ciprofibrate and troglitazone

ciprofibrate has been researched along with troglitazone in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (50.00)29.6817
2010's8 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Kiem, PV; Kim, YH; Minh, CV; Ngan, NT; Quang, TH; Song, SB; Tai, BH; Thao, NP1
Anh, Hle T; Choi, CW; Kiem, PV; Kim, YH; Luyen, BT; Minh, CV; Ngan, NT; Nhiem, NX; Quang, TH; Tai, BH; Thao, NP; Yang, SY; Yen, PH1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Laurora, S; Pizzimenti, S1
Bakke, I; Hammer, TA; Sandvik, AK; Waldum, HL1
Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Fraioli, A; Laurora, S; Maggio, M; Pizzimenti, S; Reffo, P1
Kim, HT; Kim, SH; Kim, YK; Kwon, CH; Park, JY; Yoo, CI1
Kim, YK; Kwon, CH; Yoon, CS1
Chung, C; Cornwell, M; Crawford, SE; Doll, JA; Gonzales, J; Reddy, JK; Stellmach, VM; Surapureddi, S1

Other Studies

16 other study(ies) available for ciprofibrate and troglitazone

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
    Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

    Topics: Anti-Inflammatory Agents; Asarum; Cyclooxygenase 2; Dose-Response Relationship, Drug; Furans; Hep G2 Cells; Humans; Inflammation; Magnetic Resonance Spectroscopy; Mass Spectrometry; NF-kappa B; Nitric Oxide Synthase Type II; Phenols; Plant Roots; PPAR alpha; Republic of Korea; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha

2012
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity.
    Bioorganic & medicinal chemistry letters, 2012, Nov-01, Volume: 22, Issue:21

    Topics: Antimetabolites; Diarylheptanoids; Dioscoreaceae; Enzyme Activation; Glycosides; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Methanol; Molecular Structure; NF-kappa B; Peroxisome Proliferator-Activated Receptors; Transcription, Genetic

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
    Free radical biology & medicine, 2002, Feb-01, Volume: 32, Issue:3

    Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells

2002
PPAR alpha stimulates the rat gastrin-producing cell.
    Molecular and cellular endocrinology, 2002, Sep-30, Volume: 195, Issue:1-2

    Topics: Animals; Chromans; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Ligands; Parietal Cells, Gastric; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone

2002
Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3

    Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression; HL-60 Cells; Humans; Ligands; Oncogenes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone

2003
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.
    Toxicology and applied pharmacology, 2006, Sep-01, Volume: 215, Issue:2

    Topics: 3T3 Cells; Anilides; Animals; Antioxidants; Apoptosis; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Enzyme Inhibitors; Fibric Acids; Hypoglycemic Agents; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Reactive Oxygen Species; Thiazolidinediones; Troglitazone

2006
Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
    Toxicology, 2008, Feb-03, Volume: 244, Issue:1

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Epithelial Cells; Fibric Acids; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Imidazoles; Kidney Tubules; Membrane Potential, Mitochondrial; Opossums; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Pyridines; Thiazolidinediones; Troglitazone

2008
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
    Advances in experimental medicine and biology, 2008, Volume: 617

    Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chromans; Clofibric Acid; Endothelium, Vascular; Eye Proteins; Fibric Acids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Liver Neoplasms; Neovascularization, Pathologic; Nerve Growth Factors; PPAR alpha; PPAR gamma; Serpins; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured

2008