ciprofloxacin and caffeine

ciprofloxacin has been researched along with caffeine in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (21.95)	18.7374
1990's	4 (9.76)	18.2507
2000's	10 (24.39)	29.6817
2010's	18 (43.90)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Jolivette, LJ; Ward, KW	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choo, YM; Doerksen, RJ; Gertsch, J; Hamann, MT; Jacob, MR; Khan, SI; Kudrimoti, S; Madgula, V; Mayer, AM; Odde, S; Peng, J; Pennaka, HK; Prasanna, S; Rao, KV; Tekwani, BL; Tu, LC; Wang, B	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Sen, S; Sinha, N	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Fuhr, U; Granneman, GR; Kinzig, M; Mahr, G; Muth, P; Nickel, P; Patterson, K; Sörgel, F; Stephan, U	1
Barnett, G; Carbó, M; de la Torre, R; Segura, J	1
Fuhr, U; Harder, S; Staib, AH; Wolff, T	1
Polk, RE	1
Healy, DP; Kanawati, L; Mooney, ML; Polk, RE; Rock, DT	1
Harder, S; Papenburg, A; Staib, AH; Stille, W	1
Beer, C; Harder, S; Papenburg, A; Shah, PM; Staib, AH; Stille, W	1
Beer, C; Harder, S; Mieke, S; Shah, P; Staib, AH; Stille, W	1
Beer, C; Frech, K; Harder, S; Mieke, S; Shah, PM; Staib, AH; Stille, W	2
Beer, C; Dietlein, G; Harder, S; Mieke, S; Shah, PM; Staib, AH; Stille, W	1
Choonara, I; Heaf, D; Kitteringham, NR; Parker, AC; Preston, T	1
Esguerra, EM; Fu, Q; Nicolau, DP; Nightingale, CH; Quintiliani, R; Tessier, PR; Xuan, DW	1
Kim, MK; Nicolau, D; Nightingale, C	1
Backman, JT; Granfors, MT; Neuvonen, M; Neuvonen, PJ	1
Aga, DS; Batt, AL; Bruce, IB	1
Guo, K; Ji, H; Jiang, SX; Zhang, JR; Zhang, LL; Zhang, Y	1
Becket, E; Kang, TM; Miller, JH; Nguyen, A; Yang, H; Yuan, J	1
Chen, F; Chen, H; Fu, W; Luo, W; Meng, F; Xie, Y; Yang, X; Ye, T; Young, K	1
Lightstone, FC; Navid, A; Ng, DM; Wong, SE	1
Dhodapkar, R; Kumar, A	1
Kibbey, TCG; Normile, HJ; Papelis, C	1

Reviews

2 review(s) available for ciprofloxacin and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-drug interactions with ciprofloxacin and other fluoroquinolones. The American journal of medicine, 1989, Nov-30, Volume: 87, Issue:5A Topics: Antacids; Caffeine; Ciprofloxacin; Cyclosporins; Drug Interactions; Humans; Intestinal Absorption; Rifampin; Theophylline	1989

Trials

8 trial(s) available for ciprofloxacin and caffeine

Article	Year
Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine. Clinical pharmacokinetics, 1992, Volume: 22 Suppl 1 Topics: Adult; Anti-Infective Agents; Caffeine; Ciprofloxacin; Double-Blind Method; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Quinolones	1992
4-quinolones inhibit biotransformation of caffeine. European journal of clinical pharmacology, 1988, Volume: 35, Issue:6 Topics: Adult; Biotransformation; Caffeine; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Interactions; Enoxacin; Humans; Male; Molecular Structure; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones; Random Allocation; Theophylline	1988
[Gyrase inhibitors can delay caffeine elimination]. Deutsche medizinische Wochenschrift (1946), 1986, Sep-26, Volume: 111, Issue:39 Topics: Caffeine; Ciprofloxacin; Enoxacin; Humans; Naphthyridines; Theophylline	1986
Interaction between quinolones and caffeine. Drugs, 1987, Volume: 34 Suppl 1 Topics: Adult; Anti-Infective Agents; Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Male; Middle Aged; Naphthyridines; Ofloxacin; Oxazines; Quinolines	1987
Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test. British journal of clinical pharmacology, 1994, Volume: 38, Issue:6 Topics: Adolescent; Breath Tests; Caffeine; Carbon Dioxide; Child; Child, Preschool; Ciprofloxacin; Cystic Fibrosis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Depression, Chemical; Female; Humans; Male; Oxidoreductases	1994
The effect of fleroxacin and ciprofloxacin on the pharmacokinetics of multiple dose caffeine. Drugs, 1995, Volume: 49 Suppl 2 Topics: Adult; Anti-Infective Agents; Caffeine; Central Nervous System Stimulants; Ciprofloxacin; Cross-Over Studies; Female; Fleroxacin; Humans; Male; Single-Blind Method	1995
Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine. Clinical pharmacokinetics, 2003, Volume: 42, Issue:11 Topics: Administration, Oral; Adult; Area Under Curve; Body Weight; Caffeine; Ciprofloxacin; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Female; Fleroxacin; Humans; Male; Sex Factors	2003
Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:6 Topics: Adult; Anti-Infective Agents; Area Under Curve; Blood Pressure; Caffeine; Chromatography, High Pressure Liquid; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Half-Life; Heart Rate; Humans; Muscle Relaxants, Central; Phosphodiesterase Inhibitors	2004

Other Studies

31 other study(ies) available for ciprofloxacin and caffeine

Article	Year
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Animals; Anti-Infective Agents; Carbazoles; Cerebellar Diseases; Indole Alkaloids; Mice; Microbial Sensitivity Tests; Molecular Structure; Neurogenic Inflammation; Porifera; Stereoisomerism; Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition. European journal of clinical pharmacology, 1990, Volume: 39, Issue:1 Topics: Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Male; Models, Biological; Norfloxacin; Ofloxacin; Pipemidic Acid; Quinolones	1990
Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. The American journal of medicine, 1989, Nov-30, Volume: 87, Issue:5A Topics: Adult; Caffeine; Ciprofloxacin; Dealkylation; Drug Interactions; Enoxacin; Humans; Male	1989
Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:4 Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Half-Life; Humans; Male; Theophylline	1989
[Gyrase inhibitors modify metabolising processes in the liver]. Deutsche medizinische Wochenschrift (1946), 1987, Oct-30, Volume: 112, Issue:44 Topics: Caffeine; Ciprofloxacin; DNA Topoisomerases, Type II; Enoxacin; Humans; Liver; Male; Naphthyridines; Norfloxacin; Ofloxacin; Oxazines; Pipemidic Acid; Topoisomerase II Inhibitors	1987
Gyrase-inhibitors impair caffeine elimination in man. Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:3 Topics: Adult; Caffeine; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Kinetics; Male; Naphthyridines; Ofloxacin; Oxazines; Topoisomerase II Inhibitors	1987
Decrease of caffeine elimination in man during co-administration of 4-quinolones. The Journal of antimicrobial chemotherapy, 1987, Volume: 20, Issue:5 Topics: Adult; Anti-Infective Agents; Caffeine; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Half-Life; Humans; Male; Naphthyridines; Ofloxacin; Oxazines; Quinolines	1987
Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges. Environmental pollution (Barking, Essex : 1987), 2006, Volume: 142, Issue:2 Topics: Anti-Bacterial Agents; Caffeine; Chromatography, Liquid; Ciprofloxacin; Clindamycin; Environmental Monitoring; Spectrum Analysis; Sulfamethoxazole; Tetracycline; Trimethoprim; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Water Pollution; Water Purification	2006
Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Research in veterinary science, 2011, Volume: 90, Issue:1 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Caffeine; Chickens; Ciprofloxacin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Drug Interactions; Enrofloxacin; Fluoroquinolones; Gene Expression Regulation, Enzymologic; Half-Life; Liver; Male; Organ Size; Weight Gain	2011
The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacillus anthracis; Caffeine; Ciprofloxacin; DNA Damage; Drug Interactions; Escherichia coli; Kanamycin	2012
Occurrence and fate of PPCPs and correlations with water quality parameters in urban riverine waters of the Pearl River Delta, South China. Environmental science and pollution research international, 2013, Volume: 20, Issue:8 Topics: Acetaminophen; Caffeine; Carbamazepine; Carbon; China; Ciprofloxacin; DEET; Environmental Monitoring; Erythromycin; Nitrates; Nitrites; Nitrogen; Pharmaceutical Preparations; Quaternary Ammonium Compounds; Rivers; Sulfamethoxazole; Trimethoprim; Water Pollutants, Chemical; Water Quality	2013
Application of a Physiologically Based Pharmacokinetic Model to Study Theophylline Metabolism and Its Interactions With Ciprofloxacin and Caffeine. CPT: pharmacometrics & systems pharmacology, 2016, Volume: 5, Issue:2 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Bronchodilator Agents; Caffeine; Ciprofloxacin; Computer Simulation; Dose-Response Relationship, Drug; Drug Dosage Calculations; Drug Interactions; Female; Humans; Male; Middle Aged; Models, Biological; Precision Medicine; Sex Factors; Theophylline	2016
Offline solid-phase extraction for preconcentration of pharmaceuticals and personal care products in environmental water and their simultaneous determination using the reversed phase high-performance liquid chromatography method. Environmental monitoring and assessment, 2016, Volume: 188, Issue:9 Topics: Acetaminophen; Benzophenones; Caffeine; Carbanilides; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Ciprofloxacin; Cities; Cosmetics; Environmental Monitoring; India; Limit of Detection; Reproducibility of Results; Rivers; Sensitivity and Specificity; Sewage; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical	2016
Remobilization Dynamics of Caffeine, Ciprofloxacin, and Propranolol following Evaporation-Induced Immobilization in Porous Media. Environmental science & technology, 2017, Jun-06, Volume: 51, Issue:11 Topics: Adsorption; Caffeine; Ciprofloxacin; Porosity; Propranolol; Water Pollutants, Chemical; Water Purification	2017