ciprofibrate has been researched along with clofibric acid in 361 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (18.28) | 18.7374 |
| 1990's | 194 (53.74) | 18.2507 |
| 2000's | 100 (27.70) | 29.6817 |
| 2010's | 1 (0.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Arnold, A; Beyler, AL; McAuliff, MP | 1 |
| Bonner, FW; Gibson, GG; Makowska, JM | 3 |
| Baldwin, LA; Calabrese, EJ; Leonard, DA; Ochs, JB | 1 |
| Lindroos, P; Michalopoulos, GK; Tsai, WH; Zarnegar, R | 1 |
| Anderson, NH; Johnston, D; Vojvodic, PR | 1 |
| Alvares, K; Capone, JP; Marcus, SL; Rachubinski, RA; Reddy, JK; Sajjadi, FG; Subramani, S; Zhang, B | 1 |
| Dejean, C; Fievre, JL; Martin, A; Perault, MC; Vandel, B | 1 |
| Bennett, AM; Williams, GM | 3 |
| Asayama, K; Dhaunsi, GS; Gulati, S; Orak, JK; Singh, AK; Singh, I | 1 |
| Angeloff, K; Budroe, JD; Umemura, T; Williams, GM | 1 |
| Baker, M; Borges, T; Chen, LC; Chen, LH; Glauert, HP; Lay, LT; Robertson, LW; Saxon, DM; Srinivasan, S; Tatum, VL | 1 |
| Amigo, L; Bronfman, M; Cárdenas, L; Hidalgo, PC; Morales, MN; Nuñez, L; Orellana, A | 1 |
| Lazo, O; Singh, I | 1 |
| Infante, J; Infante, R; Qin, W; Wang, SR | 1 |
| Harvengt, C | 1 |
| Tielemans, YK; Willems, GE | 1 |
| Keller, BJ; Thurman, RG; Yamanaka, H | 1 |
| Cannon, JR; Eacho, PI | 1 |
| Armstrong, DW; Kohl, C; Oelschläger, H; Rothley, D | 1 |
| Gemmell, MA; Giometti, CS; Lalwani, ND; Reddy, JK; Taylor, J; Tollaksen, SL | 2 |
| Gibson, GG; Lake, BG | 1 |
| Charmoillaux, M; Goudonnet, H; Mercenne, F; Mounié, J; Truchot, RC | 1 |
| Czejka, M | 1 |
| Harpur, ES; Kaptein, E; Visser, TJ | 1 |
| Eacho, PI; Foxworthy, PS; Hoover, DM; White, SL | 1 |
| Beaty, MM; Borges, T; Chen, LC; Chow, CK; Clark, TD; Clark, TL; Glauert, HP; Greenwell, WS; Srinivasan, SR; Tatum, V | 1 |
| Danna, TF; Randerath, E; Randerath, K; Rao, MS; Reddy, JK; Reddy, R | 1 |
| Contreras, M; Lazo, O; Singh, I | 1 |
| Rao, MS; Subbarao, V; Thangada, S | 1 |
| Beije, B; Erixon, K; Nilsson, R; Préat, V; Ramel, C | 1 |
| Frishman, WH; Kahn, S; Zimetbaum, P | 1 |
| Beaty, MM; Chow, CK; Clark, TD; Glauert, HP; Greenwell, WS | 1 |
| Clerc, C; Cloarec, L; Doualin, G; Fertil, V; Legras, B; Ruelland, A | 1 |
| Hashimoto, T; Osumi, T; Yokota, S | 1 |
| Delangre, T; Mihout, B; Moore, N; Vernier, L | 1 |
| Fox, TR; Maher, VM; McCormick, JJ; Schumann, AM; Watanabe, PG; Yano, BL | 1 |
| Glauert, HP; Srinivasan, S | 1 |
| Cherkaoui Malki, M; Corral-Debrinski, M; Latruffe, N; Lone, YC | 1 |
| Bardot, O; Cherkaoui Malki, M; Latruffe, N; Lhuguenot, JC | 1 |
| Chow, HS; Glauert, HP; Hennig, B | 1 |
| Bouckaert, A; Michel, G | 1 |
| Rao, MS; Subbarao, V; Yeldandi, AV | 1 |
| Bronfman, M; Hidalgo, PC; Mezzano, D; Morales, MN; Orellana, A | 1 |
| Baldwin, LA; Calabrese, EJ; Kostecki, PT; Yang, JH | 1 |
| Chow, CK; Glauert, HP; Srinivasan, SR | 1 |
| Anders, C; Bonner, F; Gibson, GG; Goldfarb, PS; Makowska, JM | 1 |
| Bartles, JR; Fayos, BE; Isoye, ST; Khuon, S; Lin, XH; Nehme, CL; Rao, MS; Reddy, JK; Zhang, LQ | 1 |
| Makino, T; Nemali, MR; Pitot, HC; Rao, MS; Reddy, JK; Scarpelli, DG; Usuda, N | 1 |
| Cruise, JL; Michalopoulos, GK; Tsai, WH | 1 |
| Barbolt, TA; Bonner, FW; Eason, CT; Henry, DC; Sauerschell, RJ; Spencer, AJ | 1 |
| Rajan, A; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV | 1 |
| Feller, DR; Kocarek, TA | 1 |
| Bernard, N; Cuisinaud, G; Ferry, N; Gardes, E; Labeeuw, M; Pozet, N; Sassard, J; Zech, PY | 1 |
| Hellwich, KH; Oelschläger, H; Rothley, D; Schmidt, W | 2 |
| Bonner, FW; Gibson, GG; Goldfarb, PS; Makowska, JM | 1 |
| Milano, M; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV | 1 |
| Kasai, H; Nishimura, S; Okada, Y; Rao, MS; Reddy, JK | 1 |
| Alvares, K; Mangino, M; Rao, MS; Reddy, JK; Thangada, S; Usman, MI | 1 |
| Angelin, B; Einarsson, K; Ståhlberg, D | 1 |
| Bonner, FW; Eason, CT; Henry, G; Pattison, A; Powles, P; Spencer, AJ | 1 |
| Beer, D; Coloma, J; Glauert, HP; Goldsworthy, TL; Pitot, HC; Rao, MS; Schwarz, M; Xu, YD | 1 |
| Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M | 1 |
| Rao, MS; Reddy, JK; Subbarao, V | 3 |
| Milano, M; Prasad, JD; Rao, MS; Reddy, JK | 1 |
| Hashimoto, T; Nemali, MR; Osumi, T; Oyasu, K; Rao, MS; Reddy, JK; Reddy, MK; Usuda, N | 1 |
| Dwivedi, RS; Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Bonner, FW; Eason, CT; Howells, DD; Pattison, A | 1 |
| Marlowe, C; Rao, MS; Reddy, JK; Waddell, WJ | 1 |
| Clark, TD; Glauert, HP | 1 |
| Agius, L; Alberti, KG; Gerondaes, P | 2 |
| Krause, BR; Newton, RS | 1 |
| Rao, MS; Reddy, JK; Scarpelli, DG | 1 |
| Kokkinakis, DM; Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Bonner, FW; Eason, CT; Henry, DC; Howells, DD; Pattison, A; Spencer, AJ | 1 |
| Farber, E; Mitranic, MM; Moscarello, MA; Roomi, MW | 1 |
| Oelschläger, H; Rothley, D; Schmidt, W | 1 |
| Agius, L; Bartlett, K; Bhuiyan, AK; Sherratt, HS | 1 |
| Bonnefis, MT; Infante, R; Petit, D; Rey, C | 1 |
| Bonner, FW; Eason, CT; Howells, DD; Pattison, A; Spencer, AJ | 1 |
| Palmer, RH | 1 |
| Hunninghake, DB; Peters, JR | 1 |
| Elcombe, CR; Gibson, GG; Kass, GE; Milton, MN | 1 |
| Brooks, B; Brown, P; Byers, LW; Capdevila, J; Dowell, R; Muirhead, E; Pitcock, JA | 1 |
| Carrino, JJ; Goel, SK; Hashimoto, T; Laffler, TG; Lalwani, ND; Nemali, MR; Osumi, T; Reddy, JK; Reddy, MK; Sperbeck, SJ | 1 |
| Eacho, PI; Foxworthy, PS | 1 |
| Alvares, K; Lalwani, ND; Parikh, I; Reddy, JK; Reddy, MK; Reddy, MN | 1 |
| Beaumont, JL; Beaumont, V; Buxtorf, JC; Carcone, B; Doucet, F; Edouard, L; Jacotot, B | 1 |
| Evarts, RE; Lalwani, ND; Rao, MS; Reddy, JK; Reddy, MK; Singh, B; Thorgeirsson, S; Usman, MI | 1 |
| Evarts, RP; Rao, MS; Wirth, PJ | 1 |
| Foliot, A; Mallet, L; Touchard, D | 1 |
| Lalwani, ND; Rao, MS; Reddy, JK; Reddy, MK; Usman, MI | 1 |
| Estabrook, RW; Weiss, RH | 1 |
| Amigo, L; Bronfman, M; Morales, MN | 1 |
| Capdevila, J; Estabrook, RW; Falck, JR; Kim, YR; Manna, S; Martin-Wixtrom, C | 1 |
| MacDonald, RS; Swan, PB | 1 |
| Goel, SK; Lalwani, ND; Reddy, JK | 1 |
| Bakir, R; Chanu, B; Djian, F; Goy-Loeper, J; Rouffy, J | 1 |
| Earley, K; Goel, SK; Gupta, RC; Reddy, JK; Singh, B | 1 |
| Davidson, JF; Lorimer, AR; Simpson, IA; Walker, ID | 1 |
| Lalwani, ND; Qureshi, SA; Rao, MS; Reddy, JK; Reddy, MK; Scarpelli, DG | 1 |
| Angelin, B; Einarsson, K; Leijd, B | 1 |
| Awasthi, YC; Goel, SK; Reddy, JK; Singh, SV | 1 |
| Fahl, WE; Lalwani, ND; Reddy, JK | 1 |
| Lalwani, ND; Moehle, CM; Qureshi, SA; Reddy, JK; Reddy, MK | 1 |
| Lalwani, ND; Rao, MS; Reddy, JK; Watanabe, TK | 1 |
| Connor, WE; Cook, SF; Illingworth, DR; Olsen, GD; Sexton, GJ; Wendel, HA | 1 |
| Olsson, AG; Orö, L | 1 |
| Biddlecome, CE; Edelson, J; Koblantz, C; Park, GB | 1 |
| Rao, MS; Subbarao, V | 3 |
| Baldwin, LA; Calabrese, EJ; Donohue, M; Kostecki, PT; Leonard, DA | 1 |
| Bardot, O; Cherkaoui Malki, M; Clemencet, MC; Latruffe, N | 1 |
| Kocarek, TA; Novak, RF; Woodcroft, KJ; Zangar, RC | 1 |
| Jannin, B; Latruffe, N; Passilly, P | 1 |
| Branco, MC; de Moura, JP; Ferreira, MR; Figueiredo, H; Jesus, LC; Pereira, M; Serra e Silva, P; Silva, JM | 1 |
| Ioannides, C; Irizar, A | 1 |
| Branco, MC; de Moura, JP; Ferraz, A; Ferreira, MR; Jesus, LC; Pereira, M; Serra e Silva, P; Silva, JM | 1 |
| Cornu-Chagnon, MC; Dupont, H; Edgar, A | 1 |
| Espandiari, P; Glauert, HP; Noonan, D; O'Brien, M; Robertson, LW; Thomas, VA | 1 |
| Buetler, TM; Eaton, DL; Gallagher, EP; Stahl, DL; Stapleton, PL; Wang, C | 1 |
| Eckl, PM; Reisenbichler, H | 1 |
| Lindroos, P; Michalopoulos, GK | 1 |
| Baldwin, LA; Calabrese, EJ; Kostecki, PT | 1 |
| Schonfeld, G | 1 |
| Cherkaoui Malki, M; el Kebbaj, MH; Latruffe, N | 1 |
| Brestescher, C; Chanu, B; Farge, D; Giraud, O; Parrot, F; Rouffy, J | 1 |
| Knights, KM; MacLeod, JK; Roberts, BJ; Singh, I | 1 |
| Beucler, I; Cassaigne, A; De Gennes, JL; de Zulueta, MP; Iron, A; Richard, P | 1 |
| Gulati, S; Pahan, K; Singh, I | 1 |
| Dujovne, CA; Lozada, A | 1 |
| Bonner, FW; Graham, MJ; Gray, TJ; Harpur, ES; Winham, MA | 1 |
| Chow, CK; Glauert, HP; Huang, CY; Lay, LT; Robertson, LW; Wilson, MW | 1 |
| Farmer, JA; Gotto, AM | 1 |
| Bardot, O; Caira, F; Cherkaoui Malki, M; Latruffe, N; Pacot, C | 1 |
| Chen, ZY; Eaton, DL; He, CY; Liu, YF; White, CC | 2 |
| Batchelor, AJ; Chandler, HA | 1 |
| Capps, NE | 1 |
| Dhaunsi, GS; Orak, JK; Singh, AK; Singh, I | 1 |
| Baes, MI; Castelein, H; Declercq, PE; Gulick, T; Mannaerts, GP; Moore, DD | 1 |
| Armitage, M; McLeod, AJ; Warren, RJ | 2 |
| Ide, H; Kumar, S; Rao, MS; Reddy, JK; Yeldandi, AV | 1 |
| Asayama, K; Dhaunsi, GS; Gupta, MP; Orak, JK; Singh, AK; Singh, I | 1 |
| Chen, H; Chow, CK; Glauert, HP; Huang, CY; Lay, LT; Robertson, LW; Wilson, MW | 1 |
| Devuyst, O; Goffin, E; Pirson, Y; van Ypersele de Strihou, C | 2 |
| Bonner, FW; Graham, MJ; Old, SL; Rees, JA; Spencer, AJ; Wilson, SA; Winham, MA | 1 |
| Alvares, K; Capone, JP; Dadras, SS; Fan, C; Iannaccone, PM; Rachubinski, RA; Rao, MS; Reddy, JK; Subramani, S; Yeldandi, AV | 1 |
| Hellwich, KH; Oelschläger, H; Rothley, D | 1 |
| Bartles, JR; Fayos, BE | 1 |
| Bruckert, E; Chapman, MJ; Dejager, S | 1 |
| Bronfman, M; Faúndez, V; González, A; Hidalgo, PC; Holuigue, L; Orellana, A | 1 |
| Capone, JP; Marcus, SL; Miyata, KS; Rachubinski, RA; Subramani, S; Zhang, B | 1 |
| Bournot, P; Brocard, C; Es-Souni, M; Latruffe, N; Ramirez, LC | 1 |
| Anderson, MW; Belinsky, SA; Devereux, TR; Fox, TR; Hegi, ME | 1 |
| Beamand, JA; Cunninghame, ME; Lake, BG; Price, RJ | 1 |
| Bentejac, M; Bugaut, M; Causeret, C; Clemencet, MC | 1 |
| Charmoillaux, M; Goudonnet, H; Latruffe, N; Pacot, C; Truchot, RC | 1 |
| Shepherd, J | 1 |
| Betteridge, DJ | 1 |
| Guzelian, PS; Kocarek, TA; Schuetz, EG | 1 |
| Behechti, N; Caira, F; Cavatz, C; Cherkaoui Malki, M; Grégoire, S; Moisant, M; Moreau, C; Pacot, C; Petit, M; Rollin, M | 1 |
| Chu, R; Jameson, JL; Kopp, P; Lin, Y; Madison, LD; Rao, MS; Reddy, JK | 1 |
| Chow, CK; Glauert, HP; Lay, LT; Robertson, LW; Tai, HH; Wilson, MW | 1 |
| Goolsby, CL; Rao, MS | 1 |
| Castellon, R; Chu, R; Huang, Q; Reddy, JK; Varanasi, U; Yeldandi, AV | 1 |
| Baigts, F; Bruckert, E; De Gennes, JL; Malbecq, W | 1 |
| Hassell, SJ; Jannin, B; Latruffe, N; Passilly, P | 1 |
| Althoff, J; Behechti, N; Deslex, P; Latruffe, N; Lhuguenot, JC; Moisant, M; Pacot, C; Petit, M; Rollin, M | 1 |
| Accatino, L; Amigo, L; Andrade, L; Chianale, J; Gonzalez, S; Nervi, F; Pizarro, M; Rigotti, A; Vollrath, V; Wielandt, AM | 1 |
| Bammler, TK; Buetler, TM; Eaton, DL; Hayes, JD | 1 |
| Alvares, K; Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Glauert, HP; Leung, LK | 3 |
| Crute, BE; Daniel, S; Fassihi, KS; Ha, J; Kim, KH; King, N; Noll, WW; Nutile-McMenemy, N; Schlichter, SC; Wheeler, KS; Widmer, J; Witters, LA | 1 |
| Canepo-Anson, R; Collinson, PO; Hjelm, CJ | 1 |
| Beamand, JA; Charzat, C; Lake, BG; Price, RJ; Renwick, AB; Tredger, JM | 1 |
| Crowley, VE; Olukoga, AO; Stewart, MF; Weinkove, O | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| Kotova, LA; Kukharchuk, VV; Rozhkova, TA; Semenova, OA; Tvorogova, MG | 1 |
| Cherkaoui Malki, M; el Kebbaj, MS; Latruffe, N | 1 |
| Graham, MJ; Gray, TJ; Old, SL; Winham, MA | 1 |
| Bruckert, E; Chapman, MJ | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y; Vandenplas, C | 1 |
| de Valois, JC; Kastelein, JJ; Knipscheer, HC; van den Ende, B; Wouter ten Cate, J | 1 |
| Bruckert, E; Turpin, G | 1 |
| Glauert, HP; Hong, JT; Wilson, MW | 1 |
| Martinsen, TC; Nesjan, N; Rønning, K; Sandvik, AK; Waldum, HL | 1 |
| Glauert, HP; Hong, JT | 3 |
| Novak, RF; Woodcroft, KJ; Zangar, RC | 1 |
| Cavalli, E; Cignarella, A; Nastasi, M; Puglisi, L | 1 |
| Glauert, HP; Leung, LK; Li, Y; Spear, BT | 1 |
| Blain, H; Hanesse, B; Klein, M; Leclère, J; Tréchot, P; Weryha, G | 1 |
| Singh, I | 1 |
| Bardot, O; Caira, F; Cherkaoui Malki, M; Clemencet, MC; Jannin, B; Latruffe, N; Pacot, C; Passilly, P | 1 |
| Glauert, HP; Hong, JT; Leung, LK; Wilson, MW | 2 |
| Athyros, VG; Boudoulas, H; Hatzikonstandinou, HA; Kontopoulos, AG; Mayroudi, MC; Papageorgiou, AA | 1 |
| Betteridge, DJ; O'Bryan-Tear, CG | 1 |
| Cuniberti, LA; Masnatta, LD; Rey, RH; Werba, JP | 1 |
| Murphy, MJ; O'Reilly, DS; Packard, CJ | 1 |
| de Maat, MP; Kastelein, JJ; Kluft, C; Knipscheer, HC | 1 |
| Autier, P; Muls, E; Van Gaal, L; Vansant, G | 1 |
| Bournot, P; Bride, J; Duclos, S; Ramirez, LC | 1 |
| Artur, Y; Goudonnet, H; Magdalou, J; Masmoudi, T; Mounié, J | 1 |
| Giles, PD; Hartland, A; Ramachandran, S | 1 |
| Athyros, VG; Carina, MV; Didangelos, TP; Hatzikonstandinou, HA; Kontopoulos, AG; Kranitsas, DF; Papageorgiou, AA | 1 |
| de Maat, MP; Kastelein, JJ; Kluft, C; Knipscheer, HC; Kockx, M; Kooistra, T; Princen, HM | 1 |
| Farber, E; Parke, DV; Roomi, MW | 1 |
| Anber, V; McConnell, M; Millar, JS; Packard, CJ; Shepherd, J | 1 |
| Bruckert, E | 1 |
| Perrone, CE; Williams, GM | 1 |
| Caira, F; Cherkaoui-Malki, M; Clémencet, MC; Dieuaide-Noubhani, M; Latruffe, N; Pacot, C; Van Veldhoven, PP | 1 |
| Kvetnoi, IM; Martinsen, TC; Sandvik, AK; Schulze, B; Sylte, R; Waldum, HL | 1 |
| Glauert, HP; Nilakantan, V; Spear, BT | 2 |
| Serra e Silva, P; Silva, JM | 1 |
| Perrone, CE; Shao, L; Williams, GM | 1 |
| Hammer, TA; Sandvik, AK; Waldum, HL | 1 |
| Feller, DR; Intrasuksri, U; Noonan, DJ; O'Brien, M; Rangwala, SM | 1 |
| Bluethmann, H; Ciliberto, G; Columbano, A; Curto, M; Ledda-Columbano, GM; Menegazzi, M; Piga, R; Poli, V; Sartori, C; Shinozuka, H; Zedda, AI | 1 |
| Beaugrand, M; Bertrand, HJ; Castera, L; de Leusse, A; Ganne-Carrié, N; Guettier, C; Levecq, H; Plumet, Y; Trinchet, JC | 1 |
| Danz, M; Deufel, T; Karge, E; Klinger, M; Klinger, W; Kühnel, W; Linss, W; Löbel, S; Lupp, A; Müller, M; Oelschläger, H; Rothley, D | 1 |
| Karge, E; Klinger, W; Oelschläger, H; Rothley, D; Vogelsang, H | 1 |
| Ginter, E; Nagyová, A; Raslová, K | 1 |
| Gironet, N; Jan, V; Lorette, G; Machet, L; Machet, MC; Vaillant, L | 1 |
| Arabidze, GG; Kukharchuk, VV; Susekov, AV; Tvorogova, MG | 1 |
| Bronfman, M; Chianale, J; Loyola, G; Ponce, C; Rojas, S; Roth, A; Vollrath, V | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Hong, JT; Yun, YP | 1 |
| Buhler, DR; Haasch, ML; Henderson, MC | 1 |
| Hashimoto, T; Maeda, N; Pan, J; Pulikuri, S; Qi, C; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV; Zhu, Y | 1 |
| Byrne, DJ; Ganotakis, ES; Jagroop, IA; Mikhailidis, DP; Spyropoulos, KA; Winder, AF | 1 |
| Novak, RF; Woodcroft, KJ | 1 |
| Derudas, B; Gervois, PP; Gonzalez, FJ; Kockx, M; Kooistra, T; Peters, JM; Poulain, P; Princen, HM; Staels, B | 1 |
| Wallace, KB; Zhou, S | 1 |
| Hashimoto, T; Maeda, N; Pan, J; Qi, C; Rao, MS; Reddy, JK; Usuda, N; Yeldandi, AV; Zhu, Y | 1 |
| Ganotakis, ES; Jagroop, IA; Mikhailidis, DP; Papadakis, JA; Winder, AF | 1 |
| Blaschke, G; Hüttemann, H | 1 |
| Beghin, L; Capps, N; Davies, J; Duhal, N; Luc, G; Staels, B | 1 |
| Bernat, A; Chatenet-Duchène, L; Herbert, JM | 1 |
| Anber, V; Millar, JS; Packard, CJ; Shepherd, J | 1 |
| Boscoboinik, D; Cherkaoui Malki, M; Dauça, M; Jannin, B; Latruffe, N; Passilly, P; Schohn, H | 1 |
| Desager, JP; Devuyst, O; Goffin, E; Jamar, F | 1 |
| Farioli-Vecchioli, S; Nardacci, R; Pajalunga, D; Sartori, C; Stefanini, S | 1 |
| Bellemin, B; Boillot, O; Chevallier, M; Dumortier, J; Paliard, P; Scoazec, JY; Slim, R; Thaunat, JL; Vaillant, E; Vial, T | 1 |
| Glauert, HP; Li, Y; Spear, BT | 1 |
| Cibulova, L; Fedelesova, V; Gajdos, M; Huttova, D; Krivosikova, Z; Mongiellova, V; Polak, F | 1 |
| Madden, BP; Millner, R; Parker, J; Rolfe, LM; Seymour, CA; Sharobeem, KM | 1 |
| Armstrong, CL; Barker, MG; Bondy, GS; Curran, IH; Mehta, R | 1 |
| Cunninghame, ME; Lake, BG; Price, RJ; Rumsby, PC | 1 |
| Columbano, A; Dore, M; Ledda-Columbano, GM; Loi, R; Perra, A; Pibiri, M; Piga, R; Shinozuka, H | 1 |
| Anderson, RA; Davies, S; Ellis, GR; Evans, M; Frenneaux, MP; Graham, J; Jackson, SK; Lewis, MJ; Morris, K; Rees, A | 1 |
| Ascaso, JF; Carmena, R; Hernández-Mijares, A; Lluch, I; Martínez-Triguero, ML; Vizcarra, E | 1 |
| Cabrero, A; Ciudad, CJ; Laguna, JC; Noé, V; Rodríguez, C | 1 |
| Evans, DC; Heavens, R; Jack, A; Meneses-Lorente, G; Surry, DD | 1 |
| Bakke, I; Sandvik, AK; Waldum, HL | 1 |
| Grniaková, V; Turay, J; Valka, J | 1 |
| Boscoboinik, D; Jannin, B; Latruffe, N; Motojima, K; Passilly-Degrace, P | 1 |
| Dobiásová, M; Frohlich, J | 1 |
| Ceska, R; Haas, T; Kvasnicka, T; Soska, V; Vaverková, H | 1 |
| Cook, WS; Hashimoto, T; Rao, MS; Reddy, JK; Yeldandi, AV | 1 |
| Abramowicz, D; Antoine, M; Broeders, N; Knoop, C; Tielemans, C | 1 |
| Adzet, T; Cabrero, A; Ciudad, CJ; Laguna, JC; Rodríguez, C; Roglans, N; Sánchez, RM; Vázquez, M | 1 |
| Dobiásová, M; Dusinská, M; Nagyová, A; Ptácková, K; Raslová, K | 1 |
| Athyros, VG; Kontopoulos, AG; Papageorgiou, AA | 1 |
| Elisaf, M; Liberopoulos, E; Miltiadous, G | 1 |
| Doolman, R; Gavendo, S; Harats, D; Marko, D; Sela, BA; Shaish, A; Yodfat, O | 1 |
| Császár, A; Kovács, I; Tarján, J | 1 |
| Elisaf, M; Kakafika, A; Tsimihodimos, V | 1 |
| Aguilar-Salinas, CA; Fanghänel-Salmón, G; Gómez Pérez, FJ; González-Valdez, H; Gulías-Herrero, A; Meza, E; Monterrubio-Flores, EA; Montes, J; Sánchez, L | 1 |
| Bargman, JM; Lipscombe, J | 1 |
| Cibulová, L; Dzúrik, R; Gajdos, M; Huttová, D; Krivosíková, Z; Mongiellová, V; Spustová, V | 1 |
| Duez, H; Gervois, PP; Kuipers, F; Post, SM; Princen, HM; Staels, B | 1 |
| Jagroon, IA; Mikhailidis, DP | 1 |
| Drogemuller, CJ; Knights, KM; Nunthasomboon, S | 1 |
| Cwalina, L; Herman, ZS; Kalina, Z; Kowalski, J; Lebek, M; Okopien, B; Wisniewska-Wanat, M; Zielinski, M | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Laurora, S; Pizzimenti, S | 1 |
| Araya, C; Koenig, C; Leighton, F; Santos, MJ; Skorin, C; Toro, A; Valencia, C | 1 |
| Aru, GM; Mujumdar, VS; Tummalapalli, CM; Tyagi, SC | 1 |
| Athyros, VG; Athyrou, VV; Demitriadis, DS; Kontopoulos, AG; Papageorgiou, AA; Pehlivanidis, AN | 1 |
| Cullingford, TE; Dolphin, CT; Sato, H | 1 |
| Achimastos, A; Bairaktari, E; Elisaf, M; Goudevenos, J; Kakafika, A; Liamis, G; Miltiadous, G; Tsimihodimos, V | 1 |
| Duriez, P; Fruchart, JC; Hazzan, M; Kandoussi, A; Martin, F; Noël, C; Staels, B | 1 |
| Shen, CN; Slack, JM; Tosh, D | 1 |
| Athyros, V; Bairaktari, E; Elisaf, M; Ganotakis, E; Rizos, E; Seferiades, C; Tsimihodimos, V | 1 |
| Hunt, MJ; Tyagi, SC | 1 |
| Bakke, I; Hammer, TA; Sandvik, AK; Waldum, HL | 1 |
| Bloks, VW; Havinga, R; Jansen, PL; Kok, T; Kuipers, F; Staels, B; Wolters, H | 1 |
| Gervois, PP; Kleemann, R; Kooistra, T; Princen, HM; Staels, B; Verschuren, L | 1 |
| Bairaktari, E; Elisaf, M; Ganotakis, E; Mikhailidis, DP; Rizos, E; Tsimihodimos, V | 1 |
| Hunt, MJ; Sood, HS; Tyagi, SC | 1 |
| Elisaf, M; Kostoula, A | 1 |
| Fujisaki, K; Itoh, Y; Maiguma, T; Makino, K; Oishi, R; Sasaguri, T; Takahashi-Yanaga, F; Teshima, D | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Fraioli, A; Laurora, S; Maggio, M; Pizzimenti, S; Reffo, P | 1 |
| Bendheim, MØ; Martinsen, TC; Skogaker, NE; Waldum, HL | 1 |
| Borensztajn, J; Fu, T; Kashireddy, P | 1 |
| Cao, WQ; Dyck, PA; Lee, JS; Meyer, K; Rao, MS; Reddy, JK; Thorgeirsson, SS | 1 |
| Glöckner, R; Hellwich, KH; Hofmann, B; Machts, H; Müller, D; Oelschläger, H; Seeling, A; Ueberall, S | 1 |
| Albi, E; Pieroni, S; Sartori, C; Viola Magni, MP | 1 |
| Betz, W; Devroey, D; Duquet, W; Velkeniers, B | 1 |
| Bakke, I; Komorowski, J; Kusnierczyk, W; Laegreid, A; Sandvik, AK; Waldum, HL; Yadetie, F | 1 |
| Dzúrik, R; Gajdos, M | 1 |
| Taskinen, MR | 1 |
| Ghabrial, L; Glauert, HP; Konz, EC; Nalca, A; Owens, AB; Spear, BT; Tharappel, JC | 1 |
| Andrès, E; Di Liberatore, M; Geisler, F; Imbs, JL; Pflumio, F; Ubrich, M | 1 |
| Bruckert, E; Chapman, MJ; Frisdal, E; Guerin, M; Le Goff, W; Milosavljevic, D; Schneider, S | 1 |
| Borensztajn, J; Fu, T; Kozarsky, KF | 1 |
| Romaniv, S; Vecka, M; Zák, A; Zeman, M | 1 |
| Alberici, LC; Bighetti, EJ; de Faria, EC; Degaspari, GR; Oliveira, HC; Souza, CT; Vercesi, AE | 1 |
| Ammerschlaeger, M; Beigel, J; Klein, KU; Mueller, SO | 1 |
| Borensztajn, J; Davidson, NO; Fu, T; Mukhopadhyay, D | 1 |
| Anderson, SP; Brown, AR; Brown, HR; Cariello, NF; Colton, HM; Dahl, RR; Hoivik, DJ; Kimbrough, CL; Miller, RT; Mirabile, RC; Morgan, RJ; Mudd, PN; Oliver, WB; Qualls, CW; Santostefano, MJ; Zhao, Z | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Bergum, H; Laegreid, A; Norsett, K; Sandvik, AK; Yadetie, F | 1 |
| Bournot, P; Chevillard, G; Duclos, S; Le Jossic-Corcos, C; Martin, P; Pineau, T; Ramirez, LC; Zaghini, I | 1 |
| Calfee-Mason, KG; Glauert, HP; Spear, BT | 1 |
| Benani, A; Heurtaux, T; Minn, A; Netter, P | 1 |
| Cherkaoui-Malki, M; Clémencet, MC; El Kebbaj, MS; El Kebbaj, Z; Kabine, M; Latruffe, N; Oaxaca-Castillo, D | 1 |
| Cai, H; Falany, CN; Fang, HL; Kocarek, TA; Runge-Morris, M; Strom, SC | 1 |
| Canuto, RA; Clemencet, MC; Gonzalez, FJ; Latruffe, N; Muzio, G; Peters, JM; Trombetta, A | 1 |
| Columbano, A; Ledda-Columbano, GM; Molotzu, F; Perra, A; Pibiri, M | 1 |
| Anderson, SP; Benavides, GR; Brown, R; Cariello, NF; Casey, W; Colton, HM; Creech, D; Falls, JG; Hoivik, DJ; Miller, RT; Ni, H; Romach, EH; Yoon, L | 1 |
| Aamo, T; Bakke, I; Chen, D; Martinsen, TC; Sandvik, AK; Waldum, HL; Zahlsen, K | 1 |
| Belowski, D; Herman, ZS; Kowalski, J; Krysiak, R; Madej, A; Okopień, B; Zieliński, M | 1 |
| Essid, A; Fontaine, C; Guiard-Schmid, JB; Lukiana, T; Pialoux, G; Rondeau, E; Slama, L | 1 |
| Balice, M; Chironi, G; Del-Pino, M; Gariepy, J; Levenson, J; Simon, A | 1 |
| Cooke, GM; Curran, IH; Hierlihy, AM; Karamanos, L; Mehta, R; Price, CA | 1 |
| Hauzer, A; Komsta, Ł; Majchrzak, E; Misztal, G | 1 |
| Guo, D; Rao, MS; Reddy, JK; Surapureddi, S; Viswakarma, N; Yu, S | 1 |
| Arocha-Piñango, CL; Carvajal, Z; Castillo, L; Espinosa, RA; Gil, A; Lundberg, U; Mijares, ME; Nagy, E; Rodríguez-Larralde, A; Rodríguez-Roa, E | 1 |
| Kim, HT; Kim, SH; Kim, YK; Kwon, CH; Park, JY; Yoo, CI | 1 |
| Audikovszky, M; Debreczeni, L; Erdei, A; Harangi, M; Illyés, L; Kovácsay, A; Pados, G; Paragh, G; Seres, I | 1 |
| Aguilera, MC; Amigo, L; Bronfman, M; Contador, D; Gatica, A; Loyola, G; Pinto, CO; Tichauer, JE; Zanlungo, S | 1 |
| Berneis, K; Rizzo, M | 1 |
| Hannig, M; Piper, HM; Sauer, H; Sharifpanah, F; Wartenberg, M | 1 |
| Kim, YK; Kwon, CH; Yoon, CS | 1 |
| Calfee-Mason, KG; Glauert, HP; Lee, EY; Spear, BT | 1 |
| Al Kholaifi, A; Amer, A; Bell, DR; Gray, TJ; Jeffery, B; Roberts, RA | 1 |
| Fidaleo, M; Sartori, C | 1 |
| Chung, C; Cornwell, M; Crawford, SE; Doll, JA; Gonzales, J; Reddy, JK; Stellmach, VM; Surapureddi, S | 1 |
| Deufel, T; Fleck, C; Karge, E; Lupp, A; Oelschlägers, H | 1 |
| Andreoletti, P; Cherkaoui-Malki, M; Dauça, M; El Kebbaj, MS; El Kebbaj, Z; Kabine, M; Latruffe, N; Mountassif, D; Schohn, H | 1 |
| Coleman, MC; Glauert, HP; Kania-Korwel, I; Kannan, K; Lehmler, HJ; Mariappan, SV; Spitz, DR; Telu, S; Tharappel, JC; Weydert, J; Wu, Q; Xie, W | 1 |
| Berti, JA; Bighetti, EJ; Casquero, AC; Oliveira, HC; Patrício, PR | 1 |
| Chiba, K; Fukuchi, Y; Furihata, T; Kobayashi, K; Mizuno, Y; Saito, K | 1 |
17 review(s) available for ciprofibrate and clofibric acid
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
[Growth factors of enterochromaffin-like cells and physiopathology of experimental carcinoid tumors].
Topics: Animals; Clofibric Acid; Enterochromaffin Cells; Female; Fibric Acids; Gastric Mucosa; Gastrins; Growth Substances; Hypolipidemic Agents; Male; Neoplasms, Experimental; Omeprazole; Portacaval Shunt, Surgical; Rats; Somatostatin; Stomach Neoplasms | 1991 |
Effects of gemfibrozil and other fibric acid derivatives on blood lipids and lipoproteins.
Topics: Bezafibrate; Cholesterol, HDL; Clofibric Acid; Diabetes Mellitus, Type 2; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Kidney Diseases; Lipoproteins, VLDL; Metabolic Clearance Rate; Triglycerides | 1991 |
Transdifferentiated hepatocytes in rat pancreas.
Topics: 4-Hydroxyaminoquinoline-1-oxide; Animals; Cell Differentiation; Cell Division; Clofibric Acid; Copper; Cricetinae; DNA; Fibric Acids; Fluorescent Antibody Technique; Humans; Liver; Male; Microbodies; Microscopy, Electron; Pancreas; Rats | 1986 |
Effects of fibric acid derivatives on biliary lipid composition.
Topics: Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Propionates; Random Allocation | 1987 |
Effect of fibric acid derivatives on blood lipid and lipoprotein levels.
Topics: Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Pentanoic Acids | 1987 |
The effects of fibrates on lipoprotein and hemostatic coronary risk factors.
Topics: Arteriosclerosis; Bezafibrate; Blood Coagulation; Clofibric Acid; Coronary Disease; Fenofibrate; Fibric Acids; Gemfibrozil; Hemostasis; Humans; Hypolipidemic Agents; Lipoproteins; Risk Factors | 1994 |
Drug interactions with fibric acids.
Topics: Anticoagulants; Bezafibrate; Clofibrate; Clofibric Acid; Contraceptives, Oral; Coronary Disease; Drug Interactions; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Lipids | 1994 |
Antihyperlipidaemic agents. Drug interactions of clinical significance.
Topics: Anticholesteremic Agents; Cholestyramine Resin; Clofibric Acid; Colestipol; Drug Interactions; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Niacin; Probucol | 1994 |
Mechanism of action of fibrates.
Topics: Apolipoproteins B; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Lipoproteins, LDL; Male; Receptors, LDL | 1993 |
Ciprofibrate--a profile.
Topics: Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents | 1993 |
The atherogenic role of triglycerides and small, dense low density lipoproteins: impact of ciprofibrate therapy.
Topics: Cardiovascular Diseases; Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins, LDL; Lipoproteins, VLDL; Risk Factors; Triglycerides | 1996 |
Efficacy and safety of ciprofibrate in hyperlipoproteinaemias.
Topics: Animals; Cardiovascular Diseases; Clofibric Acid; Fibric Acids; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Safety; Treatment Outcome | 1996 |
Mammalian peroxisomes: metabolism of oxygen and reactive oxygen species.
Topics: Animals; Catalase; Clofibric Acid; Fibric Acids; Kidney; Microbodies; Oxidation-Reduction; Rats; Reactive Oxygen Species; Reperfusion Injury; Stress, Physiological | 1996 |
[Treatment of familial combined hyperlipidemia].
Topics: Clinical Protocols; Clofibric Acid; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lipids; Nicotinic Acids; Simvastatin | 1997 |
LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?
Topics: Arteriosclerosis; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Controlled Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Fibric Acids; Humans; Hypolipidemic Agents; Particle Size; Risk Factors; Sex Factors; Triglycerides | 2003 |
The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates.
Topics: Bezafibrate; Clofibric Acid; Dyslipidemias; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins, LDL; Particle Size; Treatment Outcome | 2007 |
34 trial(s) available for ciprofibrate and clofibric acid
| Article | Year |
|---|---|
[An epidemiological study of hypercholesterolemia in the Grand Duchy of Luxembourg].
Topics: Adult; Aged; Cholesterol, LDL; Cholesterol, VLDL; Clofibric Acid; Epidemiologic Methods; Female; Fibric Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Luxembourg; Male; Middle Aged | 1990 |
Effects of fibric acid derivatives on biliary lipid composition.
Topics: Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Propionates; Random Allocation | 1987 |
Effects of several lipid-lowering drugs on skin total and esterified cholesterol.
Topics: Cholesterol Esters; Clinical Trials as Topic; Clofibric Acid; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Probucol; Random Allocation; Skin | 1986 |
Comparative evaluation of the effects of ciprofibrate and fenofibrate on lipids, lipoproteins and apoproteins A and B.
Topics: Adult; Apolipoproteins A; Apolipoproteins B; Clofibrate; Clofibric Acid; Drug Evaluation; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Male; Propionates; Time Factors | 1985 |
Ciprofibrate in the therapy of type II hypercholesterolemia. A double-blind trial.
Topics: Adult; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Male | 1982 |
[Effectiveness of ciprofibrate. Open study in a Portuguese population].
Topics: Adolescent; Adult; Aged; Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Portugal; Time Factors | 1995 |
[Safety of ciprofibrate. Open study in a Portuguese population].
Topics: Adolescent; Adult; Aged; Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Portugal | 1995 |
Comparison of the efficacy of simvastatin and standard fibrate therapy in the treatment of primary hypercholesterolemia and combined hyperlipidemia.
Topics: Anticholesteremic Agents; Bezafibrate; Cholesterol, LDL; Clofibric Acid; Fatty Acids, Volatile; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1995 |
[A trial of the use of the hypolipidemic preparation Lipanor (ciprofibrate) in patients with primary hyperlipidemia].
Topics: Adolescent; Adult; Clofibric Acid; Female; Fibric Acids; Hemodynamics; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Lipoproteins; Male; Middle Aged; Time Factors | 1996 |
Pharmacodynamic activity of lipoprotein lipase and hepatic lipase, and pharmacokinetic parameters measured in normolipidaemic subjects receiving ciprofibrate (100 or 200 mg/day) or micronised fenofibrate (200 mg/day) therapy for 23 days.
Topics: Adult; Chromatography, High Pressure Liquid; Clofibric Acid; Cross-Over Studies; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Fenofibrate; Fibric Acids; Half-Life; Humans; Hypolipidemic Agents; Lipase; Lipoprotein Lipase; Liver; Male; Nephelometry and Turbidimetry; Reference Values | 1996 |
Ciprofibrate versus gemfibrozil in the treatment of primary hyperlipidaemia.
Topics: Adult; Aged; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Fibrinogen; Follow-Up Studies; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Retrospective Studies | 1996 |
Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease.
Topics: Adult; Analysis of Variance; Clofibric Acid; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Female; Fibric Acids; Fibrinogen; Follow-Up Studies; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lipids; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Morbidity; Prospective Studies; Safety; Simvastatin; Survival Rate; Treatment Outcome; Ultracentrifugation | 1996 |
Comparative efficacy and safety of ciprofibrate and sustained-release bezafibrate in patients with type II hyperlipidaemia.
Topics: Adult; Aged; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Delayed-Action Preparations; Female; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 1996 |
Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia.
Topics: Adult; Clofibric Acid; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged | 1997 |
Safety and efficacy of long-term statin-fibrate combinations in patients with refractory familial combined hyperlipidemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol, LDL; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome | 1997 |
Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients.
Topics: Adult; Aged; Cholesterol; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Smoking; Tissue Plasminogen Activator; Treatment Outcome | 1997 |
Does obesity influence ciprofibrate activity?
Topics: Adult; Aged; Body Mass Index; Clofibric Acid; Female; Fibric Acids; Humans; Hypolipidemic Agents; Male; Middle Aged; Obesity | 1998 |
Oxidation resistance of LDL in hypertriglyceridaemic patients treated with ciprofibrate.
Topics: Clofibric Acid; Copper; Diet, Fat-Restricted; Fibric Acids; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Kinetics; Lipid Peroxides; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Oxidation-Reduction; Prospective Studies; Thiobarbituric Acid Reactive Substances | 1998 |
[Lipanor treatment of atherogenic hyperlipoproteinemia].
Topics: Cholesterol; Clofibric Acid; Coronary Artery Disease; Disease Progression; Drug Administration Schedule; Female; Fibric Acids; Follow-Up Studies; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Risk Factors; Safety; Treatment Outcome; Triglycerides | 1998 |
Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus.
Topics: Adult; Analysis of Variance; Area Under Curve; Cholesterol, HDL; Clofibric Acid; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelium, Vascular; Female; Fibric Acids; Humans; Hypolipidemic Agents; Lipids; Male; Middle Aged; Oxidative Stress; Postprandial Period; Triglycerides | 2000 |
Ciprofibrate effects on carbohydrate and lipid metabolism in type 2 diabetes mellitus subjects.
Topics: Adult; Aged; Apolipoproteins B; Area Under Curve; Arteriosclerosis; Blood Glucose; Carbohydrate Metabolism; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fibric Acids; Fibrinogen; Glycated Hemoglobin; Humans; Hypolipidemic Agents; Lipid Metabolism; Lipoprotein(a); Male; Middle Aged; Triglycerides | 2000 |
[Ciprofibrate in the treatment of combined hyperlipoproteinemia. Results in more than 600 patients from 23 centers in the Czech Republic].
Topics: Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged | 2000 |
Statin-fibrate combinations in patients with combined hyperlipedemia.
Topics: Clofibric Acid; Coronary Disease; Drug Therapy, Combination; Fibric Acids; Follow-Up Studies; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Myocardial Infarction; Pravastatin; Simvastatin; Stroke | 2001 |
Homocysteine elevation with fibrates: is it a class effect?
Topics: Adult; Bezafibrate; Clofibric Acid; Dietary Fats; Female; Fibric Acids; Homocysteine; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 2001 |
Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study.
Topics: Adolescent; Adult; Aged; Apolipoproteins B; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Diet; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 2001 |
Ciprofibrate increases plasma concentration of platelet-derived growth factor AB in patients with advanced atherosclerosis and hyperlipidemia independently of its hypolipidemic effects.
Topics: Aged; Arteriosclerosis; Aspirin; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Fibrinogen; Fibrinolytic Agents; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Platelet-Derived Growth Factor | 2001 |
Effects of fibrates on plasma prothrombotic activity in patients with type IIb dyslipidemia.
Topics: Adult; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Fibrinogen; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Thrombosis; Tissue Plasminogen Activator; Treatment Outcome; Triglycerides | 2001 |
Atorvastatin versus four statin-fibrate combinations in patients with familial combined hyperlipidaemia.
Topics: Adult; Aged; Atorvastatin; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lipids; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Simvastatin; Time Factors | 2002 |
Combined treatment with fibrates and small doses of atorvastatin in patients with mixed hyperlipidemia.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Clofibric Acid; Drug Administration Schedule; Drug Therapy, Combination; Female; Fenofibrate; Fibric Acids; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Lipids; Liver; Male; Middle Aged; Pyrroles; Treatment Outcome | 2002 |
Effect of ciprofibrate on lipoproteins, fibrinogen, renal function, and hepatic enzymes.
Topics: Analysis of Variance; Cholesterol; Clofibric Acid; Female; Fibric Acids; Fibrinogen; Humans; Hyperlipidemias; Kidney; Lipoproteins; Liver; Male; Statistics, Nonparametric; Triglycerides | 2002 |
Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux.
Topics: Adult; Animals; Apolipoprotein A-I; Apolipoproteins B; Arteriosclerosis; Cholesterol; Cholesterol Esters; Clofibric Acid; Cyclic AMP; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipoproteins; Lipoproteins, HDL; Lipoproteins, VLDL; Liver Neoplasms, Experimental; Macrophages; Male; Mice; Middle Aged; Phenotype; Rats; Tumor Cells, Cultured | 2003 |
[Long-term hypolipidemic treatment of mixed hyperlipidemia with a combination of statins and fibrates].
Topics: Adult; Aged; Anticholesteremic Agents; Clofibric Acid; Drug Therapy, Combination; Female; Fenofibrate; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Male; Middle Aged; Pravastatin; Simvastatin | 2003 |
Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.
Topics: Adult; Anticholesteremic Agents; C-Reactive Protein; Clofibric Acid; Cytokines; Diabetes Mellitus, Type 2; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fibric Acids; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Indoles; Inflammation; Interleukin-1; Male; Middle Aged; Monocytes; PPAR alpha; Tumor Necrosis Factor-alpha | 2005 |
[Changes in serum lipids, plasma fibrinogen and other haemostatic parameters induced by ciprofibrate action in hyperlipidemic patients with and without coronary artery disease].
Topics: Adolescent; Adult; Aged; Cholesterol; Clofibric Acid; Coronary Artery Disease; Female; Fibric Acids; Fibrinogen; Hemostasis; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Pilot Projects; Prospective Studies; Triglycerides | 2006 |
311 other study(ies) available for ciprofibrate and clofibric acid
| Article | Year |
|---|---|
Metabolic effects of a new hypolipidemic agent, ciprofibrate.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Fatty Acids, Nonesterified; Fibric Acids; Hypolipidemic Agents; Lipase; Norepinephrine; Polyethylene Glycols; Rats | 1979 |
Species differences in ciprofibrate induction of hepatic cytochrome P450 4A1 and peroxisome proliferation.
Topics: Animals; Body Weight; Callithrix; Clofibric Acid; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Guinea Pigs; Isoenzymes; Liver; Male; Mesocricetus; Mice; Microbodies; Organ Size; Rabbits; Rats; Rats, Inbred F344; RNA; Species Specificity | 1992 |
Effects of joint exposures to selected peroxisome proliferators on hepatic acyl-CoA oxidase activity in male B6C3F1 mice.
Topics: Acyl-CoA Oxidase; Animals; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Fibric Acids; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Microbodies; Oxidoreductases | 1992 |
Plasma levels of HGF in rats treated with tumor promoters.
Topics: Animals; Carcinogens; Clofibric Acid; Fibric Acids; Growth Substances; Hepatocyte Growth Factor; Hexachlorocyclohexane; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
The enantiomeric resolution of ciprofibrate and related compounds by HPLC using chiral stationary phases.
Topics: Cellulose; Chromatography, High Pressure Liquid; Clofibric Acid; Cyclodextrins; Dextrins; Fibric Acids; Hypolipidemic Agents; Orosomucoid; Stereoisomerism | 1992 |
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Base Sequence; Binding Sites; Cell Line; Chromosome Deletion; Clofibric Acid; DNA-Binding Proteins; Enoyl-CoA Hydratase; Fibric Acids; Hypolipidemic Agents; Isomerases; Liver Neoplasms, Experimental; Microbodies; Molecular Sequence Data; Multienzyme Complexes; Oligodeoxyribonucleotides; Peroxisomal Bifunctional Enzyme; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Receptors, Steroid; Transfection | 1992 |
[Cytolytic hepatic damage caused by ciprofibrate].
Topics: Aged; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fibric Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Liver Diseases | 1992 |
Reduction of rat liver endoplasmic reticulum Ca(2+)-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Clofibric Acid; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fibric Acids; Liver; Male; Microbodies; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; Time Factors | 1992 |
Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence.
Topics: Animals; Blotting, Western; Clofibric Acid; Fibric Acids; Immunohistochemistry; Liver; Male; Microbodies; Microscopy, Electron; Rats; Rats, Inbred Strains; Superoxide Dismutase | 1992 |
Dose-response relationships of hepatic acyl-CoA oxidase and catalase activity and liver mitogenesis induced by the peroxisome proliferator ciprofibrate in C57BL/6N and BALB/c mice.
Topics: Acyl-CoA Oxidase; Administration, Oral; Animals; Catalase; Clofibric Acid; Dose-Response Relationship, Drug; Enzyme Induction; Fibric Acids; Hepatomegaly; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidoreductases; Species Specificity | 1992 |
Effects of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cellular antioxidants and lipid peroxidation in rats.
Topics: Acyl-CoA Oxidase; Animals; Antioxidants; Ascorbic Acid; Clofibric Acid; Decanoic Acids; Female; Fibric Acids; Fluorocarbons; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Liver; Malondialdehyde; Microbodies; Oxidoreductases; Rats; Rats, Inbred Strains | 1992 |
Hypolipidaemic drugs are activated to acyl-CoA esters in isolated rat hepatocytes. Detection of drug activation by human liver homogenates and by human platelets.
Topics: Acyl Coenzyme A; Animals; Biotransformation; Blood Platelets; Carnitine; Cells, Cultured; Clofibric Acid; Fibric Acids; Humans; Kinetics; Lipids; Liver; Nafenopin; Octoxynol; Palmitic Acid; Palmitic Acids; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1992 |
Peroxisomal enzyme activities in brain and liver of pups of lactating mothers treated with ciprofibrate.
Topics: Animals; Animals, Suckling; Brain; Clofibric Acid; Female; Fibric Acids; Hypolipidemic Agents; Lactation; Liver; Microbodies; Rats | 1992 |
Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.
Topics: Acetates; Animals; Anticholesteremic Agents; Apolipoproteins B; Cell Line; Cholesterol; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Gene Expression Regulation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Liver; Lovastatin; Mevalonic Acid; Rats; Receptors, LDL; RNA, Messenger; Simvastatin | 1992 |
Drugs recently released in Belgium. Mefloquine--ciprofibrate.
Topics: Animals; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Malaria; Mefloquine; Plasmodium falciparum | 1991 |
Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents.
Topics: Animals; Aspirin; Cell Division; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fibric Acids; Hypolipidemic Agents; L-Lactate Dehydrogenase; Microbodies; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Trypan Blue; Valproic Acid | 1992 |
Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver.
Topics: Acetophenones; Animals; Bezafibrate; Carrier Proteins; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fibric Acids; Male; Microbodies; Neoplasm Proteins; Nerve Tissue Proteins; Oleic Acid; Oleic Acids; Pyrimidines; Rats; Rats, Inbred F344; SRS-A; Tetrazoles | 1991 |
[The pharmacokinetics of antilipemic agents. 8. Unequivocal characterization of ciprofibrate-O-beta-d-glucuronide].
Topics: Chromatography, High Pressure Liquid; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1991 |
A comparative study of the effects of clofibrate, ciprofibrate, WY-14,643, and di-(2-ethylhexyl)-phthalate on liver protein expression in mice.
Topics: Animals; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Female; Fibric Acids; Hypolipidemic Agents; Liver; Male; Membrane Proteins; Mice; Microbodies; Pyrimidines | 1991 |
Induction protocols for the cytochrome P450IVA subfamily in animals and primary hepatocyte cultures.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Enzyme Induction; Fibric Acids; Genetic Techniques; Isoenzymes; Liver; Rats; Rats, Inbred Strains; RNA, Messenger; Species Specificity; Transcription, Genetic | 1991 |
Comparative and simultaneous effects of simvastatin and ciprofibrate on plasma lipid parameters and upon hepatic drug metabolizing and peroxisome proliferation marker enzymes in the male Wistar rat.
Topics: Animals; Anticholesteremic Agents; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Lipids; Liver; Lovastatin; Male; Microbodies; Mixed Function Oxygenases; Rats; Simvastatin | 1991 |
[Ciprofibrate: erythrocyte partition coefficient and binding to serum protein].
Topics: Blood Proteins; Clofibric Acid; Erythrocytes; Fibric Acids; Humans; Hypolipidemic Agents; In Vitro Techniques; Protein Binding | 1991 |
Comparative induction of cytochrome P450IVA1 and peroxisome proliferation by ciprofibrate in the rat and marmoset.
Topics: Animals; Callitrichinae; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Hypolipidemic Agents; Isoenzymes; Liver; Male; Microbodies; Oxidation-Reduction; Rats; Rats, Inbred F344; Species Specificity | 1991 |
Differential expression and ciprofibrate induction of hepatic UDP-glucuronyltransferases for thyroxine and triiodothyronine in Fischer rats.
Topics: Androsterone; Animals; Clofibric Acid; Enzyme Induction; Fibric Acids; Glucuronosyltransferase; Liver; Male; Nitrophenols; Rats; Rats, Inbred F344; Thyroxine; Triiodothyronine | 1991 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Mice; Proteins; Pyrimidines | 1991 |
Effect of ciprofibrate, bezafibrate, and LY171883 on peroxisomal beta-oxidation in cultured rat, dog, and rhesus monkey hepatocytes.
Topics: Acetophenones; Animals; Autacoids; Azoles; Bezafibrate; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Dogs; Dose-Response Relationship, Drug; Female; Fibric Acids; Glucagon; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microbodies; Microscopy, Electron; NAD; Oxidation-Reduction; Rats; Tetrazoles; Tyrosine Transaminase | 1990 |
Effect of dietary vitamin E on the development of altered hepatic foci and hepatic tumors induced by the peroxisome proliferator ciprofibrate.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Drug Synergism; Female; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Vitamin E | 1990 |
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling.
Topics: Affinity Labels; Animals; Clofibric Acid; DNA Damage; DNA, Neoplasm; Fibric Acids; Hypolipidemic Agents; Liver; Liver Neoplasms; Male; Microbodies; Mutagens; Pyrimidines; Rats; Rats, Inbred F344 | 1991 |
Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids.
Topics: Activation Analysis; Animals; Clofibric Acid; Fatty Acids; Fibric Acids; Liver; Lysosomes; Microbodies; Microsomes, Liver; Mitochondria; Oxidation-Reduction; Palmitic Acids; Rats; Rats, Inbred Strains | 1991 |
Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.
Topics: Animals; Clofibric Acid; Fibric Acids; Lipofuscin; Liver Neoplasms, Experimental; Male; Microbodies; Microscopy, Electron; Mitochondria, Liver; Organelles; Rats; Rats, Inbred F344 | 1991 |
On the mechanism of the hepatocarcinogenicity of peroxisome proliferators.
Topics: Animals; Caprylates; Carcinogens; Clofibrate; Clofibric Acid; DNA; DNA Damage; DNA Repair; Fibric Acids; Fluorocarbons; Liver; Liver Neoplasms; Male; Microbodies; Micronucleus Tests; Mutagenicity Tests; Nafenopin; Radiation, Ionizing; Rats; Rats, Inbred Strains; S Phase | 1991 |
Effect of dietary selenium on the induction of altered hepatic foci and hepatic tumors by the peroxisome proliferator ciprofibrate.
Topics: Analysis of Variance; Animals; Clofibric Acid; Diet; Female; Fibric Acids; Glutathione Peroxidase; Liver; Liver Neoplasms, Experimental; Oxidation-Reduction; Rats; Rats, Inbred Strains; Selenium | 1990 |
Transitory deficit in high-density lipoproteins and apolipoprotein A-I.
Topics: Apolipoprotein A-I; Apolipoproteins A; Bezafibrate; Clofibric Acid; Drug Therapy, Combination; Fibric Acids; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Male; Middle Aged; Probucol | 1990 |
Proliferation of peroxisomes and induction of peroxisomal beta-oxidation enzymes in rat hepatoma H4IIEC3 by ciprofibrate.
Topics: Animals; Biomarkers; Catalase; Centrifugation, Density Gradient; Clofibric Acid; Fibric Acids; Liver Neoplasms, Experimental; Male; Microbodies; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Rats; Rats, Inbred Strains; RNA, Messenger; Tumor Cells, Cultured | 1990 |
[Acute rhabdomyolysis during treatment with ciprofibrate].
Topics: Acute Disease; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Male; Middle Aged; Rhabdomyolysis | 1990 |
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Topics: Animals; Base Sequence; Benzidines; Chloroform; Clofibric Acid; Codon; DNA Mutational Analysis; DNA, Neoplasm; Fibric Acids; Gene Amplification; Genes, ras; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phenobarbital | 1990 |
Formation of 5-hydroxymethyl-2'-deoxyuridine in hepatic DNA of rats treated with gamma-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibric Acid; Diethylnitrosamine; DNA Damage; Female; Fibric Acids; Liver; Rats; Thymidine | 1990 |
Differential proto-oncogene mRNA induction from rats treated with peroxisome proliferators.
Topics: Acyl-CoA Oxidase; Animals; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Genes, myc; Genes, ras; Hypolipidemic Agents; Kidney; Liver; Male; Microbodies; Organ Specificity; Oxidoreductases; Proto-Oncogenes; Rats; Rats, Inbred F344; RNA, Messenger | 1990 |
Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents.
Topics: Animals; Base Sequence; Cell Fractionation; Clofibrate; Clofibric Acid; DNA Probes; Fibric Acids; Hypolipidemic Agents; Immunoblotting; Liver; Male; Microbodies; Molecular Sequence Data; Organelles; Rats; Rats, Inbred F344; Rats, Inbred Strains; RNA, Messenger | 1990 |
Hepatic induction potency of hypolipidaemic drugs in the rat following long-term administration: influence of different dosing regimens.
Topics: Animals; Bezafibrate; Clofibric Acid; Fibric Acids; Glutathione Peroxidase; Hepatomegaly; Hypolipidemic Agents; Liver; Male; Microbodies; Rats | 1990 |
Induction of peroxisomal enzymes in cultured porcine endothelial cells by the hypolipidemic drug ciprofibrate.
Topics: Animals; Catalase; Cells, Cultured; Clofibric Acid; Endothelium; Enzyme Induction; Fibric Acids; Hypolipidemic Agents; Lung; Microbodies; Oxidation-Reduction; Swine | 1990 |
Quantitative analysis of hepatocellular lesions induced by di(2-ethylhexyl)phthalate in F-344 rats.
Topics: Animals; Body Weight; Clofibric Acid; Diet; Diethylhexyl Phthalate; Fibric Acids; Liver Neoplasms, Experimental; Male; Organ Size; Phthalic Acids; Rats; Rats, Inbred F344 | 1990 |
Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme.
Topics: Acyl Coenzyme A; Animals; Blood Platelets; Brain; Calcium; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diglycerides; Drug Synergism; Enzyme Activation; Fibric Acids; Glycerides; Histones; Humans; Microbodies; Palmitoyl Coenzyme A; Phosphatidylserines; Phosphorylation; Protein Kinase C; Rats | 1990 |
Induction of peroxisome proliferation in rainbow trout exposed to ciprofibrate.
Topics: Acyl-CoA Oxidase; Analysis of Variance; Animals; Blotting, Western; Body Weight; Catalase; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Hypolipidemic Agents; Liver; Microbodies; Organ Size; Oxidoreductases; Peptide Biosynthesis; Peptides; Time Factors; Trout | 1990 |
Effect of the peroxisome proliferator ciprofibrate on hepatic DNA synthesis and hepatic composition following partial hepatectomy in rats.
Topics: Administration, Oral; Animals; Body Weight; Clofibrate; Clofibric Acid; DNA; Female; Fibric Acids; Hepatectomy; Hypolipidemic Agents; Liver; Organ Size; Rats; Rats, Inbred Strains; Vitamin E | 1990 |
Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation.
Topics: Administration, Oral; Animals; Body Weight; Cell Division; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Fibric Acids; Glutathione Peroxidase; Hypolipidemic Agents; Male; Microbodies; Microsomes, Liver; Organ Size; Oxidoreductases; Oxidoreductases, N-Demethylating; Rats; Rats, Gunn; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity | 1990 |
Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Topics: Antibodies, Monoclonal; Asialoglycoprotein Receptor; Blotting, Western; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; ErbB Receptors; Fibric Acids; Fluorescent Antibody Technique; Isoelectric Point; Liver; Membrane Glycoproteins; Microbodies; Pyrimidines; Receptors, Immunologic; Sialoglycoproteins | 1990 |
Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.
Topics: alpha-Fetoproteins; Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver Neoplasms, Experimental; Microbodies; Neoplasm Transplantation; Pyrimidines; Rats; RNA, Messenger | 1988 |
Blockade of alpha-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters.
Topics: Animals; Carcinogens; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Hexachlorocyclohexane; Liver; Organ Size; Phenobarbital; Prazosin; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha | 1989 |
Gastric morphological changes including carcinoid tumors in animals treated with a potent hypolipidemic agent, ciprofibrate.
Topics: Animals; Callitrichinae; Carcinoid Tumor; Clofibrate; Clofibric Acid; Fibric Acids; Gastric Mucosa; Gastrins; Hypolipidemic Agents; Male; Mice; Microscopy, Electron; Rats; Rats, Inbred F344; Stomach Neoplasms | 1989 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Precancerous Conditions; Rats; Rats, Inbred F344 | 1989 |
Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fibric Acids; Gemfibrozil; Kinetics; Liver; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; Triglycerides | 1989 |
The influence of renal insufficiency and haemodialysis on the kinetics of ciprofibrate.
Topics: Adult; Aged; Clofibrate; Clofibric Acid; Female; Fibric Acids; Humans; Hypolipidemic Agents; Kidney Diseases; Male; Middle Aged; Renal Dialysis | 1989 |
[The pharmacokinetics of hypolipemic agents. 6. Is 2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-propane a metabolite of the hypolipemic ciprofibrate?].
Topics: Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1989 |
Species differences in the hepatic response to a potent peroxisome proliferator.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fibric Acids; Guinea Pigs; Hypolipidemic Agents; Lauric Acids; Liver; Male; Microbodies; Rats; Rats, Inbred Strains; RNA, Messenger; Species Specificity | 1989 |
Evaluation of liver cell proliferation during ciprofibrate-induced hepatocarcinogenesis.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; DNA; Ethoxyquin; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Rats; Rats, Inbred F344 | 1989 |
Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Division; Clofibrate; Clofibric Acid; Deoxyguanosine; DNA; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Rats; Rats, Inbred F344 | 1989 |
An in vitro demonstration of peroxisome proliferation and increase in peroxisomal beta-oxidation system mRNAs in cultured rat hepatocytes treated with ciprofibrate.
Topics: Animals; Blotting, Northern; Catalase; Cells, Cultured; Clofibrate; Clofibric Acid; Cycloheximide; Fibric Acids; Hypolipidemic Agents; Liver; Male; Microbodies; Oxidation-Reduction; Protein Biosynthesis; Proteins; Rats; Rats, Inbred F344; RNA, Messenger | 1989 |
[The pharmacokinetics of antilipemic agents. 5. Is 2-(4-hydroxyphenoxy)-2-methylpropionic acid a metabolite of the antilipemic ciprofibrate?].
Topics: Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1989 |
Effects of treatment with clofibrate, bezafibrate, and ciprofibrate on the metabolism of cholesterol in rat liver microsomes.
Topics: Animals; Bezafibrate; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Clofibric Acid; Fibric Acids; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase | 1989 |
The comparative pharmacokinetics and gastric toxicity of bezafibrate and ciprofibrate in the rat.
Topics: Administration, Oral; Animals; Bezafibrate; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Gastric Mucosa; Gastrins; Hypolipidemic Agents; Male; Neurosecretory Systems; Rats; Rats, Inbred F344; Stomach Ulcer | 1989 |
Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Diethylnitrosamine; Drug Administration Schedule; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Immunologic Techniques; Liver; Microbodies; Pyrimidines; Rats; Time Factors | 1986 |
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Placenta; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1986 |
Absence of gamma-glutamyltranspeptidase activity in lung metastasis in rats with hepatocellular carcinomas induced by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Microbodies; Rats; Rats, Inbred F344 | 1987 |
Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acetyltransferase; Acyl-CoA Oxidase; Animals; Catalase; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Enoyl-CoA Hydratase; Fibric Acids; Gene Expression Regulation; Heart; Hydro-Lyases; Immunohistochemistry; Intestine, Small; Isomerases; Kidney; Liver; Microbodies; Multienzyme Complexes; Myocardium; Oxidoreductases; Peroxisomal Bifunctional Enzyme; Rats; Rats, Inbred F344; RNA, Messenger | 1988 |
Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound.
Topics: Adenoma; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Microbodies | 1988 |
The effect of ciprofibrate on gastric secretion in the rat.
Topics: Animals; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fibric Acids; Gastric Mucosa; Hypolipidemic Agents; Male; Mice; Rats; Rats, Inbred F344; Reference Values | 1988 |
In vivo distribution of a carcinogenic hepatic peroxisome proliferator: whole-body autoradiography of [14C]ciprofibrate in the mouse.
Topics: Administration, Oral; Animals; Autoradiography; Carcinogens; Clofibrate; Clofibric Acid; Fibric Acids; Male; Mice; Time Factors; Tissue Distribution | 1989 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Female; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine.
Topics: Animals; Bezafibrate; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Fatty Acids; Fibric Acids; Glucagon; Humans; Hypolipidemic Agents; Insulin; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
Gemfibrozil increases both apo A-I and apo E concentrations. Comparison to other lipid regulators in cholesterol-fed rats.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Bezafibrate; Cholesterol, Dietary; Cholesterol, HDL; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Valerates | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Epoxide Hydrolases; Fibric Acids; Glucuronosyltransferase; Liver Neoplasms, Experimental; Male; Microbodies; Microsomes, Liver; Rats; Rats, Inbred F344; Sulfurtransferases | 1987 |
Species variation in gastric toxicity following chronic administration of ciprofibrate to rat, mouse, and marmoset.
Topics: Animals; Callitrichinae; Clofibrate; Clofibric Acid; Fibric Acids; Gastrins; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Stomach | 1988 |
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Topics: Animals; Clofibric Acid; Fibric Acids; Galactosyltransferases; Kinetics; Liver Neoplasms; Precancerous Conditions; Rats | 1988 |
[Pharmacokinetics of antilipemic agents. 4. Biotransformation of the antilipemic agent ciprofibrate (2-(4-(2,2-dichlorcyclopropyl)-phenoxy)-2-methylpropionic acid)].
Topics: Biotransformation; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1988 |
Effects of ciprofibrate and 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA) on the distribution of carnitine and CoA and their acyl-esters and on enzyme activities in rats. Relation between hepatic carnitine concentration and carnitine acetyltran
Topics: Acyl Coenzyme A; Animals; Carnitine; Carnitine O-Acetyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Coenzyme A; Epoxy Compounds; Ethers, Cyclic; Fibric Acids; Hypoglycemic Agents; Hypolipidemic Agents; Liver; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Effects of ciprofibrate and fenofibrate on liver lipids and lipoprotein synthesis in normo- and hyperlipidemic rats.
Topics: Animals; Apolipoproteins; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Hyperlipidemias; Lipids; Lipoproteins; Liver; Male; Propionates; Rats; Rats, Inbred Strains | 1988 |
Assessment of gastric antisecretory effects of phenoxyisobutyrate derivatives in the rat and the mouse.
Topics: Administration, Oral; Animals; Bezafibrate; Carcinoid Tumor; Clofibrate; Clofibric Acid; Fibric Acids; Gastric Juice; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Species Specificity; Stomach Neoplasms; Time Factors | 1988 |
Lack of evidence for a hepatic peroxisome proliferator receptor and an explanation for the binding of hypolipidaemic drugs to liver homogenates.
Topics: Animals; Clofibric Acid; Cytosol; Fibric Acids; Hypolipidemic Agents; Kinetics; Liver; Male; Microbodies; Microsomes, Liver; Nafenopin; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity | 1988 |
Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.
Topics: Acyltransferases; Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Epoxy Compounds; Ethers, Cyclic; Fatty Acids; Fibric Acids; Isoenzymes; Liver; Male; Rats; Rats, Inbred Strains; Time Factors; Triglycerides | 1988 |
Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney.
Topics: Animals; Blood Pressure; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Hypertension, Renovascular; Hypertrophy; Hypolipidemic Agents; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Reference Values | 1987 |
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Catalase; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Enoyl-CoA Hydratase; Fibric Acids; Hydro-Lyases; Immunoelectrophoresis; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oxidoreductases; Peroxisomal Bifunctional Enzyme; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic | 1986 |
Conditions influencing the induction of peroxisomal beta-oxidation in cultured rat hepatocytes.
Topics: Animals; Bezafibrate; Catalase; Cell Survival; Clofibric Acid; Fibric Acids; Gemfibrozil; In Vitro Techniques; Liver; Male; Microbodies; Pentanoic Acids; Rats; Rats, Inbred F344 | 1986 |
Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver.
Topics: Animals; Carrier Proteins; Clofibrate; Clofibric Acid; Fibric Acids; Intracellular Signaling Peptides and Proteins; Liver; Male; Molecular Weight; Nafenopin; Propionates; Rats; Rats, Inbred F344 | 1987 |
Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion.
Topics: Albumins; Animals; Catalase; Cell Differentiation; Clofibric Acid; Copper; Fibric Acids; Fluorescent Antibody Technique; Liver; Male; Microbodies; Microscopy, Electron; Pancreas; Penicillamine; Rats; Rats, Inbred F344 | 1986 |
Induction of peroxisome proliferation in hepatocytes transplanted into the anterior chamber of the eye. A model system for the evaluation of xenobiotic-induced effects.
Topics: Animals; Anterior Chamber; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Fibric Acids; Fluorescent Antibody Technique; Liver; Liver Transplantation; Male; Microbodies; Phthalic Acids; Rats; Rats, Inbred F344 | 1986 |
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Fibric Acids; Glutathione Transferase; Immunosorbent Techniques; Isoelectric Point; Liver; Liver Neoplasms, Experimental; Male; Molecular Weight; Neoplasm Proteins; Precancerous Conditions; Rats; Rats, Inbred F344 | 1987 |
Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate.
Topics: Animals; Bile; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Glutathione Transferase; Hypolipidemic Agents; Liver; Male; Microbodies; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1986 |
Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
Topics: Adipates; Animals; Catalase; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Microscopy, Electron; Oxidation-Reduction; Phthalic Acids; Rats; Structure-Activity Relationship | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
The mechanism of cumene hydroperoxide-dependent lipid peroxidation: the function of cytochrome P-450.
Topics: Animals; Benzene Derivatives; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanol; Fibric Acids; Heme; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipid Peroxides; Male; Microsomes, Liver; Oxygen; Phenobarbital; Rats; Substrate Specificity | 1986 |
Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
Topics: Acyl Coenzyme A; Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Coenzyme A Ligases; Fibric Acids; Hydrolysis; Male; Microsomes, Liver; Nafenopin; Propionates; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Spectrophotometry, Ultraviolet | 1986 |
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Benzphetamine; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Fibric Acids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Lauric Acids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1985 |
The effect of three hypolipidemic drugs on catalase activity and peroxisomal and mitochondrial palmitate oxidation in rat cardiac and skeletal muscle.
Topics: Animals; Body Weight; Catalase; Clofibrate; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Male; Microbodies; Mitochondria, Heart; Mitochondria, Muscle; Muscles; Myocardium; Nafenopin; Oxidation-Reduction; Palmitates; Palmitic Acids; Rats; Rats, Inbred Strains | 1986 |
Peroxisome proliferation and lipid peroxidation in rat liver.
Topics: Animals; Catalase; Clofibric Acid; Fibric Acids; Glutathione; Glutathione Transferase; Hydrogen Peroxide; Intracellular Membranes; Lipid Peroxides; Liver; Male; Membrane Lipids; Microbodies; Nuclear Envelope; Rats | 1986 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; DNA; Fibric Acids; Hypolipidemic Agents; In Vitro Techniques; Liver; Liver Neoplasms; Male; Microbodies; Phosphorus Radioisotopes; Pyrimidines; Rats | 1985 |
Effect of Ciprofibrate on platelet aggregation and fibrinolysis in patients with hypercholesterolaemia.
Topics: Adult; Alkaline Phosphatase; Cholesterol; Clofibrate; Clofibric Acid; Fibric Acids; Fibrinogen; Fibrinolysis; Humans; Hypercholesterolemia; Male; Middle Aged; Platelet Aggregation; Platelet Count | 1985 |
Induction and origin of hepatocytes in rat pancreas.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Liver; Male; Microscopy, Electron; Organ Specificity; Pancreas; Rats; Rats, Inbred F344; Staining and Labeling | 1984 |
Effect of ciprofibrate treatment on biliary lipids in patients with hyperlipoproteinaemia.
Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholesterol; Clofibrate; Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipoproteinemias; Lipids; Male; Middle Aged; Phospholipids; Triglycerides | 1984 |
Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Clofibrate; Clofibric Acid; Ethoxyquin; Fibric Acids; Glutathione Transferase; Kinetics; Liver; Macromolecular Substances; Male; Microbodies; Rats; Rats, Inbred F344 | 1984 |
Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds.
Topics: Animals; Carrier Proteins; Clofibrate; Clofibric Acid; Cytosol; Enzyme Induction; Fibric Acids; Kidney Cortex; Liver; Male; Microbodies; Nafenopin; Propionates; Rats; Rats, Inbred F344 | 1983 |
Induction of hepatic peroxisome proliferation in nonrodent species, including primates.
Topics: Animals; Catalase; Cats; Chickens; Clofibric Acid; Columbidae; Cricetinae; Fibric Acids; Liver; Macaca fascicularis; Macaca mulatta; Male; Mice; Microbodies; Organ Size; Palmitoyl Coenzyme A; Peptide Biosynthesis; Peptides; Rats; Species Specificity | 1984 |
Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.
Topics: Animals; Anisoles; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Clofibric Acid; Drug Antagonism; Ethoxyquin; Fibric Acids; Hypolipidemic Agents; Liver Neoplasms; Male; Microbodies; Quinolines; Rats; Rats, Inbred F344 | 1984 |
Dose-response study of the effect of ciprofibrate on serum lipoprotein concentrations in hyperlipoproteinaemia.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Sedimentation; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Follow-Up Studies; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Triglycerides | 1982 |
Determination of ciprofibrate in human plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Computers; Fibric Acids; Humans; Rats; Reference Values | 1982 |
Incidence of pancreatic and testicular tumors in rats treated with ciprofibrate, a peroxisome proliferator.
Topics: Animals; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Incidence; Leydig Cell Tumor; Male; Microbodies; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Testicular Neoplasms | 1995 |
Effect of hypolipidemic drugs gemfibrozil, ciprofibrate, and clofibric acid on peroxisomal beta-oxidation in primary cultures of rainbow trout hepatocytes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enoyl-CoA Hydratase; Enzyme Activation; Fibric Acids; Gemfibrozil; Hypolipidemic Agents; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oncorhynchus mykiss; Oxidation-Reduction; Oxidoreductases; Peroxisomal Bifunctional Enzyme | 1993 |
Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression.
Topics: Acyl-CoA Oxidase; Animals; Clofibric Acid; Fenofibrate; Fibric Acids; Liver; Male; Microbodies; Microsomes, Liver; Mitochondria, Liver; Oxidoreductases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Time Factors | 1995 |
Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Clofibric Acid; Collagen; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Drug Combinations; Fibric Acids; Gels; Hypolipidemic Agents; Isoenzymes; Kinetics; Laminin; Liver; Male; Oxidoreductases; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Proteoglycans; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid Hydroxylases | 1995 |
Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines.
Topics: Animals; Cell Line; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Microbodies; Oxidoreductases; Phosphoproteins; Phosphorylation; Pyrimidines; Rats | 1995 |
Expression and inducibility of cytochrome P450 proteins belonging to families 2,3 and 4 in the rabbit aorta.
Topics: Animals; Aorta; Arteriosclerosis; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Male; Microsomes; Phenobarbital; Pregnenolone Carbonitrile; Rabbits | 1995 |
Fenofibrate: metabolism and species differences for peroxisome proliferation in cultured hepatocytes.
Topics: Animals; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fenofibrate; Fibric Acids; Guinea Pigs; Humans; Liver; Male; Mass Spectrometry; Microbodies; Mixed Function Oxygenases; Palmitoyl Coenzyme A; Rats; Rats, Wistar; Species Specificity; Time Factors; Tumor Cells, Cultured | 1995 |
The herbicide dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Body Weight; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dicamba; Dose-Response Relationship, Drug; Female; Fibric Acids; Liver; Male; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Organ Size; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 1995 |
The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver.
Topics: Animals; Base Sequence; Clofibric Acid; Cytochrome P-450 Enzyme System; Diquat; DNA Probes; Fibric Acids; Gene Expression Regulation, Enzymologic; Hypolipidemic Agents; Liver; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Genotoxic effects of selected peroxisome proliferators.
Topics: Adipates; Animals; Cells, Cultured; Chromosome Aberrations; Clofibric Acid; Female; Fibric Acids; Liver; Microbodies; Micronucleus Tests; Mutagens; Nafenopin; Rats; Rats, Inbred F344; Sister Chromatid Exchange | 1993 |
Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels.
Topics: Animals; Cell Division; Cells, Cultured; Clofibric Acid; Collagen; DNA; Drug Interactions; Epidermal Growth Factor; Fibric Acids; Fibroblast Growth Factor 1; Hepatocyte Growth Factor; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1993 |
The effect of peroxisome proliferators on S-phase synthesis in primary cultures of fish hepatocytes.
Topics: Animals; Cells, Cultured; Clofibric Acid; Fibric Acids; Lead; Liver; Microbodies; Nitrates; Organometallic Compounds; Oryzias; S Phase; Trout | 1993 |
Effect of peroxisomes proliferators and hypolipemic agents on mitochondrial inner membrane linked D-3-hydroxybutyrate dehydrogenase (BDH).
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Binding, Competitive; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Hydroxybutyrate Dehydrogenase; Hypolipidemic Agents; In Vitro Techniques; Intracellular Membranes; Male; Microbodies; Mitochondria; Mitochondria, Liver; Phospholipids; Rats; Rats, Wistar; Tetrahymena pyriformis | 1995 |
[Acute rhabdomyolysis associated with digestive disorders during a voluntary overdose of ciprofibrate].
Topics: Abdominal Pain; Acute Disease; Adult; Clofibric Acid; Diarrhea; Drug Overdose; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Rhabdomyolysis; Self Medication | 1995 |
Kinetic characteristics of rat liver peroxisomal nafenopin-CoA ligase.
Topics: Animals; Clofibric Acid; Coenzyme A Ligases; Fibric Acids; Ibuprofen; Kinetics; Liver; Male; Microbodies; Palmitic Acid; Palmitic Acids; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins | 1995 |
Identification of a new apolipoprotein E variant (E2 Arg142-->Leu) in type III hyperlipidemia.
Topics: Aged; Amino Acid Sequence; Apolipoproteins E; Clofibric Acid; Fibric Acids; Genotype; Humans; Hyperlipoproteinemia Type III; Hypolipidemic Agents; Male; Middle Aged; Molecular Sequence Data; Phenotype; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA | 1995 |
Phytanic acid alpha-oxidation in rat liver mitochondria.
Topics: Animals; Carnitine; Clofibric Acid; Coenzyme A; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids; Fibric Acids; Male; Mitochondria, Liver; Oxidation-Reduction; Phytanic Acid; Rats; Rats, Sprague-Dawley | 1994 |
The relative hypolipidaemic activity and hepatic effects of ciprofibrate enantiomers in the rat.
Topics: Animals; Cholesterol; Clofibric Acid; Dose-Response Relationship, Drug; Down-Regulation; Fibric Acids; Liver; Male; Rats; Rats, Inbred F344; Stereoisomerism; Time Factors; Triglycerides | 1994 |
Increased 8-hydroxydeoxyguanosine in hepatic DNA of rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chromatography, High Pressure Liquid; Clofibric Acid; Decanoic Acids; Deoxyguanosine; DNA; DNA Damage; Fibric Acids; Fluorocarbons; Liver; Male; Rats; Rats, Sprague-Dawley | 1994 |
Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity.
Topics: Acyl-CoA Oxidase; Animals; Clofibric Acid; Fibric Acids; Liver; Male; Microbodies; Obesity; Oxidoreductases; Rats; Rats, Wistar; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic; Triglycerides | 1995 |
Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules.
Topics: Animals; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Hyperplasia; Liver; Mice; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
Ciprofibrate and lipid profile.
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Male; Middle Aged; Myocardial Infarction; Triglycerides | 1994 |
Lipid profiles on fibric-acid derivatives.
Topics: Bezafibrate; Cholesterol, HDL; Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids | 1994 |
Antioxidant enzymes in ciprofibrate-induced oxidative stress.
Topics: Animals; Catalase; Clofibric Acid; Cytoplasm; Fibric Acids; Glutathione Peroxidase; Hypolipidemic Agents; Liver; Male; Microbodies; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors | 1994 |
The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
Topics: Animals; Base Sequence; Clofibric Acid; DNA Mutational Analysis; Fibric Acids; Gene Expression Regulation, Enzymologic; Humans; Hypolipidemic Agents; Malate Dehydrogenase; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Sequence Deletion; Transcription Factors; Transcriptional Activation | 1994 |
Ciprofibrate and lipid profile.
Topics: Cholesterol; Cholesterol, HDL; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Male; Middle Aged | 1994 |
Expression of peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase enzyme and its mRNA in peroxisome proliferator-induced liver tumors.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Cell Division; Clofibric Acid; Dehydroepiandrosterone; Enoyl-CoA Hydratase; Fibric Acids; Isomerases; Liver Neoplasms, Experimental; Male; Microbodies; Multienzyme Complexes; Peroxisomal Bifunctional Enzyme; Rats; Rats, Inbred F344; RNA, Messenger | 1994 |
Demonstration of glutathione peroxidase in rat liver peroxisomes and its intraorganellar distribution.
Topics: Animals; Blotting, Western; Cell Compartmentation; Clofibric Acid; Fibric Acids; Glutathione Peroxidase; Liver; Male; Microbodies; Microscopy, Electron; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1994 |
Effect of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cell proliferation and toxicity in Sprague-Dawley rats.
Topics: Acyl-CoA Oxidase; Animals; Cell Division; Clofibric Acid; Decanoic Acids; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Female; Fibric Acids; Fluorocarbons; Liver; Liver Regeneration; Male; Microbodies; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Sprague-Dawley | 1994 |
Hypercholesterolemia treatment in a renal transplant patient.
Topics: Anticholesteremic Agents; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Humans; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Postoperative Complications; Simvastatin | 1994 |
Creatinine rise after fibrate therapy in renal graft recipients.
Topics: Bezafibrate; Clofibric Acid; Creatinine; Female; Fenofibrate; Fibric Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Kidney Transplantation; Male | 1993 |
Lack of peroxisome proliferation in marmoset liver following treatment with ciprofibrate for 3 years.
Topics: Animals; Callithrix; Clofibric Acid; Female; Fibric Acids; Lipofuscin; Liver; Male; Microbodies; Microscopy, Electron | 1994 |
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Clofibric Acid; Diethylhexyl Phthalate; Enoyl-CoA Hydratase; Fibric Acids; Genes, Reporter; Liver; Luciferases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microbodies; Nafenopin; Pyrimidines | 1994 |
[The pharmacokinetics of hypolipemic agents. 10. The dehalogenation of the hypolipemic agent ciprofibrate].
Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Male; Spectrophotometry, Ultraviolet | 1994 |
Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate.
Topics: Animals; Calcium; Cells, Cultured; Clofibric Acid; DNA; Drug Synergism; Egtazic Acid; Fibric Acids; Liver; Male; Microbodies; Rats; Rats, Inbred F344 | 1993 |
Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators.
Topics: Animals; Anticholesteremic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactosidase; beta-Galactoside alpha-2,3-Sialyltransferase; Blotting, Western; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Polyacrylamide Gel; Fibric Acids; Glycoproteins; Hypolipidemic Agents; Kinetics; Liver; Male; Membrane Glycoproteins; Microbodies; Molecular Weight; Pyrimidines; Rats; Rats, Inbred F344; RNA, Messenger; Sialoglycoproteins; Sialyltransferases | 1994 |
Ciprofibrate therapy normalises the atherogenic low-density lipoprotein subspecies profile in combined hyperlipidemia.
Topics: Adult; Apolipoprotein B-100; Apolipoproteins B; Clofibric Acid; Fibric Acids; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertriglyceridemia; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged | 1993 |
Ciprofibrate, a carcinogenic peroxisome proliferator, increases the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes.
Topics: Acyl Coenzyme A; Animals; Cells, Cultured; Clofibric Acid; Enzyme Activation; ErbB Receptors; Fibric Acids; Hypolipidemic Agents; Liver; Microbodies; Phosphorylation; Protein Kinase C; Rats | 1993 |
Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Base Sequence; Binding Sites; Cell Nucleus; Clofibric Acid; DNA-Binding Proteins; DNA, Neoplasm; Enoyl-CoA Hydratase; Fibric Acids; Gene Expression Regulation, Enzymologic; Hypolipidemic Agents; Isomerases; Liver Neoplasms, Experimental; Luciferases; Microbodies; Molecular Sequence Data; Multienzyme Complexes; Oligodeoxyribonucleotides; Peroxisomal Bifunctional Enzyme; Racemases and Epimerases; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transfection; Tumor Cells, Cultured | 1993 |
Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines: comparative studies in Fao, MH1C1 and HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Microbodies; Oxidoreductases; Tumor Cells, Cultured | 1993 |
Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.
Topics: 3T3 Cells; Animals; Base Sequence; Carcinogens; Clofibric Acid; Codon; DNA, Neoplasm; Fibric Acids; Gene Expression; Genes, ras; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Nude; Molecular Sequence Data; Point Mutation; Transfection | 1993 |
Culture of precision-cut liver slices: effect of some peroxisome proliferators.
Topics: Animals; Carnitine O-Acetyltransferase; Clofibric Acid; Culture Media; Culture Techniques; Fibric Acids; Liver; Male; Microbodies; Microscopy, Electron; Nafenopin; Oxidation-Reduction; Palmitoyl Coenzyme A; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Effects of two peroxisome proliferators (ciprofibrate and fenofibrate) on peroxisomal membrane proteins and dihydroxyacetone-phosphate acyl-transferase activity in rat liver.
Topics: Acyltransferases; Animals; Clofibric Acid; Enzyme Induction; Fenofibrate; Fibric Acids; Glycerol-3-Phosphate O-Acyltransferase; Hydrogen-Ion Concentration; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Membrane Proteins; Microbodies; Rats; Rats, Wistar | 1993 |
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Topics: Animals; Body Weight; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Gene Expression Regulation; Glucuronates; Glycerolphosphate Dehydrogenase; Male; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Protein Biosynthesis; Rats; Rats, Wistar; Thyroid Hormones | 1993 |
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fibric Acids; Hydroxycholesterols; Hypolipidemic Agents; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Mevalonic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Alteration of rat liver endoplasmic reticulum Ca(2+)-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Calcium-Transporting ATPases; Clofibric Acid; Endoplasmic Reticulum; Fibric Acids; Hypolipidemic Agents; Immunoblotting; Liver; Lysine; Male; Maleimides; Microbodies; Microsomes, Liver; Rats; Rats, Inbred F344; Sulfhydryl Compounds | 1993 |
Response of genetically obese Zucker rats to ciprofibrate, a hypolipidemic agent, with peroxisome proliferation activity as compared to Zucker lean and Sprague-Dawley rats.
Topics: Animals; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Hypolipidemic Agents; Isoenzymes; Liver; Male; Microbodies; Obesity; Rats; Rats, Sprague-Dawley; Rats, Zucker; Reference Values; Species Specificity; Triglycerides | 1993 |
Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Base Sequence; Clofibric Acid; Dose-Response Relationship, Drug; Drug Interactions; Enoyl-CoA Hydratase; Fibric Acids; Gene Expression Regulation, Enzymologic; Humans; Isomerases; Mice; Mice, Transgenic; Microbodies; Molecular Sequence Data; Multienzyme Complexes; Mutation; Oxidation-Reduction; Peroxisomal Bifunctional Enzyme; Protein Binding; Protein Conformation; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Retinoid X Receptors; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Triiodothyronine | 1995 |
Altered hepatic eicosanoid concentrations in rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid.
Topics: Acyl-CoA Oxidase; Animals; Clofibric Acid; Decanoic Acids; Dinoprost; Dinoprostone; Eicosanoids; Fibric Acids; Fluorocarbons; Gene Expression Regulation, Enzymologic; Hypolipidemic Agents; Immunoassay; Leukotriene C4; Liver; Male; Microbodies; Oxidoreductases; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1995 |
Flow cytometric analysis of neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.
Topics: Aneuploidy; Animals; Carcinoma, Hepatocellular; Clofibric Acid; DNA, Neoplasm; Fibric Acids; Flow Cytometry; Hypolipidemic Agents; Liver Neoplasms, Experimental; Male; Microbodies; Polyploidy; Rats; Rats, Inbred F344; S Phase | 1996 |
Abnormal lipid profiles on fibrate derivatives.
Topics: Bezafibrate; Cholesterol, HDL; Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids | 1996 |
Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Clofibric Acid; DNA Primers; Fibric Acids; Gene Expression Regulation, Enzymologic; Humans; Liver Neoplasms, Experimental; Microbodies; Molecular Sequence Data; Oxidoreductases; Promoter Regions, Genetic; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: analysis by flow cytometry.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Size; Clofibric Acid; Cytoplasmic Granules; DNA, Neoplasm; Fibric Acids; Flow Cytometry; Humans; Hypolipidemic Agents; Light; Liver; Liver Neoplasms; Microbodies; Oxidoreductases; Rats; Scattering, Radiation; Tumor Cells, Cultured | 1996 |
Difference between guinea pig and rat in the liver peroxisomal response to equivalent plasmatic level of ciprofibrate.
Topics: Acyl-CoA Oxidase; Animals; Blotting, Northern; Cell Fractionation; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Probes; Fibric Acids; Gene Expression; Guinea Pigs; Hypolipidemic Agents; Liver; Male; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; RNA, Messenger; Species Specificity | 1996 |
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Bezafibrate; Bile; Bile Canaliculi; Clofibrate; Clofibric Acid; DNA Primers; Drug Resistance, Multiple; Fenofibrate; Fibric Acids; Gemfibrozil; Gene Expression; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multigene Family; Phospholipids; RNA, Messenger; RNA, Ribosomal, 18S | 1996 |
Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anticarcinogenic Agents; Base Sequence; Biotransformation; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Glutathione Transferase; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Pregnenolone Carbonitrile; Pyrazines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Species Specificity; Steroid Hydroxylases; Thiones; Thiophenes | 1996 |
Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity.
Topics: Alpha-Globulins; Animals; Carcinogens; Clofibric Acid; Cyclohexenes; Enzyme Repression; Fibric Acids; Hypolipidemic Agents; In Situ Hybridization; Kidney; Limonene; Liver; Male; Microbodies; Rats; RNA, Messenger; Terpenes | 1996 |
Reduction of the concentrations of prostaglandins E2 and F2alpha, and thromboxane B2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate.
Topics: Acyl-CoA Oxidase; Analysis of Variance; Animals; Cell Division; Cells, Cultured; Clofibric Acid; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibric Acids; Gene Expression Regulation, Neoplastic; Hypolipidemic Agents; Liver; Male; Microbodies; Oxidoreductases; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1996 |
Identification of a second human acetyl-CoA carboxylase gene.
Topics: Acetyl-CoA Carboxylase; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 17; Clofibric Acid; Cricetinae; Enzyme Induction; Fibric Acids; Glucose; Humans; Isoenzymes; Liver Neoplasms, Experimental; Molecular Sequence Data; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic | 1996 |
Paradoxical high-density lipoprotein reduction induced by fenofibrate and ciprofibrate.
Topics: Clofibric Acid; Fenofibrate; Fibric Acids; Humans; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged; Monitoring, Physiologic | 1996 |
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Humans; Isoenzymes; Liver; Male; Microbodies; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Fibrate monotherapy and profound hypoalphalipoproteinaemia.
Topics: Adult; Cholesterol, HDL; Clofibric Acid; Female; Fibric Acids; Humans; Hypolipidemic Agents; Hypolipoproteinemias | 1996 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
Properties of peroxisomes from jerboa (Jaculus orientalis).
Topics: Animals; Clofibric Acid; DNA; Female; Fibric Acids; Guinea Pigs; Heart; Immunoblotting; Kidney; Liver; Male; Microbodies; Myocardium; Oxidoreductases; Proteins; Rats; Rodentia; Species Specificity | 1996 |
Comparative hypolipidaemic and peroxisomal effects of ciprofibrate, clofibric acid, and their respective difluorocyclopropyl and 4-fluoro-substituted analogues in rat.
Topics: Animals; Cholesterol; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Fibrinogen; Hypolipidemic Agents; Liver; Male; Microbodies; Microscopy, Electron; Organ Size; Oxidation-Reduction; Rats; Rats, Inbred F344; Triglycerides | 1996 |
Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes.
Topics: Animals; Biomarkers, Tumor; Cells, Cultured; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Hypolipidemic Agents; Leukotriene C4; Liver; Male; Microbodies; Phenobarbital; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1995 |
The peroxisome-proliferator ciprofibrate induces hypergastrinemia without raising gastric pH.
Topics: Animals; Clofibric Acid; Fibric Acids; Gastric Juice; Gastrins; Hydrogen-Ion Concentration; Male; Microbodies; Rats; Rats, Inbred F344; Stomach | 1996 |
Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Clofibric Acid; Dinoprost; Dinoprostone; DNA Replication; Eicosanoids; Epidermal Growth Factor; Fibric Acids; Hypolipidemic Agents; Leukotriene C4; Liver; Male; Microbodies; Mitogens; Norepinephrine; Rats; Rats, Sprague-Dawley | 1996 |
Differential effects of ciprofibrate on renal and hepatic cytochrome P450 2E1 expression.
Topics: Animals; Clofibric Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fibric Acids; Hypolipidemic Agents; Kidney; Liver; Male; Microbodies; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley | 1996 |
Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate.
Topics: Animals; Anthocyanins; Blood Glucose; Clofibric Acid; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Triglycerides; Vaccinium myrtillus | 1996 |
Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.
Topics: Animals; Binding Sites; Clofibric Acid; DNA; Electrophoresis; Fibric Acids; Hypolipidemic Agents; Liver; Microbodies; NF-kappa B; Rats | 1996 |
[Rhabdomyolysis and unexplained malaise. Role of combination of ciprofibrate and norfloxacin].
Topics: Anti-Infective Agents; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Humans; Hypolipidemic Agents; Middle Aged; Norfloxacin; Rhabdomyolysis; Syncope | 1996 |
Toxicological evaluation of peroxisome proliferators. Further cellular and molecular aspects.
Topics: Animals; Cell Cycle; Cells, Cultured; Clofibric Acid; Fibric Acids; Guinea Pigs; Humans; Liver; Microbodies; Rats; Species Specificity | 1996 |
Role of eicosanoid metabolism in carcinogenesis by peroxisome proliferators.
Topics: Animals; Cells, Cultured; Clofibric Acid; Decanoic Acids; DNA; Eicosanoids; Fibric Acids; Fluorocarbons; Hypolipidemic Agents; Liver; Microbodies; Rats | 1996 |
Determination of bezafibrate, ciprofibrate and fenofibric acid in human plasma by high-performance liquid chromatography.
Topics: Bezafibrate; Calibration; Chromatography, High Pressure Liquid; Clofibric Acid; Fenofibrate; Fibric Acids; Humans; Hypolipidemic Agents; Reproducibility of Results; Sensitivity and Specificity | 1996 |
Fibrates and HDL cholesterol.
Topics: Apolipoprotein A-I; Cholesterol, HDL; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fenofibrate; Fibric Acids; Humans; Hypolipidemic Agents; Hypolipoproteinemias; Middle Aged; Probucol | 1997 |
Effect of dexamethasone on ciprofibrate-induced cell proliferation and peroxisome proliferation.
Topics: Administration, Oral; Animals; Cell Division; Clofibric Acid; Dexamethasone; Fibric Acids; Glucocorticoids; Hypolipidemic Agents; Immunohistochemistry; Liver; Male; Microbodies; Microscopy, Electron; Organ Size; Oxidative Stress; Rats; Rats, Inbred F344 | 1997 |
Effects of initial BMI and on-treatment weight change on the lipid-lowering efficacy of fibrates.
Topics: Body Mass Index; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Middle Aged; Prospective Studies; Sex Factors; Simvastatin; Weight Loss | 1997 |
Peroxisome proliferation and beta-oxidation in Fao and MH1C1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes: effect of ciprofibrate.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Cells, Cultured; Clofibric Acid; Enoyl-CoA Hydratase; Fenofibrate; Fibric Acids; Hepatoblastoma; Humans; Isomerases; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Microbodies; Microscopy, Electron; Multienzyme Complexes; Oxidoreductases; Peroxisomal Bifunctional Enzyme; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
Comparative quantification of two hepatic UDP-glucuronosyltransferase bilirubin isoforms mRNAs in various thyroid states in rat.
Topics: Animals; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Glucuronosyltransferase; Isoenzymes; Liver; Male; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Thyroidectomy; Triiodothyronine | 1997 |
Acute renal failure due to rhabdomyolysis in presence of concurrent ciprofibrate and ibuprofen treatment.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clofibric Acid; Drug Interactions; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Ibuprofen; Male; Rhabdomyolysis | 1997 |
Dehydroepiandrosterone inhibits DNA synthesis of rat hepatocytes induced by partial hepatectomy or mitogen (ciprofibrate).
Topics: Animals; Cell Division; Clofibric Acid; Dehydroepiandrosterone; DNA; Fibric Acids; Growth Inhibitors; Hepatectomy; Hypolipidemic Agents; Liver; Liver Regeneration; Male; Microbodies; Rats; Rats, Inbred F344 | 1997 |
Lack of correlation between hepatic prostaglandin concentrations and DNA synthesis after the administration of phenobarbital and the peroxisome proliferator ciprofibrate in rats.
Topics: Acyl-CoA Oxidase; Animals; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP2B1; Dinoprost; Dinoprostone; DNA; Fibric Acids; Liver; Male; Microbodies; Microsomes, Liver; Oxidoreductases; Phenobarbital; Prostaglandins; Rats; Rats, Sprague-Dawley | 1997 |
Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens.
Topics: Animals; Blotting, Northern; Bromodeoxyuridine; Carcinogens; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; Gene Expression Regulation, Enzymologic; Liver; Male; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; RNA, Messenger | 1995 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fibric Acids; Hepatectomy; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reactive Oxygen Species | 1997 |
Interaction of very-low-density, intermediate-density, and low-density lipoproteins with human arterial wall proteoglycans.
Topics: Adult; Aged; Aorta; Apolipoproteins B; Arginine; Chondroitin Sulfates; Clofibric Acid; Coronary Artery Disease; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Lysine; Male; Middle Aged; N-Acetylneuraminic Acid; Neuraminidase; Protein Binding; Proteoglycans | 1997 |
Rodent hepatocarcinogenic peroxisome proliferators induce proliferation of rat hepatocytes in primary mixed cultures with rat liver epithelial cells.
Topics: Animals; Anticholesteremic Agents; Cell Division; Clofibric Acid; Epithelial Cells; Fibric Acids; Liver; Male; Microbodies; Mitogens; Rats; Rats, Inbred F344 | 1998 |
Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Clofibric Acid; Cloning, Molecular; DNA, Complementary; Enoyl-CoA Hydratase; Estradiol Dehydrogenases; Fibric Acids; Gene Expression Regulation; Guinea Pigs; Hypolipidemic Agents; Liver; Male; Microbodies; Molecular Sequence Data; Oxidoreductases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1998 |
The effect of the peroxisome proliferator ciprofibrate on the gastric mucosa and particularly the gastrin cell.
Topics: Animals; Anticholesteremic Agents; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Gene Expression; Histidine Decarboxylase; Hypolipidemic Agents; Lovastatin; Male; Microbodies; Rats; Rats, Inbred F344; Rats, Wistar; Simvastatin; Somatostatin; Species Specificity | 1998 |
Effect of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on eicosanoid concentrations in rat liver.
Topics: Animals; Cells, Cultured; Clofibric Acid; Decanoic Acids; Dinoprost; Dinoprostone; Eicosanoids; Fibric Acids; Fluorocarbons; Hypolipidemic Agents; Kinetics; Liver; Microbodies; Rats; Thromboxane B2; Time Factors | 1997 |
Effect of the peroxisome proliferator ciprofibrate on hepatic cyclooxygenase and phospholipase A2 in rats.
Topics: Animals; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Liver; Male; Microbodies; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley | 1998 |
Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate.
Topics: Animals; Catalase; Clofibric Acid; DNA Replication; Fibric Acids; Hydrogen Peroxide; Liver; Mice; Mice, Transgenic; Microbodies; NF-kappa B; Transcription Factor AP-1 | 1998 |
Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Catalase; Clofibric Acid; Deoxyguanosine; Enzyme Activation; Female; Fibric Acids; Lipid Peroxidation; Liver; Mice; Mice, Transgenic; Microsomes, Liver; Peroxisome Proliferators | 1998 |
Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Cell Division; Cells, Cultured; Clofibric Acid; DNA; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Microbodies; Oxidoreductases; Rats; Rats, Inbred F344; Species Specificity | 1998 |
Potentiating hypergastrinemic effect by the peroxisome proliferator ciprofibrate and omeprazole in the rat.
Topics: Animals; Anti-Ulcer Agents; Clofibric Acid; Drug Interactions; Enterochromaffin-like Cells; Female; Fibric Acids; Gastric Mucosa; Gastrins; Hypolipidemic Agents; Microbodies; Omeprazole; Rats; RNA, Messenger; Somatostatin | 1998 |
Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids.
Topics: Acyl-CoA Oxidase; Animals; Caprylates; Carnitine O-Palmitoyltransferase; Cells, Cultured; Clofibric Acid; Fatty Acids; Fibric Acids; Fluorocarbons; Humans; Liver; Male; Microbodies; Mitochondria, Liver; Nuclear Proteins; Oxidoreductases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation | 1998 |
In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.
Topics: Animals; Antigens, CD; Cell Division; Clofibric Acid; DNA-Binding Proteins; Fibric Acids; Hepatectomy; Interleukin-6; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nafenopin; Pyridines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; STAT3 Transcription Factor; Trans-Activators; Tumor Necrosis Factor-alpha | 1998 |
[Autoimmune hepatitis induced by fibrates].
Topics: Aged; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Humans; Hypolipidemic Agents; Male; Middle Aged | 1998 |
Ciprofibrate--racemate and enantiomers: effects of a four-week treatment on male inbred Fischer rats. A biochemical and morphological study.
Topics: Administration, Oral; Animals; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Fibric Acids; Hypolipidemic Agents; Kidney; Lipid Peroxidation; Liver; Luminescent Measurements; Male; Microbodies; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; Serum Albumin; Stereoisomerism; Triglycerides; Weight Gain | 1998 |
Chromatographic resolution of ciprofibrate and interaction of the racemate and both enantiomers with rat liver microsomes in vitro.
Topics: Aniline Compounds; Animals; Chromatography, High Pressure Liquid; Clofibric Acid; Cytochrome P-450 Enzyme System; Drug Interactions; Fibric Acids; Hexobarbital; Humans; Hydrogen Peroxide; Hypolipidemic Agents; In Vitro Techniques; Male; Microsomes, Liver; Neutrophils; Phagocytosis; Rats; Reactive Oxygen Species; Respiratory Burst; Stereoisomerism | 1998 |
[Chronic radiodermatitis after heart catheterization: the contributing role of ciprofibrate (Lipanor)?].
Topics: Cardiac Catheterization; Chronic Disease; Clofibric Acid; Female; Fibric Acids; Glucocorticoids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lupus Erythematosus, Systemic; Middle Aged; Prednisone; Radiation-Sensitizing Agents; Radiodermatitis | 1998 |
Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate.
Topics: CD11 Antigens; Cell Differentiation; Clofibric Acid; Drug Synergism; Fibric Acids; Granulocytes; HL-60 Cells; Humans; Macrophages; Phosphorylation; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factors | 1998 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Effects of the peroxisome proliferator ciprofibrate and prostaglandin F2 alpha combination treatment on second messengers in cultured rat hepatocytes.
Topics: Animals; Calcium; Cells, Cultured; Clofibric Acid; Collagen; Culture Media; Dinoprost; Fibric Acids; Hypolipidemic Agents; Inosine Triphosphate; Liver; Male; Peroxisome Proliferators; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Transforming Growth Factor beta | 1998 |
Stimulation of the DNA binding activity of AP-1 by the peroxisome proliferator ciprofibrate and eicosanoids in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Clofibric Acid; DNA; Eicosanoids; Fibric Acids; Male; Peroxisome Proliferators; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Transforming Growth Factor beta | 1998 |
Induction of lauric acid hydroxylase activity in catfish and bluegill by peroxisome proliferating agents.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fibric Acids; Ictaluridae; Kidney; Liver; Male; Mixed Function Oxygenases; Perciformes; Peroxisome Proliferators; Rats; Species Specificity | 1998 |
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
Topics: Animals; Cell Division; Clofibric Acid; DNA Primers; DNA-Binding Proteins; Exons; Fibric Acids; Gene Expression Regulation; Genotype; Histone Acetyltransferases; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Microbodies; Nuclear Receptor Coactivator 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 1999 |
Prothrombotic and lipoprotein variables in patients attending a cardiovascular risk management clinic: response to ciprofibrate or lifestyle advice.
Topics: Body Weight; Cardiovascular Diseases; Clofibric Acid; Female; Fibric Acids; Fibrinogen; Humans; Hyperlipidemias; Hypolipidemic Agents; Life Style; Lipoproteins; Liver Function Tests; Male; Middle Aged; Retrospective Studies; Risk Factors | 1998 |
Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Insulin; Liver; Male; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Xenobiotics | 1999 |
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; DNA-Binding Proteins; Fenofibrate; Fibric Acids; Fibrinogen; Gene Expression Regulation; Hypolipidemic Agents; Kinetics; Liver; Male; Mice; Mice, Knockout; Peroxisome Proliferators; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic; Triglycerides | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Catalase; Clofibric Acid; Enoyl-CoA Hydratase; Fatty Acids; Fibric Acids; Isomerases; Liver; Mice; Mice, Knockout; Microbodies; Multienzyme Complexes; Oxidoreductases; Peroxisomal Bifunctional Enzyme; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 1999 |
Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Bezafibrate; Cardiovascular Diseases; Clofibric Acid; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fibric Acids; Fluvastatin; Humans; Hyperlipidemias; Hypolipidemic Agents; Indoles; Male; Middle Aged; Pilot Projects; Treatment Outcome | 1999 |
Achiral and chiral determination of ciprofibrate and its glucuronide in human urine by capillary electrophoresis.
Topics: Clofibric Acid; Electrophoresis, Capillary; Fibric Acids; Glucuronates; Humans; Reproducibility of Results; Stereoisomerism | 1999 |
Metabolism of apolipoproteins AI and AII in a patient with paradoxical reduction in high-density lipoprotein due to ciprofibrate.
Topics: Apolipoprotein A-I; Apolipoprotein A-II; Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Lipoproteins, HDL; Male; Middle Aged | 1999 |
Effect of ciprofibrate on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Clofibric Acid; Dose-Response Relationship, Drug; Drug Antagonism; Fibric Acids; Fibrinogen; Humans; Hypolipidemic Agents; Interleukin-6; Liver Neoplasms; Obesity; Oncostatin M; Peptides; Rats; Rats, Zucker; Tumor Cells, Cultured | 1999 |
Sialic acid-containing components of lipoproteins influence lipoprotein-proteoglycan interactions.
Topics: Apolipoprotein B-100; Apolipoproteins B; Cholesterol; Chondroitin Sulfate Proteoglycans; Clofibric Acid; Coronary Artery Disease; Female; Fibric Acids; G(M3) Ganglioside; Glycosphingolipids; Humans; Hypolipidemic Agents; Lipoproteins, LDL; Lipoproteins, VLDL; Male; N-Acetylneuraminic Acid; Neuraminidase | 1999 |
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate.
Topics: Acyl-CoA Oxidase; Animals; Cell Line; Clofibric Acid; Enzyme Inhibitors; Fibric Acids; Gene Expression Regulation; Microbodies; Oxidoreductases; Peroxisome Proliferators; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 1999 |
Implication of fibrate therapy for homocysteine.
Topics: Clofibric Acid; Fenofibrate; Fibric Acids; Glomerular Filtration Rate; Homocysteine; Humans; Hypolipidemic Agents; Kidney Transplantation; Renal Plasma Flow, Effective | 1999 |
Liver and kidney peroxisomes in lactating rats and their pups after treatment with ciprofibrate. Biochemical and morphometric analysis.
Topics: Age Factors; Animals; Animals, Suckling; Biomarkers; Catalase; Clofibric Acid; Enzymes; Female; Fibric Acids; Histocytochemistry; Kidney; Lactation; Liver; Male; Organ Size; Peroxisome Proliferators; Peroxisomes; Rats; Rats, Inbred F344 | 1999 |
[Acute severe fibrosing hepatitis associated with ciprofibrate treatment].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Clofibric Acid; Female; Fibric Acids; Humans; Hypolipidemic Agents; Liver Cirrhosis | 1999 |
Activation of nuclear factor-kappaB by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells and its inhibition by the antioxidants N-acetylcysteine and vitamin E.
Topics: Acetylcysteine; Animals; Antioxidants; Clofibric Acid; Drug Interactions; Fibric Acids; Humans; Liver Neoplasms, Experimental; NF-kappa B; Peroxisome Proliferators; Rats; Reactive Oxygen Species; Tumor Cells, Cultured; Vitamin E | 2000 |
[The effect of monotherapy with ciprofibrate and in combination with acetylsalicylic acid on the spectrum of lipids, thromboxane and fibrinogen in patients with atherosclerosis and hyperlipoproteinemia].
Topics: Aged; Arteriosclerosis; Aspirin; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Fibrinogen; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipids; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane B2 | 1999 |
Acute renal failure after cardiopulmonary bypass: a possible association with drugs of the fibrate group.
Topics: Acute Kidney Injury; Aged; Anticholesteremic Agents; Bezafibrate; Cardiopulmonary Bypass; Clofibric Acid; Female; Fibric Acids; Humans; Male; Middle Aged; Rhabdomyolysis | 2000 |
Retrospective evaluation of serum ornithine carbamyltransferase activity as an index of hepatotoxicity in toxicological studies with rats.
Topics: Administration, Oral; Aflatoxin B1; Alanine Transaminase; Animals; Antibiotics, Antineoplastic; Aspartate Aminotransferases; Azaserine; Carboxylic Acids; Choline Deficiency; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Fumonisins; Injections, Intraperitoneal; Kidney; Liver; Male; Mycotoxins; Ornithine Carbamoyltransferase; Peroxisome Proliferators; Predictive Value of Tests; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Retrospective Studies | 2000 |
Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig.
Topics: Animals; Cell Division; Clofenapate; Clofibric Acid; Cricetinae; DNA; Fibric Acids; Gene Expression; Guinea Pigs; Liver; Male; Mesocricetus; Molecular Structure; Organ Size; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Species Specificity; Transforming Growth Factor beta | 2000 |
Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes.
Topics: Animals; Blotting, Western; Clofibric Acid; Enzyme Induction; Fibric Acids; Glutathione Transferase; Immunohistochemistry; Lead; Liver; Male; Nitrates; Peroxisome Proliferators; Placenta; Rats; Rats, Wistar; RNA Stability; RNA, Messenger; Triiodothyronine | 2000 |
Effect of extracellular matrix on the expression of peroxisome proliferation associated genes in cultured rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Blotting, Northern; Cells, Cultured; Clofibric Acid; Culture Media; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA; Epidermal Growth Factor; Extracellular Matrix; Fibric Acids; Hypolipidemic Agents; Liver; Male; Mixed Function Oxygenases; Nuclear Proteins; Oxidoreductases; Peroxisome Proliferators; Peroxisomes; Rats; Rats, Sprague-Dawley; RNA; Transcription Factor AP-1 | 2000 |
Differences in the formation of PPARalpha-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration.
Topics: Acyl-CoA Oxidase; Animals; Bezafibrate; Biopolymers; Cell Nucleus; Cells, Cultured; Clofibric Acid; Cytosol; Fibric Acids; Guinea Pigs; Humans; Hypolipidemic Agents; Liver; Male; Nuclear Proteins; Oxidoreductases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; Sp1 Transcription Factor; Transcription Factors | 2000 |
Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1.
Topics: Analysis of Variance; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Female; Fibric Acids; Genetic Techniques; Glucocorticoids; Humans; Liver; Mixed Function Oxygenases; Nucleic Acid Hybridization; Oligonucleotides, Antisense; Oxidoreductases, N-Demethylating; Peroxisome Proliferators; Protein Isoforms; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2000 |
Octreotide inhibits the enterochromaffin-like cell but not peroxisome proliferator-induced hypergastrinemia.
Topics: Animals; Chromogranin A; Chromogranins; Clofibric Acid; Enterochromaffin Cells; Female; Fibric Acids; Gastric Mucosa; Gastrins; Gene Expression; Histamine; Histidine Decarboxylase; Hyperplasia; Immunohistochemistry; Octreotide; Peroxisome Proliferators; Rats; RNA, Messenger | 2000 |
Changes in paraoxonase and apolipoprotein A-I, B, C-III and E in subjects with combined familiar hyperlipoproteinemia treated with ciprofibrate.
Topics: Adult; Apolipoprotein A-I; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins B; Apolipoproteins C; Apolipoproteins E; Aryldialkylphosphatase; Cholesterol, HDL; Clofibric Acid; Esterases; Female; Fibric Acids; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Male; Middle Aged | 2000 |
Ciprofibrate stimulates protein kinase C-dependent phosphorylation of an 85 kDa protein in rat Fao hepatic derived cells.
Topics: Animals; Cell Line; Clofibric Acid; Fibric Acids; Liver; Molecular Weight; Peroxisome Proliferators; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Serine; Substrate Specificity; Threonine | 2000 |
[The new atherogenic plasma index reflects the triglyceride and HDL-cholesterol ratio, the lipoprotein particle size and the cholesterol esterification rate: changes during lipanor therapy].
Topics: Adult; Aged; Arteriosclerosis; Child; Cholesterol; Cholesterol, HDL; Clofibric Acid; Esterification; Female; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Infant, Newborn; Lipids; Male; Middle Aged; Particle Size; Risk Factors; Triglycerides | 2000 |
Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha.
Topics: Animals; Carnitine; Cell Nucleus; Clofibric Acid; Enzyme Activation; Fatty Acids; Fibric Acids; Gene Expression Regulation, Enzymologic; Kidney; Ligands; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Liver; Myocardium; Oxygen; Peroxisome Proliferators; Peroxisomes; Rats; Receptors, Cytoplasmic and Nuclear; Ribonucleases; Tissue Distribution; Transcription Factors; Transcription, Genetic | 2000 |
Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent?
Topics: Bezafibrate; Clofibric Acid; Creatinine; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Kidney Diseases; Kidney Transplantation; Postoperative Period; Retrospective Studies; Urea | 2000 |
Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells.
Topics: Acyl-CoA Oxidase; Adipose Tissue; Animals; Bezafibrate; Clofibric Acid; Culture Media; Enzyme Induction; Fibric Acids; Humans; Hypolipidemic Agents; Liver; Male; Oxidoreductases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stearoyl-CoA Desaturase; Tumor Cells, Cultured | 2001 |
Effect of ciprofibrate on lipoprotien metabolism and oxidative stress parameters in patients with type 2 diabetes mellitus and atherogenic lipoprotein phenotype.
Topics: Blood Glucose; Cholesterol; Clofibric Acid; Comet Assay; Diabetes Mellitus, Type 2; DNA Damage; Fibric Acids; Glycated Hemoglobin; Humans; Hypolipidemic Agents; Lipoproteins; Lymphocytes; Male; Middle Aged; Oxidative Stress; Statistics, Nonparametric; Triglycerides | 2000 |
Impressive lipid changes following hypolipidaemic drug administration can unveil subclinical hyperthyroidism.
Topics: Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Fibric Acids; Humans; Hyperlipidemias; Hyperthyroidism; Hypolipidemic Agents; Lipids; Male; Middle Aged; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triglycerides; Triiodothyronine | 2001 |
[Effect of ciprofibrate on the endothelial dysfunction of patients with combined dyslipidemia].
Topics: Adult; Blood Flow Velocity; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Endothelium, Vascular; Female; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Linear Models; Lipids; Male; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome; Triglycerides; Vasodilation | 2001 |
Fibrate treatment can increase serum creatinine levels.
Topics: Clofibric Acid; Creatinine; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Kidney Diseases; Urea | 2001 |
Fibrate-induced increase in blood urea and creatinine.
Topics: Bezafibrate; Blood Urea Nitrogen; Clofibric Acid; Creatinine; Fenofibrate; Fibric Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Kidney Diseases | 2001 |
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibric Acid; Cytochrome P-450 Enzyme System; Down-Regulation; Fibric Acids; Hepatocytes; Hypolipidemic Agents; Mice; Mice, Knockout; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Steroid Hydroxylases; Transcription Factors; Transcription, Genetic | 2001 |
Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study.
Topics: Clofibric Acid; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Lipoproteins, LDL; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Treatment Outcome | 2001 |
Nafenopin-, ciprofibroyl-, and palmitoyl-CoA conjugation in vitro: kinetic and molecular characterization of marmoset liver microsomes and expressed MLCL1.
Topics: Amino Acid Sequence; Animals; Callithrix; Clofibric Acid; Coenzyme A Ligases; Fibric Acids; Humans; Male; Microsomes, Liver; Molecular Sequence Data; Nafenopin; Palmitic Acid; Recombinant Proteins; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Species Specificity; Xenobiotics | 2001 |
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells | 2002 |
Cytochemical and biochemical demonstration of an ATPase in membranes of human peroxisomes.
Topics: Adenosine Triphosphate; Animals; Ca(2+) Mg(2+)-ATPase; Clofibric Acid; Endoplasmic Reticulum; Enzyme Inhibitors; Ethylmaleimide; Fibric Acids; Fibroblasts; Histocytochemistry; Humans; Intracellular Membranes; Liver; Mitochondria; Peroxisome Proliferators; Peroxisomes; Rats; Rats, Sprague-Dawley; Skin; Substrate Specificity | 2002 |
Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR.
Topics: Antineoplastic Agents; Aorta; Cell Culture Techniques; Clofibric Acid; Collagen; Culture Media, Serum-Free; Disintegrins; Endothelium, Vascular; Fibric Acids; Homocysteine; Humans; Metalloendopeptidases; Muscle, Smooth; Peroxisome Proliferators; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Oxidase; Animals; Brain; Clofibric Acid; Coenzyme A Ligases; Fatty Acid Desaturases; Fatty Acids; Fibric Acids; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Synthase; Ketones; Liver; Male; Oxidation-Reduction; Oxidoreductases; Peroxisome Proliferators; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Up-Regulation | 2002 |
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Clofibric Acid; Cyclosporine; Endothelin-1; Endothelium, Vascular; Fibric Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lovastatin; Mevalonic Acid; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
Differentiated properties of hepatocytes induced from pancreatic cells.
Topics: Amylases; Animals; Arylsulfotransferase; Cell Adhesion Molecules; Cell Culture Techniques; Cell Differentiation; Cell Line; Chondroitin Sulfate Proteoglycans; Clofibric Acid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Fibric Acids; Gene Expression; Genes, Reporter; Glucocorticoids; Glucuronosyltransferase; Green Fluorescent Proteins; Hepatocytes; Hyaluronoglucosaminidase; Hypolipidemic Agents; Indicators and Reagents; Luminescent Proteins; Mixed Function Oxygenases; Pancreas; Phenotype; Portal Vein; Promoter Regions, Genetic | 2002 |
Effects of various fibrates on serum alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Retrospective Studies; Treatment Outcome | 2002 |
Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation.
Topics: Animals; Binding, Competitive; Cells, Cultured; Clofibric Acid; Dose-Response Relationship, Drug; Endocardium; Endothelium, Vascular; Fibric Acids; Homocysteine; Intercellular Adhesion Molecule-1; Ligands; Matrix Metalloproteinases; Mice; Myocardium; Prostaglandin D2; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
PPAR alpha stimulates the rat gastrin-producing cell.
Topics: Animals; Chromans; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Ligands; Parietal Cells, Gastric; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bile; Carrier Proteins; Cells, Cultured; Clofibric Acid; Fibric Acids; Hepatocytes; Lipid Metabolism; Lipoproteins; Liver; Male; Membrane Transport Proteins; Mice; Mice, Mutant Strains; Organ Size; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Symporters; Taurochenodeoxycholic Acid; Transcription Factors | 2003 |
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation.
Topics: Animals; Bezafibrate; C-Reactive Protein; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Clofibric Acid; Down-Regulation; Fibric Acids; Hepatocytes; Humans; Hypolipidemic Agents; Interleukin-1; Mice; Mice, Knockout; NF-kappa B; NF-kappa B p50 Subunit; Protein Binding; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic; Transfection | 2003 |
Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.
Topics: Animals; Aorta; Blood Pressure; Clofibric Acid; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Fibric Acids; Genotype; Homocysteine; Hyperhomocysteinemia; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Peroxisome Proliferators; Phenotype; Proteinuria; Tyrosine | 2003 |
Fibrates and C-reactive protein.
Topics: C-Reactive Protein; Cardiovascular Diseases; Clofibric Acid; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors | 2003 |
Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.
Topics: Bezafibrate; Clofibrate; Clofibric Acid; Disease Models, Animal; Drug Synergism; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Embryonal; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Tumor Cells, Cultured | 2003 |
Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression; HL-60 Cells; Humans; Ligands; Oncogenes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Antral G cells in rats during dosing with a PPAR alpha agonist: a morphometric and immunocytochemical study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Benzimidazoles; Clofibric Acid; Fibric Acids; Gastrin-Secreting Cells; Gastrins; Immunohistochemistry; Male; Microscopy, Immunoelectron; Omeprazole; Pantoprazole; Peroxisome Proliferators; Peroxisomes; Proton Pump Inhibitors; Pyloric Antrum; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Sulfoxides; Transcription Factors | 2003 |
The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E.
Topics: Animals; Apolipoproteins; Arteriosclerosis; Blotting, Northern; Blotting, Western; Clofibric Acid; Female; Fibric Acids; Hypercholesterolemia; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2003 |
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Biomarkers, Tumor; Blotting, Northern; Carcinoma, Hepatocellular; Clofibric Acid; Diethylnitrosamine; Fibric Acids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Ligands; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Oxidoreductases; Peroxisomes; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Up-Regulation | 2003 |
[Conjugation reactions of ciprofibrate with human and laboratory animals].
Topics: Amino Acids; Animals; Biotransformation; Chromatography, High Pressure Liquid; Clofibric Acid; Drug Stability; Feces; Fibric Acids; Glucuronic Acid; Glucuronides; Humans; Hydrolysis; Hypolipidemic Agents; Mass Spectrometry; Rats | 2003 |
Chromatin sphingomyelin changes in cell proliferation and/or apoptosis induced by ciprofibrate.
Topics: Animals; Apoptosis; Cell Division; Chromatin; Clofibric Acid; Enzyme Activation; Fibric Acids; Liver; Male; Organ Size; Phosphatidylcholines; Rats; Rats, Wistar; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2003 |
Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Male; Microfilament Proteins; Middle Aged; Muscle Proteins; Pravastatin; Pyrroles; Retrospective Studies | 2003 |
Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate.
Topics: Animals; Blotting, Northern; Carbohydrate Metabolism; Cell Division; Clofibric Acid; DNA Probes; Female; Fibric Acids; Gene Expression Regulation; Lipid Metabolism; Liver; Oligonucleotide Array Sequence Analysis; Organ Size; Peroxisome Proliferators; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; RNA; Transcription Factors | 2003 |
Fibrates and renal function.
Topics: Adult; Aged; Clofibric Acid; Creatinine; Female; Fenofibrate; Fibric Acids; Glomerular Filtration Rate; Humans; Hypolipidemic Agents; Kidney; Male; Middle Aged | 2003 |
Cell proliferation and apoptosis are altered in mice deficient in the NF-kappaB p50 subunit after treatment with the peroxisome proliferator ciprofibrate.
Topics: Administration, Oral; Animals; Apoptosis; Blotting, Western; Cell Division; Clofibric Acid; Diet; Fibric Acids; In Situ Nick-End Labeling; Liver; Male; Mice; Mice, Inbred Strains; Mice, Knockout; NF-kappa B; NF-kappa B p50 Subunit; Peroxisome Proliferators; Proto-Oncogene Proteins c-jun; RNA, Messenger | 2003 |
[Ciprofibrate-induced acute cholestatic hepatitis].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents; Male; Middle Aged | 2003 |
Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice.
Topics: Adenoviridae; Animals; Apolipoproteins E; CD36 Antigens; CHO Cells; Cholesterol; Clofibric Acid; Cricetinae; Down-Regulation; Female; Fibric Acids; Gene Transfer Techniques; Genetic Vectors; Hypercholesterolemia; Hypolipidemic Agents; Immunoblotting; Liver; Membrane Proteins; Mice; Mice, Inbred C57BL; Peroxisome Proliferators; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; Succinimides; Time Factors; Transcription Factors; Transfection | 2003 |
Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition.
Topics: Animals; Atractyloside; Cell Respiration; Clofibric Acid; Fibric Acids; Guanosine Diphosphate; Hypertriglyceridemia; Hypolipidemic Agents; Ion Channels; Liver; Membrane Potentials; Membrane Transport Proteins; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proteins; Serum Albumin, Bovine; Triglycerides; Uncoupling Protein 2 | 2003 |
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Carnitine Acyltransferases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Hepatocytes; Humans; Male; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Wistar; Response Elements; Species Specificity; Transfection | 2004 |
The peroxisome proliferator-activated receptor alpha (PPARalpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions.
Topics: Animals; Aorta; Apolipoproteins B; Arteriosclerosis; Blotting, Western; Cholesterol; Clofibric Acid; Cytoplasm; Female; Fibric Acids; Intestinal Mucosa; Lipid Metabolism; Lipoproteins; Lipoproteins, LDL; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peroxisome Proliferators; Polyethylene Glycols; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; RNA; RNA Editing; RNA, Messenger; Time Factors; Transcription Factors; Triglycerides | 2004 |
Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Area Under Curve; Catalase; Cell Division; Clofibric Acid; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Endoplasmic Reticulum, Smooth; Fenofibrate; Fibric Acids; Gene Expression Profiling; Glutathione Peroxidase; Liver; Macaca fascicularis; Male; Mitochondria; Mitotic Index; Organ Size; Oxidative Stress; Peroxisomes; Proliferating Cell Nuclear Antigen; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thioredoxin-Disulfide Reductase; Transcription Factors | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression.
Topics: Animals; Blotting, Northern; Clofibric Acid; Fibric Acids; Fluorescent Dyes; Gastrointestinal Agents; Gene Expression; Hypolipidemic Agents; Image Processing, Computer-Assisted; Liver; Microchemistry; Miniaturization; Molecular Probe Techniques; Nucleic Acid Hybridization; Octreotide; Oligonucleotide Array Sequence Analysis; Rats; Reproducibility of Results; RNA; RNA, Messenger; Sensitivity and Specificity; Time Factors | 2004 |
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Topics: Acetates; Animals; Bile Acids and Salts; Carbon Isotopes; Carboxy-Lyases; CCAAT-Enhancer-Binding Proteins; Cell Division; Cholesterol; Clofibric Acid; DNA-Binding Proteins; Fibric Acids; Hepatocytes; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Up-Regulation | 2004 |
Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate.
Topics: Administration, Oral; Animals; Antioxidants; Clofibric Acid; Fibric Acids; Liver; Male; NF-kappa B; Peroxisome Proliferators; Rats; Rats, Sprague-Dawley; Vitamin E | 2004 |
Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation.
Topics: Acyl-CoA Oxidase; Animals; Clofibric Acid; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Fibric Acids; Freund's Adjuvant; Gene Expression Regulation; Inflammation; Liver; Male; PPAR alpha; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Time Factors; Transcriptional Activation | 2004 |
Peroxisome proliferator-activated receptors as regulators of lipid metabolism; tissue differential expression in adipose tissues during cold acclimatization and hibernation of jerboa (Jaculus orientalis).
Topics: Acclimatization; Acyl-CoA Dehydrogenase; Acyl-CoA Oxidase; Adipose Tissue; Animals; Carrier Proteins; Clofibric Acid; Cold Temperature; Energy Metabolism; Fibric Acids; Gene Expression Regulation; Hibernation; Ion Channels; Lipid Metabolism; Lipids; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Oxidoreductases; Peroxisome Proliferator-Activated Receptors; Phospholipases; RNA, Messenger; Rodentia; Uncoupling Protein 1 | 2004 |
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.
Topics: Animals; Base Sequence; Cells, Cultured; Clofibric Acid; DNA-Binding Proteins; Fibric Acids; Gene Expression Regulation, Enzymologic; Humans; Liver; Molecular Sequence Data; PPAR alpha; Rats; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Sulfotransferases; Transcription Factors; Transcriptional Activation | 2005 |
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Hypolipidemic Agents; Liver; Rats | 2005 |
Induction of pancreatic acinar cell proliferation by thyroid hormone.
Topics: Administration, Oral; Animals; Biomarkers; Blotting, Western; Bromodeoxyuridine; Cell Proliferation; Clofibric Acid; Cyclin A; Cyclin D1; Female; Fibric Acids; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Pancreas; Peroxisome Proliferators; Proliferating Cell Nuclear Antigen; Pyridines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Stimulation, Chemical; Tretinoin; Triiodothyronine | 2005 |
Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver.
Topics: Animals; Clofibric Acid; Dose-Response Relationship, Drug; Fatty Acids; Fibric Acids; Gene Expression Profiling; Gene Expression Regulation; Humans; Liver; Macaca fascicularis; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; PPAR alpha; Species Specificity; Transcription, Genetic | 2005 |
Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha.
Topics: Animals; Clofibric Acid; Female; Fibric Acids; Gastric Bypass; Gastrin-Secreting Cells; Gastrins; Liver; Male; Mice; Mice, Knockout; Organ Size; PPAR alpha; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Somatostatin | 2005 |
Severe rhabdomyolysis during a hypersensitivity reaction to abacavir in a patient treated with ciprofibrate.
Topics: Anti-HIV Agents; Clofibric Acid; Dideoxynucleosides; Drug Hypersensitivity; Drug Interactions; Drug Therapy, Combination; Fibric Acids; HIV Infections; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Rhabdomyolysis | 2005 |
Differential associations of statin and fibrate treatment with carotid arterial remodeling.
Topics: Adult; Atorvastatin; Bezafibrate; Body Mass Index; Carotid Arteries; Cholesterol, HDL; Clofibric Acid; Cohort Studies; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Male; Middle Aged; Multivariate Analysis; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography | 2005 |
Effects of ciprofibrate on testicular and adrenal steroidogenic enzymes in the rat.
Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Oral; Adrenal Glands; Animals; Body Weight; Cholesterol; Clofibric Acid; Dose-Response Relationship, Drug; Enzymes; Fibric Acids; Gene Expression; Immunoblotting; Leydig Cells; Liver; Male; Multienzyme Complexes; Organ Size; Peroxisome Proliferators; Progesterone Reductase; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Isomerases; Triglycerides | 2006 |
Separation of fibrate-type antihyperlipidemic drugs by capillary electrophoresis and their quantitation in pharmaceuticals.
Topics: Bezafibrate; Buffers; Clofibric Acid; Electrophoresis, Capillary; Fibric Acids; Gemfibrozil; Hydrogen-Ion Concentration; Hypolipidemic Agents; Pharmaceutical Preparations; Reproducibility of Results; Temperature; Time Factors | 2006 |
PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cells, Cultured; Clofibric Acid; DNA Helicases; DNA-Binding Proteins; Feasibility Studies; Fibric Acids; Liver; Male; Molecular Sequence Data; Nuclear Proteins; PPAR gamma; Protein Binding; Protein Interaction Mapping; Rats; Rats, Inbred F344; Trans-Activators; Transcription Factors; Transcriptional Activation | 2006 |
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.
Topics: 3T3 Cells; Anilides; Animals; Antioxidants; Apoptosis; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Enzyme Inhibitors; Fibric Acids; Hypoglycemic Agents; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Reactive Oxygen Species; Thiazolidinediones; Troglitazone | 2006 |
Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.
Topics: Aryldialkylphosphatase; Case-Control Studies; Cholesterol, LDL; Clofibric Acid; Fibric Acids; Humans; Metabolic Syndrome; Middle Aged; Peroxisome Proliferators; Prospective Studies | 2006 |
P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fibric Acids; Hepatocytes; Hydroxyeicosatetraenoic Acids; Ligands; Peroxisomes; PPAR alpha; Rats | 2007 |
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Topics: Animals; Butyrates; Cell Differentiation; Cells, Cultured; Clofibric Acid; Embryonic Stem Cells; Enzyme Inhibitors; Fibric Acids; Free Radical Scavengers; Gene Expression; Gene Expression Regulation, Developmental; Heart; Immunohistochemistry; Indoles; Mice; Myocytes, Cardiac; NADPH Oxidases; Peroxisome Proliferators; Phenylurea Compounds; PPAR alpha; PPAR gamma; PPAR-beta; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Epithelial Cells; Fibric Acids; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Imidazoles; Kidney Tubules; Membrane Potential, Mitochondrial; Opossums; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Pyridines; Thiazolidinediones; Troglitazone | 2008 |
Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Blotting, Western; Body Weight; Cell Nucleus; Clofibric Acid; Cyclins; Diet; DNA; Electrophoretic Mobility Shift Assay; Female; Fibric Acids; Glutathione; Liver; Mice; NF-kappa B p50 Subunit; Nuclease Protection Assays; Organ Size; Peroxisome Proliferators; RNA; Transcription Factor RelA; Vitamin E | 2008 |
Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha.
Topics: Animals; Clofibric Acid; DNA; Fibric Acids; Hepatocytes; Kinetics; Ligands; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Peroxisome Proliferators; PPAR alpha; Rats; Rats, Inbred F344; Species Specificity | 2008 |
Administration of ciprofibrate to lactating mothers induces PPARalpha-signaling pathway in the liver and kidney of suckling rats.
Topics: Animals; Animals, Newborn; Animals, Suckling; Apoptosis; Cell Proliferation; Clofibric Acid; Cytochrome P-450 CYP4A; Female; Fibric Acids; Gene Expression Regulation, Enzymologic; Hypolipidemic Agents; Kidney; Lactation; Liver; Maternal Exposure; Organ Size; PPAR alpha; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction | 2008 |
Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chromans; Clofibric Acid; Endothelium, Vascular; Eye Proteins; Fibric Acids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Liver Neoplasms; Neovascularization, Pathologic; Nerve Growth Factors; PPAR alpha; PPAR gamma; Serpins; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2008 |
Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Clofibric Acid; Cytochrome P-450 Enzyme System; Fibric Acids; Glycine; Hydroxyproline; Hypolipidemic Agents; Immunohistochemistry; Isoenzymes; Liver; Male; Metabolic Syndrome; Mixed Function Oxygenases; Obesity; Organ Size; Rats; Rats, Zucker; Thiobarbituric Acid Reactive Substances | 2008 |
Differential regulation of peroxisome proliferator-activated receptor (PPAR)-alpha1 and truncated PPARalpha2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid beta-oxidation in the hibernating mammal.
Topics: Adaptation, Physiological; Animals; Clofibric Acid; Fasting; Fatty Acids; Fibric Acids; Gene Expression Regulation; Hibernation; Hypolipidemic Agents; Lipid Metabolism; Liver; Mammals; Oxidation-Reduction; Peroxisomes; PPAR alpha; Protein Isoforms; Rodentia; Transcription Factors | 2009 |
Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats.
Topics: Acyl-CoA Oxidase; Alkanesulfonic Acids; Animals; Biomarkers; Clofibric Acid; Environmental Pollutants; Female; Fibric Acids; Fluorocarbons; Hydrocarbons, Fluorinated; Liver; Oxidoreductases; Rats; Rats, Sprague-Dawley; Sulfonamides; Superoxide Dismutase; Toxicity Tests; Uterus | 2009 |
Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver.
Topics: Animals; Apolipoprotein C-III; Biological Transport; Cholesterol; Cholesterol Ester Transfer Proteins; Clofibric Acid; Fibric Acids; Gene Expression; Hypertriglyceridemia; Liver; Mice; PPAR alpha | 2009 |
Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Clofibric Acid; Constitutive Androstane Receptor; Cycloheximide; Cytochrome P-450 CYP2B1; Drug Interactions; Enzyme Induction; Fibric Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Male; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Steroid Hydroxylases | 2010 |