cimetidine has been researched along with propranolol in 183 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 109 (59.56) | 18.7374 |
| 1990's | 17 (9.29) | 18.2507 |
| 2000's | 30 (16.39) | 29.6817 |
| 2010's | 27 (14.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herbette, LG; Mason, RP; Rhodes, DG | 1 |
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bleasby, K; Brown, CD; Dudley, AJ | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Kather, H; Simon, B | 1 |
| Andersson, RG; Colldahl, H; Lindgren, BR | 1 |
| Baldi, G; Bongrani, S; Cucchini, F; di Donato, M; Visioli, O | 1 |
| Reus, VI | 1 |
| Chand, N; DeRoth, L; Eyre, P | 1 |
| Kennelly, BM; Müller, FO; Opie, LH; Warburton, S | 1 |
| Laher, IE; McNeill, JH | 1 |
| Duane, SF; Niewoehner, DE; Stewart, RM; Weir, EK | 1 |
| Black, JW | 1 |
| Chand, N; Eyre, P | 1 |
| Abacioĝlu, N; Cakici, I; Kanzik, I; Zengil, H | 1 |
| Ebihara, A; Fujimura, A; Ohashi, K; Tateishi, T | 1 |
| Imamura, T; Kawasaki, H; Taguchi, T; Takasaki, K | 1 |
| Fox, MJ; Frank, WO; Nambi, P; Palmer, RH; Wetherington, JD | 1 |
| Fisher, H; Flancbaum, LJ; Hsu, HC; Kasziba, E; Merrill, GF | 1 |
| Shane, E | 1 |
| Fujihara, A; Kamato, T; Miyata, K; Takeda, M | 1 |
| Brito, GN; Brito, LS | 1 |
| Bennardini, F; Campana, S; Failli, P; Franconi, F; Giotti, A; Matucci, R; Stendardi, I | 1 |
| Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL | 1 |
| Feniuk, W; Humphrey, PP; Trevethick, MA | 1 |
| Burtin, C; Eschalier, A; Lavarenne, J; Tounissou, P | 1 |
| Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Hyman, AL; Kadowitz, PJ; Lippton, H; Neely, CF; Neiman, M | 1 |
| Bassett, AL; Cameron, JS; Katz, D; Swigart, CR | 1 |
| O'Donnell, ME | 1 |
| Alhaider, AA; Mustafa, AA | 1 |
| Akamine, M; Kitazawa, T; Kondo, H; Ohta, T; Shimizu, T; Temma, K | 1 |
| Asahina, M; Kawamata, Y; Kojo, M; Nishigaki, R; Shibasaki, S; Umemura, K | 1 |
| Nishimura, H; Yamaguchi, K | 1 |
| Cutaia, M; Friedrich, P; Porcelli, RJ | 1 |
| Glick, SD; Hough, LB; Su, K | 1 |
| Anderson, JD; Ching, MS; Jones, DB; Morgan, DJ; Smallwood, RA | 1 |
| Brambilla, A; Giachetti, A; Pagani, F; Schiavone, A | 1 |
| Greenberger, PA; Patterson, R; Tapio, CM | 1 |
| Foreman, JC; Norris, DB; Rising, TJ; Webber, SE | 1 |
| Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Shader, RI | 1 |
| Christoforov, B; d'Athis, P; de Lauture, D; Jammet, P; Olive, G; Rey, E; Weber, S | 1 |
| Earley, KJ; Gunasegaram, S; Tenner, TE | 1 |
| Baba, M; Iishi, H; Mikuni, T; Taniguchi, H; Tatsuta, M | 1 |
| Chiba, S; Furuta, S; Horiuchi, A; Iwatsuki, K; Oguchi, H | 1 |
| Betti, R; Casanueva, FF; Cella, SG; Müller, EE | 1 |
| Bristow, MR; Goodman, M; Khan, MM; Marr-Leisy, D; Melmon, KL; Strober, S; Verlander, MS | 1 |
| Accomando, RC; Cervoni, P; Chan, PS; Ronsberg, MA; Scully, PA | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Yamagishi, F | 1 |
| Biollaz, J; Koshakji, RP; Reilly, CS; Wood, AJ | 1 |
| Foldes, J; Halperin, Y; Kidroni, G; Menczel, J | 1 |
| Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Scavone, JM; Shader, RI | 1 |
| Asgharnejad, M; Danis, M; Donn, KH; Powell, JR | 1 |
| Hayakari, M; Izumi, H | 1 |
| Edvinsson, L; McCulloch, J | 1 |
| Aoki, T; Ho, S; Izumi, H; Michelakis, AM | 1 |
| Bołdys, H; Hartleb, M; Lelek, A; Markiewicz, A; Nowak, A | 1 |
| Cirino, M; Letts, LG | 1 |
| Citak, MS; Crass, MF; Moore, PL; Pang, PK; Strickland, ML | 1 |
| Banning, JW; Dipietro, RA; Griffith, RK | 1 |
| Clark, BG; Vestal, RE | 1 |
| Gristwood, RW; Lincoln, JC; Owen, DA | 1 |
| Takagi, T; Takeda, M | 1 |
| Castleden, M; Donovan, MA; Heagerty, AM; Patel, L; Pohl, JE | 1 |
| Castleden, CM; Heagerty, AM; Patel, L | 1 |
| Esplugues, J; Morales-Olivas, FJ; Morcillo, E; Rubio, E | 1 |
| Wood, JR | 1 |
| Goadsby, PJ; Lambert, GA; Lance, JW | 1 |
| Aprea, G; Casucci, R; Masciariello, S; Santini, M; Sodo, M | 1 |
| Malè, PJ | 1 |
| Abernethy, DR; Greenblatt, DJ; Ochs, HR; Shader, RI | 1 |
| Kirch, W; Mutschler, E; Spahn, H | 2 |
| Beeley, L | 1 |
| Duchin, KL; McKinstry, DN; Stern, MA; Willard, DA | 2 |
| Arnold, R | 1 |
| Bugajski, J; Gadek, A | 1 |
| Bugajski, J; Zacny, E; Zdebska, A | 1 |
| Chand, N; DeRoth, L | 1 |
| Abbound, HE; Dousa, TP; Edis, AJ; Heath, H; Zimmerman, D | 1 |
| Frölich, JC; Klotz, U; Reimann, IW | 1 |
| Iizuka, H; Ishibashi, Y; Ohkawara, A | 1 |
| Baskin, EP; Winquist, RJ | 1 |
| Heiss, A; Honerjäger, P; Reiter, M; Schäfer-Korting, M; Schönsteiner, G | 1 |
| Ando, H; Kobayashi-Ando, S; Takeya, K; Yajima, M | 1 |
| Brennan, MF | 1 |
| Feely, J | 1 |
| Pearson, MW | 1 |
| Conaty, JM; Townshend-Piala, P; Williams, JC | 1 |
| Leung, E; Mitchelson, F | 1 |
| Pang, PK; Tenner, TE; Yang, MC | 1 |
| Brink, C; Douglas, JS; Duncan, PG | 1 |
| Antonini, G; Bennardini, F; Failli, P; Franconi, F; Giotti, A; Matucci, R; Stendardi, I | 1 |
| Arnold, R; Creutzfeldt, W; Koop, H | 1 |
| Baelum, J; Døssing, M; Hansen, SH; Lundqvist, GR | 1 |
| Kirch, W; Köhler, H; Mutschler, E; Spahn, H | 1 |
| Laska, FJ; McCulloch, MW; Rand, MJ; Sarantos-Laska, C; Story, DF | 1 |
| Boudoulas, H; MacKichan, JJ; Schaal, SF; Stine, RA | 1 |
| Fiegler, M; Gerber, E; Jávor, T; Mózsik, G; Nagy, L; Past, T; Ruzsa, C; Vezekényi, Z | 1 |
| Castleden, CM; Donovan, MA; Heagerty, AM; Hedges, A; Patel, L; Pohl, JF | 1 |
| Kitis, G | 1 |
| Bauman, JH | 1 |
| Horwitz, LD; Myers, JH | 1 |
| Cunningham, GM | 1 |
| Bilezikian, JP | 1 |
| Eisenburg, J | 1 |
| Heath, H | 1 |
| Rand, MJ; Story, DF; Wong-Dusting, HK | 1 |
| Singh, KP; Tayal, G; Tripathi, KD | 1 |
| Kirch, W; Köhler, H; Mutschler, E; Ohnhaus, EE; Spahn, H | 1 |
| Bowman, FO; Levi, R; Malm, JR; Rosen, MR | 1 |
| Becker, M; Gladziwa, U; Malchow, H; Painz, B; Ruoff, HJ; Sewing, KF | 1 |
| Babb, RR | 1 |
| Robertson, D; Robertson, RM; Wade, D | 1 |
| Andrejak, M; Coevoet, B; de Fremont, JF; Decourcelle, PH; Fournier, A; Gheerbrand, JD; Kassouf, J; Makdassi, R; Moriniere, P; Roussel, A | 1 |
| Frölich, J; Klotz, U; Reimann, IW; Siems, B | 1 |
| Ecknauer, R; Johnson, LR; Rosenfeld, GC; Thompson, WJ | 1 |
| Schaefer, K | 1 |
| Betti, R; Casanueva, F; Chieli, T; Cocchi, D; Mantegazza, P; Müller, EE | 1 |
| Feely, J; Wilkinson, GR; Wood, AJ | 1 |
| Melmon, KL; Nierenberg, DW | 1 |
| Miyazaki, M; Toda, N | 1 |
| Bos, E; Du, XY; Saxena, PR; Schoemaker, RG | 1 |
| Bevan, JA; Henrion, D; Klaasen, A; Laher, I | 1 |
| Anesini, C; Boccio, J; Borda, E; Cremaschi, G; Genaro, A; Sterin-Borda, L; Zubillaga, M | 1 |
| Bochnowicz, S; Matthews, JK; Osborn, RR; Torphy, TJ; Underwood, DC | 1 |
| Branum, JC; Kline, RS; Whisnant, CS | 1 |
| Ivanova, VV; Mineev, VN; Nesterovich, II | 1 |
| Palmer, ME; Tetler, LW; Wilson, ID | 1 |
| Kou, JH; Saha, P | 1 |
| Crespi, CL; Fox, L; Hu, M; Steimel, DT; Stocker, P | 1 |
| Chen, IM; Cheng, CY; Lin, CH; Lin, MS; Lin, PR; Lin, YH; Tsai, MC | 1 |
| Assadi, E; Oryan, S; Sahebgharani, M; Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Yao, TW; Yu, LS; Zeng, S | 1 |
| Lee, YJ; Tsai, LH; Wu, JY | 1 |
| Cheung, JH; Lam, FY; Ng, SC; Yeung, JH | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Yu, L; Zeng, S | 1 |
| Bernkop-Schnürch, A; Hombach, J; Palmberger, TF | 1 |
| Amidon, GL; Dahan, A; West, BT | 1 |
| Amidon, GL; Tsume, Y | 1 |
| Albrecht, K; Bernkop-Schnürch, A; Grabovac, V; Hombach, J; Klima, G; Leithner, K | 1 |
| Walker, MJ | 1 |
| Kühne, S; Steinert, M; Untucht, C; Wätzig, H | 1 |
| Jasper, JT; Sedlak, DL | 1 |
| Chen, DP; Diao, YP; Lin, Y; Yao, QY; Ye, DM | 1 |
| Cho, K; Choi, KJ; Hong, SW; Jeong, B; Lee, C; Lee, J; Lee, Y; Maeng, SK | 1 |
11 review(s) available for cimetidine and propranolol
| Article | Year |
|---|---|
Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes.
Topics: Cell Membrane; Chemical Phenomena; Chemistry, Physical; Kinetics; Lipid Bilayers; Membrane Lipids; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Structure-Activity Relationship | 1991 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Medical management of asymptomatic primary hyperparathyroidism.
Topics: Administration, Oral; Calcium; Calcium, Dietary; Cimetidine; Diphosphonates; Diuretics; Humans; Hyperparathyroidism; Hypertension; Parathyroid Hormone; Phosphates; Propranolol | 1991 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
Vascular actions of leukotrienes.
Topics: Aminophylline; Animals; Atropine; Blood Platelets; Blood Vessels; Capillary Permeability; Cimetidine; Guanethidine; Hexamethonium Compounds; Humans; Indomethacin; Methysergide; Muscle Contraction; Muscle, Smooth, Vascular; Propranolol; Pyrilamine; Regional Blood Flow; Skin; SRS-A; Vasoconstriction | 1985 |
Drug-induced sexual dysfunction and infertility.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine; Clonidine; Cytotoxins; Diuretics; Ejaculation; Erectile Dysfunction; Ethanol; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Ketoconazole; Libido; Male; Methyldopa; Middle Aged; Narcotics; Orgasm; Parasympatholytics; Penis; Phenothiazines; Propranolol; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Sulfasalazine | 1984 |
Primary hyperparathyroidism.
Topics: Adenoma; Aged; Cimetidine; Diphosphonates; Female; Humans; Hypercalcemia; Hyperparathyroidism; Male; Middle Aged; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Propranolol | 1983 |
Interaction of cimetidine with other drugs.
Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin | 1983 |
Asymptomatic primary hyperparathyroidism in the elderly--a review.
Topics: Aged; Cimetidine; Humans; Hyperparathyroidism; Parathyroid Glands; Propranolol | 1984 |
The medical management of primary hyperparathyroidism.
Topics: Calcitonin; Calcium, Dietary; Cimetidine; Diphosphonates; Estrogens; Humans; Hypercalcemia; Hyperparathyroidism; Parathyroid Hormone; Phosphates; Propranolol | 1982 |
[Typical risks in the treatment of acute and chronic liver diseases].
Topics: Androgens; Ascites; Cholestyramine Resin; Cimetidine; Disseminated Intravascular Coagulation; Diuretics; Esophageal and Gastric Varices; Hepatitis; Humans; Hypokalemia; Hyponatremia; Immunoglobulins; Liver Cirrhosis; Liver Diseases; Penicillamine; Peritoneovenous Shunt; Propranolol; Risk | 1982 |
7 trial(s) available for cimetidine and propranolol
| Article | Year |
|---|---|
The influence of diltiazem versus cimetidine on propranolol metabolism.
Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Diltiazem; Half-Life; Humans; Lactates; Male; Premedication; Propranolol | 1992 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
Enprostil, in contrast to cimetidine, does not inhibit propranolol metabolism.
Topics: Administration, Oral; Adult; Cimetidine; Double-Blind Method; Drug Interactions; Enprostil; Humans; Indocyanine Green; Injections, Intravenous; Kinetics; Liver Circulation; Male; Propranolol; Prostaglandins E, Synthetic | 1986 |
[Effect of treatment with cimetidine and ranitidine on biological availability and circulatory effects of propranolol].
Topics: Adult; Biological Availability; Cimetidine; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Duodenal Ulcer; Heart Rate; Humans; Male; Middle Aged; Propranolol; Ranitidine | 1985 |
Comparison of kinetic interactions of nadolol and propranolol with cimetidine.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Blood Pressure; Cimetidine; Drug Interactions; Half-Life; Heart Rate; Humans; Kinetics; Male; Nadolol; Propanolamines; Propranolol | 1984 |
Effect of ethanol, cimetidine and propranolol on toluene metabolism in man.
Topics: Adult; Cimetidine; Cresols; Drug Interactions; Ethanol; Hippurates; Humans; Male; Propranolol; Toluene | 1984 |
Cimetidine increases steady state plasma levels of propranolol.
Topics: Adult; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Propranolol; Time Factors | 1981 |
166 other study(ies) available for cimetidine and propranolol
| Article | Year |
|---|---|
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers.
Topics: Adrenergic beta-Antagonists; Biological Transport; Carrier Proteins; Cells, Cultured; Cimetidine; Hydrogen-Ion Concentration; Kidney; Metoprolol; Organic Cation Transport Proteins; Organic Cation Transporter 2; Propranolol; Quinolines | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Exploring the role of different drug transport routes in permeability screening.
Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Cimetidine; Cyclic AMP; Epinephrine; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Humans; Isoproterenol; Peptic Ulcer; Propranolol | 1977 |
Inhibitory effects of imidazolines on histamine liberation from human leukocytes and on tracheal smooth muscle tone.
Topics: Animals; Cattle; Cimetidine; Clemastine; Clonidine; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Humans; Imidazoles; Leukocytes; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Phentolamine; Phenylephrine; Propranolol; Tolazoline | 1978 |
Influence of contrast media osmolality on isolated rabbit heart performance.
Topics: Animals; Cimetidine; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Glucose; Heart; Histamine Release; Iothalamic Acid; Myocardial Contraction; Osmolar Concentration; Perfusion; Propranolol; Rabbits | 1979 |
Behavioral side effects of medical drugs.
Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Caffeine; Cimetidine; Contraceptives, Oral, Hormonal; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Levodopa; Male; Mental Disorders; Parasympatholytics; Placebos; Propranolol; Psychoses, Substance-Induced; Reserpine; Sympathomimetics; Thyroid Hormones | 1979 |
Relaxant response of goat trachea to 5-hydroxy-tryptamine mediated by D-tryptamine receptors.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Female; Goats; Indomethacin; Isoproterenol; Male; Metiamide; Propranolol; Receptors, Serotonin; Serotonin; Trachea | 1979 |
Does cimetidine alter the cardiac response to exercise and propranolol?
Topics: Adult; Blood Pressure; Cimetidine; Depression, Chemical; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Guanidines; Heart Function Tests; Heart Rate; Humans; Male; Physical Exertion; Propranolol | 1979 |
Histamine responses in cat heart.
Topics: Animals; Cats; Cimetidine; Female; Heart; Heart Rate; Histamine; In Vitro Techniques; Male; Myocardial Contraction; Promethazine; Propranolol | 1979 |
Distal airway responses to changes in oxygen and carbon dioxide tensions.
Topics: Animals; Carbon Dioxide; Cimetidine; Dogs; In Vitro Techniques; Indomethacin; Lung; Meclofenamic Acid; Muscle Tonus; Muscle, Smooth; Oxygen; Phentolamine; Propranolol; Prostaglandins; Prostaglandins E; Prostaglandins F | 1979 |
Propranolol and cimetidine.
Topics: Cimetidine; Guanidines; Heart; Humans; Propranolol; Receptors, Histamine H2 | 1979 |
Spasmolytic action of histamine in airway smooth muscle of horse.
Topics: Animals; Atropine; Bronchi; Burimamide; Cimetidine; Histamine; Horses; In Vitro Techniques; Indomethacin; Metiamide; Muscle Contraction; Muscle, Smooth; Propranolol; Pyrilamine; Respiratory System; Trachea | 1978 |
Biphasic effect of histamine on spontaneously beating rat atria.
Topics: Animals; Cimetidine; Female; Heart; Heart Rate; Histamine; In Vitro Techniques; Male; Myocardial Contraction; Pheniramine; Propranolol; Rats; Receptors, Histamine | 1992 |
Endogenous calcitonin gene-related peptide mediates nonadrenergic noncholinergic depressor response to spinal cord stimulation in the pithed rat.
Topics: Animals; Atropine; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Cimetidine; Electric Stimulation; Male; Peptide Fragments; Propranolol; Pyrilamine; Rats; Rats, Inbred Strains; Spinal Cord; Stimulation, Chemical; Vasodilation | 1992 |
Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol.
Topics: Acetaminophen; Adult; Alcohol Dehydrogenase; Animals; Cimetidine; Ethacrynic Acid; Ethanol; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; Nizatidine; Propranolol; Ranitidine; Rats; Reference Values; Salicylates; Salicylic Acid | 1991 |
Roles of in vitro- and in vivo-administered histamine and serotonin in compound 48/80-induced gastric acid secretion in isolated, perfused rat stomach.
Topics: Animals; Cimetidine; Female; Gastric Acid; Histamine; In Vitro Techniques; Methysergide; p-Methoxy-N-methylphenethylamine; Propranolol; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Cardiovascular and bronchial actions of famotidine in anesthetized dogs.
Topics: Airway Resistance; Anesthesia; Animals; Bronchi; Cimetidine; Dogs; Electrocardiography; Famotidine; Female; Halothane; Heart; Hemodynamics; Histamine; Male; Nitrous Oxide; Pentobarbital; Propranolol | 1990 |
Locomotor activity and one-way active avoidance after intrahippocampal injection of neurotransmitter antagonists.
Topics: Animals; Avoidance Learning; Cimetidine; Hippocampus; Male; Motor Activity; Propranolol; Rats; Rats, Inbred Strains; Scopolamine; Sulpiride | 1990 |
Effect of taurine, L-cysteic and orthanilic acids on cardiac tension.
Topics: Animals; beta-Alanine; Calcium Chloride; Cimetidine; Cysteic Acid; Drug Interactions; Gallopamil; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Myocardial Contraction; Phentolamine; Phenylephrine; Propranolol; Sulfanilic Acids; Taurine | 1990 |
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; Dinoprost; Histamine; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Propranolol; Prostaglandins F; Pyrilamine; Serotonin; Serotonin Antagonists; Swine; Vena Cava, Inferior | 1986 |
Acute hemodynamic effects of an antitumoral agent: elliptinium. Involvement of histamine release.
Topics: Alkaloids; Animals; Antineoplastic Agents; Aspirin; Atropine; Blood Pressure; Cardiovascular Physiological Phenomena; Cimetidine; Coronary Circulation; Dogs; Ellipticines; Female; Heart Rate; Hemodynamics; Histamine Release; Male; Myocardial Contraction; Propranolol; Pyrilamine | 1986 |
Effects of DN-9693, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cholecystokinin; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Male; Pancreas; Pancreatic Juice; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Propranolol; Quinazolines; Secretin; Sulpiride; Theophylline | 1989 |
Adenosine does not mediate the pulmonary vasodilator response of adenosine 5'-triphosphate in the feline pulmonary vascular bed.
Topics: Adenosine; Adenosine Triphosphate; Animals; Atropine; Blood Pressure; Cats; Cimetidine; Meclofenamic Acid; Nitroglycerin; Propranolol; Pulmonary Circulation; Vasodilation; Xanthines | 1989 |
Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Cimetidine; Electrocardiography; Heart; Histamine; In Vitro Techniques; Male; Membrane Potentials; Norepinephrine; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1989 |
Regulation of Na-K-Cl cotransport in endothelial cells by atrial natriuretic factor.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Biological Transport; Cattle; Cells, Cultured; Chlorides; Cimetidine; Cyclic GMP; Endothelium, Vascular; Histamine; Kinetics; Norepinephrine; Pirenzepine; Potassium; Propranolol; Receptors, Adrenergic, beta; Receptors, Histamine H2; Receptors, Muscarinic; Second Messenger Systems; Sodium | 1989 |
Acceleration of rat brain beta-adrenoceptor subsensitivity following the coadministration of histamine receptor antagonists with imipramine.
Topics: Animals; Brain; Chlorpheniramine; Cimetidine; Drinking Behavior; Drug Interactions; Female; Guinea Pigs; Heart; Histamine Antagonists; Imipramine; In Vitro Techniques; Isoproterenol; Propranolol; Ranitidine; Rats; Receptors, Adrenergic, beta | 1989 |
Histamine directly acts on beta-adrenoceptors as well as H1-histaminergic receptors, and causes positive inotropic effects in isolated ventricular muscles of carp heart (Cyprinus carpio).
Topics: Animals; Atropine; Carps; Cimetidine; Cyprinidae; Diphenhydramine; Electric Stimulation; Female; Histamine; Histamine Antagonists; In Vitro Techniques; Male; Myocardial Contraction; Propranolol; Pyrilamine; Receptors, Adrenergic, beta; Receptors, Histamine H1; Stereoisomerism | 1989 |
The inhibitory effects of cimetidine on elimination and distribution of propranolol in rats.
Topics: Administration, Oral; Animals; Blood Proteins; Cimetidine; Drug Interactions; Hydrogen-Ion Concentration; Injections, Intravenous; Liver Circulation; Male; Metabolic Clearance Rate; Propranolol; Protein Binding; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
Angiotensin II-induced relaxation of fowl aorta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Aorta, Abdominal; Chickens; Cimetidine; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Indomethacin; Methysergide; Microscopy, Electron; Muscle, Smooth, Vascular; Ouabain; Proadifen; Propranolol; Pyrilamine; Vasodilation | 1988 |
Reversal of vascular tachyphylaxis to catecholamines and histamine in the feline lung.
Topics: Animals; Blood Vessels; Cats; Cimetidine; Dose-Response Relationship, Drug; Epinephrine; Histamine; In Vitro Techniques; Indomethacin; Lung; Male; Norepinephrine; Propranolol; Pulmonary Circulation; Receptors, Adrenergic, beta; Receptors, Histamine H1; Tachyphylaxis; Vascular Resistance | 1988 |
A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
Topics: Animals; Cimetidine; Electroshock; Haloperidol; Histamine; Histamine H2 Antagonists; Male; Naloxone; Pain; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Histamine H2 | 1985 |
The inhibitory effects of ranitidine and cimetidine on propranolol elimination by the rat isolated perfused liver.
Topics: Animals; Cimetidine; Erythrocytes; In Vitro Techniques; Liver; Male; Propranolol; Ranitidine; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Cholinergic control of gastric acid secretion.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Cimetidine; Gastric Acid; Gastric Mucosa; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Parasympathetic Nervous System; Prazosin; Propranolol; Prostaglandins; Rats; Rats, Inbred Strains | 1985 |
Prophylaxis against repeated radiocontrast media reactions in 857 cases. Adverse experience with cimetidine and safety of beta-adrenergic antagonists.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anaphylaxis; Cimetidine; Contrast Media; Diphenhydramine; Drug Therapy, Combination; Ephedrine; Humans; Liver Circulation; Prednisone; Premedication; Propranolol; Prospective Studies; Recurrence | 1985 |
A study of the H2-receptor for histamine stimulating adenylate cyclase in homogenates of guinea-pig lung parenchyma.
Topics: Adenylyl Cyclases; Animals; Cimetidine; Colforsin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Lung; Male; Propranolol; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2 | 1986 |
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Bromazepam; Cimetidine; Contraceptives, Oral, Hormonal; Drug Interactions; Female; Humans; Kinetics; Male; Propranolol; Sex Characteristics | 1987 |
Effect of cimetidine on the pharmacokinetics of the new beta-blocker betaxolol.
Topics: Adrenergic beta-Antagonists; Adult; Betaxolol; Cimetidine; Drug Interactions; Humans; Male; Propanolamines; Propranolol | 1987 |
Determination of beta adrenoceptor density on rabbit mononuclear leukocytes.
Topics: Adrenergic beta-Agonists; Animals; Atropine; Cell Membrane; Cell Separation; Cimetidine; Leukocytes, Mononuclear; Male; Pindolol; Propranolol; Rabbits; Receptors, Adrenergic, beta | 1988 |
Effects of propranolol and cimetidine on cysteamine inhibition of gastric carcinogenesis induced in Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Animals; Cimetidine; Cysteamine; Gastric Acid; Gastric Mucosa; Gastrins; Male; Methylnitronitrosoguanidine; Propranolol; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1989 |
Effects of human atrial natriuretic polypeptide on pancreatic exocrine secretion in the dog.
Topics: Animals; Atrial Natriuretic Factor; Atropine; Bicarbonates; Cimetidine; Dogs; Ethacrynic Acid; Female; Haloperidol; Injections, Intra-Arterial; Male; Pancreatic Juice; Pancreatin; Perfusion; Phentolamine; Propranolol; Proteins; Secretin; Sodium; Sulpiride | 1987 |
Activation of the cholinergic system and growth hormone release in the dog: functional interactions with other neurotransmitters.
Topics: Animals; Behavior, Animal; Cimetidine; Clemastine; Diphenhydramine; Dogs; Domperidone; Female; Fenfluramine; Growth Hormone; Male; Metergoline; Naloxone; Phentolamine; Physostigmine; Pimozide; Pizotyline; Propranolol; Radioimmunoassay; Receptors, Cholinergic; Synaptic Transmission | 1985 |
The effects of derivatives of histamine on natural suppressor cells.
Topics: Adenylyl Cyclases; Animals; Cimetidine; Clone Cells; Cyclic AMP; Dose-Response Relationship, Immunologic; Enzyme Activation; Guinea Pigs; Histamine; Mice; Mice, Inbred BALB C; Myocardium; Propranolol; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory | 1986 |
Mechanism of action of a new prostaglandin antihypertensive, viprostol [CL 115 347; (dl)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 methyl ester]: (I). Vasodilation.
Topics: Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chlorpheniramine; Cimetidine; Dinoprostone; Dogs; Drug Interactions; Female; Heart Rate; Indomethacin; Male; Nephrectomy; Propranolol; Prostaglandins E; Prostaglandins E, Synthetic; Rabbits; Rats; Rats, Inbred SHR; Receptors, Adrenergic, beta; Regional Blood Flow; Vasodilation | 1986 |
Effects of forskolin on pancreatic exocrine secretion and cyclic nucleotide concentrations of the dog pancreas.
Topics: Animals; Atropine; Cimetidine; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Female; Male; Nucleotides, Cyclic; Pancreatic Juice; Phentolamine; Propranolol; Sulpiride; Verapamil | 1987 |
Medical treatment of primary hyperparathyroidism: effects on parathormone and vitamin D metabolites.
Topics: Calcitonin; Cimetidine; Dihydroxycholecalciferols; Drug Therapy, Combination; Etidronic Acid; Female; Humans; Hyperparathyroidism; Middle Aged; Propranolol; Vitamin D | 1987 |
Triazolam kinetics: interaction with cimetidine, propranolol, and the combination.
Topics: Adult; Cimetidine; Drug Interactions; Female; Humans; Male; Middle Aged; Propranolol; Triazolam | 1988 |
The effect of cimetidine dose timing on oral propranolol kinetics in adults.
Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Humans; Kinetics; Male; Propranolol; Time Factors | 1988 |
The role of the renin-angiotensin system in compound 48/80-induced thirst in rats.
Topics: Animals; Captopril; Cimetidine; Drinking; Male; Nephrectomy; p-Methoxy-N-methylphenethylamine; Polyethylene Glycols; Propranolol; Rats; Rats, Inbred Strains; Renin-Angiotensin System; Thirst; Tripelennamine | 1986 |
Distribution and vasomotor effects of peptide HI (PHI) in feline cerebral blood vessels in vitro and in situ.
Topics: Animals; Atropine; Cats; Cerebral Arteries; Cimetidine; Cocaine; Dinoprost; Immunochemistry; In Vitro Techniques; Nerve Fibers; Peptide PHI; Peptides; Pia Mater; Propranolol; Prostaglandins F; Vasoactive Intestinal Peptide; Vasodilation | 1985 |
Increase of plasma renin activity after subcutaneous application of compound 48/80 in the rat.
Topics: Animals; Blood Pressure; Capillary Permeability; Cimetidine; Diphenhydramine; Hematocrit; Histamine; Injections, Subcutaneous; Male; Nephrectomy; p-Methoxy-N-methylphenethylamine; Propranolol; Rats; Rats, Inbred Strains; Renin | 1985 |
Cardiovascular responses to parathyroid hormone.
Topics: Animals; Atropine; Blood Pressure; Cimetidine; Coronary Circulation; Coronary Vessels; Dogs; Heart Rate; Hemodynamics; Infusions, Intra-Arterial; Injections, Intra-Arterial; Myocardial Contraction; Parathyroid Hormone; Peptide Fragments; Phentolamine; Promethazine; Propranolol; Teriparatide | 1985 |
Histamine receptor activation by unsaturated (allyl and propargyl) homologs of histamine.
Topics: Adrenergic Fibers; Animals; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Propranolol; Pyrilamine; Receptors, Histamine | 1985 |
Adverse drug reactions in the elderly: case studies.
Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol | 1984 |
Effects of histamine on human isolated heart muscle: comparison with effects of noradrenaline.
Topics: Cimetidine; Dimaprit; Heart; Histamine; Humans; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Propranolol; Pyrilamine; Receptors, Histamine H2; Thiourea | 1980 |
[Effects of a new bronchodilator, (alpha RS)-3-formamido-4-hydroxy-alpha-[[[(alpha RS)-p-methoxy-alpha-methylphenethyl] amino] methyl] benzyl alcohol fumarate dihydrate (BD 40A) on gastric acid secretion and gastrointestinal motility (author's transl)].
Topics: Adrenergic beta-Agonists; Animals; Bronchodilator Agents; Cimetidine; Depression, Chemical; Dogs; Ethanolamines; Formoterol Fumarate; Gastric Acid; Gastrointestinal Motility; Hexoprenaline; Isoproterenol; Male; Propranolol; Rats | 1980 |
Cimetidine and bioavailability of propranolol.
Topics: Biological Availability; Cimetidine; Drug Interactions; Guanidines; Humans; Male; Middle Aged; Propranolol | 1981 |
Failure of ranitidine to interact with propranolol.
Topics: Adult; Aged; Cimetidine; Drug Interactions; Female; Furans; Histamine H2 Antagonists; Humans; Liver; Male; Middle Aged; Propranolol; Ranitidine | 1982 |
Indirect sympathomimetic effect of some H2-histamine receptor antagonists in the isolated uterus of the rat.
Topics: Animals; Cimetidine; Female; Furans; Histamine H2 Antagonists; Hydroxydopamines; In Vitro Techniques; Metiamide; Propranolol; Ranitidine; Rats; Rats, Inbred Strains; Sympathomimetics; Uterus | 1982 |
H2 receptor antagonists: cimetidine and ranitidine.
Topics: Cimetidine; Drug Interactions; Furans; Guanidines; Histamine H2 Antagonists; Humans; Lidocaine; Propranolol; Ranitidine | 1983 |
Effects of locus coeruleus stimulation on carotid vascular resistance in the cat.
Topics: Animals; Atropine; Carotid Arteries; Cats; Cimetidine; Electric Stimulation; Female; Hexamethonium; Hexamethonium Compounds; Locus Coeruleus; Male; Phentolamine; Propranolol; Vagus Nerve; Vascular Resistance | 1983 |
[Recent developments in the medical treatment of emergency cirrhotic hemorrhage. Vasopressin and glipressin, prostaglandins, somatostatin, propranolol, cimetidine and ranitidine].
Topics: Cimetidine; Emergencies; Hemorrhage; Humans; Liver Cirrhosis; Lypressin; Propranolol; Prostaglandins; Ranitidine; Somatostatin; Terlipressin; Vasopressins | 1983 |
[Beta-blockers in gastroenterology and hepatology].
Topics: Adrenergic beta-Antagonists; Cimetidine; Drug Combinations; Gastrointestinal Diseases; Humans; Liver Diseases; Propranolol | 1984 |
Benzodiazepine drug-drug interactions commonly occurring in clinical practice.
Topics: Anti-Anxiety Agents; Benzodiazepines; Cimetidine; Contraceptives, Oral; Disulfiram; Drug Interactions; Enzyme Induction; Ethanol; Humans; Isoniazid; Kinetics; Liver; Mixed Function Oxygenases; Propranolol | 1984 |
The interaction between H2-receptor antagonists and beta-adrenoceptor blockers.
Topics: Adrenergic beta-Antagonists; Atenolol; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Kinetics; Metoprolol; Penbutolol; Pindolol; Propranolol; Ranitidine | 1984 |
[Criticism of drug therapy of gastrointestinal hemorrhage].
Topics: Cimetidine; Gastrointestinal Hemorrhage; Humans; Propranolol; Somatostatin; Vasopressins | 1984 |
Effect of intracerebroventricular impromidine on pituitary-adrenocortical response to stress in rats.
Topics: Adrenal Cortex; Animals; Atropine; Cimetidine; Corticosterone; Dimaprit; Imidazoles; Impromidine; Injections, Intraventricular; Male; Methylhistamines; Pituitary Gland; Propranolol; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Restraint, Physical; Stress, Physiological; Sympatholytics; Thiourea | 1984 |
The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat.
Topics: Animals; Body Temperature; Cimetidine; Clonidine; Drug Interactions; Injections, Intraperitoneal; Injections, Intraventricular; Male; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Histamine; Receptors, Histamine H2; Time Factors | 1980 |
Acute systemic anaphylaxis in adult domestic fowl: evidence for the protective role of H2-histaminergic and beta 2-adrenergic receptors.
Topics: Anaphylaxis; Animals; Blood Pressure; Carotid Arteries; Chickens; Chromones; Cimetidine; Dimaprit; Ethers; Heart Rate; Metiamide; Poultry Diseases; Propranolol; Pyrilamine; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Histamine; Receptors, Histamine H2; Terbutaline; Thiourea | 1980 |
Histamine and human parathyroid adenoma: effect on adenosine 3',5'-monophosphate accumulation in vitro.
Topics: Adenoma; Cimetidine; Cyclic AMP; Female; Histamine; Humans; In Vitro Techniques; Isoproterenol; Male; Parathyroid Hormone; Parathyroid Neoplasms; Propranolol; Pyrilamine | 1981 |
Effects of cimetidine and ranitidine on steady-state propranolol kinetics and dynamics.
Topics: Adult; Cimetidine; Drug Interactions; Female; Furans; Guanidines; Heart Rate; Humans; Kinetics; Liver; Male; Physical Exertion; Propranolol; Ranitidine | 1982 |
Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Cimetidine; Cyclic AMP; Darier Disease; Epidermis; Epinephrine; Humans; In Vitro Techniques; Middle Aged; Propranolol; Proteins; Receptors, Adrenergic, beta; Theophylline | 1983 |
Calcium channels resistant to organic calcium entry blockers in a rabbit vein.
Topics: Animals; Benzazepines; Calcium; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Face; Histamine; Ion Channels; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phentolamine; Propranolol; Rabbits; Temperature; Veins; Verapamil | 1983 |
UD-CG 115--a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle.
Topics: Action Potentials; Animals; Carbachol; Cardiotonic Agents; Cimetidine; Cyclic AMP; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Propranolol; Pyridazines; Reserpine; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical | 1984 |
Positive inotropic effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1 -piperazinyl]-2(1H)-quinolinone (OPC-8212) and mechanism of action in guinea pig ventricular myocardium.
Topics: Animals; Carbachol; Cardiotonic Agents; Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Myocardial Contraction; Propranolol; Pyrazines; Quinolines; Reserpine | 1984 |
On the mechanism of histamine-induced bronchodilation in conscious guinea-pigs.
Topics: Aerosols; Animals; Bronchial Spasm; Bronchodilator Agents; Chlorpheniramine; Cimetidine; Guinea Pigs; Histamine; Histamine Antagonists; Male; Methacholine Chloride; Methacholine Compounds; Metiamide; Propranolol; Receptors, Histamine H1 | 1984 |
A simple technique to study the effect of drugs on the negative inotropic response elicited by postganglionic cholinergic nerve stimulation in guinea pig atria.
Topics: Animals; Atrial Function; Atropine; Cimetidine; Depression, Chemical; Electric Stimulation; Guinea Pigs; Heart; Hydroxydopamines; Isoflurophate; Mecamylamine; Myocardial Contraction; Oxidopamine; Pancuronium; Propranolol; Receptors, Muscarinic; Stimulation, Chemical; Tetrodotoxin | 1983 |
Lack of histamine involvement in parathyroid hormone hypotensive action.
Topics: Animals; Blood Pressure; Cimetidine; Dimaprit; Female; Histamine; Hypotension; Male; p-Methoxy-N-methylphenethylamine; Parathyroid Hormone; Peptide Fragments; Promethazine; Propranolol; Pyridines; Rats; Thiourea | 1981 |
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Methylhistamines; Muscle Contraction; Propranolol; Receptors, Histamine; Receptors, Histamine H2; Thiourea; Trachea | 1982 |
Inotropic effect of taurine in guinea-pig ventricular strips.
Topics: Alanine; Animals; Calcium; Cimetidine; Drug Interactions; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Myocardial Contraction; Propranolol; Taurine | 1984 |
Pancreatic polypeptide and gastrin release during sham feeding in man.
Topics: Adult; Atropine; Cimetidine; Food; Gastric Acid; Gastrins; Humans; Kinetics; Male; Pancreatic Polypeptide; Propranolol | 1984 |
Accumulation and adverse effects of metoprolol and propranolol after concurrent administration of cimetidine.
Topics: Adult; Blood Pressure; Cimetidine; Drug Interactions; Heart Rate; Humans; Kinetics; Male; Metoprolol; Physical Exertion; Propranolol | 1983 |
Release of noradrenaline from rabbit atria by isoprenaline and histamine.
Topics: Animals; Cimetidine; Heart Rate; Histamine; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Norepinephrine; Propranolol; Rabbits; Tetrodotoxin | 1983 |
Kinetic interactions of nadolol and propranolol with cimetidine.
Topics: Adolescent; Adult; Cimetidine; Drug Interactions; Humans; Kinetics; Male; Nadolol; Propanolamines; Propranolol | 1984 |
Indocyanine green clearance following single and chronic cimetidine doses.
Topics: Adult; Cimetidine; Drug Administration Schedule; Female; Humans; Indocyanine Green; Kinetics; Liver; Male; Metabolic Clearance Rate; Propranolol; Quinidine; Regional Blood Flow | 1984 |
Effects of drugs on the production of stress ulcer in the rat.
Topics: Animals; Atropine; Cimetidine; Epoprostenol; Female; Male; Peptic Ulcer; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stress, Physiological | 1982 |
Influence of cimetidine on pharmacokinetics of propranolol.
Topics: Adult; Aged; Biological Availability; Cimetidine; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Propranolol | 1981 |
Influence of cimetidine on pharmacokinetics of propranolol.
Topics: Cimetidine; Guanidines; Humans; Kinetics; Propranolol | 1981 |
Influence of cimetidine on pharmacokinetics of propranolol.
Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Kinetics; Propranolol | 1981 |
Ethanol-induced alterations in pancreatic blood flow in conscious dogs.
Topics: Animals; Cimetidine; Dogs; Ethanol; Mannitol; Meclofenamic Acid; Pancreas; Pancreatitis; Phenoxybenzamine; Propranolol; Regional Blood Flow; Vascular Resistance | 1982 |
Drug-induced internuclear ophthalmoplegia.
Topics: Aged; Cimetidine; Drug Interactions; Esophagitis; Female; Guanidines; Humans; Male; Middle Aged; Mitral Valve Prolapse; Ophthalmoplegia; Propranolol | 1983 |
The interaction of cimetidine with metoprolol, atenolol, propranolol, pindolol and penbutolol.
Topics: Atenolol; Biological Availability; Cimetidine; Drug Interactions; Guanidines; Humans; Metoprolol; Penbutolol; Pindolol; Propanolamines; Propranolol | 1983 |
Medical treatment of primary hyperparathyroidism.
Topics: Cimetidine; Guanidines; Humans; Hyperparathyroidism; Propranolol | 1982 |
Effects of histamine on the resting and stimulation-induced release of [3H]-noradrenaline in guinea-pig isolated atria.
Topics: Animals; Atropine; Cimetidine; Cocaine; Electric Stimulation; Female; Guinea Pigs; Heart Atria; Histamine; In Vitro Techniques; Indomethacin; Male; Myocardium; Norepinephrine; Phentolamine; Propranolol; Pyrilamine | 1982 |
Intracerebroventricular aconitine induced cardiac arrhythmia: involvement of central histaminergic receptors.
Topics: Aconitine; Aconitum; Animals; Arrhythmias, Cardiac; Blood Pressure; Cimetidine; Dogs; Heart; Heart Rate; Injections, Intraventricular; Propranolol; Pyrilamine; Receptors, Histamine | 1982 |
Interaction of metoprolol, propranolol and atenolol with concurrent administration of cimetidine.
Topics: Adult; Atenolol; Cimetidine; Drug Interactions; Guanidines; Humans; Kinetics; Male; Metoprolol; Propanolamines; Propranolol | 1982 |
The arrhythmogenic actions of histamine on human atrial fibers.
Topics: Action Potentials; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Child, Preschool; Cimetidine; Epinephrine; Heart Atria; Histamine; Humans; Infant; Middle Aged; Myocardial Contraction; Propranolol; Verapamil | 1981 |
Adrenaline sensitive adenylate cyclase in human gastric mucosa.
Topics: Adenylyl Cyclases; Adult; Aged; Cimetidine; Duodenal Ulcer; Epinephrine; Female; Gastric Mucosa; Humans; Male; Middle Aged; Propranolol; Stomach Ulcer | 1981 |
Drug interactions with cimetidine.
Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin | 1981 |
Postprandial alterations in cardiovascular hemodynamics in autonomic dysfunction states.
Topics: Aged; Autonomic Nervous System Diseases; Blood Pressure; Cardiovascular System; Cimetidine; Diastole; Diphenhydramine; Eating; Female; Heart Rate; Hemodynamics; Humans; Indomethacin; Male; Middle Aged; Propranolol; Systole; Time Factors | 1981 |
Blockers of beta and H2 receptors and secondary hyperparathyroidism in uraemia.
Topics: Adult; Aged; Atenolol; Cimetidine; Female; Guanidines; Humans; Hyperparathyroidism, Secondary; Male; Middle Aged; Parathyroid Hormone; Propanolamines; Propranolol; Uremia | 1981 |
Isolated parietal cells: [3H]QNB binding to putative cholinergic receptors.
Topics: Animals; Atropine; Cell Separation; Cimetidine; Epinephrine; Female; Gastric Mucosa; Hexamethonium Compounds; Histamine; Neostigmine; Phentolamine; Physostigmine; Propranolol; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine | 1980 |
[Therapy of uremic osteopathy].
Topics: Aluminum Hydroxide; Aluminum Oxide; Calcitonin; Chronic Kidney Disease-Mineral and Bone Disorder; Cimetidine; Humans; Propranolol; Sodium Fluoride; Vitamin D | 1980 |
Proof for histaminergic but not for adrenergic involvement in the growth hormone-releasing effect of an enkephalin analog in the dog.
Topics: Animals; Cimetidine; Clemastine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diphenhydramine; Dogs; Endorphins; Enkephalins; Female; Glucose; Growth Hormone; Histamine; Male; Phentolamine; Propranolol; Sympathetic Nervous System | 1981 |
Reduction of liver blood flow and propranolol metabolism by cimetidine.
Topics: Administration, Oral; Adult; Cimetidine; Guanidines; Humans; Indocyanine Green; Injections, Intravenous; Liver Circulation; Male; Propranolol | 1981 |
Drug interactions and the prepared observer.
Topics: Cimetidine; Computers; Drug Information Services; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Propranolol | 1981 |
Angiotensin-induced relaxation in isolated dog renal and cerebral arteries.
Topics: Aminophylline; Angiotensin II; Animals; Arteries; Aspirin; Atropine; Brain; Cimetidine; Cocaine; Depression, Chemical; Dogs; Female; Hexamethonium Compounds; In Vitro Techniques; Kidney; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ouabain; Propranolol; Prostaglandins F; Saralasin | 1981 |
Effects of histamine on porcine isolated myocardium: differentiation from effects on human tissue.
Topics: Adolescent; Adult; Analysis of Variance; Animals; Child; Cimetidine; Dose-Response Relationship, Drug; Female; Heart Atria; Heart Ventricles; Histamine; Humans; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Propranolol; Pyrilamine; Swine | 1993 |
Myogenic tone of rabbit facial vein and posterior cerebral artery is influenced by changes in extracellular sodium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Analysis of Variance; Animals; Bicarbonates; Cerebral Arteries; Cimetidine; Histamine; In Vitro Techniques; Isometric Contraction; Meglumine; Monensin; Mouth; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Ouabain; Propranolol; Rabbits; Sodium; Veins | 1994 |
"In vivo" and "in vitro" antitumoral action of Larrea divaricata Cav.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Division; Cimetidine; Cyclic AMP; Female; Histamine; Lymphoma, T-Cell; Mammary Neoplasms, Animal; Phytotherapy; Plant Extracts; Plants, Medicinal; Pregnancy; Propranolol; Pyrilamine; Rats; Thymidine | 1996 |
The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.
Topics: Adrenalectomy; Animals; Antigens; Catecholamines; Cimetidine; Guinea Pigs; Indomethacin; Male; Nadolol; Phosphodiesterase Inhibitors; Propranolol; Pyrrolidinones; Rolipram | 1997 |
The effects of neurotransmitter antagonists and glucose on luteinizing hormone secretion in growth-restricted wethers.
Topics: Animals; Cimetidine; Cyproheptadine; Food Deprivation; Glucose; Luteinizing Hormone; Male; Neurotransmitter Agents; Pimozide; Propranolol; Pyrilamine; Sheep | 1997 |
[Membrane-receptor disorders in adrenergic and histaminergic systems under peroxide exposure in bronchial asthma patients].
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Asthma; Cimetidine; Diphenhydramine; Epinephrine; Erythrocyte Membrane; Hemolysis; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Peroxides; Prognosis; Propranolol; Receptors, Adrenergic; Receptors, Histamine | 2000 |
Hydrogen/deuterium exchange using a coaxial sheath-flow interface for capillary electrophoresis/mass spectrometry.
Topics: Atenolol; Cimetidine; Deuterium; Electrophoresis, Capillary; Hydrogen; Mass Spectrometry; Molecular Structure; Propranolol | 2000 |
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles | 2000 |
Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression.
Topics: Animals; Atenolol; Biological Transport; Cell Line; Cell Membrane Permeability; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Erythromycin; Glucose; Humans; Mammals; Mannitol; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenylalanine; Propranolol; Recombinant Proteins; Testosterone; Tumor Cells, Cultured; Verapamil | 2000 |
A new isoquinolinone derivative with noble vasorelaxation activity.
Topics: Acetylcholine; Adrenergic Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Atropine; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Isoquinolines; Magnetic Resonance Spectroscopy; Male; Muscarinic Antagonists; Phenylephrine; Propranolol; Pyridines; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Yohimbine | 2003 |
Influence of histamine, cimetidine and pyrilamine on naloxone-induced jumping in morphine-dependent mice.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Interactions; Histamine; Histamine H2 Antagonists; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Prazosin; Propranolol; Pyrilamine; Receptors, Histamine H2; Yohimbine | 2003 |
In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan.
Topics: Animals; beta-Naphthoflavone; Cimetidine; Cytochrome P-450 CYP1A2; Diazepam; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fluvoxamine; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Moclobemide; Oxazolidinones; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Species Specificity; Tryptamines | 2003 |
Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine.
Topics: Acids; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspartic Acid; Cimetidine; Drug Interactions; Gastric Mucosa; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Immunohistochemistry; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Time Factors; Tripelennamine; Valine; Yohimbine | 2004 |
Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Cimetidine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flurbiprofen; Hindlimb; Histamine Antagonists; Joints; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Propranolol; Prostaglandins; Pyrilamine; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Vasodilator Agents | 2006 |
A comparison between the cardiovascular actions of urocortin 1 and urocortin 2 (stresscopin-related peptide) in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Cardiovascular Agents; Cimetidine; Corticotropin-Releasing Hormone; Heart Rate; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Muscarinic Antagonists; Peptide Fragments; Propranolol; Pyrilamine; Rats; Rats, Sprague-Dawley; Urocortins | 2007 |
Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2.
Topics: Aspirin; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Cetirizine; Cimetidine; Diffusion; Dose-Response Relationship, Drug; Drug Interactions; Flunarizine; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Oxazolidinones; Permeability; Propranolol; Serotonin Receptor Agonists; Sodium-Hydrogen Exchangers; Tryptamines | 2007 |
Thiolated chitosan: development and in vitro evaluation of an oral delivery system for acyclovir.
Topics: Acyclovir; Adjuvants, Pharmaceutic; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chitin; Cimetidine; Drug Delivery Systems; Drug Evaluation, Preclinical; Electric Impedance; Glutathione; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Propranolol; Rats; Tablets; Verapamil | 2008 |
Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat.
Topics: Administration, Oral; Algorithms; Animals; Cimetidine; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Male; Metoprolol; Models, Animal; Perfusion; Permeability; Propranolol; Rats; Rats, Wistar | 2009 |
The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation.
Topics: Amoxicillin; Atenolol; Cell Membrane Permeability; Cimetidine; Computer Simulation; Gastric Emptying; Gastrointestinal Tract; Humans; Metoprolol; Pharmaceutical Preparations; Propranolol; Software | 2010 |
Permeation studies on freshly excised rat gastric mucosa: influence of pH.
Topics: Animals; Bacitracin; Cimetidine; Fluorescein; Fluorescein-5-isothiocyanate; Gastric Mucosa; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Permeability; Pharmacokinetics; Propranolol; Rats; Rats, Sprague-Dawley | 2011 |
The major impacts of James Black's drug discoveries on medicine and pharmacology.
Topics: Adrenergic beta-Antagonists; Cimetidine; Drug Discovery; Histamine H2 Antagonists; History, 20th Century; Humans; Pharmacology; Propranolol; Research | 2011 |
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution | 2012 |
Phototransformation of wastewater-derived trace organic contaminants in open-water unit process treatment wetlands.
Topics: Atenolol; Carbamazepine; Carbonates; Cimetidine; Dimethylnitrosamine; Diuron; Estradiol; Hydroxyl Radical; Models, Chemical; Photolysis; Propranolol; Sulfamethoxazole; Sunlight; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Wetlands | 2013 |
Modulatory effects of taurine on jejunal contractility.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Calcium Channel Blockers; Cimetidine; Diphenhydramine; Enteric Nervous System; Histamine H1 Antagonists; Histamine H2 Antagonists; Jejunum; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Nitric Oxide; Nitric Oxide Synthase; Phentolamine; Phosphorylation; Propranolol; Rats, Sprague-Dawley; Taurine; Tetrodotoxin; Verapamil | 2014 |
Substrate-immobilized electrospun TiO2 nanofibers for photocatalytic degradation of pharmaceuticals: The effects of pH and dissolved organic matter characteristics.
Topics: Carbamazepine; Catalysis; Cimetidine; Hydrogen-Ion Concentration; Nanofibers; Organic Chemicals; Photolysis; Propranolol; Titanium; Ultraviolet Rays; Water Pollutants, Chemical; Water Purification | 2015 |