ciprofloxacin and gemifloxacin

ciprofloxacin has been researched along with gemifloxacin in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.43)	18.2507
2000's	44 (62.86)	29.6817
2010's	23 (32.86)	24.3611
2020's	2 (2.86)	2.80

Authors

Authors	Studies
Inagaki, H; Kawakami, K; Kawato, HC; Matsuhashi, N; Miyauchi, RN; Miyauchi, S; Ohki, H; Takahashi, H; Takemura, M	1
Choi, DR; Jung, YH; Shin, JH; Yang, J; Yoon, SH	1
Bradbury, BJ; Cheng, J; Deshpande, M; Hashimoto, A; Lucien, E; Marlor, CW; Ou, Y; Podos, SD; Pucci, MJ; Song, Y; Thanassi, JA; Thoma, CL; Wang, Q; Wiles, JA	1
Klugman, KP; Levin, BR; McGee, L; Rozen, DE	1
Bradbury, BJ; Buechter, DD; Cheng, J; Deshpande, M; Hashimoto, A; Lucien, E; Marlor, CW; Nelson, DM; Ou, Y; Pais, GC; Podos, SD; Pucci, MJ; Song, Y; Thanassi, JA; Thoma, CL; Wang, Q; Wiles, JA	1
Bradbury, BJ; Buechter, DD; Cheng, J; Deshpande, M; Mushtaq, G; Podos, SD; Pucci, MJ; Thanassi, JA; Thoma, CL; Vigliotti, GA	1
Bradbury, BJ; Cheng, J; Deshpande, M; Pucci, MJ; Thanassi, JA; Thoma, CL	1
Morgan-Linnell, SK; Zechiedrich, L	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Appelbaum, PC; Bogdanovich, T; Clark, C; Dewasse, B; Ednie, L; McGhee, P; Smith, K	1
Ekambaram, R; Raghunathan, M; Raghunathan, R; Rao, SS	1
Larruskain, J; Montes, M; Orden, B; Perez-Trallero, E; Tamayo, E	1
Appelbaum, PC; Credito, K; Kosowska-Shick, K; McGhee, P; Pankuch, GA	1
Amsler, KM; Bush, K; Foleno, BD; He, W; Lynch, AS; Macielag, MJ; Morrow, BJ	1
Al-Trawneh, SA; Alfieri, RR; Cavazzoni, A; El-Abadelah, MM; Incerti, M; Kamal, MR; Petronini, PG; Vicini, P; Zahra, JA; Zani, F	1
Baek, SY; Chae, SE; Cho, YL; Jeong, JW; Jung, SJ; Kim, YZ; Kwak, JH; Lee, HH; Lee, HS; Park, TK; Woo, SH	1
Cao, J; Feng, L; Guo, H; Li, G; Liu, M; Lv, K; You, X; Zhang, Y	1
Bradbury, BJ; Deshpande, M; Hashimoto, A; Kim, HY; Lucien, E; Nelson, DM; Pais, GC; Podos, SD; Pucci, MJ; Thanassi, JA; Wang, Q; Wiles, JA	1
Bradbury, BJ; Deshpande, M; Phadke, AS; Pucci, MJ; Thanassi, JA; Wiles, JA	1
Al-Taweel, SA; Al-Trawneh, SA; Cavazzoni, A; El-Abadelah, MM; Incerti, M; Vicini, P; Zahra, JA; Zani, F	1
Chai, Y; Guo, H; Liu, M; Sun, L; Wang, J; Yi, H; You, X	1
Feng, LS; Guo, HQ; Liu, ML; Lv, K; Sun, LY; Sun, YX; Wei, ZQ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Cao, J; Guo, H; Liu, M; Lv, K; Sun, Y; Wang, J; Wei, Z; Wu, J	1
Inagaki, H; Kitamura, T; Komoriya, S; Kuroyanagi, J; Miyauchi, RN; Nagamochi, M; Odagiri, T; Sugimoto, Y; Takahashi, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blaskovich, MAT; Pham, TDM; Ziora, ZM	1
Brady, SF; Koirala, B; Peek, J	1
Ambler, JE; Fisher, LM; Goldsmith, CE; Heaton, VJ	1
Amsterdam, D; Hardy, D; Mandell, LA; Rotstein, C	1
Aguilar, L; Alou, L; Fuentes, F; Giménez, MJ; Marco, F; Prieto, J	1
Appelbaum, PC; Ednie, LM; Jacobs, MR	1
Edmond, M; Heinemann, B; Seifert, H; Wisplinghoff, H	1
Erwin, ME; Jones, RN	1
Kanayama, A; Kobayashi, I; Mochida, O; Naito, S; Saika, T; Tanaka, M; Tunoe, H	1
Ambler, JE; Fisher, LM; Heaton, VJ	1
Hollauer, K; Kirchbauer, D; Naber, KG; Witte, W	1
Firsov, AA; Vostrov, SN; Zinner, SH	1
Boos, M; Fluit, AC; Hafner, D; Jagusch, H; Mayer, S; Schmitz, FJ; Verhoef, J	1
Appelbaum, PC; Davies, TA; Dewasse, BE; Jacobs, MR; Nagai, K	1
Aguilar, L; Alou, L; Dal-Ré, R; Frías, J; Fuentes, F; Giménez, MJ; Prieto, J; Sörgel, F	1
Bouchillon, SK; Butler, DL; Hoban, DJ; Johnson, JL; Miller, LA; Poupard, JA; Zhanel, GG	1
Aguilar, L; García, I; Giménez, MJ; Joyanes, P; Pascual, A; Perea, E	1
Evans, ME	1
Biedenbach, DJ; Jones, RN	1
Aguilar, L; Alou, L; Calvo, A; Giménez, MJ; Gómez-Lus, ML; Prieto, J	1
Firsov, AA; Lubenko, IY; Portnoy, YA; Vostrov, SN; Zinner, SH	2
Cheong, HJ; Choo, YS; Kang, MW; Kim, WJ; Kim, YS; Lee, KW; Park, YJ; Woo, JH; Yong, DE	1
Ambler, JE; Dickens, A; Gillespie, SH; Traini, C; Voelker, LL	1
Aguilar, L; García-Calvo, G; García-Olmos, M; Giménez, MJ; Parra, A; Ponte, C; Soriano, F	1
Aguilar, L; Garcia-Mendez, E; Jiménez De Anta, MT; Marco, F; Mensa, J; Ruiz, J; Sierra, JM; Vila, J	1
Leggett, J; Saravolatz, LD	1
Aguilar, L; Alkorta, M; Giménez, MJ; Pérez-Trallero, E; Vicente, D	1
Cabeza, JG; Hernandez, J; Llagostera, M; Mensa, J; Montero, T; Ruiz Chaler, M; Sierra, JM; Vila, J	1
Hooper, DC; Strahilevitz, J; Truong-Bolduc, QC	1
Bae, CS; Bae, JG; Jeong, MJ; Kim, JC; Kim, SG; Kim, SH; Kim, YS; Lim, SC; Oh, DM	1
Appelbaum, PC; Bozdogan, B; Choi, DR; Credito, K; Dewasse, B; Kosowska-Shick, K; Lin, G; McGhee, P; Pankuch, GA; Ryu, JM	1
Adam, HJ; Baudry, TJ; Hoban, CJ; Hoban, DJ; Laing, NM; Nichol, KA; Schurek, KN; Zhanel, GG	1
Comuzzi, V; Fisher, LM; Giaretta, G; Leo, E; Maxwell, A; Mitchenall, LA; Palumbo, M; Richter, SN	1
Al-Balla, SA; Al-Bekairi, AM; Al-Khamis, KI; Al-Mohizea, AM; Al-Yamani, MJ; El-Sayed, YM; Kadi, AA; Niazy, EM	1
Horstkotte, MA; Knobloch, JK; Mack, D; Rohde, H; Von Osten, H	1
Chang, CL; Choi, GE; Kang, JE; Kim, JM; Kim, KH; Lee, EY; Tateda, K; Yamaguchi, K	1
Hsueh, PR; Lee, PI; Yang, JC	1
Lemaire, S; Marquez, B; Mingeot-Leclercq, MP; Ngabirano, E; Tulkens, PM; Vallet, CM; Van Bambeke, F	1
Cass, QB; Denadai, M	1
Jeong, J; Koh, YI; Sim, DW; Yu, JE	1
Ajiboye, TO; Ibitoye, OB	1
Hu, XX; Jiang, JD; Li, CR; Lu, X; Nie, TY; Pang, J; Wang, Q; Wang, X; Yang, XY; You, XF; Zhao, R	1
Bykov, K; Fischer, MA; Gagne, JJ; Kattinakere-Sreedhara, S; Wang, J	1

Reviews

2 review(s) available for ciprofloxacin and gemifloxacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Quinolone antibiotics. MedChemComm, 2019, Oct-01, Volume: 10, Issue:10 Topics:	2019

Trials

3 trial(s) available for ciprofloxacin and gemifloxacin

Article	Year
Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers. International journal of antimicrobial agents, 2001, Volume: 18, Issue:3 Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Male; Microbial Sensitivity Tests; Naphthyridines; Serum Bactericidal Test; Streptococcus pneumoniae	2001
Ex vivo serum activity (killing rates) after gemifloxacin 320 mg versus trovafloxacin 200 mg single doses against ciprofloxacin-susceptible and -resistant Streptococcus pneumoniae. International journal of antimicrobial agents, 2002, Volume: 20, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Cross-Over Studies; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Humans; Male; Microbial Sensitivity Tests; Naphthyridines; Serum Bactericidal Test; Streptococcus pneumoniae	2002
Bioequivalence evaluation of 320 mg gemifloxacin tablets in healthy volunteers. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:11 Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Area Under Curve; Chromatography, High Pressure Liquid; Ciprofloxacin; Cross-Over Studies; Drugs, Generic; Fluoroquinolones; Gemifloxacin; Half-Life; Humans; Male; Naphthyridines; Reference Standards; Tablets; Therapeutic Equivalency	2007

Other Studies

65 other study(ies) available for ciprofloxacin and gemifloxacin

Article	Year
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 Topics: Anti-Bacterial Agents; Cyclopropanes; Drug Resistance, Bacterial; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Stereoisomerism; Structure-Activity Relationship	2003
Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine. Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5 Topics: Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Fluoroquinolones; Microbial Sensitivity Tests; Pyrrolidines; Rats; Stereoisomerism	2004
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells. Bioorganic & medicinal chemistry letters, 2006, Mar-01, Volume: 16, Issue:5 Topics: Anti-Bacterial Agents; Azo Compounds; Cell Line; Escherichia coli; Humans; Hydrocarbons, Aromatic; Microbial Sensitivity Tests; Molecular Structure; Quinolines; Staphylococcus aureus; Sulfhydryl Compounds	2006
Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mutation; Pneumococcal Infections; Streptococcus pneumoniae; Transformation, Bacterial	2007
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. Journal of medicinal chemistry, 2007, Jan-25, Volume: 50, Issue:2 Topics: Animals; Anti-Bacterial Agents; Cell Line, Tumor; Drug Resistance, Multiple, Bacterial; Female; Humans; Methicillin Resistance; Mice; Quinolones; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors	2007
In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Animals; Anti-Infective Agents; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Mice; Microbial Sensitivity Tests; Quinolones; Thiazoles	2007
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Mutation; Quinolones; Staphylococcus aureus; Thiazoles; Topoisomerase II Inhibitors	2007
Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: DNA Topoisomerases; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; Microbial Sensitivity Tests; Mutation	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Culture Media; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mutation; Streptococcus pneumoniae	2008
In vitro activity of a new quinoline derivative, ER-2, against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Topics: Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycoplasma hominis; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Quinolines	2009
Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Adult; Anti-Bacterial Agents; Child; Drug Resistance, Bacterial; Female; Fluoroquinolones; Genes, Bacterial; Humans; Male; Microbial Sensitivity Tests; Mutation; Prospective Studies; Spain; Streptococcal Infections; Streptococcus pyogenes	2010
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2 Topics: Anti-Bacterial Agents; Aza Compounds; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Naphthyridines; Ofloxacin; Polymerase Chain Reaction; Quinolines; Streptococcus pneumoniae	2010
In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Design; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; Methicillin-Resistant Staphylococcus aureus; Streptococcus pneumoniae	2010
Synthesis and biological evaluation of tetracyclic fluoroquinolones as antibacterial and anticancer agents. Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line; Cell Line, Tumor; DNA Gyrase; DNA Topoisomerase IV; Escherichia coli; Escherichia coli Infections; Female; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Topoisomerase II Inhibitors	2010
In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Acetamides; Animals; Anti-Bacterial Agents; Bacterial Infections; Gram-Positive Bacteria; Linezolid; Male; Mice; Mice, Inbred ICR; Oxazolidinones; Staphylococcus aureus; Vancomycin	2010
Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives. Bioorganic & medicinal chemistry letters, 2011, Feb-01, Volume: 21, Issue:3 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; Microbial Sensitivity Tests; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae	2011
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Anti-Bacterial Agents; DNA Topoisomerase IV; Drug Resistance, Multiple, Bacterial; Escherichia coli; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrrolidines; Quinolones; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors	2011
Selenophene-containing inhibitors of type IIA bacterial topoisomerases. Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Anti-Bacterial Agents; Cell Line, Tumor; DNA Topoisomerase IV; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Methicillin-Resistant Staphylococcus aureus; Organoselenium Compounds; Piperidines; Quinolines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Topoisomerase II Inhibitors	2011
Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Thienopyridines; Topoisomerase II Inhibitors	2011
Design, synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl)fluoroquinolone derivatives. Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11 Topics: Anti-Bacterial Agents; Drug Design; Fluoroquinolones; Imino Pyranoses; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa	2011
Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds. European journal of medicinal chemistry, 2012, Volume: 47, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacteria; Male; Mice; Naphthyridines; Oximes; Pyrrolidines	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds. Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Piperidines; Quinolones; Structure-Activity Relationship	2013
Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. Journal of medicinal chemistry, 2013, Mar-14, Volume: 56, Issue:5 Topics: Animals; Anti-Bacterial Agents; Drug Design; Fluoroquinolones; Haemophilus influenzae; Male; Mice; Microbial Sensitivity Tests; Quinolones; Rats; Respiratory Tract Infections; Spiro Compounds; Staphylococcus aureus; Streptococcus pneumoniae	2013
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics. Bioorganic & medicinal chemistry letters, 2022, 02-01, Volume: 57 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; HEK293 Cells; Humans; Microbial Sensitivity Tests; Rifamycins; Staphylococcus aureus	2022
Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type I; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Naphthyridines; Northern Ireland; Penicillin Resistance; Phenotype; Pneumococcal Infections; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus pneumoniae	1999
Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Bacteremia; Ciprofloxacin; Fluoroquinolones; Gemifloxacin; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines	2000
In vitro susceptibility to gemifloxacin and trovafloxacin of Streptococcus pneumoniae strains exhibiting decreased susceptibility to ciprofloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2000, Volume: 19, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Microbial Sensitivity Tests; Naphthyridines; Pneumococcal Infections; Respiratory Tract Infections; Streptococcus pneumoniae	2000
Activity of gemifloxacin, a new broad-spectrum quinolone, against 200 pneumococci by four different susceptibility testing methods. The Journal of antimicrobial chemotherapy, 2000, Volume: 45, Issue:4 Topics: Agar; Anti-Infective Agents; Ciprofloxacin; Culture Media; Diffusion; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Indicator Dilution Techniques; Microbial Sensitivity Tests; Naphthyridines; Streptococcus pneumoniae	2000
Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:8 Topics: Acinetobacter; Acinetobacter Infections; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Disease Outbreaks; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Germany; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	2000
Development of gemifloxacin in vitro susceptibility test methods for gonococci including quality control guidelines. The Quality Control Study Group. Diagnostic microbiology and infectious disease, 2000, Volume: 37, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Fluoroquinolones; Gemifloxacin; Microbial Sensitivity Tests; Naphthyridines; Neisseria gonorrhoeae; Quality Control; Reference Standards; Reproducibility of Results	2000
Antimicrobial activity of gemifloxacin (SB-265805), a newer fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae, including fluoroquinolone-resistant isolates. Diagnostic microbiology and infectious disease, 2000, Volume: 38, Issue:2 Topics: Amoxicillin; Anti-Infective Agents; Ciprofloxacin; Clavulanic Acid; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Gonorrhea; Humans; Levofloxacin; Naphthyridines; Neisseria gonorrhoeae; Norfloxacin; Ofloxacin	2000
Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Microbial Sensitivity Tests; Mutation; Naphthyridines; Streptococcus pneumoniae	2000
In vitro activity of gatifloxacin compared with gemifloxacin, moxifloxacin, trovafloxacin, ciprofloxacin and ofloxacin against uropathogens cultured from patients with complicated urinary tract infections. International journal of antimicrobial agents, 2000, Volume: 16, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Escherichia coli; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Klebsiella; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Urinary Tract Infections	2000
Gemifloxacin and ciprofloxacin pharmacodynamics in an in-vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and doses. International journal of antimicrobial agents, 2000, Volume: 16, Issue:4 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Gemifloxacin; Humans; Microbial Sensitivity Tests; Models, Biological; Naphthyridines; Predictive Value of Tests; Staphylococcal Infections; Staphylococcus aureus	2000
Propensity of fluoroquinolones with different moieties at position 8 to cause resistance development in clinical isolates of Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Streptococcus pneumoniae	2001
Single- and multi-step resistance selection study of gemifloxacin compared with trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin in Streptococcus pneumoniae. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Biological Transport; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Naphthyridines; Quinolines; Selection, Genetic; Serotyping; Streptococcus pneumoniae	2001
Comparative in vitro potency of gemifloxacin and fluoroquinolones against recent European clinical isolates from a global surveillance study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2001, Volume: 20, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Europe; Fluoroquinolones; Gemifloxacin; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	2001
Differences between two new quinolones (gemifloxacin and trovafloxacin) and ciprofloxacin in their concentration-dependent killing of Streptococcus pneumoniae. Chemotherapy, 2001, Volume: 47, Issue:6 Topics: Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Microbial Sensitivity Tests; Naphthyridines; Streptococcus pneumoniae	2001
Determining the frequency of resistance of Streptococcus pneumoniae to ciprofloxacin, levofloxacin, trovafloxacin, grepafloxacin, and gemifloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2001, Volume: 20, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Streptococcus pneumoniae	2001
Evaluation of in vitro susceptibility testing criteria for gemifloxacin when tested against Haemophilus influenzae strains with reduced susceptibility to ciprofloxacin and ofloxacin. Diagnostic microbiology and infectious disease, 2002, Volume: 43, Issue:4 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	2002
Species-independent pharmacodynamics of gemifloxacin and ciprofloxacin with Haemophilus influenzae and Moraxella catarrhalis in an in vitro dynamic model. International journal of antimicrobial agents, 2002, Volume: 20, Issue:3 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Haemophilus influenzae; Half-Life; Humans; Kinetics; Microbial Sensitivity Tests; Moraxella catarrhalis; Naphthyridines; Species Specificity	2002
In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea. Journal of Korean medical science, 2002, Volume: 17, Issue:6 Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Haemophilus influenzae; Korea; Levofloxacin; Microbial Sensitivity Tests; Moraxella; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Streptococcus pneumoniae	2002
Simulated in vitro quinolone pharmacodynamics at clinically achievable AUC/MIC ratios: advantage of I E over other integral parameters. Chemotherapy, 2002, Volume: 48, Issue:6 Topics: Anti-Bacterial Agents; Area Under Curve; Aza Compounds; Ciprofloxacin; Fluoroquinolones; Gemifloxacin; Levofloxacin; Microbial Sensitivity Tests; Moraxella catarrhalis; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Time Factors	2002
Fluoroquinolone resistance in Streptococcus pneumoniae: evidence that gyrA mutations arise at a lower rate and that mutation in gyrA or parC predisposes to further mutation. Microbial drug resistance (Larchmont, N.Y.), 2003,Spring, Volume: 9, Issue:1 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Streptococcus pneumoniae	2003
Efficacy and pharmacodynamics of gemifloxacin versus levofloxacin in guinea pig pneumococcal pneumonia induced by strains with decreased ciprofloxacin susceptibility. International journal of antimicrobial agents, 2003, Volume: 21, Issue:6 Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Guinea Pigs; Levofloxacin; Lung; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Analysis	2003
In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene. International journal of antimicrobial agents, 2003, Volume: 22, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Genes, Bacterial; Gonorrhea; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Nalidixic Acid; Naphthyridines; Neisseria gonorrhoeae; Ofloxacin; Quinolines	2003
Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Nov-01, Volume: 37, Issue:9 Topics: Aza Compounds; Bacteroides fragilis; Ciprofloxacin; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Streptococcus pneumoniae	2003
In vivo activity of gemifloxacin, moxifloxacin and levofloxacin against pneumococci with gyrA and parC point mutations in a sepsis mouse model measured with the all or nothing mortality end-point. International journal of antimicrobial agents, 2005, Volume: 25, Issue:2 Topics: Animals; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Disease Models, Animal; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Female; Fluoroquinolones; Gemifloxacin; Levofloxacin; Mice; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Pneumococcal Infections; Point Mutation; Quinolines; Sepsis; Streptococcus pneumoniae; Treatment Outcome	2005
The selection of resistance to and the mutagenicity of different fluoroquinolones in Staphylococcus aureus and Streptococcus pneumoniae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:9 Topics: Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Levofloxacin; Moxifloxacin; Mutagenicity Tests; Naphthyridines; Ofloxacin; Quinolines; Selection, Genetic; Staphylococcus aureus; Streptococcus pneumoniae	2005
DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Pyrrolidines; Quinolones; Staphylococcus aureus; Topoisomerase II Inhibitors	2005
Ultrastructural changes of the gemifloxacin on Achilles tendon in immature rats: comparison with those of ciproxacin and ofloxacin. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:4 Topics: Achilles Tendon; Animals; Anti-Bacterial Agents; Ciprofloxacin; Fluoroquinolones; Gemifloxacin; Male; Microscopy, Electron, Transmission; Naphthyridines; Ofloxacin; Rats; Rats, Sprague-Dawley	2006
Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:6 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Azithromycin; Cefuroxime; Ciprofloxacin; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Genes, Bacterial; Levofloxacin; Microbial Sensitivity Tests; Molecular Structure; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Streptococcus pneumoniae	2006
Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aza Compounds; Bacterial Proteins; Canada; Child; Child, Preschool; Ciprofloxacin; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Genotype; Humans; Infant; Infant, Newborn; Levofloxacin; Middle Aged; Moxifloxacin; Naphthyridines; Ofloxacin; Pneumococcal Infections; Quinolines; Serotyping; Streptococcus pneumoniae	2007
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic acids research, 2007, Volume: 35, Issue:18 Topics: Anti-Bacterial Agents; Base Sequence; Ciprofloxacin; Consensus Sequence; DNA; DNA Gyrase; DNA Topoisomerase IV; Escherichia coli; Fluoroquinolones; Gemifloxacin; Guanine; Naphthyridines; Streptococcus pneumoniae; Substrate Specificity	2007
Biofilm formation is not necessary for development of quinolone-resistant "persister" cells in an attached Staphylococcus epidermidis population. The International journal of artificial organs, 2008, Volume: 31, Issue:9 Topics: Anti-Infective Agents; Aza Compounds; Bacterial Adhesion; Biofilms; Ciprofloxacin; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Naphthyridines; Prosthesis-Related Infections; Quinolines; Quinolones; Staphylococcal Infections; Staphylococcus epidermidis	2008
[Antimicrobial susceptibility patterns of Legionella isolates in the environment and in patients]. The Korean journal of laboratory medicine, 2010, Volume: 30, Issue:1 Topics: Anti-Bacterial Agents; Azithromycin; Ciprofloxacin; Clarithromycin; Clindamycin; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Legionella; Legionellosis; Microbial Sensitivity Tests; Naphthyridines	2010
In vitro activity of nemonoxacin, tigecycline, and other antimicrobial agents against Helicobacter pylori isolates in Taiwan, 1998-2007. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2010, Volume: 29, Issue:11 Topics: Amino Acid Substitution; Amoxicillin; Anti-Bacterial Agents; Aza Compounds; Ciprofloxacin; Clarithromycin; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Gemifloxacin; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Microbial Sensitivity Tests; Minocycline; Moxifloxacin; Mutation; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Sequence Analysis, Protein; Taiwan; Tetracyclines; Tigecycline	2010
Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages. International journal of antimicrobial agents, 2011, Volume: 38, Issue:3 Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Cell Line; Ciprofloxacin; Fluoroquinolones; Gemifloxacin; Humans; Listeria monocytogenes; Macrophages; Mice; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Quinolines; Staphylococcus aureus	2011
Simultaneous determination of fluoroquinolones in environmental water by liquid chromatography-tandem mass spectrometry with direct injection: A green approach. Journal of chromatography. A, 2015, Oct-30, Volume: 1418 Topics: Anti-Bacterial Agents; Brazil; Chromatography, Liquid; Ciprofloxacin; Enrofloxacin; Fluoroquinolones; Fresh Water; Gemifloxacin; Green Chemistry Technology; Moxifloxacin; Naphthyridines; Norfloxacin; Ofloxacin; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical	2015
Ciprofloxacin-induced immune-mediated thrombocytopenia: No cross-reactivity with gemifloxacin. Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:1 Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Fluoroquinolones; Gemifloxacin; Humans; Naphthyridines; Pneumonia; Thrombocytopenia	2018
(+)-Catechin potentiates the oxidative response of Acinetobacter baumannii to quinolone-based antibiotics. Microbial pathogenesis, 2019, Volume: 127 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Catechin; Ciprofloxacin; Drug Synergism; Gemifloxacin; Microbial Sensitivity Tests; Oxidative Stress; Quinolones; Reactive Oxygen Species	2019
Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats. PloS one, 2019, Volume: 14, Issue:6 Topics: Animals; Blood Proteins; Chromatography, Liquid; Ciprofloxacin; Disease Models, Animal; Gemifloxacin; Male; Methicillin-Resistant Staphylococcus aureus; Microdialysis; Muscles; Protein Binding; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Thigh; Tissue Distribution	2019
Association between initiation of fluoroquinolones and hospital admission or emergency department visit for suicidality: population based cohort study. BMJ (Clinical research ed.), 2022, 10-04, Volume: 379 Topics: Adult; Anti-Bacterial Agents; Azithromycin; Ciprofloxacin; Cohort Studies; Emergency Service, Hospital; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Hospitals; Humans; Levofloxacin; Moxifloxacin; Norfloxacin; Retrospective Studies; Suicidal Ideation; Suicide; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections	2022