ciprofloxacin and ly-146032

ciprofloxacin has been researched along with ly-146032 in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (54.17)29.6817
2010's11 (45.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Appelbaum, PC; Bhawsar, SB; Bozdogan, B; de Souza, NJ; Desai, VN; Deshpande, PK; Gupte, SV; Hooper, DC; Jacobs, MR; Jha, R; Khorakiwala, HF; Patel, MV; Shetty, N; Shukla, MC; Strahilevitz, J; Yeole, RD1
Cheung, A; Götz, F; Herbert, S; Meehl, M1
Jansen, WT; Milatovic, D; Verel, A; Verhoef, J1
Alder, JD; Mascio, CT; Silverman, JA1
Baudry, PJ; DeCorby, M; Hoban, DJ; Johnson, J; Karlowsky, JA; Lagacé-Wiens, P; Laing, N; McCracken, M; Mulvey, MR; Nichol, KA; Tailor, F; Vashisht, R; Walkty, A; Weshnoweski, B; Wierzbowski, A; Zhanel, GG1
Beveridge, T; Cotroneo, N; Harris, R; Perlmutter, N; Silverman, JA1
Lombardo, F; Obach, RS; Waters, NJ1
Benton, BM; Debabov, DV; Difuntorum, S; Krause, KM; Renelli, M; Wu, TX1
del Pozo, JL; Mandrekar, JN; Patel, R; Rouse, MS; Sampedro, MF; Steckelberg, JM1
Cui, L; Hiramatsu, K; Neoh, HM; Shoji, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Bavari, S; Bowlin, T; Butler, MM; Gussio, R; Houseweart, C; Lane, D; Moir, DT; Nguyen, T; Opperman, T; Panchal, RG; Peet, NP; Ulrich, RL; Williams, JD1
Arhin, FF; Draghi, DC; Moeck, G; Parr, TR; Pillar, CM; Sahm, DF1
Bavari, S; Bowlin, TL; Butler, MM; Moir, DT; Panchal, RG; Peet, NP; Shinabarger, DL; Williams, JD1
Bassett, J; Byrne, WR; Heine, HS; Miller, L; Purcell, BK1
Crandon, JL; Kuti, JL; Nicolau, DP1
Barnes, MH; Brown, NC; Butler, MM; Dvoskin, S; Gambino, JJ; Long, ZY; Wright, GE; Xu, WC; Zhi, CX1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bisht, GS; Cameotra, SS; Lohan, S; Monga, J1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abouelhassan, Y; Bai, F; Burch, GM; Garrison, AT; Huigens, RW; Jin, S; Kallifidas, D; Luesch, H; Nguyen, MT; Norwood, VM; Rolfe, M1
Steenbergen, J; Tanaka, SK; Villano, S1
Claypool, WD; Ghosh, M; Huang, W; Li, S; Miller, MJ; Miller, PA; Möllmann, U; Schroeder, VA; Suckow, M; Wolter, WR; Yu, H; Zajicek, J1
Bartůněk, P; Benada, O; Bogdanová, K; Ehn, M; Fišer, R; Kolář, M; Krásný, L; Křížek, T; Panova, N; Pohl, R; Pospíšil, J; Rejman, D; Šanderová, H; Sedlák, D; Seydlová, G; Šimák, O; Sudzinová, P; Večeřová, R; Vítovská, D; Zborníková, E1

Reviews

2 review(s) available for ciprofloxacin and ly-146032

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic.
    Bioorganic & medicinal chemistry, 2016, 12-15, Volume: 24, Issue:24

    Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Drug Discovery; Humans; Microbial Sensitivity Tests; Molecular Conformation; Tetracyclines

2016

Other Studies

22 other study(ies) available for ciprofloxacin and ly-146032

ArticleYear
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.
    Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Dogs; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Mutation; Prodrugs; Quinolizines; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vancomycin Resistance

2005
Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Gene Expression Regulation, Bacterial; Humans; Microbial Sensitivity Tests; Polymyxin B; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2007
In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes; Vancomycin Resistance; Viridans Streptococci

2007
Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Anti-Bacterial Agents; Cell Division; Ciprofloxacin; Daptomycin; Erythromycin; Gentamicins; Hydrazones; Microbial Sensitivity Tests; Nafcillin; Staphylococcus aureus; Vancomycin

2007
Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamases; Canada; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Population Surveillance

2008
Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Anti-Bacterial Agents; Bacteriolysis; Cell Membrane; Daptomycin; Fluoresceins; Fluorescent Dyes; Microscopy, Electron, Transmission; Staphylococcus aureus

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
In vitro activity of telavancin against resistant gram-positive bacteria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus; Streptococcus

2008
Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1

    Topics: Anti-Infective Agents; Biofilms; Bioreactors; Electricity; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus; Staphylococcus epidermidis

2009
Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chromosome Walking; DNA-Binding Proteins; Genetic Engineering; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Point Mutation; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Bacillus anthracis; Cell Death; Cell Line; Gram-Negative Bacteria; Gram-Positive Bacteria; Macrophages; Mice; Staphylococcus aureus; Yersinia pestis

2009
Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Gram-Positive Bacteria; Humans; Lipoglycopeptides; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus

2009
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Indoles; Microbial Sensitivity Tests

2010
Efficacy of Daptomycin against Bacillus anthracis in a murine model of anthrax spore inhalation.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Animals; Anthrax; Anti-Bacterial Agents; Bacillus anthracis; Ciprofloxacin; Daptomycin; Female; Mice; Mice, Inbred BALB C; Spores, Bacterial

2010
Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Lipoglycopeptides; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pneumonia; Staphylococcal Infections; Vancomycin

2010
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Animals; Anti-Bacterial Agents; DNA Polymerase III; Enzyme Inhibitors; Escherichia coli; Gram-Positive Bacteria; Guanine; Mice; Microbial Sensitivity Tests; Staphylococcal Infections

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
In vitro and in vivo antibacterial evaluation and mechanistic study of ornithine based small cationic lipopeptides against antibiotic resistant clinical isolates.
    European journal of medicinal chemistry, 2014, Dec-17, Volume: 88

    Topics: Anti-Bacterial Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Molecular Structure; Ornithine; Structure-Activity Relationship

2014
Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.
    Journal of medicinal chemistry, 2016, 04-28, Volume: 59, Issue:8

    Topics: Biofilms; Carbon-13 Magnetic Resonance Spectroscopy; Drug Resistance, Bacterial; Drug Screening Assays, Antitumor; Halogens; HeLa Cells; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Phenazines; Proton Magnetic Resonance Spectroscopy; Structure-Activity Relationship

2016
Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo.
    Journal of medicinal chemistry, 2017, 06-08, Volume: 60, Issue:11

    Topics: Acinetobacter baumannii; Daptomycin; Drug Resistance, Multiple, Bacterial; Humans; In Vitro Techniques; Siderophores

2017
Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents.
    Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Survival; Drug Design; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Lipid Bilayers; Male; Mice, Inbred ICR; Microbial Sensitivity Tests; Phospholipids; Pyrazoles; Rabbits; Skin Irritancy Tests; Stereoisomerism; Structure-Activity Relationship; Uridine Monophosphate

2017