cis-3-4--5-trimethoxy-3--aminostilbene has been researched along with fosbretabulin* in 1 studies
1 other study(ies) available for cis-3-4--5-trimethoxy-3--aminostilbene and fosbretabulin
| Article | Year |
|---|---|
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
A novel class of combretastatins, modified at A-ring or both A- and B-rings, mainly by replacement with benzofuran or benzo[b]thiophene, were synthesized. The new heterocombretastatins showed good cytotoxic activity on BMEC and H-460 cell lines. The aminocombretastatin 9f potently inhibits cell growth of BMEC and combretastatin-resistant HT-29 cell lines, with potential interest to treat colon carcinoma. Heterocombretastatins 9a,b inhibit tubulin polymerization similarly to CA-4 by having a binding to colchicine site five times stronger. Topics: Animals; Binding Sites; Cattle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Endothelial Cells; Humans; Molecular Structure; Stereoisomerism; Stilbenes; Structure-Activity Relationship; Tubulin | 2008 |