cimetidine and warfarin

cimetidine has been researched along with warfarin in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (45.12)	18.7374
1990's	20 (24.39)	18.2507
2000's	12 (14.63)	29.6817
2010's	13 (15.85)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Flind, AC	2
Atwood, JL; Breckenridge, AM; Mossman, S; Serlin, MJ; Sibeon, RG; Williams, JR; Willoughby, JM	1
Birkett, D; Hetzel, D; Miners, J	1
Bell, WR; Silver, BA	1
Ovedoff, DL	1
Jacknowitz, A; Raich, PC; Wallin, BA	1
Breckenridge, AM; Challiner, M; Mossman, S; Park, BK; Serlin, MJ; Sibeon, RG; Williams, JR; Willoughby, JM	1
Kajfez, F; Rendić, S; Ruf, HH; Sunjić, V; Toso, R	1
Gibaldi, M	2
Aarons, L; Holt, B; Parker, EM; Pitsiu, M; Rowland, M	1
Stein, GE	1
Butler, K; Fried, A; Marshall, ME	1
Hermans, JJ; Thijssen, HH	1
Fentem, JH; Fry, JR	1
Niopas, I; Rowland, M; Toon, S	1
Gasser, G; Kokron, O; Maca, S; Schmidt, PR	1
Egeblad, H; Fugleholm, AM; Heaf, J; Ladefoged, K; Launbjerg, J; Nielsen, NH	1
Hennig, FW; Herrmann, R; Manegold, C; Matthiessen, W; Maurer, B	1
Amato, R; Dexeus, FH; Dozier, N; Fitz, K; Logothetis, CJ; Reuben, JM; Sella, A	1
Butler, K; Hermansen, D; Marshall, ME	1
Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL	1
Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG	1
Rieth, H; Sauerbrey, N	1
Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C	1
Frank, WO	1
Davenport, Y; Tseng, A; Venook, AP	1
Cibull, M; Eichhorn, T; Jennings, CD; Marshall, ME; Rhoades, J; Riley, LK; Thompson, J	1
Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK	1
Butler, K; Cantrell, J; Harvey, J; Macdonald, J; Marshall, ME; Mendelsohn, L	1
Baciewicz, AM	1
Garstang, FM; Hopkins, KJ; Rowland, M; Toon, S	1
Ernstoff, MS; Kirkwood, JM	1
Butler, K; Cantrell, J; Macdonald, JS; Marshall, ME; Mendelsohn, L; Riley, L; Taylor, R; Wiseman, C	1
Braverman, AJ; Chretien, S; Frank, WO; Gray, DR; Jackson, BJ; McCree, LC; Peace, KE; Randolph, WC; Sax, MJ; Wyle, F	1
Anderson, KC; Bell, WR; Noe, DA; Silver, BA	1
Langvad, E; Pedersen, L; Rose, C	1
Diquet, B; Garstang, FM; Gill, TS; Hopkins, KJ; Rowland, M; Toon, S	1
Lynch, G; Sheehan, MV; Thornes, RD	2
Greene, WL; Levinson, MJ; Self, TH	1
Breen, KJ; Desmond, PV; Harman, PJ; Mashford, ML; Morphett, BJ; Wang, YM	1
O'Reilly, RA	1
Feely, J	1
Crooks, J	1
D'Arcy, PF	1
Ali, M; Kerley, B	1
Babb, RR	1
Breckenridge, AM; Challiner, M; Park, BK; Serlin, MJ; Turcan, PA	1
Buters, JT; Friedman, FK; Koley, AP; Markowitz, A; Robinson, RC	1
Bueschen, A; Butler, K; Edmonds, K; Markiewicz, M; Marshall, ME; Mohler, JL; Ryles, M; Urban, D; Weiss, L; Williams, B	1
Flamm, J; Ludwig, H; Micksche, M; Sagaster, P	1
Cappelli, J; Lamy, V; Lenaerts, A; Moisse, R; Ramdani, B	1
Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y	1
Aarons, L; Niopas, I; Rowland, M; Toon, S	1
Feely, J; Kelly, A; Williams, D	1
Chen, H; Hu, JP; Li, Y; Sheng, L	1
Miller, GP	1

Reviews

9 review(s) available for cimetidine and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions: Part I. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5 Topics: Antidepressive Agents, Tricyclic; Caffeine; Cimetidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluconazole; Fluoxetine; Hexobarbital; Humans; Ketoconazole; Nimodipine; Oxidoreductases; Pharmaceutical Preparations; Rifampin; Stereoisomerism; Warfarin; Zidovudine	1992
Drug interactions with fluoroquinolones. The American journal of medicine, 1991, Dec-30, Volume: 91, Issue:6A Topics: 4-Quinolones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Cyclosporine; Drug Interactions; Humans; Metals; Probenecid; Warfarin; Xanthines	1991
Clinical pharmacokinetics of moricizine. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin	1990
Safety: cimetidine and concomitant theophylline or warfarin--drug interactions and their implications. Clinical therapeutics, 1986, Volume: 8 Suppl A Topics: Adolescent; Adult; Aged; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Kinetics; Male; Middle Aged; Theophylline; Warfarin	1986
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986
Interaction of cimetidine with other drugs. Southern medical journal, 1983, Volume: 76, Issue:6 Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin	1983
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin. Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl Topics: Adult; Aged; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Cimetidine; Coumarins; Drug Therapy, Combination; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Survival Analysis; Treatment Outcome; Umbelliferones	1994
Stereoselective and isozyme-selective drug interactions. Chirality, 1993, Volume: 5, Issue:6 Topics: Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Quinidine; Rifampin; Stereoisomerism; Warfarin	1993

Trials

11 trial(s) available for cimetidine and warfarin

Article	Year
Cimetidine: interaction with oral anticoagulants in man. Lancet (London, England), 1979, Aug-18, Volume: 2, Issue:8138 Topics: Acenocoumarol; Administration, Oral; Adult; Aged; Antipyrine; Biological Availability; Cimetidine; Clinical Trials as Topic; Drug Synergism; Female; Guanidines; Half-Life; Humans; Male; Middle Aged; Phenindione; Prothrombin Time; Warfarin	1979
Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies. Molecular biotherapy, 1991, Volume: 3, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Radiography	1991
Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study. Oncology, 1991, Volume: 48, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Pilot Projects	1991
Phase II trial of coumarin and cimetidine in advanced renal cell carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 1990, Volume: 1, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Pleural Neoplasms; Survival Rate	1990
Clinical pharmacokinetics of moricizine. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin	1990
[Interaction studies with fluconazole, a new triazole antifungal drug]. Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16 Topics: Adult; Antipyrine; Cimetidine; Clinical Trials as Topic; Contraceptives, Oral; Cyclosporins; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Male; Testosterone; Tolbutamide; Warfarin	1989
Stereoselective interaction between the R enantiomer of warfarin and cimetidine. British journal of clinical pharmacology, 1986, Volume: 21, Issue:3 Topics: Administration, Oral; Bradycardia; Cimetidine; Drug Eruptions; Drug Interactions; Half-Life; Humans; Hypotension; Injections, Intravenous; Kinetics; Protein Binding; Prothrombin Time; Random Allocation; Stereoisomerism; Vitamin K 1; Warfarin	1986
Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in man. European journal of clinical pharmacology, 1987, Volume: 32, Issue:2 Topics: Adult; Blood Coagulation; Cimetidine; Drug Interactions; Factor VII; Humans; Kinetics; Male; Prothrombin Time; Ranitidine; Stereoisomerism; Warfarin	1987
The warfarin-cimetidine interaction: stereochemical considerations. British journal of clinical pharmacology, 1986, Volume: 21, Issue:2 Topics: Blood Coagulation; Cimetidine; Drug Interactions; Half-Life; Humans; Kinetics; Male; Stereoisomerism; Warfarin	1986
Comparative interaction of cimetidine and ranitidine with racemic warfarin in man. Archives of internal medicine, 1984, Volume: 144, Issue:5 Topics: Adult; Blood Coagulation; Chromatography, High Pressure Liquid; Cimetidine; Drug Synergism; Humans; Male; Prothrombin Time; Ranitidine; Stereoisomerism; Warfarin	1984
Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Female; Humans; Interferon alpha-2; Interferon-alpha; Kidney Neoplasms; Male; Middle Aged; Prospective Studies; Recombinant Proteins	1995

Other Studies

63 other study(ies) available for cimetidine and warfarin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Cimetidine and oral anticoagulants. Lancet (London, England), 1978, Nov-11, Volume: 2, Issue:8098 Topics: Administration, Oral; Blood Coagulation; Cimetidine; Coagulants; Drug Antagonism; Guanidines; Humans; Warfarin	1978
Cimetidine interaction with warfarin. Lancet (London, England), 1979, Sep-22, Volume: 2, Issue:8143 Topics: Biotransformation; Cimetidine; Drug Synergism; Guanidines; Humans; Middle Aged; Prothrombin Time; Warfarin	1979
Cimetidine potentiation of the hypoprothrombinemic effect of warfarin. Annals of internal medicine, 1979, Volume: 90, Issue:3 Topics: Aged; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Hypoprothrombinemias; Warfarin	1979
Cimetidine and warfarin. The Medical journal of Australia, 1979, Feb-10, Volume: 1, Issue:3 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Prothrombin Time; Warfarin	1979
Cimetidine and effect of warfarin. Annals of internal medicine, 1979, Volume: 90, Issue:6 Topics: Cimetidine; Drug Synergism; Guanidines; Humans; Male; Middle Aged; Prothrombin; Prothrombin Time; Warfarin	1979
Cimetidine increases the action of warfarin in man [proceedings]. British journal of clinical pharmacology, 1979, Volume: 8, Issue:4 Topics: Adult; Blood Coagulation; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Male; Middle Aged; Warfarin	1979
Interaction of cimetidine with liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1979, Volume: 9, Issue:9 Topics: Animals; Binding, Competitive; Cimetidine; Coumarins; Cytochrome P-450 Enzyme System; Guanidines; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats	1979
Cimetidine and oral anticoagulants. British medical journal, 1978, Nov-11, Volume: 2, Issue:6148 Topics: Blood Coagulation; Cimetidine; Drug Synergism; Guanidines; Humans; Warfarin	1978
A comparison of the relative sensitivities of factor VII and prothrombin time measurements in detecting drug interactions with warfarin. European journal of clinical pharmacology, 1992, Volume: 42, Issue:6 Topics: Adult; Chlorophenols; Cimetidine; Drug Interactions; Enoxacin; Factor VII; Humans; Male; Prothrombin Time; Ranitidine; Stereoisomerism; Warfarin; Whole Blood Coagulation Time	1992
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol). Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:3 Topics: Acenocoumarol; Animals; Chromatography, High Pressure Liquid; Cimetidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin	1991
Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Animals; Cimetidine; Coumarins; Drug Interactions; Gerbillinae; Humans; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones	1991
Further insight into the stereoselective interaction between warfarin and cimetidine in man. British journal of clinical pharmacology, 1991, Volume: 32, Issue:4 Topics: Cimetidine; Drug Interactions; Humans; Hydroxylation; Male; Stereoisomerism; Warfarin	1991
Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients. Journal of internal medicine, 1991, Volume: 229, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care; Anticoagulants; Cimetidine; Drug Interactions; Female; Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Phenprocoumon; Retrospective Studies; Risk Factors; Vitamin K; Warfarin	1991
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:2 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Kidney Neoplasms; Lymphocyte Activation; Male; Middle Aged; Remission Induction; T-Lymphocytes, Regulatory	1990
Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. The Prostate, 1990, Volume: 17, Issue:2 Topics: Aged; Bone Neoplasms; Cimetidine; Coumarins; Drug Therapy, Combination; Humans; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Prostatic Neoplasms	1990
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin. Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350 Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin	1989
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Female; Humans; Male; Melanoma; Middle Aged; Pilot Projects	1989
Activity of coumarin and cimetidine in metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:3 Topics: Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Drug Therapy, Combination; Humans; Kidney Neoplasms	1989
Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies. Journal of biological response modifiers, 1989, Volume: 8, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coumarins; Female; Humans; Killer Cells, Natural; Lymphocytes; Male; Middle Aged; Monocytes; Neoplasms	1989
Treatment of non-small cell lung cancer with coumarin and cimetidine. Cancer treatment reports, 1987, Volume: 71, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged	1987
Coumarin plus cimetidine: yet another angle for therapy of renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Humans; Kidney Neoplasms; Pilot Projects	1987
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Nephrectomy; Pilot Projects; Remission Induction	1987
Effect of two cimetidine regimens on prothrombin time and warfarin pharmacokinetics during long-term warfarin therapy. Clinical pharmacy, 1987, Volume: 6, Issue:6 Topics: Adult; Aged; Cimetidine; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Middle Aged; Prothrombin Time; Time Factors; Warfarin	1987
Reduction in the plasma clearance rate of warfarin induced by cimetidine. Archives of internal medicine, 1986, Volume: 146, Issue:12 Topics: Aged; Cimetidine; Drug Interactions; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Prospective Studies; Prothrombin Time; Random Allocation; Warfarin	1986
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. Cancer immunology, immunotherapy : CII, 1987, Volume: 24, Issue:2 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms	1987
Cimetidine and coumarin therapy of melanoma. Lancet (London, England), 1982, Aug-07, Volume: 2, Issue:8293 Topics: Adult; Aged; Cimetidine; Coumarins; Drug Antagonism; Drug Therapy, Combination; Female; Guanidines; Humans; Male; Melanoma; Middle Aged	1982
Cimetidine drug interactions. The Journal of family practice, 1983, Volume: 16, Issue:6 Topics: Adrenergic beta-Antagonists; Analgesics, Opioid; Anti-Arrhythmia Agents; Anticonvulsants; Benzodiazepines; Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Peptic Ulcer; Warfarin	1983
Combination of cimetidine with other drugs for treatment of cancer. The New England journal of medicine, 1983, Mar-10, Volume: 308, Issue:10 Topics: Aged; Animals; Cimetidine; Coumarins; Female; Guanidines; Histamine; Humans; Interferons; Male; Melanoma; Metiamide; Mice; Middle Aged; Neoplasms; Thiourea	1983
Decreased oral warfarin clearance after ranitidine and cimetidine. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Humans; Kinetics; Male; Middle Aged; Ranitidine; Warfarin	1984
Drug epidemiology and clinical pharmacology: their contribution to patient care. British journal of clinical pharmacology, 1983, Volume: 16, Issue:4 Topics: Anticoagulants; Cimetidine; Drug Information Services; Drug Prescriptions; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; Humans; Hypnotics and Sedatives; Kinetics; Patient Care Planning; Patient Compliance; Pharmacology, Clinical; Thrombophlebitis; Warfarin	1983
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Coumarin and cimetidine in malignant melanoma. Irish medical journal, 1983, Volume: 76, Issue:1 Topics: Adult; Aged; Cimetidine; Coumarins; Female; Guanidines; Humans; Male; Melanoma; Middle Aged	1983
Cimetidine potentiation of warfarin action. Canadian Medical Association journal, 1982, Jan-15, Volume: 126, Issue:2 Topics: Adult; Cimetidine; Drug Synergism; Guanidines; Hematoma; Humans; Male; Retroperitoneal Space; Warfarin	1982
Drug interactions with cimetidine. Postgraduate medicine, 1981, Volume: 70, Issue:5 Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin	1981
Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism. Biochemical pharmacology, 1980, Jul-01, Volume: 29, Issue:13 Topics: Animals; Blood Coagulation; Cimetidine; Drug Synergism; Guanidines; Kinetics; Liver; Male; Paralysis; Pentobarbital; Rats; Time Factors; Warfarin; Zoxazolamine	1980
CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers. The Journal of biological chemistry, 1995, Mar-10, Volume: 270, Issue:10 Topics: Animals; Carbon Monoxide; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Ethinyl Estradiol; Humans; Kinetics; Mixed Function Oxygenases; Nifedipine; Protein Binding; Quinidine; Recombinant Proteins; Spodoptera; Substrate Specificity; Testosterone; Time Factors; Transfection; Warfarin	1995
[Clinical case of the month. Intramural hematoma of the small intestine associated with anticoagulants, potentiated by interaction with cimetidine]. Revue medicale de Liege, 1997, Volume: 52, Issue:12 Topics: Adult; Anti-Ulcer Agents; Anticoagulants; Cimetidine; Coumarins; Drug Interactions; Gastrointestinal Hemorrhage; Gastrointestinal Transit; Hematoma; Humans; Jejunal Diseases; Male; Tomography, X-Ray Computed	1997
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:2 Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin	1998
The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans. European journal of clinical pharmacology, 1999, Volume: 55, Issue:5 Topics: Adolescent; Adult; Anticoagulants; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Factor VII; Histamine H2 Antagonists; Humans; Male; Prothrombin Time; Warfarin	1999
Drug interactions avoided-a useful indicator of good prescribing practice. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticoagulants; Anticonvulsants; Cimetidine; Drug Interactions; Drug Prescriptions; Histamine H2 Antagonists; Humans; Ireland; Odds Ratio; Phenytoin; Theophylline; Vasodilator Agents; Warfarin	2000
[Metabolism of nicousamide in rat and human liver in vitro]. Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:9 Topics: Adenosine Monophosphate; Allopurinol; Aniline Compounds; Animals; Cimetidine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P450 Family 2; Cytochrome-B(5) Reductase; Cytosol; Dicumarol; Enzyme Inhibitors; Female; Humans; Liver; Male; Microsomes, Liver; Mitochondria, Liver; NAD(P)H Dehydrogenase (Quinone); Propylthiouracil; Rats; Rats, Sprague-Dawley; Steroid 21-Hydroxylase; Xanthine Oxidase	2008
Warfarin therapy: how the less interesting half just got interesting. Journal of thrombosis and haemostasis : JTH, 2010, Volume: 8, Issue:12 Topics: Acetaminophen; Anticoagulants; Azithromycin; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Gefitinib; Humans; Omeprazole; Quinazolines; Stereoisomerism; Substrate Specificity; Warfarin	2010