ciprofloxacin and etoposide

ciprofloxacin has been researched along with etoposide in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.22)18.7374
1990's7 (15.56)18.2507
2000's12 (26.67)29.6817
2010's25 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gibbons, S; Kaatz, GW; Zloh, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Avdeef, A; Tam, KY1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Bao, L; Cai, L; Chen, JL; Huang, P; Liu, HW; Liu, MM; Qi, QY; Wang, QX; Yang, JL; Yang, XL; Zhang, LX1
Jardosh, HH; Patel, MP1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Abdel-Aziz, M; Abuo-Rahma, Gel-D; Kwon, Y; Park, SE; Sayed, MA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Crespín, GD; Daranas, AH; Febles, M; Fernández, JJ; Montalvão, S; Norte, M; Padrón, JM; Tammela, P1
Amesty, Á; Anaissi-Afonso, L; Estévez-Braun, A; Hueso-Falcón, I; Lorenzo-Castrillejo, I; Machín, F1
Gedawy, EM; Kassab, AE1
Benedetto Tiz, D; Draskovits, G; Durante Cruz, C; Durcik, M; Ilaš, J; Kikelj, D; Lovison, D; Nyerges, Á; Pál, C; Peterlin Mašič, L; Skok, Ž; Tammela, P; Tomašič, T; Zidar, N1
Dellos-Nolan, S; English, A; Karmahapatra, S; Li, L; Li, Z; Mitton-Fry, MJ; Okumu, A; Wozniak, DJ; Yalowich, JC1
Gao, F; Wang, T; Xiao, J; Zhang, X1
Cruz, CD; Draskovits, G; Durcik, M; Ilaš, J; Kikelj, D; Mašič, LP; Nyerges, Á; Pál, C; Révész, T; Skok, Ž; Tammela, P; Tiz, DB; Tomašič, T; Zega, A; Zidar, N; Žigon, D1
Brant, M; Bredberg, A; Jaszyk, M1
Forterre, P; Sioud, M1
Kato, M; Takada, S; Takayama, S1
Agarwal, K; Mukherjee, A; Sen, S1
Burgess, R; Dawson, D; Haller, J1
Burden, DA; Elsea, SH; Lomenick, JP; Osheroff, N; Westergaard, M1
Rowe, TC; Vetro-Widenhouse, TS; Weissig, V1
Anderson, VE; Gootz, TD; Kaczmarek, FS; Osheroff, N; Zaniewski, RP1
Chatterji, M; Mahadevan, S; Nagaraja, V; Unniraman, S1
Bunn, PA1
Ardizzoni, A; Postmus, PE; Tjan-Heijnen, VC1
Aranha, O; Aslam, N; El-Rayes, BF; Grignon, R; Sarkar, FH1
Andresen, SW; Avery, RK; Bernhard, L; Bolwell, BJ; Goormastic, M; Kalaycio, ME; Kuczkowski, E; Longworth, DL; Mossad, SB; Ostendorf, H; Pohlman, BL; Sobecks, RM; Wise, K1
Aylott, M; Burman, M; Harvey, J; Lynch, A; Nicholas, E; Rees, R; Siddiqui, A; Walker, S1
Adang, EM; Akkermans, J; Biesma, B; Bootsma, GP; Cheragwandi, SA; de Boo, TM; Hensing, CA; Smit, HJ; Termeer, A; Timmer-Bonte, JN; Tjan-Heijnen, VC; Wilschut, FA1
Boudabous, A; Cekaite, L; Sioud, M1
Ângelo, S; Moreira, JN; Pinto, AC; Simões, S1
Egbert, SF; Hartemink, KJ; Koen, HJ; Marinus, PA; Paul, MA; Pieter, PE; Postmus, PE; Romane, SM; Schook, RM; Smit, EF1
Herbrecht, R; Jarfaut, A; Levêque, D; Santucci, R1
Nenortas, E; Shapiro, TA; Tang Girdwood, SC1

Reviews

3 review(s) available for ciprofloxacin and etoposide

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Quinolone hybrids and their anti-cancer activities: An overview.
    European journal of medicinal chemistry, 2019, Mar-01, Volume: 165

    Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Quinolones; Structure-Activity Relationship

2019

Trials

1 trial(s) available for ciprofloxacin and etoposide

ArticleYear
Prevention of chemotherapy-induced febrile neutropenia by prophylactic antibiotics plus or minus granulocyte colony-stimulating factor in small-cell lung cancer: a Dutch Randomized Phase III Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Nov-01, Volume: 23, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Ciprofloxacin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fever; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Risk Factors; Roxithromycin; Treatment Outcome

2005

Other Studies

41 other study(ies) available for ciprofloxacin and etoposide

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
    Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae.
    Bioorganic & medicinal chemistry letters, 2013, Jun-15, Volume: 23, Issue:12

    Topics: Apoptosis; Cell Death; Drug Screening Assays, Antitumor; Flow Cytometry; Hep G2 Cells; Humans; K562 Cells; Methicillin-Resistant Staphylococcus aureus; Oryza; Sesterterpenes; Structure-Activity Relationship

2013
Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents.
    European journal of medicinal chemistry, 2013, Volume: 65

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antitubercular Agents; Artemia; Bacteria; Dose-Response Relationship, Drug; Drug Design; Fungi; Isoniazid; Microbial Sensitivity Tests; Molecular Structure; Motor Activity; Quinolones; Structure-Activity Relationship; Tuberculosis

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Ciprofloxacin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperazines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2013
Synthesis and biological evaluation of crown ether acyl derivatives.
    Bioorganic & medicinal chemistry letters, 2016, 11-15, Volume: 26, Issue:22

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antineoplastic Agents; Candida albicans; Candidiasis; Cell Line, Tumor; Cell Proliferation; Crown Ethers; Drug Screening Assays, Antitumor; Humans; Neoplasms; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship

2016
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3

    Topics: Coumarins; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Humans; Molecular Structure; Naphthoquinones; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    European journal of medicinal chemistry, 2018, Apr-25, Volume: 150

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Bacillus subtilis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Escherichia coli; Humans; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors

2018
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
    European journal of medicinal chemistry, 2018, Jun-25, Volume: 154

    Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors

2018
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.
    Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14

    Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Dioxanes; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Potassium Channel Blockers; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors

2018
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrrolidines; Topoisomerase II Inhibitors

2019
Ciprofloxacin-induced inhibition of topoisomerase II in human lymphoblastoid cells.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:3

    Topics: Cell Line; Ciprofloxacin; DNA; DNA Topoisomerases, Type II; Etoposide; Humans; Topoisomerase II Inhibitors

1991
Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium.
    Biochemistry, 1989, May-02, Volume: 28, Issue:9

    Topics: Ciprofloxacin; DNA Damage; Etoposide; Halobacterium; Novobiocin; Plasmids

1989
Comparison of lesions induced by intra-articular injections of quinolones and compounds damaging cartilage components in rat femoral condyles.
    Journal of toxicology and environmental health, 1994, Volume: 42, Issue:1

    Topics: Administration, Oral; Animals; Bleomycin; Camptothecin; Cartilage, Articular; Chondroitin Lyases; Ciprofloxacin; Collagenases; Cycloheximide; Ethylmaleimide; Etoposide; Fluorescent Dyes; Hydroxyurea; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Irinotecan; Levofloxacin; Male; Ofloxacin; Papain; Rats; Rats, Sprague-Dawley; Rhodamines; Topoisomerase I Inhibitors

1994
Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo.
    Mutation research, 1993, Volume: 301, Issue:2

    Topics: Analysis of Variance; Animals; Bone Marrow Cells; Chromosome Aberrations; Ciprofloxacin; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Male; Mice; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange

1993
Increased cytotoxicity of squamous cell carcinoma of the head and neck by combining cisplatin with VP-16 and ciprofloxacin.
    The Laryngoscope, 1993, Volume: 103, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Survival; Ciprofloxacin; Cisplatin; Drug Screening Assays, Antitumor; Etoposide; Head and Neck Neoplasms; Humans; Tumor Cells, Cultured

1993
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; CHO Cells; Ciprofloxacin; Cricetinae; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Electrophoresis, Agar Gel; Enzyme Activation; Etoposide; Fluoroquinolones; Genistein; Isoflavones; Kinetics; Molecular Structure; Quinolones

1997
Topoisomerase II inhibitors induce cleavage of nuclear and 35-kb plastid DNAs in the malarial parasite Plasmodium falciparum.
    DNA and cell biology, 1997, Volume: 16, Issue:12

    Topics: Animals; Ciprofloxacin; DNA Topoisomerases, Type II; DNA, Circular; DNA, Protozoan; Enzyme Inhibitors; Etoposide; Exonucleases; Hot Temperature; Plasmodium falciparum; Topoisomerase II Inhibitors

1997
Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries.
    The Journal of biological chemistry, 1999, Dec-10, Volume: 274, Issue:50

    Topics: Anti-Infective Agents; Biological Evolution; Ciprofloxacin; DNA Damage; DNA Repair; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Escherichia coli; Etoposide; Fluoroquinolones; Gram-Positive Bacteria; Kinetics; Quinolones; Staphylococcus aureus

1999
Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis.
    The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:4

    Topics: Adenosine Triphosphatases; Anti-Infective Agents; Bacterial Proteins; Bacterial Toxins; Bacteriocins; Ciprofloxacin; DNA Gyrase; Enzyme Inhibitors; Escherichia coli; Etoposide; Mycobacterium smegmatis; Nucleic Acid Synthesis Inhibitors; Plasmids; Topoisomerase II Inhibitors

2001
Editorial comments on 'Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III study'.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:10

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Ciprofloxacin; Cyclophosphamide; Doxorubicin; Endpoint Determination; Etoposide; Fever; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Neutropenia; Palliative Care; Randomized Controlled Trials as Topic; Research Design; Roxithromycin

2001
Reply to the article "Editorial comments on 'reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III study'", by P.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:3

    Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Ciprofloxacin; Clinical Trials, Phase III as Topic; Cyclophosphamide; Double-Blind Method; Doxorubicin; Drug Therapy, Combination; Etoposide; Fever; Humans; Lung Neoplasms; Neutropenia; Palliative Care; Randomized Controlled Trials as Topic; Roxithromycin

2002
Ciprofloxacin inhibits cell growth and synergises the effect of etoposide in hormone resistant prostate cancer cells.
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Cell Division; Ciprofloxacin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Drug Synergism; Electrophoretic Mobility Shift Assay; Etoposide; Gene Expression Regulation; Humans; Male; Middle Aged; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Tumor Cells, Cultured

2002
The efficacy of prophylactic outpatient antibiotics for the prevention of neutropenic fever associated with high-dose etoposide (VP-16) for stem cell mobilization.
    Bone marrow transplantation, 2002, Volume: 30, Issue:5

    Topics: Ambulatory Care; Antibiotic Prophylaxis; Cefepime; Cephalosporins; Ciprofloxacin; Clarithromycin; Data Collection; Drug Therapy, Combination; Etoposide; Female; Fever; Hematopoietic Stem Cell Mobilization; Humans; Male; Middle Aged; Neutropenia; Opportunistic Infections; Vancomycin

2002
Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity.
    Mutagenesis, 2003, Volume: 18, Issue:4

    Topics: Animals; Anti-Infective Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Ciprofloxacin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Genistein; Lymphoma; Mice; Mutagens; Topoisomerase I Inhibitors

2003
Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs.
    International journal of molecular medicine, 2009, Volume: 23, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacillus subtilis; Bacillus thuringiensis; Ciprofloxacin; DNA; DNA Gyrase; Etoposide; Gene Expression Regulation; Novobiocin; Plasmids; SOS Response, Genetics; Transcription, Genetic

2009
Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:2

    Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Etoposide; Humans; Imatinib Mesylate; Inhibitory Concentration 50; Male; Mitoxantrone; Neoplasm Metastasis; Piperazines; Prostatic Neoplasms; Pyrimidines; Vinblastine

2011
Benefit of a second opinion for lung cancer: no recurrent disease, but infection.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2012, Volume: 7, Issue:8

    Topics: Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Ciprofloxacin; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Etoposide; Female; Glutamates; Guanine; Humans; Lung Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Pemetrexed; Postoperative Care; Prognosis; Referral and Consultation

2012
Severe methotrexate toxicity due to a concomitant administration of ciprofloxacin.
    Medecine et maladies infectieuses, 2013, Volume: 43, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bicarbonates; Bleomycin; Ciprofloxacin; Crystallization; Cyclophosphamide; Cytarabine; Diarrhea; Doxorubicin; Drug Eruptions; Drug Interactions; Etoposide; Female; Fluid Therapy; Fungemia; Humans; Hydrogen-Ion Concentration; Ifosfamide; Lymphoma, B-Cell; Mediastinal Neoplasms; Metabolic Clearance Rate; Methotrexate; Mucositis; Pancytopenia; Prednisone; Solubility; Urine; Vindesine

2013
Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons.
    Biochemical pharmacology, 2015, Jun-15, Volume: 95, Issue:4

    Topics: Antimalarials; Apicoplasts; Ciprofloxacin; DNA Gyrase; Etoposide; Fluoroquinolones; Genome, Protozoan; Plasmodium falciparum; Structure-Activity Relationship; Topoisomerase II Inhibitors

2015