lluka, LJ; Pow, DV; Williams, SM | 1 |
| Bjelik, A; Hugyecz, M; Janka, Z; Kálmán, J; Kása, P; Pákáski, M | 1 |
| Baumann, P; Brawand-Amey, M; Brogli, C; Cochard, N; de Mendonça Lima, CA; Eap, CB; Jacquet, S; Powell-Golay, K | 1 |
| Bobula, B; Grzegorzewska, M; Hess, G; Pitra, P; Tokarski, K; Zahorodna, A | 1 |
| Coppinger, D; Maciag, D; Paul, IA; Williams, L | 1 |
| Bourin, M; Chenu, F; Dailly, E | 1 |
| Cano, E; Fraiz, N; Orallo, F; Yáñez, M | 1 |
| Hess, G; Zahorodna, A | 1 |
| Chojnacka-Wójcik, E; Nikiforuk, A; Tatarczyńska, E; Wesołowska, A | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Kuśmider, M | 1 |
| Breuer, ME; Groenink, L; Olivier, B; Oosting, RS; Westenberg, HG | 1 |
| Craig, DA; David, DJ; Dong, D; Gerald, CP; Hegde, LG; Hen, R; Holick, KA; Klemenhagen, KC; Marzabadi, MR; Mendez, I; Ping, XI; Santarelli, L; Saxe, MD; Swanson, CJ; Zhong, H | 1 |
| Boyce, P; Huskic, S; Jones, M; Kellow, JE; Talley, NJ; Tennant, C | 1 |
| Hutson, PH; Murray, F | 1 |
| Bylund, DB; Deupree, JD; Montgomery, MD | 1 |
| Brański, P; Kłak, K; Pałucha, A; Pilc, A; Wierońska, JM | 1 |
| Bylund, DB; Happe, HK; Petty, F; Reed, AL | 1 |
| Del-Ben, CM; Graeff, FG; Pinheiro, SN; Zangrossi, H | 1 |
| Nikiforuk, A; Wesołowska, A | 1 |
| Burke, TF; Hensler, JG; Rossi, DV | 1 |
| Pinhasov, A; Rehavi, M; Reichenstein, M | 1 |
| Garg, R; Kumar, A | 1 |
| Baś, B; Gołembiowska, K; Kowalska, M; Nowak, G; Opoka, W; Pilc, A; Sowa-Kućma, M; Szlósarczyk, M | 1 |
| Fisar, Z; Hroudová, J; Raboch, J | 1 |
| Avissar, S; Golan, M; Schreiber, G | 1 |
| Bevins, RA; Dion, AM; Murrin, LC; Sanderson, SC | 1 |
| Huq, Y; Huston, JP; Komorowski, M; Topic, B; van den Brink, J | 1 |
| Młyniec, K; Nowak, G | 3 |
| De Witte, O; Lefranc, F; Pouleau, HB; Rynkowski, M | 1 |
| Holsboer, F; Perisic, T; Rein, T; Yu, S; Zimmermann, N; Zschocke, J | 1 |
| Huston, JP; Kröger, I; Topic, B; Vildirasova, PG | 1 |
| Anokhin, K; Anthony, DC; Dolgov, O; Kubatiev, A; Schroeter, C; Steinbusch, HM; Strekalova, T | 1 |
| Nowak, G; Pilc, A; Poleszak, E; Popik, P; Siwek, A; Szewczyk, B; Wolak, M | 1 |
| Cadeddu, R; Carboni, E; Ibba, M; Sadile, A | 1 |
| Cho, HY; Kim, JE; Kim, YH; Lee, BJ; Lee, CH; Lee, JG; Park, SW; Seo, MK; Seol, W | 1 |
| Bystrowska, B; Filip, M; Gawliński, D; Pomierny, B; Smaga, I; Stankowicz, P | 1 |
| Niedzielska, E; Nowak, G; Pałucha-Poniewiera, A; Pilc, A; Pomierny, B; Pomierny-Chamioło, L; Siwek, A | 1 |
| Poleszak, E; Serefko, A; Wlaź, P; Wróbel, A | 1 |
| Krakowska, A; Mlyniec, K; Nowak, G; Opoka, W; Ostachowicz, B; Reczynski, W | 1 |
| Gaweł, M; Młyniec, K; Nowak, G | 1 |
| Oniszczuk, A; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wośko, S; Wyska, E | 1 |
| Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X | 1 |
| Amari, E; Dougall, D; Galizia, I; Jones, TN; Lam, RW; Macritchie, K; Massei, GJ; Oldani, L; Yatham, LN; Young, AH | 1 |
| Filip, M; Frankowska, M; Jastrzębska, J; Nowak, E; Przegaliński, E; Suder, A; Wydra, K | 1 |
| Bogatko, K; Doboszewska, U; Dudka, J; Poleszak, E; Serefko, A; Świąder, K; Szopa, A; Wlaź, A; Wlaź, P; Wośko, S; Wróbel, A; Wyska, E | 1 |
| Gruca, P; Lason, M; Litwa, E; Niemczyk, M; Papp, M; Tota-Glowczyk, K; Willner, P | 2 |
| Arias, HR; Drenan, RM; Elgoyhen, AB; Feuerbach, D; Gallino, S; García-Colunga, J; Jin, XT; Ortells, MO; Peng, C | 1 |
| Faron-Górecka, A; Filip, M; Gawlińska, K; Gawliński, D; Smaga, I; Zaniewska, M | 1 |
| Abramyan, AM; Bang-Andersen, B; Gether, U; Loland, CJ; Mørk, A; Plenge, P; Shi, L; Sørensen, G; Weikop, P | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Kusmider, M; Pabian, P; Solich, J | 1 |
| Bazovkina, DV; Evsyukova, VS; Kulikov, AV; Kulikova, EA | 1 |
| Chmielarz, P; Chorązka, K; Kowalska, M; Kuśmierczyk, J; Nalepa, I; Rafa-Zabłocka, K; Satała, G | 1 |
| Adutwum-Ofosu, KK; Amoateng, P; Amponsah, SK; Appiah, F; Begyinah, R; Burns, FB; Ferka, YT; Koomson, AE; Kukuia, KKE; Tagoe, TA | 1 |
| Ebrahimzadeh, H; Hosseini, FS; Kharazmi, F | 1 |
10 review(s) available for citalopram and imipramine
| Article | Year |
|---|---|
Polypharmacology - foe or friend?
Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Topics: Allosteric Regulation; Clinical Trials as Topic; Humans; Ligands; Nervous System Diseases; Piperidines; Receptors, sigma; Sigma-1 Receptor; Small Molecule Libraries | 2020 |
Therapeutic effects of serotonin uptake inhibitors in depression.
Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine | 1986 |
From clomipramine to mianserin: therapeutic relevance of interactions with serotonin uptake and storage, as studied in the blood platelet model.
Topics: Antidepressive Agents; Biological Transport; Blood Platelets; Blood Proteins; Citalopram; Clomipramine; Cytoplasmic Granules; Depression, Chemical; Humans; Imipramine; Kinetics; Propylamines; Protein Binding; Reserpine; Serotonin | 1985 |
Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions.
Topics: Amitriptyline; Animals; Citalopram; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Humans; Imipramine; Isoenzymes; Mixed Function Oxygenases | 1994 |
The antidepressant efficacy of citalopram.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Clinical Trials as Topic; Depressive Disorder; Humans; Imipramine; Meta-Analysis as Topic; Selective Serotonin Reuptake Inhibitors | 1996 |
Depression and dementia: comorbidities, identification, and treatment.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cognition Disorders; Comorbidity; Dementia; Depression; Female; Fluoxetine; Fluvoxamine; Humans; Imipramine; Male; Middle Aged; Moclobemide; Monoamine Oxidase Inhibitors; Neuropsychological Tests; Nortriptyline; Selective Serotonin Reuptake Inhibitors; Sertraline | 1998 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 2016 |
S-adenosyl methionine (SAMe) for depression in adults.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Citalopram; Depression; Humans; Imipramine; Middle Aged; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors | 2016 |
4 trial(s) available for citalopram and imipramine
| Article | Year |
|---|---|
Citalopram and imipramine in the treatment of depressive patients in general practice. A Nordic multicentre clinical study.
Topics: Adolescent; Adult; Aged; Citalopram; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Family Practice; Female; Humans; Imipramine; Long-Term Care; Male; Middle Aged; Netherlands; Patient Care Team; Personality Inventory | 1994 |
Screening and treating depressed patients. A comparison of two controlled citalopram trials across treatment settings: hospitalized patients vs. patients treated by their family doctors. Danish University Antidepressant Group.
Topics: Citalopram; Clomipramine; Depressive Disorder; Family Practice; Female; Humans; Imipramine; Male; Observer Variation; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors | 1996 |
Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Citalopram; Depression; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Male; Middle Aged; Retrospective Studies; Sex Characteristics | 2005 |
Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Female; Follow-Up Studies; Humans; Imipramine; Irritable Bowel Syndrome; Male; Patient Satisfaction; Pilot Projects; Prospective Studies; Treatment Outcome | 2008 |
166 other study(ies) available for citalopram and imipramine
| Article | Year |
|---|---|
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
Topics: Animals; Antidepressive Agents; Biological Assay; Biological Transport; Dose-Response Relationship, Drug; Isoquinolines; Mice; Pyrroles; Rats; Serotonin; Structure-Activity Relationship | 1990 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
Topics: Affect; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Dementia; Dopamine Agonists; Drug Design; Humans; Indoles; Ligands; Models, Molecular; Pyridines; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists | 2017 |
[Experimental model of depression: neurochemical changes and the effects of imipramine and citalopram].
Topics: Animals; Antidepressive Agents; Brain; Catecholamines; Citalopram; Depression; Disease Models, Animal; Imipramine; Mice; Mice, Inbred C57BL; Models, Psychological; Serotonin; Serotonin Antagonists; Stress, Psychological | 1992 |
Autoradiographic characterization of [3H]imipramine and [3H]citalopram binding in rat and human brain: species differences and relationships to serotonin innervation patterns.
Topics: 5,7-Dihydroxytryptamine; Adult; Animals; Autoradiography; Brain; Brain Mapping; Carrier Proteins; Citalopram; Female; Humans; Imipramine; Male; Middle Aged; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Species Specificity; Tritium | 1992 |
Effect of antidepressant drugs on monoamine synthesis in brain in vivo.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Citalopram; Clorgyline; Cyclopropanes; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Haloperidol; Hydrazines; Imipramine; Male; Milnacipran; Norepinephrine; Organ Specificity; Parietal Lobe; Rats; Rats, Wistar; Serotonin; Tyrosine 3-Monooxygenase | 1992 |
Potentiation of 5-hydroxytryptamine-induced contraction in rat aorta by chlorpheniramine, citalopram and fluoxetine.
Topics: Animals; Aorta, Thoracic; Chlorpheniramine; Citalopram; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Histamine H1 Antagonists; Imipramine; In Vitro Techniques; Male; Pargyline; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction | 1992 |
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramine; Isomerism; Male; Maprotiline; Motor Activity; Prazosin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Sulpiride | 1992 |
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Dizocilpine Maleate; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Swimming | 1992 |
Role of calcium channels in effects of antidepressant drugs on responsiveness to pain.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Calcium Channels; Cerebral Cortex; Chlorprothixene; Citalopram; Imipramine; Male; Membranes; Nifedipine; Nitrendipine; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Vasodilator Agents | 1991 |
Effect of some cationic amphiphilic drugs on phospholipid methylation in the central nervous system of rats.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Citalopram; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Methylation; Methyltransferases; Phospholipids; Rats; Rats, Inbred Strains; Synaptic Membranes | 1991 |
[3H]citalopram binding to brain and platelet membranes of human and rat.
Topics: Animals; Binding Sites; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Humans; Imipramine; Kinetics; Neurons; Paroxetine; Piperidines; Rats; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Temperature; Thermodynamics | 1991 |
Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets.
Topics: Animals; Blood Platelets; Brain; Carrier Proteins; Cell Membrane; Citalopram; Half-Life; Humans; Imipramine; In Vitro Techniques; Membrane Proteins; Paroxetine; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins | 1991 |
Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Dizocilpine Maleate; Drug Interactions; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains | 1991 |
The effect of repeated administration of antidepressant drugs on the thyrotropin-releasing hormone (TRH) content of rat brain structures.
Topics: Amitriptyline; Amygdala; Animals; Brain Chemistry; Cerebral Cortex; Citalopram; Corpus Striatum; Hippocampus; Hypothalamus; Imipramine; Male; Mianserin; Nucleus Accumbens; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1990 |
Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine.
Topics: Adolescent; Adult; Aged; Binding, Competitive; Biological Transport; Brain; Citalopram; Female; Humans; Imipramine; Kinetics; Male; Membranes; Middle Aged; Organ Specificity; Paroxetine; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1990 |
Effect of imipramine in the "learned helplessness" model of depression in rats is not mimicked by combinations of specific reuptake inhibitors and scopolamine.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Citalopram; Depression; Drug Synergism; Electroshock; Helplessness, Learned; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Rats; Rats, Inbred Strains; Scopolamine; Thiophenes | 1990 |
A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Binding, Competitive; Biological Transport; Cerebral Cortex; Citalopram; Dose-Response Relationship, Drug; Ethylmaleimide; Fluoxetine; Imipramine; Male; Neurons; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sodium | 1989 |
Long-term effect of antidepressant drugs and electroconvulsive shock (ECS) on cortical alpha 1-adrenoceptors following destruction of dopaminergic nerve terminals.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Citalopram; Dopamine; Electroshock; Hydroxydopamines; Imipramine; Male; Nerve Endings; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1989 |
The effect of repeated treatment with antidepressant drugs on the thyrotropin-releasing hormone (TRH)-induced hyperthermia in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Body Temperature; Citalopram; Imipramine; Male; Mianserin; Mice; Thyrotropin-Releasing Hormone | 1989 |
Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus.
Topics: 5-Methoxytryptamine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Citalopram; Electric Stimulation; Fenclonine; Hypothalamus; Imipramine; Lysergic Acid Diethylamide; Male; Methiothepin; Neurotransmitter Agents; Pargyline; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin | 1985 |
Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes.
Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blood Platelets; Brain; Cell Membrane; Citalopram; Imipramine; In Vitro Techniques; Kinetics; Paroxetine; Piperidines; Propylamines; Rats; Serotonin; Serotonin Antagonists; Synaptic Membranes | 1985 |
High- and low-affinity binding of [3H]imipramine in rat hypothalamus.
Topics: Amitriptyline; Animals; Citalopram; Clomipramine; Cyclopropanes; Hypothalamus; Imipramine; Kinetics; Male; Milnacipran; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Sodium | 1986 |
Characterization of [3H]paroxetine binding in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Citalopram; Fluoxetine; Imipramine; Male; Paroxetine; Peptide Hydrolases; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tritium | 1988 |
Dissociation kinetics of [3H]paroxetine binding to rat brain consistent with a single-site model of the antidepressant binding/5-hydroxytryptamine uptake site.
Topics: Animals; Brain; Cell Membrane; Citalopram; Clomipramine; Imipramine; Kinetics; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Zimeldine | 1988 |
Receptor assay based on 3H-imipramine binding.
Topics: Antidepressive Agents; Binding, Competitive; Blood Platelets; Chromatography, Thin Layer; Citalopram; Clomipramine; Humans; Imipramine; Propylamines; Radioligand Assay | 1987 |
Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cell Membrane; Citalopram; Imipramine; Kinetics; Male; p-Chloroamphetamine; Propylamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tissue Distribution; Tritium | 1987 |
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Imipramine; Male; Nortriptyline; Pain; Propylamines; Rats; Rats, Inbred Strains | 1987 |
Aminergic systems in Alzheimer's disease and Parkinson's disease.
Topics: Alzheimer Disease; Biogenic Amines; Brain; Choline O-Acetyltransferase; Citalopram; Humans; Imipramine; Mazindol; Norepinephrine; Parkinson Disease; Propylamines; Reference Values; Serotonin; Tissue Distribution | 1987 |
Effects of oral administration of nortriptyline, imipramine and citalopram on morphine hot-plate and tail-immersion analgesia in rats.
Topics: Analgesia; Animals; Antidepressive Agents; Citalopram; Drug Interactions; Imipramine; Male; Morphine; Nortriptyline; Propylamines; Rats; Reaction Time | 1987 |
Antidepressants and endogenous opioid peptide systems.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Chlorprothixene; Citalopram; Endorphins; Imipramine; Male; Methotrimeprazine; Pituitary Gland, Anterior; Propylamines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1985 |
Ro 11-2465 (cyan-imipramine), citalopram and their N-desmethyl metabolites: effects on the uptake of 5-hydroxytryptamine and noradrenaline in vivo and related pharmacological activities.
Topics: Animals; Antidepressive Agents; Brain; Citalopram; Drug Interactions; Imipramine; Male; Mice; Norepinephrine; Propylamines; Rats; Rats, Inbred Strains; Reserpine; Serotonin; Thyrotropin-Releasing Hormone; Tyramine | 1985 |
Increase in rat cortical [3H]naloxone binding site density after chronic administration of antidepressant agents.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Chlorprothixene; Citalopram; Imipramine; Kinetics; Male; Methotrimeprazine; Propylamines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Chronic administration of antidepressant drugs increases the density of cortical [3H]prazosin binding sites in the rat.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Binding Sites; Cerebral Cortex; Chlorprothixene; Citalopram; Imipramine; Male; Methotrimeprazine; Prazosin; Propylamines; Quinazolines; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Citalopram; Drug Synergism; Imipramine; Male; Mianserin; Propylamines; Rats; Rats, Inbred Strains; Zimeldine | 1984 |
CNS effects of citalopram, a new serotonin inhibitor antidepressant (a quantitative pharmaco-electroencephalography study).
Topics: Adult; Antidepressive Agents; Brain; Citalopram; Computers; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Humans; Imipramine; Propylamines; Reaction Time; Structure-Activity Relationship; Thiophenes | 1984 |
Antidepressants and serotonin neurons of the raphe.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzofurans; Brain Stem; Citalopram; Clomipramine; Ethers; Fluvoxamine; Imipramine; Indoles; Locus Coeruleus; Male; Microscopy, Fluorescence; Norepinephrine; Oximes; Piperidines; Propylamines; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin | 1981 |
Effect of a specific 5HT uptake inhibitor (citalopram) on drug accumulation by rat lung slices.
Topics: Animals; Benzofurans; Citalopram; Imipramine; In Vitro Techniques; Lung; Male; Norepinephrine; Paraquat; Pharmaceutical Preparations; Propylamines; Rats; Serotonin; Serotonin Antagonists | 1980 |
Differences in brain 5-HT transporter dissociation rates among animal species.
Topics: Adrenergic Uptake Inhibitors; Animals; Biological Transport, Active; Brain Chemistry; Citalopram; Humans; Imipramine; Mice; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Swine | 1995 |
Heterogeneity of antidepressant binding sites on the recombinant rat serotonin transporter SERT1.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Binding, Competitive; Carrier Proteins; Cell Line; Citalopram; Humans; Imipramine; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium | 1995 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine | 1995 |
Differential inhibition of serotonin release by 5-HT and NA reuptake blockers after systemic administration.
Topics: 1-Naphthylamine; Animals; Citalopram; Hippocampus; Imipramine; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Time Factors | 1995 |
Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents.
Topics: Animals; Anxiety; Citalopram; Emotions; Exploratory Behavior; Imipramine; Male; Mice; Motor Activity; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Time Factors | 1994 |
Different effects of antidepressants on dissociation of 3H-imipramine from solubilized binding sites of rat brain.
Topics: Animals; Antidepressive Agents; Binding Sites; Brain; Carrier Proteins; Citalopram; Dose-Response Relationship, Drug; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1994 |
Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine.
Topics: Adult; Biomarkers; Blood Platelets; Cell Membrane; Citalopram; Depressive Disorder; Desipramine; Female; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Paroxetine; Receptors, Serotonin; Sodium | 1993 |
Up-regulation of beta 1-adrenergic receptors in rat brain after chronic citalopram and fluoxetine treatments.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Autoradiography; Brain Chemistry; Citalopram; Fluoxetine; Image Processing, Computer-Assisted; Imipramine; Iodocyanopindolol; Male; Pindolol; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Up-Regulation | 1994 |
Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats.
Topics: Animals; Arousal; Brain; Citalopram; Clonidine; Dose-Response Relationship, Drug; Imipramine; Male; Norepinephrine; Nortriptyline; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, GABA; Reserpine; Serotonin; Yohimbine | 1994 |
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, Drug; Electroshock; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Strychnine; Time Factors; Tritium | 1994 |
Citalopram: interaction studies with levomepromazine, imipramine, and lithium.
Topics: Adult; Citalopram; Drug Interactions; Humans; Imipramine; Lithium; Male; Methotrimeprazine | 1993 |
The serotonin transporter in depressed patients: a qualitative study based on dissociation kinetics.
Topics: Adult; Aged; Blood Platelets; Carrier Proteins; Citalopram; Female; Half-Life; Humans; Imipramine; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Paroxetine; Protein Binding; Serotonin; Serotonin Plasma Membrane Transport Proteins; Statistics, Nonparametric | 1995 |
The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Depressive Disorder; Disease Models, Animal; Imipramine; Male; Rats; Rats, Wistar; Receptors, Serotonin; Time Factors | 1995 |
Evaluation of three transporter ligands as quantitative markers of serotonin innervation density in rat brain.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Citalopram; Corpus Striatum; Densitometry; Imipramine; In Vitro Techniques; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Endings; Nerve Tissue Proteins; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins | 1995 |
In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cerebral Cortex; Citalopram; Clonidine; Desipramine; Fluoxetine; Fluvoxamine; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1996 |
Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.
Topics: Animals; Antidepressive Agents, Tricyclic; Choroid Plexus; Citalopram; Fluoxetine; Imipramine; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors | 1996 |
Synthesis of serotonin from 5-hydroxytryptophan in the post-crush retina: inhibition of in vitro outgrowth by the intraocular administration of the precursor.
Topics: 5-Hydroxytryptophan; Animals; Chromatography, High Pressure Liquid; Citalopram; Goldfish; Hydroxyindoleacetic Acid; Imipramine; Injections; Kinetics; Nerve Crush; Nerve Regeneration; Neurons; Optic Nerve; Organ Culture Techniques; Retina; Serotonin; Time Factors | 1996 |
Protective effect of citalopram against the attenuation of the alpha 1-potentiation of cAMP formation in Fischer 344 strain rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Citalopram; Cyclic AMP; Depression; Imipramine; Male; Motor Activity; Nerve Tissue Proteins; Paroxetine; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha-1; Selective Serotonin Reuptake Inhibitors; Stress, Psychological | 1997 |
Dysregulation of bcl-2, c-myc, and Fas expression during tricyclic antidepressant-induced apoptosis in human peripheral lymphocytes.
Topics: Antidepressive Agents, Tricyclic; Apoptosis; Cell Membrane; Citalopram; Clomipramine; fas Receptor; Gene Expression Regulation; Humans; Imipramine; Lymphocytes; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc | 1996 |
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
Topics: Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Desipramine; Drug Interactions; Fluoxetine; Fluvoxamine; Imipramine; Ketanserin; Male; Maprotiline; Mice; Ondansetron; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 1997 |
Tricyclic antidepressant-induced lipidosis in human peripheral monocytes in vitro, as well as in a monocyte-derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red.
Topics: Antidepressive Agents, Tricyclic; Cell Line; Citalopram; Clomipramine; Flow Cytometry; Fluorescent Dyes; Humans; Imipramine; Lipidoses; Lipopolysaccharide Receptors; Microscopy, Electron; Microscopy, Fluorescence; Monocytes; Oxazines; Spectrometry, Fluorescence | 1997 |
Repeated administration of antidepressant drugs affects the levels of mRNA coding for D1 and D2 dopamine receptors in the rat brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Citalopram; Imipramine; Male; Maprotiline; Norepinephrine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors | 1997 |
Density of guanine nucleotide-binding proteins in platelets of patients with major depression: increased abundance of the G alpha i2 subunit and down-regulation by antidepressant drug treatment.
Topics: Adult; Antidepressive Agents; Blood Platelets; Citalopram; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Down-Regulation; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Humans; Imipramine; Male; Middle Aged; Personality Inventory; Receptors, Adrenergic, alpha-2; Signal Transduction | 1997 |
The rat serotonin transporter: identification of cysteine residues important for substrate transport.
Topics: Alanine; Amino Acid Substitution; Animals; Carrier Proteins; Cell Line; Cell Membrane; Citalopram; Cysteine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Rats; Recombinant Proteins; Serine; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1997 |
Selective serotonin reuptake inhibitors potentiate 8-OH-DPAT-induced stimulus control in the pigeon.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Columbidae; Conditioning, Operant; Discrimination, Psychological; Drug Synergism; Fluoxetine; Generalization, Stimulus; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 1998 |
Distinct effects of imipramine on 5-hydroxytryptamine uptake mediated by the recombinant rat serotonin transporter SERT1.
Topics: Allosteric Site; Animals; Antidepressive Agents, Tricyclic; Biological Transport; Carrier Proteins; Cell Line; Citalopram; Clomipramine; Desipramine; Humans; Imipramine; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium | 1998 |
Effect of antidepressant drugs administered repeatedly on the dopamine D3 receptors in the rat brain.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents; Autoradiography; Brain; Citalopram; Dopamine Agonists; Imipramine; Injections, Subcutaneous; Male; Mianserin; Motor Activity; Nucleus Accumbens; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes | 1998 |
The pharmacology of impulsive behaviour in rats II: the effects of amphetamine, haloperidol, imipramine, chlordiazepoxide and other drugs on fixed consecutive number schedules (FCN 8 and FCN 32).
Topics: Amphetamine; Animals; Chlordiazepoxide; Citalopram; Ethanol; Haloperidol; Imipramine; Impulsive Behavior; Learning; Male; Metergoline; Psychotropic Drugs; Rats; Rats, Sprague-Dawley | 1998 |
Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. A quantitative in situ hybridization study.
Topics: Amygdala; Animals; Antidepressive Agents; Antisense Elements (Genetics); Brain; Cerebellum; Cerebral Cortex; Citalopram; Gene Expression; Hippocampus; Imipramine; In Situ Hybridization; Male; Mice; Neostriatum; Organ Specificity; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamus | 1998 |
Induction of Fos-like-immunoreactivity in the central extended amygdala by antidepressant drugs.
Topics: Adrenergic Uptake Inhibitors; Amygdala; Animals; Antidepressive Agents; Citalopram; Imipramine; Immunohistochemistry; Male; Nerve Tissue Proteins; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 1999 |
Alterations in serum and brain trace element levels after antidepressant treatment: part I. Zinc.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Citalopram; Electroshock; Imipramine; Male; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Zinc | 1999 |
Effects of antidepressant drugs on the dopamine D2/D3 receptors in the rat brain differentiated by agonist and antagonist binding--an autoradiographic analysis.
Topics: Animals; Antidepressive Agents; Autoradiography; Citalopram; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Imipramine; In Vitro Techniques; Ligands; Male; Mianserin; Nucleus Accumbens; Prosencephalon; Protein Binding; Quinpirole; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Time Factors | 1999 |
Molecular cloning, expression and characterization of a bovine serotonin transporter.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1999 |
Antidepressants and atypical neuroleptics induce Fos-like immunoreactivity in the central extended amygdala.
Topics: Amygdala; Animals; Antidepressive Agents; Antipsychotic Agents; Citalopram; Clozapine; Gene Expression Regulation; Genes, fos; Haloperidol; Imipramine; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1999 |
The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation.
Topics: Antidepressive Agents; Apoptosis; Caspase 3; Caspases; Citalopram; Clomipramine; DNA Fragmentation; Flow Cytometry; HL-60 Cells; Humans; Imipramine; In Situ Nick-End Labeling; Leukemia, Promyelocytic, Acute; Reactive Oxygen Species | 1999 |
The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Body Weight; Chronic Disease; Citalopram; Depression; Eating; Imipramine; Indoles; Ligands; Male; Rats; Rats, Wistar; Receptors, sigma; Spiro Compounds; Stress, Psychological; Sucrose | 2000 |
Alterations in serum and brain trace element levels after antidepressant treatment. Part II. Copper.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Cerebellum; Citalopram; Copper; Electroshock; Hippocampus; Imipramine; Male; Rats; Rats, Wistar | 2000 |
Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain Chemistry; Citalopram; DNA; DNA-Binding Proteins; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Imipramine; Lithium; Male; Nuclear Proteins; Oligonucleotide Probes; Rats; Rats, Sprague-Dawley; Transcription Factor AP-2; Transcription Factors | 2000 |
Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L).
Topics: Antidepressive Agents; Apoptosis; bcl-X Protein; Cell Survival; Citalopram; Clomipramine; HL-60 Cells; Humans; Imipramine; Membrane Potentials; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Transfection | 1999 |
Some behavioural effects of antidepressant drugs are time-dependent.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Antidepressive Agents; Cell Membrane; Cerebral Cortex; Citalopram; Clonidine; Drug Administration Schedule; Exploratory Behavior; Imipramine; Male; Motor Activity; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Receptors, Dopamine D3; Synapses; Tetrahydronaphthalenes; Time Factors; Tritium | 2001 |
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brain; Carrier Proteins; Citalopram; Depressive Disorder; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Imipramine; Ketanserin; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Thyroid Gland; Time Factors; Triiodothyronine | 2001 |
Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity.
Topics: Animals; Cells, Cultured; Citalopram; Hippocampus; Imipramine; Male; Microdialysis; Nitric Oxide; Nitroarginine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiazepines; Time Factors | 2003 |
Tricyclic antidepressants prevent the differentiation of monocytes into macrophage-like cells in vitro.
Topics: Antidepressive Agents, Tricyclic; Antigens, Surface; Cell Differentiation; Citalopram; Clomipramine; Humans; Imipramine; Macrophages; Monocytes; Phagocytosis | 2002 |
Adaptive changes in the reactivity of 5-HT1A and 5-HT2 receptors induced in rat frontal cortex by repeated imipramine and citalopram.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Physiological; Administration, Topical; Amphetamines; Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cortical Synchronization; Dose-Response Relationship, Drug; Frontal Lobe; Imipramine; Male; Neurons; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2 | 2003 |
Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram.
Topics: Animals; Antidepressive Agents; Citalopram; Drug Synergism; Hindlimb Suspension; Imipramine; Immobilization; Locomotion; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 2003 |
Functional coupling of serotonin and noradrenaline transporters.
Topics: Amino Acid Sequence; Animals; Antidepressive Agents; Binding, Competitive; Carrier Proteins; Cell Line; Cell Membrane; Citalopram; Fluoxetine; Humans; Imipramine; Immunoblotting; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Recombinant Fusion Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Transfection; Tritium | 2003 |
Repeated administration of antidepressants decreases field potentials in rat frontal cortex.
Topics: Animals; Antidepressive Agents; Citalopram; Electrophysiology; Frontal Lobe; Imipramine; Male; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission | 2003 |
Antidepressant-like effects in various mice strains in the tail suspension test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Citalopram; Depression; Desipramine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Paroxetine; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2003 |
Specific modulation of sigma binding sites by the anxiolytic drug opipramol.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Cell Membrane; Citalopram; Imipramine; Male; Morpholines; Opipramol; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Adrenergic, beta; Receptors, Serotonin, 5-HT2; Receptors, sigma; Swimming | 2003 |
Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Depression; Desipramine; Imipramine; Male; Moclobemide; Monoamine Oxidase Inhibitors; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Swimming | 2004 |
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride | 2004 |
DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer.
Topics: Adrenergic Uptake Inhibitors; Benzylamines; Binding, Competitive; Carbon Isotopes; Carrier Proteins; Cell Line; Citalopram; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Imipramine; Inhibitory Concentration 50; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Recombinant Proteins; Regression Analysis; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors; Tomography, Emission-Computed; Tritium | 2004 |
Gene expression profile analysis of the rat cortex following treatment with imipramine and citalopram.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules; Cell Cycle; Cell Survival; Cerebral Cortex; Citalopram; Gene Expression; Gene Expression Profiling; Imipramine; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission | 2004 |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Citalopram; Drug Interactions; Electric Stimulation; Fluoxetine; Ganglia, Invertebrate; Imipramine; In Vitro Techniques; Interneurons; Leeches; Membrane Potentials; Neural Networks, Computer; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin; Synapses | 2005 |
Screening antidepressants in the chick separation-stress paradigm.
Topics: Animals; Antidepressive Agents; Anxiety, Separation; Chickens; Citalopram; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Imipramine; Maprotiline; Phenelzine; Sleep Wake Disorders; Stress, Psychological | 2005 |
Quantitative analysis of immunolabeling for serotonin and for glutamate transporters after administration of imipramine and citalopram.
Topics: Amino Acid Transport System X-AG; Animals; Brain Chemistry; Citalopram; Evaluation Studies as Topic; Imipramine; Immunohistochemistry; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Serotonin Plasma Membrane Transport Proteins | 2005 |
Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antidepressive Agents, Tricyclic; Basal Nucleus of Meynert; Cells, Cultured; Citalopram; Culture Media, Conditioned; Depressive Disorder; Dose-Response Relationship, Drug; Imipramine; Neurons; Protein Kinase C; Rats; Selective Serotonin Reuptake Inhibitors; Up-Regulation | 2005 |
Repeated administration of citalopram and imipramine alters the responsiveness of rat hippocampal circuitry to the activation of 5-HT7 receptors.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, Drug; Hippocampus; Imipramine; In Vitro Techniques; Male; Phenols; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Time Factors | 2005 |
Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment.
Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Imipramine; Male; Motor Activity; Rats; Rats, Long-Evans; Reproducibility of Results; Sexual Behavior, Animal | 2006 |
Effect of antidepressant drugs on 6-OHDA-treated mice in the FST.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Cerebral Cortex; Citalopram; Depression; Desipramine; Dopamine Uptake Inhibitors; Hippocampus; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Mice; Neostriatum; Oxidopamine; Paroxetine; Swimming | 2007 |
(-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.
Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Clorgyline; Dose-Response Relationship, Drug; Fluoxetine; Humans; Imipramine; Iproniazid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Selegiline; Serotonin; Stilbenes; Synaptosomes; Tritium; Wine | 2006 |
Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Corticosterone; Depression; Frontal Lobe; Imipramine; Male; Models, Animal; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological | 2006 |
Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Citalopram; Desipramine; Drug Interactions; Imipramine; Male; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Phenols; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulfonamides; Swimming | 2007 |
Delayed effects of antidepressant drugs in rats.
Topics: Adrenergic beta-Agonists; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Citalopram; Desipramine; Imipramine; Male; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Selective Serotonin Reuptake Inhibitors; Swimming | 2006 |
Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Imipramine; Male; Olfaction Disorders; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocam
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antimetabolites; Anxiety; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Citalopram; Drug Evaluation, Preclinical; Feeding Behavior; Hippocampus; Imipramine; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Motor Activity; Neurons; Piperidines; Receptors, Somatostatin; Selective Serotonin Reuptake Inhibitors; X-Rays | 2007 |
Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Citalopram; Fluorobenzenes; Hippocampus; Imipramine; Indoles; Male; Mice; Piperazines; Piperidines; Proto-Oncogene Proteins c-bcl-2; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sulfonamides | 2007 |
Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram.
Topics: Animals; Antidepressive Agents; Citalopram; Desipramine; Imipramine; Male; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin Plasma Membrane Transport Proteins | 2007 |
Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cerebral Cortex; Citalopram; Colforsin; Cyclic AMP; Cyclopentanes; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Imipramine; Male; Rats; Receptors, Metabotropic Glutamate; Tricarboxylic Acids | 2007 |
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Topics: Adolescent; Age Factors; Animals; Antidepressive Agents; Child; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Escape Reaction; Fluoxetine; Helplessness, Learned; Humans; Imipramine; Injections, Intraperitoneal; Male; Motivation; Rats; Rats, Sprague-Dawley; Swimming; Tranylcypromine | 2008 |
Anxiolytic and panicolytic effects of escitalopram in the elevated T-maze.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Avoidance Learning; Citalopram; Dose-Response Relationship, Drug; Escape Reaction; Fear; Imipramine; Long-Term Care; Male; Maze Learning; Panic; Rats; Rats, Wistar | 2008 |
The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Bupropion; Citalopram; Dopamine Uptake Inhibitors; Drug Synergism; Imipramine; Injections, Intraperitoneal; Male; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulfonamides | 2008 |
Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding, Competitive; Citalopram; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Imipramine; In Vitro Techniques; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 2008 |
Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Citalopram; Imipramine; Neurons; Paroxetine; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Selective Serotonin Reuptake Inhibitors; Signal Transduction | 2008 |
Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Citalopram; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fatigue Syndrome, Chronic; Imipramine; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Oxidative Stress; Swimming | 2009 |
Chronic treatment with zinc and antidepressants induces enhancement of presynaptic/extracellular zinc concentration in the rat prefrontal cortex.
Topics: Animals; Antidepressive Agents; Citalopram; Extracellular Space; Hippocampus; Humans; Imipramine; Injections, Intraperitoneal; Male; Prefrontal Cortex; Rats; Rats, Wistar; Zinc | 2011 |
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride | 2010 |
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Arrestins; beta-Arrestins; Brain Neoplasms; Cell Line, Tumor; Citalopram; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Glial Cell Line-Derived Neurotrophic Factor; Glioblastoma; Haloperidol; Imipramine; Neurotransmitter Uptake Inhibitors; Phosphorylation; Rats; RNA Interference; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Transcription, Genetic; Transfection; Up-Regulation; Valproic Acid | 2011 |
Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Generalization, Response; Imipramine; Male; Morpholines; Nicotine; Nicotinic Agonists; Norepinephrine Plasma Membrane Transport Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Tobacco Use Disorder | 2012 |
Antidepressants reduce extinction-induced withdrawal and biting behaviors: a model for depressive-like behavior.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Disease Models, Animal; Extinction, Psychological; Imipramine; Male; Rats; Rats, Wistar | 2012 |
Zinc deficiency induces behavioral alterations in the tail suspension test in mice. Effect of antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Citalopram; Depression; Drug Resistance; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Activity; Time Factors; Zinc | 2012 |
Voltage-dependent K+ channels as oncotargets in malignant gliomas.
Topics: Animals; Antidepressive Agents; Apoptosis; Brain Neoplasms; Cell Movement; Citalopram; Drug Resistance; Glioma; Humans; Imipramine; Molecular Targeted Therapy; Potassium Channels, Voltage-Gated | 2012 |
Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels.
Topics: Animals; Antidepressive Agents; Astrocytes; Carbamazepine; Cells, Cultured; Cerebral Cortex; Citalopram; Cyclohexanols; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Glycolipids; Histone-Lysine N-Methyltransferase; Imipramine; Indoles; Maleimides; Mice; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Paroxetine; Protein Interaction Mapping; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Venlafaxine Hydrochloride | 2012 |
Indices of extinction-induced "depression" after operant learning using a runway vs. a cued free-reward delivery schedule.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Citalopram; Conditioning, Operant; Depression; Extinction, Psychological; Imipramine; Male; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Selective Serotonin Reuptake Inhibitors | 2012 |
The differential effects of chronic imipramine or citalopram administration on physiological and behavioral outcomes in naïve mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Citalopram; Drinking; Drug Delivery Systems; Exploratory Behavior; Imipramine; Male; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Psychomotor Performance; Recognition, Psychology; Selective Serotonin Reuptake Inhibitors; Sucrose | 2013 |
GPR39 up-regulation after selective antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Bupropion; Citalopram; Imipramine; Male; Mice; Morpholines; Reboxetine; Receptors, G-Protein-Coupled; Up-Regulation; Zinc | 2013 |
Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Citalopram; Cyclopropanes; Imipramine; Immobility Response, Tonic; Male; Mice; Milnacipran; Morpholines; Motor Activity; N-Methylaspartate; Oxazines; Quinoxalines; Reboxetine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2013 |
Antidepressants share the ability to increase catecholamine output in the bed nucleus of stria terminalis: a possible role in antidepressant therapy?
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Citalopram; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Male; Morpholines; Norepinephrine; Rats, Sprague-Dawley; Reboxetine; Septal Nuclei; Time Factors | 2014 |
Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cell Enlargement; Cells, Cultured; Citalopram; Dendrites; Fluoxetine; Hippocampus; Imipramine; Nerve Tissue Proteins; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Sertraline; Thiazepines; Tranylcypromine | 2014 |
Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
Topics: Acetylcysteine; Amides; Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Brain; Carbamates; Citalopram; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Expectorants; Glycerides; Imipramine; Male; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; Thiazepines | 2014 |
Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors.
Topics: Animals; Antidepressive Agents; Blotting, Western; Brain; Cerebral Cortex; Citalopram; Excitatory Amino Acid Antagonists; Hippocampus; Imipramine; Male; Moclobemide; Morpholines; Pyridines; Radioligand Assay; Rats, Wistar; Reboxetine; Receptor, Metabotropic Glutamate 5; Thiazoles; Tritium | 2014 |
The depressogenic-like effect of acute and chronic treatment with dexamethasone and its influence on the activity of antidepressant drugs in the forced swim test in adult mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Depression; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Imipramine; Male; Mianserin; Mice; Moclobemide; Motor Activity; Neuropsychological Tests; Swimming; Thiazepines | 2014 |
Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice.
Topics: Animals; Antidepressive Agents; Bupropion; Citalopram; Copper; Depression; Disease Models, Animal; Imipramine; Male; Mice; Morpholines; Reboxetine; Sodium Chloride; Zinc | 2014 |
Study of antidepressant drugs in GPR39 (zinc receptor⁻/⁻) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Imipramine; Ketamine; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Activity; Psychological Tests; Reboxetine; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Swimming | 2015 |
Up-regulation of the GPR39 Zn2+-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Bupropion; Citalopram; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Drug Administration Schedule; Frontal Lobe; Imipramine; Male; Mice; Morpholines; Reboxetine; Receptor, trkB; Receptors, G-Protein-Coupled; Signal Transduction; Up-Regulation; Zinc | 2015 |
Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fluoxetine; Imipramine; Mice; Motor Activity; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Treatment Outcome | 2016 |
Effects of escitalopram and imipramine on cocaine reinforcement and drug-seeking behaviors in a rat model of depression.
Topics: Animals; Citalopram; Cocaine; Cocaine-Related Disorders; Cues; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Imipramine; Male; Motor Activity; Olfactory Bulb; Psychotropic Drugs; Rats, Wistar; Reinforcement, Psychology; Self Administration | 2017 |
DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests.
Topics: Adenosine A1 Receptor Antagonists; Animals; Antidepressive Agents; Brain; Citalopram; Depression; Drug Interactions; Drug Therapy, Combination; Hindlimb Suspension; Imipramine; Male; Mice; Motor Activity; Reboxetine; Serotonin Antagonists; Xanthines | 2018 |
Rapid antidepressant effects of deep brain stimulation of the pre-frontal cortex in an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Deep Brain Stimulation; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Imipramine; Male; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological; Venlafaxine Hydrochloride | 2018 |
Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Imipramine; Ketamine; Male; Prefrontal Cortex; Rats; Rats, Inbred WKY; Rats, Wistar; Stress, Psychological; Venlafaxine Hydrochloride | 2019 |
Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Binding, Competitive; Calcium; Citalopram; Habenula; HEK293 Cells; Humans; Imipramine; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Patch-Clamp Techniques; Receptors, Nicotinic; Xenopus | 2019 |
Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT
Topics: Acetylcysteine; Animals; Antidepressive Agents; Autoradiography; Benzamides; Brain; Carbamates; Citalopram; Imipramine; Ketanserin; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Thiazepines | 2019 |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter.
Topics: Allosteric Regulation; Allosteric Site; Animals; Antidepressive Agents; Citalopram; Drug Development; Genetic Engineering; Imipramine; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Protein Conformation; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2020 |
Time-course of changes in key catecholaminergic receptors and trophic systems in rat brain after antidepressant administration.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Citalopram; Desipramine; Imipramine; Male; Membrane Proteins; Rats; Receptor, trkB; Receptors, Adrenergic; Receptors, Catecholamine; Receptors, Dopamine | 2020 |
Acute Administration of Imipramine and Citalopram Increases Activity of Striatal-Enriched Tyrosine Protein Phosphatase (STEP) in Brain of Zebrafish Danio rerio.
Topics: Animals; Antidepressive Agents; Brain; Citalopram; Enzyme Activation; Female; Imipramine; Male; Protein Tyrosine Phosphatases; Zebrafish | 2021 |
Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Fluoxetine; Gene Expression Regulation; Humans; Imipramine; Mianserin; Mice; PC12 Cells; Rats; Reboxetine; Receptors, Adrenergic, alpha-1; Signal Transduction | 2021 |
Increased Brain-Derived Neurotrophic Factor and Hippocampal Dendritic Spine Density Are Associated with the Rapid Antidepressant-like Effect of Iron-citalopram and Iron-Imipramine Combinations in Mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Citalopram; Deferoxamine; Dendritic Spines; Depression; Female; Hippocampus; Imipramine; Mice; Rats; Swimming | 2023 |
Polyvinyl alcohol/citric acid/β-cyclodextrin/CuONP composite nanofibers as an effective and green absorbent for the simultaneous extraction of three antidepressant drugs in biological fluids prior to GC-FID analysis.
Topics: Antidepressive Agents; beta-Cyclodextrins; Chromatography, Gas; Citalopram; Clozapine; Imipramine; Nanofibers; Polyvinyl Alcohol; Spectroscopy, Fourier Transform Infrared | 2023 |