cimetidine has been researched along with tetraethylammonium in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.88) | 18.7374 |
| 1990's | 24 (35.29) | 18.2507 |
| 2000's | 31 (45.59) | 29.6817 |
| 2010's | 8 (11.76) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L | 1 |
| Babbitt, PC; Chun, JK; Dresser, MJ; Giacomini, KM; Zhang, L | 1 |
| Inui, KI; Ito, T; Tanaka, K; Yano, I | 1 |
| Fei, YJ; Ganapathy, V; Kekuda, R; Leibach, FH; Prasad, PD; Wang, H; Wu, X | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Inui, KI; Masuda, S; Okuda, M; Saito, H; Urakami, Y | 1 |
| Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Chen, R; Nelson, JA; Pan, BF; Pritchard, JB; Sweet, DH | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Gründemann, D; Kiefer, N; Köster, S; Liebich, G; Schömig, E | 1 |
| Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Buitelaar, M; Jonker, JW; Koepsell, H; Mol, CA; Schinkel, AH; Smit, JW; Wagenaar, E | 1 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Kakehi, M; Koyabu, N; Kuwano, M; Nakamura, T; Ohtani, H; Sawada, Y; Uchiumi, T | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Dutt, A; Kuo, MT; Nelson, JA; Priebe, TS; Teeter, LD | 1 |
| Hirai, M; Hori, R; Kaneko, S; Katsura, T; Satoh, M; Takano, M; Yasuhara, M | 1 |
| Brink, C; Gorenne, I; Labat, C; Norel, X; Ortiz, JL; Verley, J | 1 |
| Haseley, TS; Hosford, M; Lesniak, ME; McKinney, TD; Scheller, MB | 1 |
| Brändle, E; Greven, J | 1 |
| DeLeon, C; McKinney, TD; Speeg, KV | 1 |
| Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y; Suzuki, H | 1 |
| Herbert, BH; Nelson, JA; Santos, G | 1 |
| Cacini, W; Grund, VR; Keller, MB | 1 |
| Bendayan, R; Lo, B; Silverman, M | 1 |
| Gross, AS; Simmons, N; Somogyi, AA | 1 |
| Hori, R; Inui, K; Katsura, T; Takano, M; Tomita, Y; Yasuhara, M | 1 |
| Inui, K; Okuda, M; Saito, H; Takano, M; Urakami, Y | 1 |
| Bendayan, R | 1 |
| Hashimoto, Y; Inui, K; Ito, T; Masuda, S; Yano, I | 1 |
| Hashimoto, Y; Inui, K; Ito, T; Yano, I | 1 |
| Aavula, BR; Bednarczyk, D; Mash, EA; Wright, SH | 1 |
| Hagen, SJ; Morrison, SW; Wu, H | 1 |
| Duggin, GG; Lazzaro, V; Machaalani, R | 1 |
| Fukada, A; Inui, KI; Ohnishi, S; Saito, H | 1 |
| Doi, Y; Hasegawa, T; Kitaichi, K; Matsushima, M; Morishita, Y; Takagi, K; Ueyama, J; Zhao, YL | 1 |
| Chatsudthipong, V; Dantzler, WH; Evans, KK; Kaewmokul, S; Wright, SH | 1 |
| O'Donnell, MJ; Rheault, MR | 1 |
| Dohgu, S; Higuchi, S; Katamine, S; Kataoka, Y; Naito, M; Niwa, M; Sawada, Y; Shirabe, S; Takata, F; Tsuruo, T; Yamauchi, A | 1 |
| Endou, H; Hirono, S; Kusuhara, H; Nagata, Y; Sugiyama, Y | 1 |
| Inui, K; Katsura, T; Kimura, N; Masuda, S; Okuda, M; Urakami, Y | 1 |
| Bijelic, G; Kim, NR; O'Donnell, MJ | 1 |
| O'Donnell, MJ; Plaumann, JS; Rheault, MR | 1 |
| Hayashi, Y; Inoue, K; Ohta, KY; Yuasa, H | 1 |
| Cherrington, NJ; Wright, SH; Zhang, X | 1 |
| Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI | 2 |
| Abe, F; Hasegawa, T; Kato, M; Kimura, M; Kurono, S; Nadai, M; Saito, H; Yoshizumi, H | 1 |
| Inui, K; Katsura, T; Masuda, S; Sato, T; Tanihara, Y; Yonezawa, A | 1 |
| Rodriguez-Proteau, R; Taur, JS | 1 |
| Hashimoto, Y; Kagawa, Y; Taguchi, M; Tahara, K; Takaai, M | 1 |
| Hayashi, M; Kishimoto, H; Takizawa, Y; Tomita, M | 1 |
| Inoue, K; Ishimaru, M; Ohta, KY; Yasujima, T; Yuasa, H | 1 |
| Inoue, K; Ito, S; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Yokochi, M; Yuasa, H | 1 |
| Harper, JN; Wright, SH | 1 |
| Al-Monajjed, R; Ciarimboli, G; Gorboulev, V; Keller, T; Koepsell, H; Lee, WK; Leistner, M; Schatz, I; Thévenod, F; Wolff, NA | 1 |
| Chen, J; Chen, X; Li, J; Li, X; Lu, Y; Sun, X; Wang, C; Zhang, Q; Zhang, Y; Zhao, D | 1 |
| Kaddoumi, A; Mohamed, LA | 1 |
| Goda, M; Ikehara, M; Ishizawa, K; Oda, K; Otsuka, M; Sakitani, M | 1 |
1 review(s) available for cimetidine and tetraethylammonium
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
67 other study(ies) available for cimetidine and tetraethylammonium
| Article | Year |
|---|---|
Cloning and functional expression of a human liver organic cation transporter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis | 1997 |
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; Kidney; Membrane Proteins; Molecular Sequence Data; Organic Cation Transporter 1; Protein Biosynthesis; Rats; RNA, Messenger; Tetraethylammonium Compounds; Xenopus laevis | 1997 |
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1.
Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Epithelial Cells; Epithelium; Fluoroquinolones; Humans; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Quinolones; Swine | 1997 |
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; DNA-Binding Proteins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Octamer Transcription Factor-3; Oocytes; Placenta; Protein Conformation; Rats; Transcription Factors; Xenopus laevis | 1998 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
Topics: Animals; Base Sequence; Carrier Proteins; Cations; Cell Line; Cell Membrane; DNA Primers; Dogs; Kidney Tubules; Membrane Proteins; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Tetraethylammonium | 1998 |
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Buffers; Carrier Proteins; Cells, Cultured; Hydrogen-Ion Concentration; Levofloxacin; Membrane Proteins; Ofloxacin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Potassium; Rats; Tetraethylammonium; Transfection; Xenopus laevis | 1999 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
A transfected cell model for the renal toxin transporter, rOCT2.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Carrier Proteins; Cisplatin; Daunorubicin; Deoxyadenosines; DNA, Complementary; Kidney; Kinetics; Mice; Models, Genetic; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tetraethylammonium Compounds; Transfection; Vinblastine | 1999 |
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Selective substrates for non-neuronal monoamine transporters.
Topics: Amino Acid Sequence; Animals; Biological Transport; Carrier Proteins; Cells, Cultured; DNA, Complementary; Guanidine; Histamine; Humans; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Neuropeptides; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Sequence Homology, Amino Acid; Vesicular Biogenic Amine Transport Proteins | 1999 |
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis | 2000 |
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil | 2000 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.
Topics: Animals; Carrier Proteins; Cations; Intestinal Mucosa; Ion Transport; Liver; Membrane Proteins; Mice; Mice, Knockout; Organic Cation Transporter 1 | 2001 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Base Sequence; Biological Transport; Cations; Cells, Cultured; Cloning, Molecular; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Mice; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Tetraethylammonium; Xenopus | 2002 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Postnatal development of organic cation transport and mdr gene expression in mouse kidney.
Topics: Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cimetidine; Culture Techniques; Gene Expression; Kidney; Liver; Membrane Glycoproteins; Mice; Niacinamide; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Expression of renal organic cation transporter in Xenopus laevis oocytes.
Topics: Animals; Carrier Proteins; Cimetidine; Gene Expression; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Male; Mercuric Chloride; Oocytes; p-Aminohippuric Acid; Poly A; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Tetraethylammonium; Tetraethylammonium Compounds; Xenopus laevis | 1992 |
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Pulmonary Artery; Receptors, Histamine; Serotonin; Tetraethylammonium; Tetraethylammonium Compounds; Thiourea | 1992 |
Basolateral transport of tetraethylammonium by a clone of LLC-PK1 cells.
Topics: Animals; Basement Membrane; Biological Transport, Active; Cimetidine; Clone Cells; Kidney; Kinetics; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1992 |
Transport of cimetidine across the basolateral membrane of rabbit kidney proximal tubules: characterization of transport mechanisms.
Topics: Animals; Basement Membrane; Biological Transport; Chlorides; Cimetidine; Female; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Proximal; Male; Membrane Potentials; Niacinamide; Osmolar Concentration; Potassium; Quinine; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Organic cation uptake by a cultured renal epithelium.
Topics: Animals; Azides; Biological Transport; Cell Line; Cimetidine; Epithelial Cells; Epithelium; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Kinetics; Quinidine; Sodium Azide; Temperature; Tetraethylammonium; Tetraethylammonium Compounds | 1988 |
Comparative uptake of cimetidine by rat choroid plexus between the lateral and the 4th ventricles.
Topics: Animals; Cerebral Ventricles; Choroid Plexus; Cimetidine; In Vitro Techniques; Kinetics; Male; Penicillin G; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds | 1986 |
Mechanisms for the renal secretion of cisplatin.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Cimetidine; Cisplatin; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred AKR; p-Aminohippuric Acid; Platinum; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds | 1984 |
Accumulation of cimetidine by kidney cortex slices.
Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1982 |
Characterization of cimetidine transport in LLCPK1 cells.
Topics: Amiloride; Animals; Anti-Bacterial Agents; Azides; Biological Transport; Carrier Proteins; Cell Line; Cimetidine; Guanidine; Guanidines; Kidney; Macrolides; Microscopy, Fluorescence; Models, Biological; Niacinamide; Proton-Translocating ATPases; Quinidine; Quinine; Sodium Azide; Sodium-Hydrogen Exchangers; Swine; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
In-vitro potencies of histamine H2-receptor antagonists on tetraethylammonium uptake in rat renal brush-border membrane vesicles.
Topics: Alkaline Phosphatase; Animals; Cimetidine; Famotidine; In Vitro Techniques; Kidney; Male; Microvilli; Ranitidine; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Characteristics of organic cation transporter in rat renal basolateral membrane.
Topics: Amiloride; Animals; Carrier Proteins; Cations; Cell Membrane; Cimetidine; Ion Transport; Kidney Cortex; Male; Mercuric Chloride; Microvilli; Phenylglyoxal; Procainamide; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds | 1993 |
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Blotting, Northern; Carrier Proteins; Cimetidine; Cloning, Molecular; DNA Primers; DNA, Complementary; Female; In Vitro Techniques; Kidney; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymerase Chain Reaction; Procainamide; Quinidine; Rats; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Tetraethylammonium; Tetraethylammonium Compounds; Xenopus laevis | 1996 |
Interaction of dipyridamole, a nucleoside transport inhibitor, with the renal transport of organic cations by LLCPK1 cells.
Topics: Animals; Biological Transport; Cell Line; Cimetidine; Dipyridamole; Epithelium; Ions; Kidney; Kinetics; Niacinamide; Swine; Tetraethylammonium; Tetraethylammonium Compounds | 1997 |
Distribution characteristics of levofloxacin and grepafloxacin in rat kidney.
Topics: Animals; Anti-Infective Agents; Carbon Radioisotopes; Cimetidine; Dose-Response Relationship, Drug; Fluoroquinolones; In Vitro Techniques; Kidney Cortex; Kinetics; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Tissue Distribution | 1999 |
Transepithelial transport of levofloxacin in the isolated perfused rat kidney.
Topics: Animals; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biological Transport; Carbon Radioisotopes; Cimetidine; Coloring Agents; Enzyme Inhibitors; Epithelial Cells; Evans Blue; Fluoroquinolones; In Vitro Techniques; Inulin; Kidney; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Perfusion; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Urine | 2000 |
NBD-TMA: a novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Survival; Cimetidine; Diffusion Chambers, Culture; Fluorescence; Fluorescent Dyes; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Models, Biological; Niacinamide; Quaternary Ammonium Compounds; Rabbits; Reproducibility of Results; Tetraethylammonium | 2000 |
NH(4)Cl inhibition of acid secretion: possible involvement of an apical K(+) channel in bullfrog oxyntic cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Ammonia; Ammonium Chloride; Animals; Barium; Biological Transport; Bumetanide; Carbachol; Carbon Radioisotopes; Cholinergic Agents; Cimetidine; Clotrimazole; Diuretics; Enzyme Inhibitors; Gastric Mucosa; Growth Inhibitors; Histamine; Hydrochloric Acid; Hypoglycemic Agents; Imidazoles; Methylamines; Microscopy, Electron; Omeprazole; Ouabain; Parietal Cells, Gastric; Potassium Channel Blockers; Potassium Channels; Protons; Rana catesbeiana; Tetraethylammonium; Tolbutamide | 2000 |
The characterisation and uptake of paraquat in cultured baboon kidney proximal tubule cells (bPTC).
Topics: Adjuvants, Immunologic; Animals; Biological Transport; Cations; Cell Line; Cells, Cultured; Cimetidine; Dogs; Herbicides; Kidney Tubules, Distal; Kidney Tubules, Proximal; Papio; Paraquat; Swine; Tetraethylammonium | 2001 |
Independent organic cation transport activity of Na(+)-L-carnitine cotransport system in LLC-PK(1) cells.
Topics: Animals; Carnitine; Carrier Proteins; Cations; Cell Line; Cell Polarity; Cephaloridine; Cephalosporins; Cimetidine; Enzyme Inhibitors; Epithelial Cells; Hydrogen-Ion Concentration; Ion Transport; Kidney Tubules, Proximal; Kinetics; Quinidine; Sodium; Swine; Tetraethylammonium | 2001 |
Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats.
Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Carnitine; Carrier Proteins; Central Nervous System Stimulants; Cimetidine; Dialysis Solutions; Gene Expression Regulation; Kidney; Male; Membrane Proteins; Metabolic Clearance Rate; Methamphetamine; Motor Activity; Myocardium; Organic Cation Transport Proteins; p-Aminohippuric Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium; Time Factors; Tissue Distribution | 2003 |
Functional mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule.
Topics: Animals; CHO Cells; Cimetidine; COS Cells; Cricetinae; Enzyme Inhibitors; Gene Expression; Kidney Tubules, Proximal; Organic Cation Transport Proteins; Organic Cation Transporter 1; Potassium Channel Blockers; Rabbits; RNA, Messenger; Tetraethylammonium; Tritium | 2003 |
Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods.
Topics: Animals; Biological Transport, Active; Cimetidine; Drosophila melanogaster; Electrophysiology; Ion Transport; Malpighian Tubules; Microelectrodes; Potassium; Quinidine; Tetraethylammonium; Tetraphenylborate; Verapamil; Vinblastine | 2004 |
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cation Transport Proteins; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Cyclosporine; Endothelial Cells; Fluorescein; Membrane Potentials; Mice; Prion Diseases; Quinacrine; Tetraethylammonium; Verapamil | 2004 |
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cerebrospinal Fluid; Choroid Plexus; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Male; Models, Molecular; Molecular Structure; Organic Cation Transport Proteins; Penicillin G; Probenecid; Ranitidine; Rats; Rats, Sprague-Dawley; Static Electricity; Tetraethylammonium; Tritium | 2004 |
Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.
Topics: Animals; Anions; Biological Transport; Cations; Cimetidine; Creatinine; Kidney Tubules; LLC-PK1 Cells; Membrane Potentials; Swine; Tetraethylammonium; Trimethoprim | 2005 |
Effects of dietary or injected organic cations on larval Drosophila melanogaster: mortality and elimination of tetraethylammonium from the hemolymph.
Topics: Animals; Biological Transport, Active; Cations; Cimetidine; Diet; Dose-Response Relationship, Drug; Drosophila melanogaster; Hemolymph; Larva; Lethal Dose 50; Malpighian Tubules; Quinidine; Survival Rate; Temperature; Tetraethylammonium | 2005 |
Tetraethylammonium and nicotine transport by the Malpighian tubules of insects.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, Thin Layer; Cimetidine; Female; In Vitro Techniques; Insecta; Male; Malpighian Tubules; Niacinamide; Nicotine; Quinidine; Rhodnius; Tetraethylammonium; Time Factors | 2006 |
Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.
Topics: Animals; Antiporters; Biological Transport; Blotting, Northern; Cations; Cell Line; Cimetidine; Cloning, Molecular; Humans; Hydrogen-Ion Concentration; Kidney; Organic Cation Transport Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Substrate Specificity; Tetraethylammonium; Transfection | 2006 |
Molecular identification and functional characterization of rabbit MATE1 and MATE2-K.
Topics: 1-Methyl-4-phenylpyridinium; Algorithms; Amino Acid Sequence; Animals; Biological Transport, Active; CHO Cells; Cimetidine; Cloning, Molecular; Cricetinae; Cricetulus; Dopamine Agents; Histamine H2 Antagonists; Hydrogen-Ion Concentration; Microvilli; Molecular Sequence Data; Organic Cation Transport Proteins; Protein Structure, Secondary; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Tetraethylammonium; Transfection | 2007 |
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium | 2007 |
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cimetidine; Cryopreservation; DNA, Complementary; Hepatocytes; Humans; Metformin; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Pyridinium Compounds; Rats; Tetraethylammonium; Transfection; Tritium | 2007 |
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Topics: Animals; Cimetidine; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Organic Anion Transporters; Organic Cation Transport Proteins; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Substrate Specificity; Tetraethylammonium; Time Factors; Xanthines | 2007 |
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Dogs; Humans; Metformin; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Procainamide; Quinidine; Tetraethylammonium; Transfection | 2008 |
Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cimetidine; Flavanones; Flavonoids; Genistein; Humans; LLC-PK1 Cells; Organic Cation Transport Proteins; Propiophenones; Quercetin; Swine; Tetraethylammonium | 2008 |
Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 Cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bisoprolol; Cells, Cultured; Cimetidine; LLC-PK1 Cells; Organic Cation Transport Proteins; Quinidine; Swine; Tetraethylammonium | 2008 |
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosporine; Kidney; Liver; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Tetraethylammonium; Verapamil | 2009 |
Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds.
Topics: Animals; Antiporters; Cell Line, Tumor; Cimetidine; DNA, Complementary; Enzyme Inhibitors; Humans; Kidney; Kinetics; Organic Cation Transport Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Tetraethylammonium; Transfection | 2009 |
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
Topics: 1-Methyl-4-phenylpyridinium; 3-Iodobenzylguanidine; Animals; Binding, Competitive; Biological Transport; Cephalexin; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Kidney; Kinetics; Liver; Male; Metformin; Mice; Mice, Inbred Strains; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pyridines; Tetraethylammonium; Transfection | 2012 |
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.
Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium | 2013 |
Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.
Topics: Animals; Apoptosis; Cadmium; Catecholamine Plasma Membrane Transport Proteins; Cell Line; Cimetidine; Corticosterone; Humans; Kidney Tubules, Proximal; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Tetraethylammonium | 2013 |
Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cimetidine; Guanfacine; HEK293 Cells; Humans; Kidney; Male; Organic Cation Transport Proteins; Organic Cation Transporter 2; Random Allocation; Rats, Sprague-Dawley; Tetraethylammonium | 2015 |
Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.
Topics: Animals; Cells, Cultured; Cimetidine; Dose-Response Relationship, Drug; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; Tacrine; Tetraethylammonium; Tissue Distribution; Verapamil | 2014 |
Involvement of Human Multidrug and Toxic Compound Extrusion (MATE) Transporters in Testosterone Transport.
Topics: Animals; Cimetidine; Estradiol; HEK293 Cells; Humans; LLC-PK1 Cells; Models, Molecular; Organic Cation Transport Proteins; Swine; Testosterone; Tetraethylammonium | 2021 |