ciprofloxacin and novobiocin

ciprofloxacin has been researched along with novobiocin in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (5.33)	18.7374
1990's	14 (18.67)	18.2507
2000's	22 (29.33)	29.6817
2010's	29 (38.67)	24.3611
2020's	6 (8.00)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Angehrn, P; Buchmann, S; Funk, C; Gmuender, H; Goetschi, E; Hebeisen, P; Kostrewa, D; Link, H; Luebbers, T; Masciadri, R; Nielsen, J; Reindl, P; Ricklin, F; Schmitt-Hoffmann, A; Theil, FP	1
Bartels, DJ; Charifson, PS; Grillot, AL; Gross, CH; Grossman, TH; Liao, Y; Mani, N; Mullin, S; Olson, ER; Parsons, JD; Stamos, D	1
Hall, P; Hudock, MP; Leon, A; Liu, L; Morita, CT; Oldfield, E; Puan, KJ; Studer, D; Yang, Y; Yin, F	1
Elkins, CA; Mullis, LB	1
Kwon, DH; Lu, CD	1
Cheung, A; Götz, F; Herbert, S; Meehl, M	1
Beceiro, A; Bou, G; Canle, D; Fernández, A; Lasa, I; Latasa, C; Mallo, S; Molina, F; Pérez, A; Pérez, S; Poza, M; Tomás, Mdel M; Villanueva, R	1
Birch, RG; Hashimi, SM; Huang, G; Maxwell, A	1
Chen, T; Khalil, H; Riffon, R; Wang, R; Wang, Z	1
Chopra, I; Ingham, E; Miller, K; O'Neill, AJ; Wilcox, MH	1
Bammert, GF; Banitt, LS; Barbachyn, MR; Boyle, TP; Bundy, GL; Dolak, LA; Ford, CW; Graber, DR; Hamel, JC; Han, F; Harris, DW; Hromockyj, AE; Hurd, AR; Kamilar, GM; Marotti, KR; Martin, GE; Miller, AA; Mott, JE; Munzner, JB; Palmer, JR; Ruble, JC; Seest, EP; Skepner, JE; Sweeney, MT; Zhong, WZ; Zurenko, GE	1
Long, F; Rouquette-Loughlin, C; Shafer, WM; Yu, EW	1
Bailey, AM; Paulsen, IT; Piddock, LJ	1
Bengoechea, JA; Giménez, P; Llobet, E; March, C	1
Manian, RD; Raghunathan, M; Raghunathan, R; Ramesh, E; Sainath, S	1
Attrée, I; Ducruix, A; El Garch, F; Llanes, C; Muller, C; Phan, G; Plésiat, P; Vettoretti, L	1
Gebreyes, WA; Rajamohan, G; Srinivasan, VB	1
Kamal, N; Shafer, WM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Elkins, CA; Jung, CM; Lacher, DW; Mullis, LB	1
Bavari, S; Bowlin, TL; Houseweart, C; Moir, DT; Opperman, TJ; Panchal, RG; Peet, NP; Williams, JD	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Bohnert, JA; Karamian, B; Nikaido, H	1
Anderson, KC; Kellogg, GE; Sarkar, A	1
Allocco, J; de la Cruz, M; Donald, RG; Dorso, K; Genilloud, O; Goetz, MA; Martín, J; Onishi, R; Phillips, JW; Polishook, J; Salowe, S; Sigmund, J; Singh, SB; Smith, SK; Vicente, F; Wiltsie, J; Zink, DL	1
Chung, TT; Collin, F; Greive, SJ; Karkare, S; Lall, N; Maxwell, A; McKay, AR; Meyer, JJ; Mitchenall, LA	1
Basarab, GS; Bist, S; Boriack-Sjodin, PA; Dangel, B; Eakin, AE; Illingworth, R; Manchester, JI; Sherer, BA; Sriram, S; Uria-Nickelsen, M	1
Genta-Jouve, G; Greff, S; Massi, L; Perez, T; Thomas, OP; Zubia, M	1
Basarab, GS; Brassil, P; Doig, P; Galullo, V; Gowravaram, M; Haimes, HB; Kern, G; Kutschke, A; McNulty, J; Schuck, VJ; Stone, G	1
Bobesh, KA; Chennubhotla, KS; Devi, PB; Janupally, R; Jeankumar, VU; Kulkarni, P; Pulla, VK; Soni, V; Sriram, D; Suryadevara, P; Yogeeswari, P	1
Almayah, AA; Bolandnazar, Z; Ebrahimi, A; Ebrahimi, HP; Hadi, JS; Swadi, AG	1
Brvar, M; Ilaš, J; Kikelj, D; Macut, H; Montalvão, S; Sirc, A; Tammela, P; Tomašič, T; Zidar, N	1
Barančoková, M; Ilaš, J; Kikelj, D; Mirt, M; Tammela, P; Tomašič, T; Zidar, N	1
Alegaon, SG; Salve, PS; Sriram, D	1
Blumstein, AC; Bruyère, T; Bur, D; Chambovey, A; Ertel, EA; Gude, M; Hubschwerlen, C; Jacob, L; Kimmerlin, T; Panchaud, P; Pfeifer, T; Prade, L; Ritz, D; Rueedi, G; Seiler, P	1
Domalaon, R; Gorityala, BK; Goswami, S; Idowu, T; Lyu, Y; Schweizer, F; Shan, A; Yang, X; Zhanel, GG	1
Benedetto Tiz, D; Draskovits, G; Durante Cruz, C; Durcik, M; Ilaš, J; Kikelj, D; Lovison, D; Nyerges, Á; Pál, C; Peterlin Mašič, L; Skok, Ž; Tammela, P; Tomašič, T; Zidar, N	1
Balmond, EI; Blahnik, BJ; Faulkner, KC; Fensterwald, MR; Foss, MH; Heinrich, VA; Hurley, KA; Lammers, MG; Moore, JT; Moore, LC; Rajendran, M; Reynolds, GD; Santos, TMA; Shaw, JT; Shearn-Nance, GP; Stearns, BA; Weibel, DB; Yao, ZW	1
Chu, MJ; Gong, JX; Liu, H; Lv, XH; Ma, QW; Ren, ZL; Wang, JC; Wang, W	1
Cruz, CD; Draskovits, G; Durcik, M; Ilaš, J; Kikelj, D; Mašič, LP; Nyerges, Á; Pál, C; Révész, T; Skok, Ž; Tammela, P; Tiz, DB; Tomašič, T; Zega, A; Zidar, N; Žigon, D	1
Ammeter, D; Idowu, T; Rossong, H; Schweizer, F; Zhanel, GG	1
Amada, H; Endo, M; Hitaka, K; Kamitani, M; Masuko, A; Mihara, Y; Mima, M; Ohtake, N; Sugiyama, H; Takata, I; Takeuchi, T; Tamura, Y; Tanaka-Yamamoto, N; Ushiyama, F; Wada, R	1
Barančoková, M; Benek, O; Cruz, CD; Ilaš, J; Kikelj, D; Lawson, DM; Mašič, LP; Maxwell, A; Mundy, JEA; Skok, Ž; Stevenson, CEM; Tammela, P; Tomašič, T; Zega, A; Zidar, N	1
Abbott, LR; Bury, BKL; Feng, L; Fishwick, CWG; Germe, T; Grossman, S; Jackson, HL; Maxwell, A; McPhillie, MJ; Newell, JF; Orritt, KM; Sutton, JN	1
Angeles-Solano, M; Brock, JW; Grosser, MR; Murphy, KE; Pugh, BA; Rao, AB; Wolfe, AL	1
Nishino, T; Okamoto, S; Okuda, J; Takahata, M	1
Gocke, E	1
Bailly, C; Grimont, F; Llanes, C; Michel-Briand, Y; Thouverez, M	1
Forterre, P; Sioud, M	1
Elie, C; Forterre, P; Possot, O; Sibold, L; Sioud, M	1
Bia, FJ; Divo, AA; Patton, CL; Sartorelli, AC	1
Grosse, F; Hussy, P; Maass, G; Schomburg, U; Tümmler, B	1
Landman, D; Mobarakai, N; Quale, JM	1
Cooper, B; Freeman, C; Mazens-Sullivan, M; Nightingale, C; Quintiliani, R; Robinson, A	1
Fraimow, HS; French, P; Venuti, E	1
Buchrieser, C; Kaspar, CW	1
Howard, BM; Pinney, RJ; Smith, JT	2
Erdem, I; Korten, V; Murray, BE	1
Garcia, R; Raad, I	1
Muszynski, MJ; Rajyaguru, JM	1
Canawati, HN; Montgomerie, JZ; Schick, DG	1
Chen, SN; Lee, KK; Liu, PC	1
Evers, S; Gmuender, H; Gray, CP; Keck, W; Kuratli, K	1
Heinrichs, A	1
Jain, P; Nagaraja, V	1
Boudabous, A; Cekaite, L; Sioud, M	1
Asiimwe, BB; Asiimwe, J; Boom, WH; Joloba, ML; Katabazi, FA; Kateete, DP; Kyobe, S; Musinguzi, C; Okee, M; Okeng, A	1
Klesius, PH; Pridgeon, JW; Yildirim-Aksoy, M	1
Corcoran, MA; Hooper, DC; Jacoby, GA; Vinué, L	1
Bloodworth, RA; Cardona, ST; Choy, M; Gislason, AS; Li, X; Qu, W; Stietz, MS; Zhang, C	1
Dages, K; Dages, S; Leng, F; Zhi, X	1
Abdelazeem, AH; Cao, Y; Frejat, FOA; Gomaa, HAM; Wang, L; Wu, C; Youssif, BGM; Zhai, H	1
Ebrahimzadeh, F; Gholami, S; Jafari-Sales, A; Rostami, A; Zadeh, FA	1

Reviews

2 review(s) available for ciprofloxacin and novobiocin

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
Globally Vibrio cholera antibiotics resistance to RNA and DNA effective antibiotics: A systematic review and meta-analysis. Microbial pathogenesis, 2022, Volume: 172 Topics: Anti-Bacterial Agents; Cephalothin; Cholera; Cholera Toxin; Ciprofloxacin; Drug Resistance, Bacterial; Furazolidone; Gatifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Nalidixic Acid; Nitrofurantoin; Norfloxacin; Novobiocin; Rifampin; Vibrio cholerae; Virulence Factors	2022

Article

Year

Membrane transporters in drug development.

Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Globally Vibrio cholera antibiotics resistance to RNA and DNA effective antibiotics: A systematic review and meta-analysis.

Microbial pathogenesis, 2022, Volume: 172

Topics: Anti-Bacterial Agents; Cephalothin; Cholera; Cholera Toxin; Ciprofloxacin; Drug Resistance, Bacterial; Furazolidone; Gatifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Nalidixic Acid; Nitrofurantoin; Norfloxacin; Novobiocin; Rifampin; Vibrio cholerae; Virulence Factors

2022

Other Studies

73 other study(ies) available for ciprofloxacin and novobiocin

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6 Topics: Animals; Anti-Bacterial Agents; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Gram-Positive Bacteria; HeLa Cells; Humans; Lactams; Lactones; Mice; Microbial Sensitivity Tests; Models, Molecular; Oxadiazoles; Peptides, Cyclic; Protein Subunits; Staphylococcal Infections; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors; Toxicity Tests	2004
Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Anti-Bacterial Agents; Benzimidazoles; DNA Topoisomerase IV; Drug Design; Escherichia coli; Microbial Sensitivity Tests; Mutation; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Topoisomerase II Inhibitors; Urea	2007
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25 Topics: Anti-Bacterial Agents; Cluster Analysis; Diphosphonates; Drug Synergism; Escherichia coli K12; Fosfomycin; Gene Expression; Geranyltranstransferase; Models, Molecular; Oligonucleotide Array Sequence Analysis; Quantitative Structure-Activity Relationship; Terpenes	2006
Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:3 Topics: Anti-Bacterial Agents; Bacterial Proteins; Binding, Competitive; Carrier Proteins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Indicators and Reagents; Microbial Sensitivity Tests; Progesterone; Steroids	2007
Polyamine effects on antibiotic susceptibility in bacteria. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Drug Resistance, Bacterial; Drug Synergism; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Polyamines; Spermine; Staphylococcus aureus	2007
Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Gene Expression Regulation, Bacterial; Humans; Microbial Sensitivity Tests; Polymyxin B; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance	2007
Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Bacterial Proteins; Base Sequence; beta-Lactamases; Carrier Proteins; Cloning, Molecular; DNA, Bacterial; Drug Resistance, Bacterial; Enterobacter cloacae; Enterobacteriaceae Infections; Genes, MDR; Genetic Vectors; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Porins	2007
DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Cloning, Molecular; Computational Biology; DNA Gyrase; DNA, Superhelical; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Molecular Sequence Data; Organic Chemicals; Sequence Analysis, DNA; Xanthomonas	2008
Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbenicillin; Ceftazidime; Ciprofloxacin; Drug Resistance, Bacterial; Drug Synergism; Humans; Microbial Sensitivity Tests; Novobiocin; Ofloxacin; Piperacillin; Polyethyleneimine; Pseudomonas aeruginosa; Pseudomonas Infections; Rifampin; Ticarcillin; Tobramycin	2008
Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6 Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fusidic Acid; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Oxazolidinones; Recombination, Genetic; Rifampin; RNA, Ribosomal, 23S; Staphylococcus aureus; Time Factors	2008
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Bacteria; Bacterial Infections; Bacterial Proteins; Cell Line; Cell Proliferation; Metabolic Clearance Rate; Mice; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Stereoisomerism; Topoisomerase II Inhibitors	2008
Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9 Topics: Anti-Bacterial Agents; Antiporters; ATP-Binding Cassette Transporters; Bacterial Proteins; Cloning, Molecular; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Ethidium; Fluorescence Polarization; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Norfloxacin	2008
RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Anti-Bacterial Agents; Antipsychotic Agents; Bacterial Proteins; Base Sequence; Chlorpromazine; DNA Primers; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Synergism; Ethidium; Gene Expression; Genes, Bacterial; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Oligonucleotide Array Sequence Analysis; Phenothiazines; Salmonella typhimurium; Trans-Activators	2008
Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Outer Membrane Proteins; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Klebsiella pneumoniae; Mutation	2009
Synthesis and antibacterial property of quinolines with potent DNA gyrase activity. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Anti-Bacterial Agents; Ciprofloxacin; Escherichia coli; Microbial Sensitivity Tests; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors	2009
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactams; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Sputum	2009
Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Topics: Acinetobacter baumannii; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Membrane Transport Proteins; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Homology, Amino Acid	2009
Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Hemolysin Proteins; Humans; Microbial Sensitivity Tests; Neisseria meningitidis	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Animals; Anti-Bacterial Agents; Catfishes; Cattle; Disease Reservoirs; Escherichia coli; Escherichia coli Proteins; Feces; Gene Expression Regulation, Bacterial; Intestines; Mice; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Mutation; Phylogeny; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Rats; Recombination, Genetic; Sequence Analysis, DNA; Structure-Activity Relationship	2010
Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Bacterial Proteins; Drug Resistance, Bacterial; Indoles; Microbial Sensitivity Tests; Mutation; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus; Structure-Activity Relationship; Substrate Specificity	2010
Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9 Topics: Anti-Bacterial Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlortetracycline; Dipeptides; Doxorubicin; Doxycycline; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Minocycline; Onium Compounds; Organophosphorus Compounds; Tetracycline	2010
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. European journal of medicinal chemistry, 2012, Volume: 52 Topics: Anti-Bacterial Agents; beta-Lactams; Computational Biology; Drug Resistance, Bacterial; Hydrophobic and Hydrophilic Interactions; Ligands; Membrane Transport Proteins; Microbial Sensitivity Tests; Models, Molecular; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Regression Analysis; Thermodynamics	2012
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. Bioorganic & medicinal chemistry letters, 2012, Dec-01, Volume: 22, Issue:23 Topics: Actinomycetales; Aminoglycosides; Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Enzyme Inhibitors; Escherichia coli; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Conformation; Naphthalenes; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors	2012
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. The Journal of biological chemistry, 2013, Feb-15, Volume: 288, Issue:7 Topics: Adenosine Triphosphate; Anti-Infective Agents; Binding Sites; Catalytic Domain; DNA; DNA Gyrase; Escherichia coli; Humans; Inhibitory Concentration 50; Mass Spectrometry; Models, Chemical; Mycobacterium tuberculosis; Naphthoquinones; Protein Binding; Protein Structure, Tertiary; Staphylococcus aureus; Surface Plasmon Resonance; Tuberculosis	2013
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21 Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Bacteria; Disease Models, Animal; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Discovery; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Staphylococcal Infections; Structure-Activity Relationship; Topoisomerase II Inhibitors; Urea	2013
Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis. Journal of natural products, 2014, May-23, Volume: 77, Issue:5 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Antifungal Agents; Cyclopentanes; Humans; Hydrocarbons, Brominated; Indian Ocean; Molecular Structure; Rhodophyta	2014
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. Journal of medicinal chemistry, 2014, Nov-13, Volume: 57, Issue:21 Topics: Animals; Anti-Bacterial Agents; Barbiturates; Female; Fluoroquinolones; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitory Concentration 50; Isoxazoles; Male; Mice; Pyridones; Rats, Wistar; Spiro Compounds; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors	2014
Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; DNA Gyrase; Female; HEK293 Cells; Humans; Mice; Models, Molecular; Staphylococcal Infections; Staphylococcus aureus; Topoisomerase II Inhibitors; Zebrafish	2014
Metal-based biologically active azoles and β-lactams derived from sulfa drugs. Bioorganic & medicinal chemistry, 2016, Mar-01, Volume: 24, Issue:5 Topics: Anti-Bacterial Agents; Azoles; Bacteria; Bacterial Infections; beta-Lactams; Coordination Complexes; Humans; Ligands; Microbial Sensitivity Tests; Models, Molecular; Schiff Bases; Sulfamethoxazole; Sulfathiazole; Sulfathiazoles	2016
New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase. European journal of medicinal chemistry, 2016, Jul-19, Volume: 117 Topics: Amides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Indoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors	2016
Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors. Bioorganic & medicinal chemistry, 2017, 01-01, Volume: 25, Issue:1 Topics: Acetanilides; Anti-Bacterial Agents; Benzothiazoles; Drug Design; Enterococcus faecalis; Escherichia coli; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Pseudomonas aeruginosa; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors	2017
Three-component, one-pot synthesis of anthranilamide Schiff bases bearing 4-aminoquinoline moiety as Mycobacterium tuberculosis gyrase inhibitors. Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8 Topics: Aminoquinolines; Animals; Antitubercular Agents; DNA Gyrase; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; ortho-Aminobenzoates; Schiff Bases; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tuberculosis; Vero Cells	2017
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. Journal of medicinal chemistry, 2017, 05-11, Volume: 60, Issue:9 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Drug Discovery; Gram-Negative Bacteria; Half-Life; Hydrogen Bonding; Isoquinolines; Microbial Sensitivity Tests; Potassium Channels; Rats; Respiratory Tract Infections; Solubility; Urea	2017
Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. Journal of medicinal chemistry, 2017, 05-11, Volume: 60, Issue:9 Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Lysine; Microbial Sensitivity Tests; Minocycline; Models, Biological; Rifampin; Tobramycin	2017
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity. European journal of medicinal chemistry, 2018, Jun-25, Volume: 154 Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors	2018
Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase. MedChemComm, 2017, Volume: 8, Issue:5 Topics:	2017
Novel coumarin-pyrazole carboxamide derivatives as potential topoisomerase II inhibitors: Design, synthesis and antibacterial activity. European journal of medicinal chemistry, 2018, Sep-05, Volume: 157 Topics: Anti-Bacterial Agents; Coumarins; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Humans; Listeria monocytogenes; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Salmonella; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors	2018
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors. European journal of medicinal chemistry, 2019, Apr-01, Volume: 167 Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrrolidines; Topoisomerase II Inhibitors	2019
Homodimeric Tobramycin Adjuvant Repurposes Novobiocin as an Effective Antibacterial Agent against Gram-Negative Bacteria. Journal of medicinal chemistry, 2019, 10-24, Volume: 62, Issue:20 Topics: Anti-Bacterial Agents; Dimerization; Gram-Negative Bacteria; Novobiocin; Tobramycin	2019
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorganic & medicinal chemistry, 2020, 11-15, Volume: 28, Issue:22 Topics: Anti-Bacterial Agents; Cell Survival; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Hep G2 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quinolines; Streptococcus pneumoniae; Structure-Activity Relationship; Topoisomerase II Inhibitors; Transcriptional Regulator ERG; Vancomycin-Resistant Enterococci	2020
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors. ACS medicinal chemistry letters, 2020, Dec-10, Volume: 11, Issue:12 Topics:	2020
RSC medicinal chemistry, 2022, Jul-20, Volume: 13, Issue:7 Topics:	2022
Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. RSC medicinal chemistry, 2022, Sep-21, Volume: 13, Issue:9 Topics:	2022
Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type II; DNA, Superhelical; Drug Resistance, Microbial; Fluoroquinolones; Methicillin Resistance; Microbial Sensitivity Tests; Novobiocin; Quinolones; Staphylococcus aureus; Topoisomerase II Inhibitors	1991
Mechanism of quinolone mutagenicity in bacteria. Mutation research, 1991, Volume: 248, Issue:1 Topics: Anti-Infective Agents; Blotting, Southern; Ciprofloxacin; DNA Topoisomerases, Type II; Enrofloxacin; Escherichia coli; Fleroxacin; Fluoroquinolones; Genes, Bacterial; Mutation; Novobiocin; Ofloxacin; Oxolinic Acid; Quinolones; Salmonella	1991
Stability of conjugative and non-conjugative R-plasmids from Serratia marcescens to gyrase inhibitors. Microbiologica, 1990, Volume: 13, Issue:2 Topics: Ciprofloxacin; Conjugation, Genetic; DNA, Bacterial; Novobiocin; R Factors; Serratia marcescens; Topoisomerase II Inhibitors	1990
Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium. Biochemistry, 1989, May-02, Volume: 28, Issue:9 Topics: Ciprofloxacin; DNA Damage; Etoposide; Halobacterium; Novobiocin; Plasmids	1989
Coumarin and quinolone action in archaebacteria: evidence for the presence of a DNA gyrase-like enzyme. Journal of bacteriology, 1988, Volume: 170, Issue:2 Topics: Aminocoumarins; Anti-Bacterial Agents; Archaea; Autoradiography; Bacteria; Ciprofloxacin; Coumarins; DNA Replication; DNA Topoisomerases, Type II; Drug Interactions; Electrophoresis, Agar Gel; Euryarchaeota; Halobacterium; Novobiocin; Plasmids	1988
Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:8 Topics: Aminocoumarins; Animals; Anti-Infective Agents; Chloroquine; Ciprofloxacin; Coumarins; Drug Interactions; Drug Resistance; Enoxacin; Fluoroquinolones; Nalidixic Acid; Norfloxacin; Novobiocin; Ofloxacin; Oxolinic Acid; Pefloxacin; Plasmodium falciparum; Tetracycline; Topoisomerase II Inhibitors	1988
Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:6 Topics: Cell Division; Cell Line; Ciprofloxacin; DNA Polymerase II; DNA Topoisomerases, Type I; DNA, Bacterial; Electrophoresis, Agar Gel; Humans; Lymphocytes; Novobiocin; Ofloxacin; Oxazines; Quinolines; Spheroplasts; Thymus Gland	1986
Treatment of experimental endocarditis due to multidrug resistant Enterococcus faecium with ciprofloxacin and novobiocin. The Journal of antimicrobial chemotherapy, 1994, Volume: 34, Issue:5 Topics: Animals; Ciprofloxacin; Drug Therapy, Combination; Endocarditis, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Microbial Sensitivity Tests; Novobiocin; Rabbits	1994
In vitro antimicrobial susceptibility of glycopeptide-resistant enterococci. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Depsipeptides; Drug Resistance, Microbial; Enterococcus; Fluoroquinolones; Fusidic Acid; Microbial Sensitivity Tests; Minocycline; Naphthyridines; Novobiocin; Peptides, Cyclic; Quinolones; Teicoplanin; Vancomycin; Virginiamycin	1995
In vitro activity of novobiocin against multiresistant strains of Enterococcus faecium. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Drug Resistance, Microbial; Enterococcus faecium; Novobiocin; Ofloxacin	1993
An improved direct viable count for the enumeration of bacteria in milk. International journal of food microbiology, 1993, Volume: 20, Issue:4 Topics: Animals; Bacteria; Cell Division; Ciprofloxacin; Colony Count, Microbial; Food Microbiology; Milk; Mitomycin; Nalidixic Acid; Novobiocin	1993
Antagonism between bactericidal activities of 4-quinolones and coumarins gives insight into 4-quinolone killing mechanisms. Microbios, 1994, Volume: 77, Issue:311 Topics: Aminocoumarins; Anti-Infective Agents; Ciprofloxacin; Coumarins; DNA Topoisomerases, Type II; Escherichia coli; Genes, Bacterial; Microbial Sensitivity Tests; Mutation; Nalidixic Acid; Norfloxacin; Novobiocin; Ofloxacin; Rifampin	1994
Studies on mutational cross-resistance between ciprofloxacin, novobiocin and coumermycin in Escherichia coli and Staphylococcus warneri. Microbios, 1993, Volume: 75, Issue:304 Topics: Aminocoumarins; Ciprofloxacin; Coumarins; Drug Resistance, Microbial; Escherichia coli; Mutation; Novobiocin; Phenotype; Staphylococcus	1993
Bactericidal activity of the fluoroquinolone DU-6859a alone and in combination with other antimicrobial agents against multiresistant enterococci. Diagnostic microbiology and infectious disease, 1996, Volume: 26, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Ciprofloxacin; DNA Gyrase; DNA Topoisomerases, Type II; Drug Antagonism; Drug Combinations; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Synergism; Enterococcus; Fluoroquinolones; Genetic Variation; Gentamicins; Lactams; Microbial Sensitivity Tests; Novobiocin; Quinolones; Rifampin	1996
In vitro study of the potential role of quinupristin/dalfopristin in the treatment of catheter-related staphylococcal infections. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:12 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Bacteremia; Catheterization, Central Venous; Cefamandole; Cephalosporins; Ciprofloxacin; Clindamycin; Daptomycin; Humans; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Neoplasms; Novobiocin; Oxacillin; Penicillins; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Teicoplanin; Vancomycin; Virginiamycin	1996
Enhancement of Burkholderia cepacia antimicrobial susceptibility by cationic compounds. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:3 Topics: 1-Naphthylamine; Anti-Infective Agents; Azithromycin; Bacterial Outer Membrane Proteins; Burkholderia cepacia; Cations; Ceftazidime; Cell Membrane Permeability; Ciprofloxacin; Clarithromycin; Fleroxacin; Fluorescent Dyes; Fluoroquinolones; Gentamicins; Magnesium; Microbial Sensitivity Tests; Microscopy, Electron; Novobiocin; Oxolinic Acid; Polysaccharides, Bacterial; Tobramycin	1997
In vitro activity of the combination of trovafloxacin and other antibiotics against enterococci. Diagnostic microbiology and infectious disease, 1997, Volume: 29, Issue:4 Topics: Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Enterococcus; Enterococcus faecalis; Fluoroquinolones; Gentamicins; Humans; Microbial Sensitivity Tests; Naphthyridines; Novobiocin; Rifampin; Sulbactam; Teicoplanin; Vancomycin	1997
Susceptibility of different isolates of Vibrio harveyi to antibiotics. Microbios, 1997, Volume: 91, Issue:368-369 Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Ciprofloxacin; Decapoda; Doxycycline; Drug Resistance, Microbial; Erythromycin; Fish Diseases; Fishes; Microbial Sensitivity Tests; Nalidixic Acid; Nitrofurantoin; Novobiocin; Oxolinic Acid; Oxytetracycline; Penicillins; Seawater; Streptomycin; Sulfonamides; Vancomycin; Vibrio; Vibrio Infections; Water Microbiology	1997
Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis. Genome research, 2001, Volume: 11, Issue:1 Topics: Bacterial Proteins; Ciprofloxacin; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Haemophilus influenzae; Novobiocin; Protein Biosynthesis; Reproducibility of Results; RNA, Bacterial; RNA, Messenger; Sensitivity and Specificity; Topoisomerase II Inhibitors; Transcription, Genetic	2001
Ups and downs. Trends in molecular medicine, 2001, Volume: 7, Issue:3 Topics: Anti-Bacterial Agents; Ciprofloxacin; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Haemophilus influenzae; Novobiocin; Protein Biosynthesis; RNA, Bacterial; RNA, Messenger; Transcription, Genetic; Up-Regulation	2001
An atypical type II topoisomerase from Mycobacterium smegmatis with positive supercoiling activity. Molecular microbiology, 2005, Volume: 58, Issue:5 Topics: Ciprofloxacin; DNA Topoisomerases, Type II; DNA, Superhelical; Electrophoresis; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Mycobacterium smegmatis; Novobiocin; Phylogeny; Topoisomerase II Inhibitors	2005
Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs. International journal of molecular medicine, 2009, Volume: 23, Issue:1 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacillus subtilis; Bacillus thuringiensis; Ciprofloxacin; DNA; DNA Gyrase; Etoposide; Gene Expression Regulation; Novobiocin; Plasmids; SOS Response, Genetics; Transcription, Genetic	2009
Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis. PloS one, 2012, Volume: 7, Issue:9 Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Ciprofloxacin; Drug Resistance, Bacterial; Gene Knockout Techniques; Genetic Complementation Test; Mycobacterium smegmatis; Novobiocin; Peptide Hydrolases; Phenotype; Providencia	2012
Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. Vaccine, 2013, Apr-26, Volume: 31, Issue:18 Topics: Aeromonas hydrophila; Animals; Bacterial Vaccines; Ciprofloxacin; Drug Resistance, Bacterial; Edwardsiella tarda; Fish Diseases; Gossypol; Ictaluridae; Novobiocin; Proflavine; Streptococcus; Tilapia; Vaccines, Attenuated; Virulence	2013
Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1. Antimicrobial agents and chemotherapy, 2015, Dec-28, Volume: 60, Issue:3 Topics: Anti-Bacterial Agents; Bacterial Proteins; Ciprofloxacin; DNA Gyrase; DNA-Binding Proteins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Lipopolysaccharides; Lipoproteins; Membrane Proteins; Membrane Transport Proteins; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Novobiocin; Porins; Repressor Proteins; Trans-Activators; Transcription Factors	2015
Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepacia. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:1 Topics: Anti-Bacterial Agents; Burkholderia cenocepacia; Chloramphenicol; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Hydrazones; Kanamycin; Meropenem; Microbial Sensitivity Tests; Novobiocin; Tetracycline; Thienamycins	2017
Inhibition of the gyrA promoter by transcription-coupled DNA supercoiling in Escherichia coli. Scientific reports, 2018, 10-03, Volume: 8, Issue:1 Topics: Anti-Bacterial Agents; Base Sequence; beta-Galactosidase; Chromosomes, Bacterial; Ciprofloxacin; DNA Gyrase; DNA, Bacterial; DNA, Superhelical; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Reporter; Isopropyl Thiogalactoside; Luciferases; Models, Genetic; Novobiocin; Plasmids; Promoter Regions, Genetic; Transcription, Genetic	2018
New 1,2,4-oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity. Archiv der Pharmazie, 2022, Volume: 355, Issue:7 Topics: Anti-Bacterial Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Escherichia coli; Microbial Sensitivity Tests; Novobiocin; Oxadiazoles; Pyrrolidines; Structure-Activity Relationship; Topoisomerase II Inhibitors	2022