cimetidine and theophylline

cimetidine has been researched along with theophylline in 140 studies

Research

Studies (140)

Timeframe	Studies, this research(%)	All Research%
pre-1990	74 (52.86)	18.7374
1990's	31 (22.14)	18.2507
2000's	18 (12.86)	29.6817
2010's	17 (12.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Barbara, L; Borghi, E; Casadio, R; Corinaldesi, R; Paparo, GF; Stanghellini, V; Tonon, R	1
Fiegler, M; Lörincz, P; Mózsik, G; Nagy, L; Tárnok, F	1
Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK	1
Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D	1
Araki, Y; Eto, K; Furuno, K; Gomita, Y	1
Gordon, T; Hamilton, RA	1
Bachmann, K; Jauregui, L; Levine, L; Martin, M; Mauro, LS; Sullivan, TJ	1
Davis, RL; Kelly, HW; Powell, JR; Quenzer, RW	1
Hopkins, S	1
Gaska, JA; Rocci, ML; Tietze, KJ; Vlasses, PH	1
Añibarro Bausera, B; Díaz Pena, JM; Escobar Castro, H; García Ara, MC; Martín Muñoz, F; Ojeda Casas, JA	1
Anderson, KE; Kappas, A; McCleery, RB; Vesell, ES; Vickers, FF	1
Bachmann, KA; Sullivan, TJ	1
Boehning, W	1
Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL	1
Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H	1
Javaheri, S; Krstenansky, PM; Thomas, JP; Thomas, RL	1
Kelly, HW	1
Aoi, R; Ishioka, T; Ogata, H; Takeuchi, H; Yoshimura, N	1
Cremer, KF; Secor, J; Speeg, KV	1
Gutfeld, MB; Harrison, NJ; Walawander, CA; Welage, LS; Wilton, JH	1
Frank, WO	1
Chiou, R; Chremos, AN; Lin, JH; Williams, R; Yeh, KC	1
Birkett, DJ; Kjellen, G; Lelo, A; Miners, JO	1
Adebayo, GI; Mabadeje, AF	1
Goldie, RG; Papadimitriou, JM; Paterson, JW; Rigby, PJ; Self, HM; Spina, D	1
Lalegerie, P; Lehuede, J; Metaye, T; Mettey, Y; Vierfond, JM	1
Baronti, A; Di Carlo, S; Verdiani, P	1
Advenier, C; Naline, E; Pays, M; Sanceaume, M	1
Birkett, DJ; Matthews, AP; McManus, ME; Meller, D; Miners, JO; Robson, RA; Stupans, I	1
Al-Turk, WA; Shaheen, O; Sliman, NA	1
Miyazaki, K; Okazaki, O; Tachizawa, H	1
Cusack, BJ; Dawson, GW; Mercer, GD; Park, BK; Vestal, RE	1
Donohue, JF; Kelly, HW; Powell, JR	1
Bottino, G; Gianotti, A	1
Giacomini, VA; Reis, CC	1
Farnam, J; Grant, JA; Henry, DP; Lett-Brown, MA; Lord, RA; Russell, WL	1
Nell, PA	1
Banerjee, PS; Cacini, W; Hassan, M; Pesce, AJ; Ritschel, WA	1
Cusack, BJ; Dawson, GW; Mercer, GD; Vestal, RE	1
Achem, SR; Berardi, RR; Cohen, IA; Hyneck, ML; Johnson, CE	1
Clark, BG; Vestal, RE	1
Hsieh, KH	1
Breen, KJ; Bury, R; Desmond, PV; Mashford, ML; Morphett, B; Shaw, RG; Westwood, B	1
Bauman, JH; Beck, GJ; Caraccio, TR; Kimelblatt, BJ; Silverman, HM; Simon, GI	1
Bauman, JH; Kimelblatt, BJ	1
Cárdenas, P; Chacín, J	1
Sedman, AJ	1
Greene, W	1
Ceriani, T; Moggio, R; Ventura, U	1
Iizuka, H; Ishibashi, Y; Ohkawara, A	1
Cross, RE; Eshelman, FN; Powell, JR; Rogers, JF; Wargin, WA	1
Carloni, C; Dal Negro, R; Pomari, C; Trevisan, F; Turco, P; Zoccatelli, O	1
Barragán Rastrollo, F; Escarrabill Sanglas, J; Frey González, E; Rodríguez Sanchón, B; Sabaté Salvía, I	1
Garton, A; Herbert, FA; Hsu, K; Legatt, D; Sproule, BJ; Tam, YK	1
DiPiro, JT; Griffin, JW; May, JR	1
Ebling, WF; Gardner, MJ; Green, AW; Jusko, WJ	1
Breen, KJ; Desmond, PV; Ghabrial, H; Harman, PJ; Mashford, ML	1
Gugler, R; Hansen, HH; Jensen, JC; Wolf, M	1
Bussac, JJ; Colavolpe, C; François, G; Gineyt, G	1
Bigelow, SW; Lazarte, RA; Levitt, RC; Nebert, DW	1
Grice, J; McGuffie, C; Roberts, RK	1
Birkett, DJ; Drew, R; Grygiel, JJ; Miners, JO	1
Balsys, AJ; Koob, RA; Lalonde, RL; McLean, WM	1
Anderson, JR; Poklis, A; Slavin, RG	1
Christensen, JM; Lee, RY; Parrott, KA	1
Mercer, GD; Musser, B; Thummel, KE; Vestal, RE	1
Alcorn, GJ; Ritschel, WA; Streng, WH; Zoglio, MA	1
Bentley, J; Dorr, R; Jackson, JE; Powell, JR; Wandell, M	1
Fantoli, U	1
Cluxton, RJ; Hanenson, IB; Pesce, AJ; Ritschel, WA; Rivera, JO	1
Baltodano, A; Fenje, PC; Isles, AF; MacLeod, SM; Soldin, S	1
Bernard, N; Caubarrere, I; Uzzan, B; Uzzan, D	1
Howald, WN; Jue, SG; Mercer, GD; Musser, B; Thummel, KE; Vestal, RE	1
Luderer, JR	1
Grice, J; McGuffie, C; Petroff, V; Roberts, RK; Wood, L	1
Campbell, MA; Finley, PR; Jackson, JE; Moon, JF; Plachetka, JR	1
Ambrose, PJ; Harralson, AF	1
Bernhard, H; Reitberg, DP; Schentag, JJ	1
Babb, RR	1
Schneck, DW	1
Arnold, G; Reinhardt, D; Walkenhorst, R	1
Hendeles, L; Milavetz, G; Smith, G; Weinberger, MM	1
Deamer, RL; Pride, M	1
Chiou, WL; Choi, YM	1
Bachmann, K; Jauregui, L; King, JD; Miller, K; Reese, JH; Schwartz, J; Scott, M; Stepanavage, M; Sullivan, TJ; Yeh, KC	1
Bachmann, KA; Jauregui, L; Levine, L; Miller, K; Reese, J; Sullivan, TJ	1
Calvo, B; Domínguez-Gil, A; Gascón, AR; Hernández, RM; Pedraz, JL	1
Ebihara, A; Fujimura, A; Ohashi, K; Sakamoto, K; Shiga, T; Sudo, T; Tateishi, T	1
Bertino, JS; Davidson, L; Jennings, TS; Nafziger, AN	1
Dal Negro, R; Pomari, C; Turco, P	1
Cheung, LY; Darnell, MP; Wood, JG	1
Furuhata, M; Nagai, N; Ogata, H	1
Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE	1
Cusack, BJ; Loi, CM; Parker, BM; Vestal, R	1
Derendorf, H; Schifferer, H; Sourgens, H	1
Dawidek-Pietryka, K; Dudka, J; Mazur, M; Szczepaniak, S	1
Zbrozek, AS	1
Bauman, JH; Fuentes, RJ	1
Boike, SC; Boyle, DA; Di Cicco, RA; Jorkasky, DK; Miller, AK; Nix, DE; Schentag, JJ; Zariffa, N	1
Gilhar, D; Habib, G; Hoffman, A; Perlstein, I; Pinto, E	1
Butters, CJ; McKillop, D; Wild, MJ	1
Hatorp, V; Thomsen, MS	1
Feely, J; Kelly, A; Williams, D	1
Caldwell, GG; Evangelisto, M; Jones, WW; Juzwin, SS; Masucci, JJ; Sasso, PP	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Attwood, D; Itoh, K; Kubo, W; Miyazaki, S	1
Augsburger, LL; Cantor, SL; Hoag, SW	2
Alhaj, M; Bozarov, A; Christofi, FL; Cooke, HJ; Grants, I; Hassanain, HH; Ren, T; Wang, YZ; Wunderlich, J; Yu, JG	1
Cantor, SL; Ellison, CD; Hoag, SW; Khan, MA; Lyon, RC	1
Block, F; Dafotakis, M	1
Haenen, GRMM; Vrolijk, M; Zhang, M	1

Reviews

10 review(s) available for cimetidine and theophylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Asthma and gastroesophageal reflux. Outcome of asthma after longterm medical treatment of the reflux]. Anales espanoles de pediatria, 1990, Volume: 33, Issue:4 Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Child; Child, Preschool; Cimetidine; Esophagitis; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Infant; Theophylline	1990
Clinical pharmacokinetics of moricizine. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin	1990
Safety: cimetidine and concomitant theophylline or warfarin--drug interactions and their implications. Clinical therapeutics, 1986, Volume: 8 Suppl A Topics: Adolescent; Adult; Aged; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Kinetics; Male; Middle Aged; Theophylline; Warfarin	1986
Cimetidine as an inhibitor of drug metabolism: therapeutic implications and review of the literature. Drug intelligence & clinical pharmacy, 1982, Volume: 16, Issue:5 Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Benzodiazepines; Cimetidine; Drug Interactions; Guanidines; Humans; Imidazoles; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Theophylline	1982
Cimetidine-drug interactions. The American journal of medicine, 1984, Volume: 76, Issue:1 Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Chlormethiazole; Cimetidine; Drug Interactions; Humans; Ketoconazole; Kidney; Lidocaine; Morphine; Penicillins; Theophylline	1984
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
[Interaction between theophylline and cimetidine]. Recenti progressi in medicina, 1981, Volume: 71, Issue:3 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Theophylline	1981
Pharmacokinetic profile of cefaclor. International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:9 Topics: Aged; Antacids; Area Under Curve; Cefaclor; Cephalosporins; Child; Cimetidine; Drug Interactions; Half-Life; Humans; Infant; Renal Insufficiency; Theophylline	1997
[Drug-induced tremor]. Fortschritte der Neurologie-Psychiatrie, 2011, Volume: 79, Issue:10 Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bronchodilator Agents; Cimetidine; Histamine H2 Antagonists; Humans; Immunosuppressive Agents; Lamotrigine; Lithium Compounds; Pindolol; Theophylline; Tremor; Triazines; Valproic Acid	2011

Trials

13 trial(s) available for cimetidine and theophylline

Article	Year
Effect of the addition of ciprofloxacin on theophylline pharmacokinetics in subjects inhibited by cimetidine. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:1 Topics: Adult; Cimetidine; Ciprofloxacin; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Infusions, Intravenous; Liver; Male; Metabolic Clearance Rate; Theophylline	1992
Clinical toleration and safety of azithromycin. The American journal of medicine, 1991, Sep-12, Volume: 91, Issue:3A Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Azithromycin; Bacterial Infections; Carbamazepine; Child; Child, Preschool; Cimetidine; Contraindications; Drug Evaluation; Drug Interactions; Eating; Erythromycin; Female; Humans; Male; Methylprednisolone; Middle Aged; Respiratory Tract Infections; Skin Diseases, Infectious; Theophylline; Urethritis; Uterine Cervicitis	1991
Theophylline pharmacokinetics: effect of continuous versus intermittent cimetidine i.v. infusion. Journal of clinical pharmacology, 1991, Volume: 31, Issue:7 Topics: Adult; Cimetidine; Drug Interactions; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Theophylline	1991
Effect of cimetidine and ranitidine on plasma theophylline in patients with chronic obstructive airways disease treated with theophylline and corticosteroids. European journal of clinical pharmacology, 1990, Volume: 38, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Delayed-Action Preparations; Drug Interactions; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Random Allocation; Ranitidine; Theophylline; Time Factors	1990
Clinical pharmacokinetics of moricizine. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin	1990
Effects of roxatidine acetate hydrochloride and cimetidine on the pharmacokinetics of theophylline in healthy subjects. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:6 Topics: Adult; Aminophylline; Cimetidine; Half-Life; Humans; Infusions, Intravenous; Male; Piperidines; Smoking; Theophylline	1989
Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers. British journal of clinical pharmacology, 1987, Volume: 24, Issue:5 Topics: Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; Injections, Intravenous; Male; Theophylline; Thiazoles	1987
Famotidine effects on theophylline pharmacokinetics in subjects affected by COPD. Comparison with cimetidine and placebo. Chest, 1988, Volume: 94, Issue:4 Topics: Aged; Cimetidine; Famotidine; Female; Half-Life; Humans; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Middle Aged; Theophylline; Thiazoles	1988
Alteration of theophylline clearance and half-life by cimetidine in normal volunteers. Annals of internal medicine, 1981, Volume: 95, Issue:5 Topics: Adult; Cimetidine; Drug Interactions; Guanidines; Half-Life; Humans; Male; Metabolic Clearance Rate; Random Allocation; Theophylline	1981
Controlled study of the putative interaction between famotidine and theophylline in patients with chronic obstructive pulmonary disease. Journal of clinical pharmacology, 1995, Volume: 35, Issue:5 Topics: Adult; Aged; Cimetidine; Cross-Over Studies; Drug Interactions; Famotidine; Female; Humans; Infusions, Intravenous; Lung Diseases, Obstructive; Male; Middle Aged; Theophylline	1995
Effects of diltiazem and cimetidine on theophylline oxidative metabolism. Journal of clinical pharmacology, 1993, Volume: 33, Issue:12 Topics: Adult; Biotransformation; Cimetidine; Depression, Chemical; Diltiazem; Half-Life; Humans; Male; Oxidation-Reduction; Theophylline	1993
Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers. British journal of clinical pharmacology, 1993, Volume: 36, Issue:3 Topics: Adult; Bronchodilator Agents; Cimetidine; Ciprofloxacin; Drug Interactions; Humans; Male; Smoking; Theophylline	1993
The effect of low-dose cimetidine (200 mg twice daily) on the pharmacokinetics of theophylline. Journal of clinical pharmacology, 1999, Volume: 39, Issue:8 Topics: Adult; Aged; Area Under Curve; Cimetidine; Circadian Rhythm; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Male; Metabolic Clearance Rate; Middle Aged; Single-Blind Method; Smoking; Theophylline; Vasodilator Agents	1999

Other Studies

118 other study(ies) available for cimetidine and theophylline

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Intravenous cimetidine and methylxanthines stimulated gastric acid secretion in man. Il Farmaco; edizione pratica, 1979, Volume: 34, Issue:11 Topics: Adult; Caffeine; Cimetidine; Female; Gastric Juice; Guanidines; Histamine H2 Antagonists; Humans; Male; Stimulation, Chemical; Theophylline	1979
The role of the ATP--adenylate cyclase--cAMP system and its pharmacological regulation in the development of gastric hypersecretion and ulceration. Acta medica Academiae Scientiarum Hungaricae, 1979, Volume: 36, Issue:4 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Atropine; Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Histamine; Male; Peptic Ulcer; Rats; Theophylline	1979
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. Mechanisms of ageing and development, 1992, Volume: 66, Issue:1 Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Drugs, Chinese Herbal; Phenobarbital; Rats; Rats, Sprague-Dawley; Theophylline	1992
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. European journal of clinical pharmacology, 1992, Volume: 43, Issue:2 Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline	1992
Effects of exposure to standard- and nicotine-reduced-cigarette smoke on pharmacokinetics of theophylline and cimetidine in rats. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:11 Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Male; Nicotine; Rats; Rats, Wistar; Smoking; Theophylline	1992
Incidence and cost of hospital admissions secondary to drug interactions involving theophylline. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:12 Topics: Aged; Aged, 80 and over; Cimetidine; Ciprofloxacin; Drug Interactions; Erythromycin; Health Care Costs; Hospitalization; Hospitals, Veterans; Humans; Male; New York; Patient Admission; Theophylline	1992
Comparative investigation of the influence of nizatidine, ranitidine, and cimetidine on the steady-state pharmacokinetics of theophylline in COPD patients. Journal of clinical pharmacology, 1992, Volume: 32, Issue:5 Topics: Administration, Oral; Aged; Cimetidine; Delayed-Action Preparations; Humans; Lung Diseases, Obstructive; Middle Aged; Nizatidine; Ranitidine; Theophylline	1992
Diet and cimetidine induce comparable changes in theophylline metabolism in normal subjects. Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:5 Topics: Adult; Cimetidine; Dietary Carbohydrates; Dietary Proteins; Half-Life; Humans; Liver; Male; Theophylline	1991
Method for assessing the probability of toxicity from drug interactions having a pharmacokinetic basis. Clinical pharmacy, 1990, Volume: 9, Issue:2 Topics: Anti-Bacterial Agents; Cimetidine; Ciprofloxacin; Drug Interactions; Humans; Lactams; Models, Biological; Pharmacokinetics; Probability; Theophylline	1990
Effects of DN-9693, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion in dogs. Japanese journal of pharmacology, 1989, Volume: 49, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cholecystokinin; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Male; Pancreas; Pancreatic Juice; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Propranolol; Quinazolines; Secretin; Sulpiride; Theophylline	1989
Effect of continuous cimetidine infusion on steady-state theophylline concentration. Clinical pharmacy, 1989, Volume: 8, Issue:3 Topics: Adult; Blood Pressure; Body Temperature; Cimetidine; Delayed-Action Preparations; Drug Interactions; Heart Rate; Humans; Infusions, Intravenous; Theophylline	1989
Lack of evidence for reduction of theophylline clearance by ranitidine. The American journal of medicine, 1989, Volume: 86, Issue:5 Topics: Cimetidine; Drug Interactions; Humans; Metabolic Clearance Rate; Ranitidine; Theophylline	1989
The effect of route of administration on the cimetidine-theophylline drug interaction. Journal of clinical pharmacology, 1989, Volume: 29, Issue:5 Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Liver; Male; Theophylline	1989
The influence of intravenous cimetidine dosage regimens on the disposition of theophylline. Journal of clinical pharmacology, 1989, Volume: 29, Issue:7 Topics: Adult; Cimetidine; Drug Combinations; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Theophylline; Time Factors	1989
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1 Topics: Acetylation; Adult; Allopurinol; Caffeine; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Kidney; Male; Metabolic Clearance Rate; Theophylline	1989
Theophylline disposition--effects of cimetidine, mebendazole and albendazole. Alimentary pharmacology & therapeutics, 1988, Volume: 2, Issue:4 Topics: Adolescent; Adult; Albendazole; Cimetidine; Drug Interactions; Humans; Male; Mebendazole; Theophylline	1988
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists. British journal of pharmacology, 1986, Volume: 87, Issue:1 Topics: Acetylcholine; Animals; Asthma; Autoradiography; Carbachol; Cimetidine; Colforsin; Dose-Response Relationship, Drug; Epithelium; Female; Guinea Pigs; Histamine; In Vitro Techniques; Iodocyanopindolol; Isoproterenol; Kinetics; Male; Muscle Contraction; Nitroglycerin; Pindolol; Potassium; Receptors, Adrenergic, beta; Theophylline; Trachea	1986
Comparative inhibition of human alkaline phosphatase and diamine oxidase by bromo-levamisole, cimetidine and various derivatives. Biochemical pharmacology, 1988, Nov-15, Volume: 37, Issue:22 Topics: Alkaline Phosphatase; Amine Oxidase (Copper-Containing); Cimetidine; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Levamisole; Liver; Placenta; Structure-Activity Relationship; Tetramisole; Theophylline	1988
Application of theophylline metabolite assays to the exploration of liver microsome oxidative function in man. Fundamental & clinical pharmacology, 1988, Volume: 2, Issue:4 Topics: Adult; Biotransformation; Cimetidine; Humans; Ketoconazole; Male; Microsomes, Liver; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Theophylline; Troleandomycin	1988
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies. Biochemical pharmacology, 1988, May-01, Volume: 37, Issue:9 Topics: Adult; Benzoflavones; Caffeine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Humans; Immunologic Techniques; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Verapamil	1988
Effect of cimetidine on the pharmacokinetics of theophylline. General pharmacology, 1988, Volume: 19, Issue:3 Topics: Adult; Cimetidine; Drug Interactions; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline	1988
Lack of effect of ofloxacin on theophylline pharmacokinetics in rats. Chemotherapy, 1987, Volume: 33, Issue:6 Topics: Animals; Anti-Infective Agents; Blood Proteins; Cimetidine; Enoxacin; Male; Microsomes, Liver; Naphthyridines; Ofloxacin; Oxazines; Oxidoreductases; Protein Binding; Rats; Theophylline	1987
Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Drug Interactions; Half-Life; Humans; Hydrocortisone; Kidney; Kidney Function Tests; Kinetics; Male; Mathematics; Smoking; Theophylline	1987
Ranitidine at very large doses does not inhibit theophylline elimination. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Female; Humans; Kinetics; Male; Ranitidine; Theophylline	1986
[Changes in plasma levels of theophylline in therapeutic combination with cimetidine and ranitidine]. La Clinica terapeutica, 1986, Feb-28, Volume: 116, Issue:4 Topics: Adult; Asthma; Cimetidine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peptic Ulcer; Ranitidine; Theophylline	1986
Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium. General pharmacology, 1986, Volume: 17, Issue:2 Topics: Animals; Cimetidine; Guinea Pigs; Heart Rate; Histamine; Histamine Antagonists; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Practolol; Theophylline	1986
Combined cold- and heat-induced cholinergic urticaria. The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:2 Topics: Adult; Cholinergic Fibers; Cimetidine; Cold Temperature; Doxepin; Drug Therapy, Combination; Female; Hot Temperature; Humans; Metaproterenol; Physical Exertion; Theophylline; Urticaria	1986
A 15-year-old girl with a perforated gastric ulcer. Annals of allergy, 1986, Volume: 57, Issue:6 Topics: Adolescent; Asthma; Cimetidine; Female; Humans; Peptic Ulcer Perforation; Stomach Ulcer; Theophylline	1986
Animal model for theophylline--cimetidine drug interaction. Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:12 Topics: Animals; Cimetidine; Dogs; Drug Interactions; Kinetics; Male; Models, Biological; Theophylline	1985
Cigarette smoking and theophylline metabolism: effects of cimetidine. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3 Topics: Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Smoking; Theophylline; Thiocyanates	1985
Cimetidine-theophylline interaction: effects of age and cimetidine dose. Therapeutic drug monitoring, 1985, Volume: 7, Issue:4 Topics: Administration, Oral; Adult; Age Factors; Aged; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Kinetics; Middle Aged; Theophylline	1985
Adverse drug reactions in the elderly: case studies. Geriatrics, 1984, Volume: 39, Issue:12 Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol	1984
The effects of histamine, antihistamines, isoproterenol and theophylline on the Fc and complement receptor functions of polymorphonuclear leukocytes in asthmatic children. Annals of allergy, 1981, Volume: 47, Issue:1 Topics: Adolescent; Asthma; Child; Child, Preschool; Cimetidine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Humans; Isoproterenol; Neutrophils; Receptors, Complement; Receptors, Fc; Theophylline	1981
Effects of cimetidine and ranitidine on hepatic drug metabolism. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Liver; Male; Mixed Function Oxygenases; Ranitidine; Theophylline	1982
Cimetidine-theophylline interaction: report of four patients. Annals of allergy, 1982, Volume: 48, Issue:2 Topics: Adrenergic beta-Agonists; Aged; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Lung Diseases, Obstructive; Middle Aged; Peptic Ulcer; Seizures; Theophylline	1982
Inhibition by cimetidine of the secretory and respiratory responses induced by theophylline and cyclic AMP in the amphibian gastric mucosa. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1983, Volume: 74, Issue:1 Topics: Animals; Bufo marinus; Cimetidine; Cyclic AMP; Drug Antagonism; Gastric Juice; Gastric Mucosa; Guanidines; Histamine; Oxygen Consumption; Theophylline	1983
Gastric mucosa permeability and HCO3- secretion 'in vivo' during perfusion of damaging and protective agents across canine Heidenhain pouches. Scandinavian journal of gastroenterology. Supplement, 1984, Volume: 92 Topics: 1-Methyl-3-isobutylxanthine; Acetazolamide; Animals; Bicarbonates; Butyrates; Butyric Acid; Cimetidine; Dogs; Gastric Mucosa; Hydrogen-Ion Concentration; Perfusion; Permeability; Stomach; Theophylline	1984
Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease. Current problems in dermatology, 1983, Volume: 11 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Cimetidine; Cyclic AMP; Darier Disease; Epidermis; Epinephrine; Humans; In Vitro Techniques; Middle Aged; Propranolol; Proteins; Receptors, Adrenergic, beta; Theophylline	1983
Inhibition of theophylline clearance by cimetidine but not ranitidine. Archives of internal medicine, 1984, Volume: 144, Issue:3 Topics: Adult; Cimetidine; Drug Interactions; Humans; Kinetics; Male; Random Allocation; Ranitidine; Theophylline	1984
Pharmacokinetics of theophylline and the H2-antagonist drugs cimetidine and ranitidine. International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:4 Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Middle Aged; Ranitidine; Theophylline; Time Factors	1984
[Interaction between theophylline and cimetidine. Effect of cimetidine on the serum clearance of theophylline]. Medicina clinica, 1984, Sep-15, Volume: 83, Issue:7 Topics: Adult; Aged; Asthma; Cimetidine; Drug Interactions; Female; Humans; Male; Middle Aged; Theophylline	1984
The influence of orally administered cimetidine and theophylline on the elimination of each drug in patients with chronic airways obstruction. The American review of respiratory disease, 1984, Volume: 130, Issue:5 Topics: Age Factors; Aged; Bronchodilator Agents; Choline; Cimetidine; Drug Interactions; Half-Life; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Theophylline; Time Factors	1984
Drug interactions: theory versus practice. The American journal of medicine, 1984, Nov-19, Volume: 77, Issue:5B Topics: Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Therapy, Combination; Humans; Phenytoin; Retrospective Studies; Theophylline; Time Factors	1984
Cimetidine-methylprednisolone-theophylline metabolic interaction. The American journal of medicine, 1984, Volume: 77, Issue:6 Topics: Adult; Asthma; Biological Availability; Biotransformation; Cimetidine; Drug Interactions; Female; Humans; Kinetics; Metabolic Clearance Rate; Methylprednisolone; Theophylline	1984
Use of single doses and rapid sampling to detect interactions with cimetidine. European journal of clinical pharmacology, 1984, Volume: 27, Issue:5 Topics: Adolescent; Adult; Blood Specimen Collection; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Theophylline	1984
The inhibition of drug metabolism by cimetidine in patients with liver cirrhosis. Klinische Wochenschrift, 1984, Dec-03, Volume: 62, Issue:23 Topics: Adult; Aged; Cimetidine; Drug Antagonism; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Theophylline	1984
[Severe confusion following a theophylline-cimetidine combination]. Annales francaises d'anesthesie et de reanimation, 1983, Volume: 2, Issue:2 Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Drug Interactions; Humans; Male; Theophylline	1983
Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse. Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Female; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Theophylline; Zoxazolamine	1984
Cimetidine-theophylline interaction in patients with chronic obstructive airways disease. The Medical journal of Australia, 1984, Mar-03, Volume: 140, Issue:5 Topics: Aged; Cimetidine; Drug Interactions; Female; Humans; Kinetics; Lung Diseases, Obstructive; Middle Aged; Theophylline	1984
Differential effects of cimetidine on theophylline metabolic pathways. European journal of clinical pharmacology, 1984, Volume: 26, Issue:3 Topics: Adult; Cimetidine; Drug Administration Schedule; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Smoking; Theophylline	1984
The effects of cimetidine on theophylline pharmacokinetics at steady state. Chest, 1983, Volume: 83, Issue:2 Topics: Adult; Cimetidine; Guanidines; Humans; Kinetics; Male; Metabolic Clearance Rate; Theophylline	1983
A fatal case of theophylline intoxication. Archives of internal medicine, 1983, Volume: 143, Issue:3 Topics: Aged; Cimetidine; Drug Administration Schedule; Drug Interactions; Humans; Male; Peptic Ulcer; Theophylline	1983
Stability of three oral liquid drug products repackaged in unit dose containers. American journal of hospital pharmacy, 1983, Volume: 40, Issue:4 Topics: Cimetidine; Drug Packaging; Drug Stability; Furosemide; Guanidines; Medication Systems, Hospital; Temperature; Theophylline; Time Factors	1983
Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration. British journal of clinical pharmacology, 1983, Volume: 15, Issue:4 Topics: Administration, Oral; Aged; Carbon Isotopes; Cimetidine; Drug Interactions; Guanidines; Humans; Lung Diseases, Obstructive; Metabolic Clearance Rate; Middle Aged; Nitrogen Isotopes; Theophylline; Time Factors	1983
Cimetidine-theophylline complex formation. Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:1 Topics: Chemical Phenomena; Chemistry; Cimetidine; Drug Interactions; Guanidines; Humans; Theophylline	1983
Cimetidine decreases theophylline clearance. The American review of respiratory disease, 1981, Volume: 123, Issue:6 Topics: Administration, Oral; Adult; Cimetidine; Guanidines; Humans; Immunoenzyme Techniques; Injections, Intravenous; Male; Metabolic Clearance Rate; Theophylline	1981
Cimetidine-theophylline-terbutaline. Annals of internal medicine, 1982, Volume: 96, Issue:4 Topics: Aged; Chorea; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Terbutaline; Theophylline	1982
Cimetidine-theophylline interaction. Annals of internal medicine, 1982, Volume: 96, Issue:5 Topics: Aminophylline; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Middle Aged; Theophylline	1982
Interaction of cimetidine and theophylline in two infants. Canadian Medical Association journal, 1982, May-15, Volume: 126, Issue:10 Topics: Asthma; Child, Preschool; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Infant; Theophylline	1982
[Drug interaction between cimetidine and theophylline]. La Nouvelle presse medicale, 1982, May-29, Volume: 11, Issue:25 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Theophylline	1982
Stable isotope methodology in a pharmacokinetic study of the interaction of theophylline and cimetidine. Biomedical mass spectrometry, 1982, Volume: 9, Issue:8 Topics: Carbon Isotopes; Chromatography, High Pressure Liquid; Chronic Disease; Cimetidine; Drug Interactions; Guanidines; Humans; Kinetics; Lung Diseases, Obstructive; Male; Mass Spectrometry; Middle Aged; Nitrogen Isotopes; Theophylline; Time Factors	1982
Therapeutic rounds at The Milton S. Hershey Medical Center. Clinical therapeutics, 1982, Volume: 5, Issue:2 Topics: Aminophylline; Cimetidine; Drug Interactions; Guanidines; Humans; Liver; Male; Middle Aged; Theophylline	1982
Cimetidine impairs the elimination of theophylline and antipyrine. Gastroenterology, 1981, Volume: 81, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Theophylline	1981
Cimetidine decreases theophylline clearance. Annals of internal medicine, 1981, Volume: 95, Issue:1 Topics: Aged; Aminophylline; Cimetidine; Drug Interactions; Guanidines; Humans; Male; Theophylline	1981
Lack of effect of cimetidine on theophylline clearance. Drug intelligence & clinical pharmacy, 1981, Volume: 15, Issue:5 Topics: Aged; Cimetidine; Guanidines; Humans; Middle Aged; Theophylline	1981
Comment on effect of cimetidine on theophylline clearance. Drug intelligence & clinical pharmacy, 1981, Volume: 15, Issue:10 Topics: Adolescent; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Theophylline	1981
Drug interactions with cimetidine. Postgraduate medicine, 1981, Volume: 70, Issue:5 Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin	1981
Therapeutic rounds at the Milton S. Hershey Medical Center. Clinical therapeutics, 1981, Volume: 4, Issue:3 Topics: Adolescent; Asthma; Cimetidine; Female; Guanidines; Headache; Humans; Nausea; Theophylline	1981
Identification of histamine H1- and H-2-receptors by means of mepyramine, cimetidine and theophylline in the cardiovascular system of the dog. Agents and actions, 1980, Volume: 10, Issue:1 Pt 2 Topics: Animals; Cardiovascular System; Cimetidine; Dogs; Female; Hemodynamics; Histamine; Male; Organ Specificity; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Theophylline	1980
Decreased theophylline clearance due to cimetidine. The New England journal of medicine, 1981, 03-12, Volume: 304, Issue:11 Topics: Adolescent; Cimetidine; Female; Guanidines; Humans; Theophylline	1981
Over-the-counter cimetidine and theophylline interaction. American family physician, 1995, Volume: 52, Issue:8 Topics: Aged; Anti-Ulcer Agents; Bronchodilator Agents; Cimetidine; Drug Interactions; Female; Humans; Nonprescription Drugs; Theophylline	1995
Unbound total (plasma) clearance approach in interspecies pharmacokinetics correlation: theophylline-cimetidine interaction. Pharmaceutical research, 1995, Volume: 12, Issue:8 Topics: Animals; Blood Proteins; Body Weight; Cimetidine; Dogs; Drug Interactions; Humans; Metabolic Clearance Rate; Protein Binding; Rabbits; Rats; Species Specificity; Theophylline	1995
Drug interactions of H2-receptor antagonists. Scandinavian journal of gastroenterology. Supplement, 1994, Volume: 206 Topics: Adolescent; Adult; Aged; Antacids; Biological Availability; Cimetidine; Drug Interactions; Famotidine; Histamine H2 Antagonists; Humans; Middle Aged; Nizatidine; Omeprazole; Phenytoin; Ranitidine; Theophylline	1994
Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions. Pharmaceutical research, 1994, Volume: 11, Issue:7 Topics: Animals; Cimetidine; Dogs; Drug Interactions; Half-Life; Humans; Male; Rabbits; Rats; Species Specificity; Theophylline	1994
Gender differences in hepatic induction and inhibition of theophylline pharmacokinetics and metabolism. The Journal of laboratory and clinical medicine, 1993, Volume: 122, Issue:2 Topics: Adult; Analysis of Variance; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Liver; Male; Middle Aged; Mixed Function Oxygenases; Sex Characteristics; Smoking; Theophylline	1993
Famotidine and theophylline pharmacokinetics. An unexpected cimetidine-like interaction in patients with chronic obstructive pulmonary disease. Clinical pharmacokinetics, 1993, Volume: 24, Issue:3 Topics: Cimetidine; Drug Interactions; Famotidine; Humans; Infusions, Intravenous; Lung Diseases, Obstructive; Male; Middle Aged; Peptic Ulcer; Theophylline	1993
Adenosine is a mediator of ethanol-induced gastric vasodilation in dogs. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 1 Topics: Adenosine; Animals; Cimetidine; Dogs; Ethanol; Histamine; Indomethacin; Male; Muscle, Smooth; Purinergic Antagonists; Pyrilamine; Regional Blood Flow; Stomach; Theophylline; Vascular Resistance; Vasodilation	1993
Drug interactions between theophylline and H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic analysis in rats in vivo. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:11 Topics: Animals; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Histamine H2 Antagonists; Male; Piperidines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Theophylline	1995
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin; Creatinine; Drug Interactions; Female; Humans; Male; Metabolic Clearance Rate; Regression Analysis; Sex Characteristics; Theophylline	1997
In vitro studies of human alcohol dehydrogenase inhibition in the process of methanol and ethylene glycol oxidation. Archives of toxicology, 1998, Volume: 72, Issue:9 Topics: Alcohol Dehydrogenase; Cimetidine; Enzyme Inhibitors; Ethylene Glycol; Fomepizole; Humans; In Vitro Techniques; Liver; Methanol; Methylene Blue; Pyrazoles; Theophylline	1998
Clarifying the costs of theophylline toxicity. PharmacoEconomics, 1994, Volume: 6, Issue:5 Topics: Cimetidine; Clinical Competence; Cost-Benefit Analysis; Drug Interactions; Drug Prescriptions; Humans; Patient Education as Topic; Physicians; Theophylline	1994
Cimetidine impairs the elimination of theophylline and antipyrine. Gastroenterology, 1982, Volume: 82, Issue:3 Topics: Antipyrine; Biotransformation; Bronchodilator Agents; Cimetidine; Drug Interactions; Enzyme Inhibitors; Humans; Theophylline	1982
The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity. Pharmacology & toxicology, 1999, Volume: 85, Issue:3 Topics: Animals; Anti-Ulcer Agents; Brain; Cimetidine; Drug Interactions; Ethanol; Female; Hypnosis; Posture; Rats; Rats, Inbred Strains; Reflex, Abnormal; Seizures; Theophylline	1999
Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:8 Topics: Cimetidine; Clorgyline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Omeprazole; Oxazoles; Oxazolidinones; Recombinant Proteins; Serotonin Receptor Agonists; Theophylline; Tryptamines	1999
Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics. Journal of clinical pharmacology, 2000, Volume: 40, Issue:2 Topics: Adolescent; Adult; Carbamates; Cimetidine; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Mixed Function Oxygenases; Piperidines; Theophylline	2000
Drug interactions avoided-a useful indicator of good prescribing practice. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticoagulants; Anticonvulsants; Cimetidine; Drug Interactions; Drug Prescriptions; Histamine H2 Antagonists; Humans; Ireland; Odds Ratio; Phenytoin; Theophylline; Vasodilator Agents; Warfarin	2000
The use of on-line and off-line chromatographic extraction techniques coupled with mass spectrometry for support of in vivo and in vitro assays in drug discovery. Current topics in medicinal chemistry, 2001, Volume: 1, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antihypertensive Agents; Aspirin; Caco-2 Cells; Chromatography, Liquid; Cimetidine; Drug Evaluation, Preclinical; Gas Chromatography-Mass Spectrometry; Histamine H1 Antagonists; Humans; Hydrochlorothiazide; Pharmaceutical Preparations; Phosphodiesterase Inhibitors; Promethazine; Theophylline	2001
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
Oral sustained delivery of theophylline and cimetidine from in situ gelling pectin formulations in rabbits. Drug development and industrial pharmacy, 2005, Volume: 31, Issue:8 Topics: Administration, Oral; Animals; Cimetidine; Delayed-Action Preparations; Gastric Juice; Gels; Male; Pectins; Rabbits; Theophylline	2005
Formulation and characterization of a compacted multiparticulate system for modified release of water-soluble drugs--Part II theophylline and cimetidine. Drug development and industrial pharmacy, 2009, Volume: 35, Issue:5 Topics: Algorithms; Bronchodilator Agents; Cellulose; Chemistry, Pharmaceutical; Cimetidine; Drug Compounding; Excipients; Histamine H2 Antagonists; Humidity; Kinetics; Lipids; Particle Size; Particulate Matter; Polymethacrylic Acids; Solubility; Tablets; Theophylline; Water	2009
Evaluation of the mechanical properties of extrusion-spheronized beads and multiparticulate systems. Drug development and industrial pharmacy, 2009, Volume: 35, Issue:6 Topics: Cellulose; Cimetidine; Excipients; Glycerides; Methacrylates; Polymers; Tablets; Technology, Pharmaceutical; Theophylline; Time Factors	2009
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:6 Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Intestinal Secretions; Male; Mecamylamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neural Inhibition; Neurogenic Bowel; Neurokinin-1 Receptor Antagonists; Nicotinic Antagonists; Piperidines; Propane; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Histamine H2; Receptors, Neurokinin-1; Reflex; Theophylline; Xanthines	2009
NIR spectroscopy applications in the development of a compacted multiparticulate system for modified release. AAPS PharmSciTech, 2011, Volume: 12, Issue:1 Topics: Anti-Ulcer Agents; Bronchodilator Agents; Cellulose; Cimetidine; Delayed-Action Preparations; Dosage Forms; Drug Delivery Systems; Excipients; Humans; Lipids; Methacrylates; Models, Statistical; Placebos; Polymers; Spectroscopy, Near-Infrared; Tablets; Theophylline	2011
The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. International journal of molecular sciences, 2017, Dec-21, Volume: 19, Issue:1 Topics: Animals; Atropine; Cimetidine; Drugs, Chinese Herbal; Ephedra sinica; Humans; Male; Medicine, Chinese Traditional; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Inbred WKY; Receptors, Cholinergic; Risperidone; Theophylline	2017