cimicoxib has been researched along with rofecoxib in 3 studies
| Studies (cimicoxib) | Trials (cimicoxib) | Recent Studies (post-2010) (cimicoxib) | Studies (rofecoxib) | Trials (rofecoxib) | Recent Studies (post-2010) (rofecoxib) |
|---|---|---|---|---|---|
| 16 | 7 | 13 | 1,914 | 307 | 163 |
| Protein | Taxonomy | cimicoxib (IC50) | rofecoxib (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.43 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 1.51 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.5 | |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | 0.5 | |
| Calpain-2 catalytic subunit | Homo sapiens (human) | 0.02 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 1.8 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.3602 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.76 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 0.486 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.036 | |
| Sodium-dependent serotonin transporter | Macaca mulatta (Rhesus monkey) | 0.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alfón, J; Almansa, C; Bartrolí, J; Carceller, E; Cavalcanti, FL; de Arriba, AF; Escamilla, I; García-Rafanell, J; Gómez, LA; Merlos, M; Miralles, A; Soliva, R | 1 |
| Carrupt, PA; Cena, C; Chegaev, K; Fruttero, R; Gasco, A; Lazzarato, L; Marini, E; Rolando, B; Tosco, P | 1 |
| Ramajayam, R | 1 |
1 review(s) available for cimicoxib and rofecoxib
| Article | Year |
|---|---|
Medicinal chemistry of vicinal diaryl scaffold: A mini review.
Topics: Carbonic Anhydrase IV; Chemistry, Pharmaceutical; Cyclooxygenase 2 Inhibitors; Drug Discovery; Humans; Hydrocarbons, Aromatic; Structure-Activity Relationship | 2019 |
2 other study(ies) available for cimicoxib and rofecoxib
| Article | Year |
|---|---|
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Inflammation; Isoenzymes; Male; Membrane Proteins; Models, Molecular; Pain Measurement; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2003 |
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.
Topics: Animals; Aorta; Cyclooxygenase 2 Inhibitors; Humans; Imidazoles; In Vitro Techniques; Models, Molecular; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Rats; Structure-Activity Relationship; Sulfonamides; Vasodilator Agents | 2007 |