cimetidine has been researched along with piperidines in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (19.46) | 18.7374 |
| 1990's | 74 (49.66) | 18.2507 |
| 2000's | 38 (25.50) | 29.6817 |
| 2010's | 8 (5.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hough, LB; Nalwalk, JW | 1 |
| Arrang, JM; de Waele, C; Khateb, A; Mulhethaler, M; Serafin, M; Vibert, N; Vidal, PP; Yabe, T | 1 |
| Bent, S; Braam, U; Fehling, U; Schmutzler, W; Schunack, W | 1 |
| Orsetti, M; Sorba, G | 2 |
| Aihara, H; Hirose-Kijima, H; Muramatsu, M; Otomo, S | 1 |
| Bockbrader, HN; Cetnarowski-Cropp, AB; Chang, T; Goldfarb, AL; Lebsack, ME; Radulovic, LL; Sedman, AJ; Stringer, KA | 1 |
| Almdal, TP; Bjerrum, K; Dalhoff, K; Keiding, S; Lund, J; Mengel, H | 1 |
| Aihara, H; Isobe, Y; Muramatsu, M; Otomo, S | 1 |
| Bonfils, S; Chen, WW; Kolsky, H; Lewin, MJ | 1 |
| Aihara, H; Isobe, Y; Muramatsu, M; Nagai, H; Otomo, S | 1 |
| Chida, Y; Nishikawa, M; Ohnishi, H; Sekine, A; Shibata, M; Yamaura, T | 1 |
| Barnes, PJ; Ichinose, M | 1 |
| Crowe, J; Dimitrov, B; Maleev, A; Mendizova, A; Mihova, A; Popov, P; Routhier, G; Silveira, J; Thomson, A; Vlahov, V | 1 |
| Evreux, M; Filoche, B; Fournet, J; Fraitag, B; Galmiche, JP; Soule, JC; Vitaux, J; Zeitoun, P | 1 |
| Campbell, AM; Glatfelter, A; Kunkel, RG; Ulevitch, RJ; Wiggins, RC | 1 |
| Bannister, SJ; Houser, VP; Hulse, JD; Kisicki, JC; Rasmussen, JG | 1 |
| Buscher, G; Dierdorf, HD; Greb, WH; Köster, FE; Mellows, G; Wolf, D | 1 |
| Eberle, NB; Glick, SD; Gogas, KR; Hough, LB; Lyon, RA; Parsons, ME; Ward, SJ; Young, RC | 1 |
| Nakamura, K; Tanaka, E | 1 |
| Bender, W; Labs, R; Merki, HS | 1 |
| Aoi, R; Ishioka, T; Ogata, H; Takeuchi, H; Yoshimura, N | 1 |
| Janisch, HD; Kirch, W; Ohnhaus, EE; van Peer, A | 1 |
| Mieda, M; Sakuma, H; Shiratsuchi, K; Tarutani, M | 1 |
| Aono, M; Mizuta, K; Moriga, M; Narusawa, H | 1 |
| Gertner, SB; O'Neill, KA | 1 |
| Konishi, H; Morita, K; Ono, T; Shimakawa, H | 1 |
| Calcutt, CR; Ganellin, CR; Griffiths, R; Leigh, BK; Maguire, JP; Mitchell, RC; Mylek, ME; Parsons, ME; Smith, IR; Young, RC | 1 |
| Nio, CY; Tytgat, GN | 1 |
| Guslandi, M | 1 |
| Inoue, M | 1 |
| Brockmeier, D; Lameire, N; Rosenkranz, B | 1 |
| Bender, W; Dammann, HG; de Looze, SM; Labs, R | 1 |
| Collins, JD | 1 |
| Kawasaki, H; Takasaki, K | 1 |
| Brandstätter, G; Evreux, M; Galmiche, JP; Hentschel, E; Kerstan, E; Kratochvil, P; Reichel, W; Schütze, K; Soule, JC; Vitaux, J | 1 |
| de Schepper, PJ; Tjandra-Maga, TB; van Hecken, A; van Melle, P; Verbesselt, R | 1 |
| Gjerris, A; Mengel, H; Rafaelsen, OJ; Schmidt, J; Sørensen, AS | 1 |
| Danzinger, RG; Hofmann, AF; Nakagaki, M; René, E | 1 |
| Daly, MJ; Humphray, JM; Stables, R | 1 |
| Langwiński, R; Malec, D | 1 |
| Bonfilio, AC; Corcoran, T; Jacoby, HI; Lopez, I; Scott, M | 1 |
| Emami, S; Gespach, C; Menez, I | 1 |
| Bolser, DC; Chapman, RW; DeGennaro, FC; Hey, JA; O'Reilly, S | 1 |
| Fujimoto, K; Gotoh, Y; Granger, DN; Kang, M; Sakai, T; Sakata, T; Tso, P; Tsunada, S | 1 |
| Kohno, S; Nabe, T; Nakao, S; Ogawa, K; Ohata, K; Yamamura, H | 1 |
| Wong, CL | 1 |
| Ballabeni, V; Barocelli, E; Chiavarini, M; Impicciatore, M | 1 |
| Kohno, S; Nabe, T; Ogawa, K; Ohata, K; Yamamura, H | 1 |
| Inaba, N; Ohnishi, H; Onodera, S; Shibata, M; Suzuki, T; Tanaka, M; Yamaura, T | 1 |
| Carson, CC; Davies, MG; Hagen, PO; Kim, YC; Lee, TH | 1 |
| Kagoshima, M; Kodaira, H; Shimada, H | 1 |
| Hey, JA; Hutchison, RW | 1 |
| Daake, H; Eisold, H; Gorbauch, T; Kriech, W; Raedsch, R; Schreiber, H | 1 |
| Beil, W; Sewing, KF | 1 |
| Amarapurkar, DN; Desai, HG; Parikh, SS | 1 |
| Aoki, T; Fukuda, S; Hanyu, N; Hashimoto, Y; Iikura, M; Ohira, Y | 1 |
| Brignoli, R; Halter, F; Miazza, B | 1 |
| Gertner, SB; Hey, JA; McLeod, RL | 1 |
| Kamondi, A; Reiner, PB | 1 |
| Koss, MC | 1 |
| Hamada, K; Kobayashi, F; Sekiguchi, H; Taga, F; Uchida, H | 1 |
| Chida, Y; Inaba, N; Ohnishi, H; Onodera, S; Shibata, M; Yamaura, T | 1 |
| Breimer, DD; Bruno, R; Cohen, AF; Reinhoudt, JF; Schoemaker, HC; Van Rooij, J | 1 |
| Abe, K; Furukawa, Y; Katano, K; Mizunashi, K | 1 |
| Ikarashi, Y; Kawano, O; Misaki, N; Ohba, S; Uchida, M | 1 |
| Fan, A; Fang, Z; Wang, J; Wang, Y; Zhang, L | 1 |
| Kamei, C; Tasaka, K | 1 |
| Arrang, JM; de Waele, C; Mühlethaler, M; Serafin, M; Vibert, N; Vidal, PP; Yabe, T | 1 |
| Everaert, E; Germonpré, PR; Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Fort, P; Jones, BE; Khateb, A; Mühlethaler, M; Pegna, A | 1 |
| Furuhata, M; Nagai, N; Ogata, H | 1 |
| Fujimoto, K; Gotoh, Y; Ogata, S; Ohyama, T; Okamoto, K; Ootani, A; Sakata, T; Tsunada, S | 1 |
| Konno, K; Nakata, J; Takeyama, K; Tamaoki, J | 1 |
| Kobayashi, F; Ohkubo, H; Ohsawa, A; Sekiguchi, H; Taga, F | 1 |
| Csepregi, A; Nemesánszky, E | 1 |
| Corbel, S; Dy, M | 1 |
| Milenov, K; Shahbazian, A; Todorov, S; Vassileva, M; Zamfirova, R | 1 |
| KAMEI, CH | 1 |
| Ea-Kim, L; Javellaud, J; Oudart, N | 1 |
| Akiyama, K; Maeda, Y; Mita, H; Saito, H; Shimizu, H | 1 |
| Eaton, SJ; Eoh, S; Harrington, ME; Hoque, S; Meyer, J | 1 |
| Shulman, RJ | 1 |
| Chiyotani, A; Konno, K; Nakata, J; Takeyama, K; Tamaoki, J | 1 |
| Hough, LB; Li, BY; Nalwalk, JW | 1 |
| Inaba, N; Onodera, S; Shibata, M; Suzuki, T; Tanaka, M; Yamaura, T | 1 |
| Berant, M; Berkowitz, D; Naveh, Y | 1 |
| Berstad, A; Hatlebakk, JG | 1 |
| Harada, N; Iwai, H; Nagata, M; Tomoda, K; Yamashita, T | 1 |
| Beukers, MW; De Grip, WJ; Klaassen, CH; Leurs, R; Timmerman, H; Verzijl, D | 1 |
| Bivalacqua, TJ; Champion, HC; Czapla, MA; Ilgenfritz, C; Kadowitz, PJ; Santiago, JA | 1 |
| Laurikainen, E; Miller, JM; Nuttall, AL; Quirk, WS | 1 |
| Acuña, Y; Campos, HA; Israel, A; Mathison, Y | 1 |
| Aoyama, M; Arai, Y; Ohnishi, H; Onodera, S; Shibata, M; Tanaka, M; Yamaura, T | 1 |
| Field, SK; Sutherland, LR | 1 |
| Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 1 |
| Friedhoff, LT; Perdomo, CA; Tiseo, PJ | 1 |
| Flood, JF; Morley, JE; Uezu, K | 1 |
| Higuchi, S; Isobe, Y; Kaku, S; Kiuchi, Y; Muramatsu, M; Tanaka, M | 1 |
| Bacciottini, L; Blandina, P; Chiappetta, M; Giovannini, MG; Mannaioni, PF | 1 |
| Aoyama, M; Arai, Y; Inaba, N; Nishizawa, A; Onodera, S; Sekine, Y; Shibata, M; Suzuki, T; Tanaka, M | 1 |
| Ayukawa, O; Kariyazono, H; Moriyama, Y; Nakamura, K; Shinkawa, T; Taira, A; Toyohira, H; Yamada, K; Yamaguchi, T; Yamashita, T; Yotsumoto, G | 1 |
| Fujita, A; Nishiwaki, H; Takeuchi, K; Umeda, M | 1 |
| Hatorp, V; Thomsen, MS | 1 |
| Asano, T; Fukushima, Y; Kajiwara, T; Katsube, T; Mori, H; Ogawa, K; Ohkawa, SI; Otsuka, H; Saitoh, T; Takahashi, H; Tamai, M | 1 |
| Rojas-Fernandez, C | 1 |
| Gao, C; Hu, Hz; Liu, S; Ren, J; Wood, JD; Xia, Y | 1 |
| Bacciottini, L; Blandina, P; Cangioli, I; Mannaioni, PF; Passani, MB | 1 |
| Anichtchik, OV; Panula, P; Peitsaro, N | 1 |
| Kou, JH; Saha, P | 1 |
| Ikarashi, Y; Ishige, A; Kuribara, H; Maruyama, Y; Sasaki, H; Yuzurihara, M | 1 |
| Bittinger, F; Brockerhoff, P; Deutsch, C; Kilbinger, H; Kirkpatrick, CJ; Roth, E; Wessler, I | 1 |
| Bürckstümmer, T; Buschauer, A; Dove, S; Kelley, MT; Seifert, R; Wenzel-Seifert, K | 1 |
| Ghosh, AK; Hirasawa, N; Ohuchi, K | 1 |
| Anai, M; Asano, T; Fukushima, Y; Ishikawa, M; Ishikawa, T; Kajiwara, T; Katsube, T; Ogawa, K; Ohkawa, S; Omata, M; Otsuka, H; Saitoh, T | 1 |
| Anai, M; Asano, T; Fukushima, Y; Ishikawa, M; Ishikawa, T; Kajiwara, T; Katsube, T; Mori, H; Ogawa, K; Ohkawa, S; Omata, M; Otsuka, H; Saitoh, T; Takahashi, H; Tamai, M | 1 |
| Dey, SK; Hough, LB; Leurs, R; Nalwalk, JW; Paria, BC; Stadel, R; Timmerman, H; Wang, X | 1 |
| Gründemann, D; Haag, C; Honold, C; Koschker, AC; Schömig, E; Zimmermann, T | 1 |
| Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G | 1 |
| Desmecht, D; Jolly, S | 1 |
| Bischoff, AM; Büsselberg, D; Dutschmann, M; Richter, DW | 1 |
| Mikawa, K; Nishina, K; Obara, H; Shiga, M; Uesugi, T | 1 |
| Bacon, KB; Gantner, F; Sakai, K; Takeshita, K | 1 |
| Izumi, K; Okabe, S; Tomita, K | 1 |
| Arias, F; Currie, CA; Halsall, HB; Heineman, WR; Limbach, PA; Seliskar, CJ; Wehmeyer, KR | 1 |
| Hough, LB; Lu, Q; Montero, MJ; Nalwalk, JW; Shan, Z; Svokos, K; Wentland, MP | 1 |
| Nakamura, E; Okabe, S; Tomita, K | 1 |
| Gálfi, M; Juhász, A; László, F; László, FA; Molnár, A; Radács, M; Varga, C | 1 |
| Abood, ME; de Esch, IJ; Hough, LB; Janssen, E; Kern, B; Leurs, R; Nalwalk, JW; Phillips, J; Svokos, K; Trachler, J | 1 |
| Anichtchik, OV; Kaslin, J; Panula, P; Peitsaro, N; Sundvik, M | 1 |
| Hough, LB; Nalwalk, JW; Salussolia, CL | 1 |
| Abood, ME; Gehani, NC; Hough, LB; Martin, BR; Nalwalk, JW; Razdan, RK; Sun, X; Wentland, M | 1 |
| Kotani, T; Murashima, Y; Nakagiri, A; Takeuchi, K | 1 |
| Alò, R; Canonaco, M; Crudo, M; Facciolo, RM; Giusi, G | 1 |
| Brus, R; Jochem, J; Josko, J; Kostrzewa, RM; Noras, L; Nowak, P; Zwirska-Korczala, K | 1 |
| Hough, LB; Nalwalk, JW; Svokos, K | 1 |
| Hirasawa, N; Hong, J; Ishihara, K; Katoh, G; Ohsawa, Y; Ohuchi, K; Seyama, T; Shibata, K; Tamura, S | 1 |
| Drevensek, G; Ziberna, L; Zorman, T | 1 |
| Edelsbrunner, ME; Holzer, P; Nakano, M | 1 |
| Alhaj, M; Bozarov, A; Christofi, FL; Cooke, HJ; Grants, I; Hassanain, HH; Ren, T; Wang, YZ; Wunderlich, J; Yu, JG | 1 |
| Hasanein, P | 1 |
| Chen, Y; Sun, X; Tian, Y; Zhang, Z | 1 |
| Christopher, R; Covington, P; Davenport, M; Fleck, P; Karim, A; Li, X; Mekki, Q; Wann, E | 1 |
| Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K | 1 |
| Higuchi, K; Murano, M; Tokioka, S; Umegaki, E; Yoda, Y | 1 |
| Giardini, JL; Heyland, A; Leguia, M; Nguyen, J; Sutherby, J; Wessel, G | 1 |
| Harper, JN; Wright, SH | 1 |
| Alisch, R; Buschauer, A; Elz, S; Sadek, B | 1 |
| Barbaro, KC; Basílio, ABC; Boia-Ferreira, M; Chaim, OM; da Silva, LP; Donatti, L; Gremski, LH; Moreno, KG; Senff-Ribeiro, A; Soley, B; Veiga, SS; Vuitika, L; Wille, ACM | 1 |
7 review(s) available for cimetidine and piperidines
| Article | Year |
|---|---|
The medical therapy of reflux oesophagitis.
Topics: Antacids; Bethanechol; Bethanechol Compounds; Cimetidine; Cisapride; Domperidone; Esophagitis, Peptic; Gastroesophageal Reflux; Humans; Metoclopramide; Omeprazole; Piperidines; Ranitidine; Sucralfate | 1987 |
Pharmacokinetics of histamine (H2)-receptor antagonists, including roxatidine, in chronic renal failure.
Topics: Anti-Ulcer Agents; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; Kidney Failure, Chronic; Piperidines; Ranitidine; Renal Dialysis; Thiazoles | 1988 |
Clinical characteristics of roxatidine acetate: a review.
Topics: Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Gastric Acid; Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; Stomach Ulcer | 1988 |
Therapeutic approach in patients with concomitant disease/drug--drug interactions (roxatidine acetate).
Topics: Anti-Ulcer Agents; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Peptic Ulcer; Piperidines; Ranitidine; Structure-Activity Relationship | 1988 |
[H2-receptor antagonists and alcohol: clinical significance].
Topics: Cimetidine; Clinical Medicine; Drug Interactions; Ethanol; Famotidine; Gastric Mucosa; Histamine H2 Antagonists; Humans; Liver; Nizatidine; Piperidines; Ranitidine | 1996 |
Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antacids; Benzimidazoles; Cimetidine; Cisapride; Domperidone; Famotidine; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Lansoprazole; Metoclopramide; Nizatidine; Omeprazole; Pantoprazole; Piperidines; Proton Pump Inhibitors; Ranitidine; Sucralfate; Sulfoxides | 1996 |
Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux?: a critical review of the literature.
Topics: Antacids; Anti-Asthmatic Agents; Anti-Ulcer Agents; Asthma; Cimetidine; Circadian Rhythm; Cisapride; Gastroesophageal Reflux; Humans; Lung; Omeprazole; Peak Expiratory Flow Rate; Piperidines; Placebos; Randomized Controlled Trials as Topic; Ranitidine; Spirometry | 1998 |
17 trial(s) available for cimetidine and piperidines
| Article | Year |
|---|---|
[Plasma pharmacokinetics of roxatidine in the healthy man: correlation with gastric antisecretory effect].
Topics: Adult; Cimetidine; Double-Blind Method; Gastric Juice; Histamine H2 Antagonists; Humans; Male; Piperidines; Random Allocation; Ranitidine | 1990 |
Cisapride and cimetidine in the treatment of erosive esophagitis.
Topics: Cimetidine; Cisapride; Double-Blind Method; Drug Administration Schedule; Esophagitis, Peptic; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; Piperidines | 1990 |
Double-blind comparison of cisapride and cimetidine in treatment of reflux esophagitis.
Topics: Adult; Cimetidine; Cisapride; Double-Blind Method; Drug Evaluation; Esophagitis; Esophagoscopy; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Piperidines; Random Allocation; Serotonin Antagonists | 1990 |
The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.
Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Clinical Trials as Topic; Enzyme Induction; Enzymes; Half-Life; Humans; Male; Microsomes, Liver; Paroxetine; Phenobarbital; Piperidines; Serotonin Antagonists | 1989 |
The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates.
Topics: Adult; Antipyrine; Cimetidine; Half-Life; Histamine H2 Antagonists; Humans; Indocyanine Green; Liver; Male; Pharmaceutical Preparations; Piperidines; Trimethadione | 1989 |
Safety and efficacy of roxatidine acetate. Evidence from pharmacodynamic and clinical trials.
Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Histamine H2 Antagonists; Humans; Peptic Ulcer; Piperidines; Random Allocation; Ranitidine | 1989 |
Effects of roxatidine acetate hydrochloride and cimetidine on the pharmacokinetics of theophylline in healthy subjects.
Topics: Adult; Aminophylline; Cimetidine; Half-Life; Humans; Infusions, Intravenous; Male; Piperidines; Smoking; Theophylline | 1989 |
Clinical studies on the use of roxatidine acetate for the treatment of peptic ulcer in Japan.
Topics: Adult; Cimetidine; Duodenal Ulcer; Female; Gastrins; Histamine H2 Antagonists; Humans; Japan; Male; Middle Aged; Pepsinogens; Peptic Ulcer; Piperidines; Prolactin; Stomach Ulcer; Time Factors | 1988 |
Clinical characteristics of roxatidine acetate: a review.
Topics: Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Gastric Acid; Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; Stomach Ulcer | 1988 |
Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
Topics: Adult; Aged; Cimetidine; Cisapride; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Esophagitis, Peptic; Esophagoscopy; Female; Heartburn; Humans; Male; Middle Aged; Piperidines; Random Allocation | 1988 |
[Treatment of peptic ulcer in internal medicine practice. A multicenter comparative study with roxatidine and cimetidine].
Topics: Adolescent; Adult; Aged; Cimetidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Piperidines | 1993 |
[Effects of the histamine H2 receptor antagonist roxatidine acetate on stomach and liver alcohol dehydrogenase and serum alcohol level].
Topics: Adult; Alcohol Dehydrogenase; Alcohol Drinking; Animals; Cimetidine; Ethanol; Female; Guinea Pigs; Histamine H2 Antagonists; Humans; Liver; Male; Metabolic Clearance Rate; Piperidines; Stomach | 1993 |
New H2-receptor antagonist--roxatidine acetate--in treatment of duodenal ulcer.
Topics: Cimetidine; Double-Blind Method; Duodenal Ulcer; Female; Histamine H2 Antagonists; Humans; Male; Piperidines | 1993 |
Cisapride or cimetidine in the treatment of functional dyspepsia. Results of a double-blind, randomized, Swiss multicentre study.
Topics: Adult; Cimetidine; Cisapride; Double-Blind Method; Dyspepsia; Female; Humans; Male; Piperidines; Treatment Outcome | 1994 |
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.
Topics: Adult; Blood Pressure; Butyrophenones; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines | 1993 |
Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses.
Topics: Administration, Oral; Adult; Cholinesterase Inhibitors; Cimetidine; Cross-Over Studies; Donepezil; Drug Interactions; Histamine H2 Antagonists; Humans; Indans; Male; Middle Aged; Piperidines | 1998 |
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Cimetidine; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Food-Drug Interactions; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Uracil; Young Adult | 2010 |
126 other study(ies) available for cimetidine and piperidines
| Article | Year |
|---|---|
Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists.
Topics: Animals; Benzothiazoles; Brain; Cimetidine; Histamine H2 Antagonists; Injections, Intraventricular; Male; Morphine; Nociceptors; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Thiazoles | 1992 |
An in vivo and in vitro study of the vestibular nuclei histaminergic receptors in the guinea pig.
Topics: Animals; Brain Stem; Cimetidine; Electric Stimulation; Eye Movements; Guanidines; Guinea Pigs; Head; Imidazoles; Impromidine; In Vitro Techniques; Methylhistamines; Piperidines; Receptors, Histamine; Receptors, Histamine H2; Reflex, Vestibulo-Ocular; Rotation; Vestibular Nuclei | 1992 |
The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells.
Topics: Adenoids; Cimetidine; Concanavalin A; Guanidines; Histamine Antagonists; Humans; Hydroxyzine; Imidazoles; Impromidine; Mast Cells; Meclizine; Methylhistamines; Piperidines; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3 | 1991 |
Characterization of an accessory binding area in the histamine H2 receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Cimetidine; Guinea Pigs; Heart Atria; Histamine H2 Antagonists; Ileum; Male; Piperidines; Ranitidine; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles | 1991 |
Time-dependent interaction of a new H2-receptor antagonist, IT-066, with the receptor in the atria of guinea pig.
Topics: Animals; Binding, Competitive; Cimetidine; Famotidine; Guinea Pigs; Heart Atria; Heart Rate; Histamine H2 Antagonists; Kinetics; Male; Myocardium; Piperidines; Pyridines; Receptors, Histamine H2; Stimulation, Chemical; Time Factors | 1991 |
Effect of cimetidine administration on the pharmacokinetics of pirmenol.
Topics: Administration, Oral; Adult; Cimetidine; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Piperidines | 1992 |
Pharmacokinetics of paroxetine in patients with cirrhosis.
Topics: Adult; Aged; Cimetidine; Disulfiram; Drug Interactions; Female; Half-Life; Humans; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists | 1991 |
H2-receptor antagonism by a novel compound IT-066 assessed from [14C]aminopyrine accumulation in rabbit parietal cells.
Topics: Aminopyrine; Animals; Anti-Ulcer Agents; Bucladesine; Carbachol; Cimetidine; Famotidine; Gastric Mucosa; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Piperidines; Pyridines; Rabbits | 1990 |
Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats.
Topics: Animals; Cimetidine; Cold Temperature; Cysteamine; Dose-Response Relationship, Drug; Duodenal Neoplasms; Famotidine; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Perfusion; Piperidines; Pyridines; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1990 |
Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats.
Topics: Acetamides; Animals; Cimetidine; Duodenal Ulcer; Famotidine; Gastric Acid; Gastric Mucosa; Guinea Pigs; Heart Atria; Heart Rate; Histamine H2 Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Pylorus; Rats; Rats, Inbred Strains; Stomach Ulcer | 1990 |
Histamine H3 receptors modulate antigen-induced bronchoconstriction in guinea pigs.
Topics: Animals; Antigens; Bronchoconstriction; Cimetidine; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Guinea Pigs; Histamine; Immunization; Male; Ovalbumin; Piperidines; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Skin Tests | 1990 |
Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous System; Blood Platelets; Bradycardia; Chemoreceptor Cells; Cimetidine; Complement C3; Dextran Sulfate; Dextrans; Factor XII; Histamine; Histamine Release; Hypotension; Injections, Intravenous; Ketanserin; Leukocyte Count; Lung; Male; Methysergide; Piperidines; Rabbits; Serotonin | 1985 |
Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin.
Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Diazepam; Digoxin; Drug Interactions; Humans; Male; Paroxetine; Piperidines; Serotonin Antagonists; Warfarin | 1989 |
A role for histamine and H2-receptors in opioid antinociception.
Topics: Analgesia; Animals; Benzothiazoles; Cimetidine; Histamine; Male; Morphine; Phenoxypropanolamines; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Receptors, Opioid; Thiazoles | 1989 |
Cisapride-cimetidine interaction: enhanced cisapride bioavailability and accelerated cimetidine absorption.
Topics: Adult; Biological Availability; Cimetidine; Cisapride; Drug Interactions; Female; Half-Life; Humans; Male; Piperidines | 1989 |
Histamine H2-receptor antagonistic action of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)acetoxyacetamide hydrochloride (TZU-0460).
Topics: Animals; Cimetidine; Dimaprit; Dogs; Female; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Relaxation; Piperidines; Rats; Thiourea; Uterus | 1985 |
Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase.
Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cimetidine; Famotidine; Guinea Pigs; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Ranitidine; Thiazoles | 1986 |
Effects of centrally administered H2 antagonists on motor activity.
Topics: Animals; Chlorpheniramine; Cimetidine; Histamine H2 Antagonists; Imidazoles; Impromidine; Male; Mice; Motor Activity; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2 | 1987 |
A comparison of the inhibitory effects of roxatidine acetate hydrochloride and cimetidine on cytochrome P-450-mediated drug-metabolism in mouse hepatic microsomes and in man in vivo.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Histamine H2 Antagonists; Humans; Inactivation, Metabolic; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Piperidines; Steroid 16-alpha-Hydroxylase | 1987 |
Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist.
Topics: Animals; Benzothiazoles; Binding, Competitive; Brain Chemistry; Cimetidine; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine H2 Antagonists; In Vitro Techniques; Male; Phenoxypropanolamines; Piperidines; Rats; Thiazoles; Uterus | 1988 |
Pharmacological profile of new histamine H2-receptor antagonists related to cimetidine, ranitidine and lamtidine.
Topics: Animals; Cimetidine; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Male; Piperidines; Rana temporaria; Ranitidine; Rats; Receptors, Histamine H2; Stomach; Triazoles | 1988 |
Cimetidine plus cisapride for reflux oesophagitis.
Topics: Cimetidine; Cisapride; Drug Therapy, Combination; Esophagitis, Peptic; Humans; Piperidines | 1988 |
Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats.
Topics: Animals; Azepines; Blood Pressure; Brain; Cimetidine; Clonidine; Hydroxydopamines; Injections, Intraventricular; Ketanserin; Male; Methoxamine; Oxidopamine; Piperidines; Prazosin; Procaine; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
Altered pharmacokinetics of oral flecainide by cimetidine.
Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Flecainide; Half-Life; Humans; Kinetics; Male; Piperidines | 1986 |
Femoxetine and cimetidine: interaction in healthy volunteers.
Topics: Adult; Antidepressive Agents; Cimetidine; Drug Interactions; Female; Humans; Kinetics; Male; Piperidines | 1986 |
Pharmacologic effect of somatostatin on bile formation in the dog. Enhanced ductular reabsorption as the major mechanism of anticholeresis.
Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Bile Ducts; Cimetidine; Depression, Chemical; Dogs; Erythritol; Piperidines; Secretin; Somatostatin; Vagus Nerve | 1983 |
Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog.
Topics: Animals; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Histamine H2 Antagonists; Male; Piperidines; Pyrimidinones; Ranitidine; Time Factors; Triazoles | 1983 |
The effect of antihistaminics on cataleptogenic action of analgesics and haloperidol.
Topics: Analgesics; Analgesics, Opioid; Animals; Catalepsy; Cimetidine; Diphenhydramine; Drug Interactions; Female; Haloperidol; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Piperidines; Pyrilamine; Rats; Rats, Inbred Strains | 1983 |
Antisecretory activity of fenoctimine in rat and dog.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cimetidine; Dogs; Drug Evaluation, Preclinical; Drug Tolerance; Female; Gastric Fistula; Gastric Mucosa; Injections, Intraperitoneal; Piperidines; Rats; Rats, Inbred Strains | 1984 |
Potent and specific blockade by AH 22216 of histamine-H2-receptor-mediated acid secretion in isolated rabbit gastric cells.
Topics: Aminopyrine; Animals; Cimetidine; Gastric Acid; Gastric Mucosa; Histamine; Male; Piperidines; Rabbits; Receptors, Histamine; Receptors, Histamine H2; Triazoles | 1983 |
Pharmacological studies of allergic cough in the guinea pig.
Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsaicin; Chlorpheniramine; Cimetidine; Codeine; Cough; Drug Hypersensitivity; Guinea Pigs; Hexamethonium; Histamine Antagonists; Indomethacin; Injections, Subcutaneous; Ipratropium; Loratadine; Male; Ovalbumin; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2 | 1995 |
Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats.
Topics: Animals; Biological Transport; Chlorpheniramine; Cimetidine; Dietary Fats; Histamine Antagonists; Histamine Release; Intestinal Mucosa; Intestines; Lymph; Male; Ornithine Decarboxylase; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Reperfusion Injury | 1994 |
Possible participation of histamine H3-receptors in the regulation of anaphylactic histamine release from isolated rat peritoneal mast cells.
Topics: Anaphylaxis; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Histamine; Histamine Agonists; Histamine Antagonists; Histamine Release; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mast Cells; Methylhistamines; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Peritoneum; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H3 | 1994 |
Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice.
Topics: Animals; Benzothiazoles; Cimetidine; Dimaprit; Female; Histamine Agonists; Histamine H2 Antagonists; Mice; Mice, Inbred Strains; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Restraint, Physical; Stress, Psychological; Thiazoles | 1995 |
R-alpha-methylhistamine-induced inhibition of gastric acid secretion in pylorus-ligated rats via central histamine H3 receptors.
Topics: Animals; Cimetidine; Female; Gastric Acid; Gastric Mucosa; Histamine Agonists; Histamine Antagonists; Injections, Intraventricular; Methylhistamines; Piperidines; Pylorus; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H3 | 1995 |
Dimaprit, a histamine H2-agonist, inhibits anaphylactic histamine release from mast cells and the decreased release is restored by thioperamide (H3-antagonist), but not by cimetidine (H2-antagonist).
Topics: Anaphylaxis; Animals; Anticonvulsants; Betahistine; Cimetidine; Dimaprit; Histamine H2 Antagonists; Histamine Release; In Vitro Techniques; Indicators and Reagents; Male; Mast Cells; Piperidines; Pyrilamine; Rats; Rats, Wistar | 1993 |
[Studies on histamine H2-receptor antagonistic property of FRG-8813, a novel anti-ulcer drug].
Topics: Acetamides; Aminopyrine; Animals; Cerebral Cortex; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Pyridines; Stimulation, Chemical; Time Factors | 1995 |
Characterization and function of histamine receptors in corpus cavernosum.
Topics: Acetylcholine; Animals; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Electric Stimulation; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Male; Methylhistamines; Muscle Contraction; Papaverine; Penis; Piperidines; Pyrilamine; Rabbits; Receptors, Histamine; Thiazoles | 1995 |
[Effects of FRG-8813, a new histamine H2-receptor antagonist, on gastric mucus in rats].
Topics: Acetamides; Administration, Oral; Animals; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Gastric Mucosa; Hexoses; Histamine H2 Antagonists; Male; Mucus; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley | 1994 |
Pharmacological characterization of the inhibitory effect of (R)-alpha-methylhistamine on sympathetic cardiopressor responses in the pithed guinea-pig.
Topics: Adrenalectomy; Animals; Blood Pressure; Chlorpheniramine; Cimetidine; Drug Interactions; Electric Stimulation; Epinephrine; Guinea Pigs; Heart; Heart Rate; Histamine Agonists; Male; Methylhistamines; Piperidines; Prazosin; Spinal Cord; Sympathetic Nervous System; Vagotomy; Yohimbine | 1994 |
[Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying].
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Famotidine; Gastric Emptying; Gastrointestinal Motility; Histamine H2 Antagonists; Nizatidine; Piperidines; Ranitidine | 1993 |
Species differences in the cardiovascular responses to histamine H3 receptor activation.
Topics: Animals; Blood Pressure; Cimetidine; Guinea Pigs; Heart Rate; Hemodynamics; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Piperidines; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Histamine H3; Species Specificity | 1994 |
Mechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current.
Topics: Cerebral Cortex; Cimetidine; Evoked Potentials; Histamine; Histamine Antagonists; Humans; Hypnotics and Sedatives; Membrane Potentials; Neurons; Piperidines; Potassium Channels; Pyrilamine; Receptors, Histamine H1 | 1994 |
Histamine H3 receptor activation inhibits sympathetic-cholinergic responses in cats.
Topics: Animals; Cats; Chlorpheniramine; Cimetidine; Electric Stimulation; Female; Histamine Agonists; Male; Methacholine Chloride; Methylhistamines; Parasympathetic Nervous System; Piperidines; Receptors, Histamine H3; Skin; Sympathetic Nervous System | 1994 |
Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea.
Topics: Animals; Cerebral Cortex; Cimetidine; Dogs; Famotidine; Food; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine H2 Antagonists; In Vitro Techniques; Kinetics; Male; Phenylurea Compounds; Piperidines; Pylorus; Rats; Rats, Wistar; Tetragastrin | 1993 |
Gastric antisecretory effect of FRG-8813, a new histamine H2 receptor antagonist, in rats and dogs.
Topics: Acetamides; Animals; Cimetidine; Dogs; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Ligation; Male; Perfusion; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley | 1993 |
Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Body Weight; Bone Resorption; Calcium; Child; Cimetidine; Female; Histamine H2 Antagonists; Humans; Hydroxyproline; Male; Middle Aged; Omeprazole; Osteocalcin; Piperidines; Proton Pump Inhibitors; Stomach Ulcer | 1993 |
Effect of the novel histamine H2-antagonist 5,6-dimethyl-2-[4-[3-(1- piperidinomethyl)phenoxy]-(z)-2-butenylamino]-4(1H)-pyrimidine dihydrochloride on histamine-induced gastric acid secretion in Heidenhain pouch dogs.
Topics: Administration, Oral; Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Injections, Intravenous; Male; Piperidines; Pyrimidinones | 1993 |
[The pharmacodynamics of troxipide on experimental gastric ulcers in rats].
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Male; Piperidines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Physiological | 1993 |
Effect of histamine on memory retrieval in old rats.
Topics: Acetylcholine; Aging; Animals; Anticonvulsants; Avoidance Learning; Cerebrovascular Circulation; Cimetidine; Dose-Response Relationship, Drug; Exploratory Behavior; Histamine; Histamine Agonists; Injections, Intraventricular; Male; Memory; Methylhistamines; Motor Activity; Piperidines; Pyrilamine; Rats; Rats, Wistar | 1993 |
Medial vestibular nucleus in the guinea-pig: histaminergic receptors. II. An in vivo study.
Topics: Animals; Anticonvulsants; Cimetidine; Electroencephalography; Guinea Pigs; Impromidine; Injections, Intraperitoneal; Perfusion; Piperidines; Posture; Receptors, Histamine; Reflex, Vestibulo-Ocular; Vestibular Nuclei | 1993 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Coloring Agents; Dose-Response Relationship, Drug; Evans Blue; Histamine Antagonists; Indoles; Inflammation; Isoindoles; Methysergide; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Neurokinin-1; Serotonin; Serotonin Antagonists; Substance P; Trachea | 1995 |
Cholinergic nucleus basalis neurons are excited by histamine in vitro.
Topics: Action Potentials; Animals; Cholinergic Fibers; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Antagonists; In Vitro Techniques; Neurons; Piperidines; Substantia Innominata | 1995 |
Drug interactions between theophylline and H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic analysis in rats in vivo.
Topics: Animals; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Histamine H2 Antagonists; Male; Piperidines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Theophylline | 1995 |
Histaminergic control of mucosal repair in the small intestine.
Topics: Animals; Biological Transport; Chlorpheniramine; Cimetidine; Enzyme Inhibitors; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine Decarboxylase; Intestinal Mucosa; Ischemia; Lipid Metabolism; Lymph; Male; Methylhistidines; Piperidines; Rats; Rats, Sprague-Dawley; Reperfusion | 1995 |
Effect of oxitropium bromide on histamine-induced airway goblet cell secretion.
Topics: Administration, Inhalation; Aerosols; Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Antagonists; Histocytochemistry; Injections, Intravenous; Male; Mucus; Muscarinic Antagonists; Piperidines; Pyrilamine; Receptors, Histamine; Scopolamine Derivatives; Trachea; Vagus Nerve | 1996 |
[Influence of KU-1257 on the recurrence and relapse of acetic acid-induced chronic gastric ulcers in rats].
Topics: Acetates; Acetic Acid; Animals; Chronic Disease; Cimetidine; Histamine H2 Antagonists; Male; Phenylurea Compounds; Piperidines; Rats; Rats, Wistar; Recurrence; Stomach Ulcer; Time Factors | 1996 |
Evidence for bidirectional histamine transport by murine hematopoietic progenitor cells.
Topics: Animals; Biological Transport; Calcium; Cell Line; Cetirizine; Cimetidine; Female; Hematopoietic Stem Cells; Histamine; Histamine Antagonists; Interleukin-3; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidinones; Sodium | 1996 |
Different effects of H1 and H2 blockers on the tone and the contractile activity of guinea pig stomach fundus.
Topics: Acetylcholine; Animals; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Muscle, Smooth; Piperidines; Ranitidine; Stomach | 1995 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; Iris; Lethal Dose 50; Male; Methylhistamines; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Piperidines; Potassium; Pyrilamine; Ranitidine; Receptors, Histamine H1; Substance P | 1996 |
Reduction of the pressor response to nicotine in the guinea pigs by a histamine (H3) agonist is attenuated by an inhibitor of nitric oxide synthesis.
Topics: Adrenalectomy; Animals; Arginine; Blood Pressure; Cimetidine; Guinea Pigs; Heart Rate; Histamine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide Synthase; Piperidines | 1996 |
Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.
Topics: Amanitins; Antibodies, Blocking; Antigens, CD; Cell Adhesion; Cells, Cultured; Cimetidine; Eosinophils; Histamine; Histamine Antagonists; Humans; Immunohistochemistry; Integrin alpha4; Interleukin-4; Piperidines; Platelet Activating Factor; Pyrilamine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1996 |
Circadian rhythm photic phase shifts are not altered by histamine receptor antagonists.
Topics: Animals; Benzothiazoles; Cimetidine; Circadian Rhythm; Cricetinae; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mesocricetus; Phenoxypropanolamines; Photoperiod; Piperidines; Pyrilamine; Receptors, Histamine H3; Thiazoles | 1996 |
Report from the NASPGN Therapeutics Subcommittee. Cisapride and the attack of the P-450s.
Topics: Anti-Ulcer Agents; Child; Cimetidine; Cisapride; Cytochrome P-450 Enzyme System; Drug Interactions; Gastroesophageal Reflux; Humans; Piperidines; Ranitidine | 1996 |
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycoproteins; Guanidines; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine N-Methyltransferase; Male; Methylhistamines; Mucus; Piperidines; Pyrilamine; Recombinant Proteins; Trachea | 1997 |
Effects of naltrexone and histamine antagonists on the antinociceptive activity of the cimetidine analog SKF92374 in rats.
Topics: Analgesics, Non-Narcotic; Animals; Cimetidine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Naltrexone; Narcotic Antagonists; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1997 |
[Effect of a novel antiulcer drug, lafutidine, on experimental chronic gastritis in rats].
Topics: Acetamides; Ammonia; Animals; Anti-Ulcer Agents; Cell Count; Chronic Disease; Cimetidine; Famotidine; Gastric Mucosa; Gastritis; Humans; Male; Parietal Cells, Gastric; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 1997 |
"Infantile colic" as the sole manifestation of gastroesophageal reflux.
Topics: Administration, Oral; Anti-Ulcer Agents; Cimetidine; Cisapride; Colic; Esophagus; Female; Follow-Up Studies; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Infant; Male; Piperidines; Prospective Studies | 1997 |
Effect of histamine on intracellular Ca2+ concentration in guinea pig isolated vestibular hair cells.
Topics: Afferent Pathways; Animals; Calcium; Cimetidine; Cytoplasm; Endolymphatic Sac; Extracellular Space; Fluorescent Dyes; Fura-2; Guinea Pigs; Hair Cells, Vestibular; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Mast Cells; Piperidines; Promethazine; Receptors, Cell Surface; Signal Transduction; Vestibular Nerve | 1997 |
Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells.
Topics: Adenylyl Cyclases; Animals; Baculoviridae; beta-Cyclodextrins; Blotting, Western; Cell Line, Transformed; Cholesterol; Cimetidine; Cyclic AMP; Cyclodextrins; Epitopes; Fluorescent Antibody Technique; Guanidines; Histamine H2 Antagonists; Histidine; Insecta; Microscopy, Confocal; Oligonucleotides; Piperidines; Ranitidine; Rats; Receptors, Histamine H2; Transfection | 1997 |
Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat.
Topics: Adamantane; Analysis of Variance; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cats; Cimetidine; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Histamine Antagonists; Male; Meclofenamic Acid; Mesentery; Morpholines; NG-Nitroarginine Methyl Ester; Piperidines; Potassium Channels; Pyrilamine | 1997 |
The vascular mechanism of action of betahistine in the inner ear of the guinea pig.
Topics: Animals; Betahistine; Cimetidine; Cochlea; Ear, Inner; Female; Guinea Pigs; Histamine Antagonists; Idazoxan; Male; Methylhistamines; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Vasodilator Agents | 1998 |
Thioperamide, a histamine H3-receptor blocker, facilitates vasopressor response to footshocks.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cimetidine; Electric Stimulation; Enzyme Inhibitors; Heart Rate; Hindlimb; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Methylhistidines; Norepinephrine; Phentolamine; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Vasoconstrictor Agents | 1998 |
[Effect of lafutidine, a novel antiulcer agent, on healing and relapse of acetic acid-induced gastric ulcer in rats].
Topics: Acetamides; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Recurrence; Stomach Ulcer | 1998 |
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin | 1998 |
Effect of histamine H2 and H3 receptor modulation in the septum on post-training memory processing.
Topics: Animals; Cimetidine; Dimaprit; Histamine Agonists; Histamine Antagonists; Imidazoles; Limbic System; Male; Memory; Mice; Piperidines; Thiourea | 1998 |
Interaction of the new histamine H2-receptor antagonist pibutidine hydrochloride with canine cloned H2-receptor expressed cells.
Topics: Alanine; Animals; Cell Line; Cimetidine; Dogs; Famotidine; Histamine H2 Antagonists; Ligands; Mice; Mutation; Piperidines; Pyridines; Ranitidine; Receptors, Histamine H2; Transfection | 1999 |
Acetylcholine release from hippocampus of freely moving rats is modulated by thioperamide and cimetidine.
Topics: Acetylcholine; Animals; Cimetidine; Hippocampus; Histamine Antagonists; Histamine H2 Antagonists; Male; Piperidines; Rats; Rats, Wistar | 1999 |
Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Capsaicin; Cimetidine; Denervation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Famotidine; Food; Indomethacin; Male; Nitroarginine; Piperidines; Pyloric Antrum; Pyridines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Wound Healing | 1999 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Effect of lafutidine, a novel histamine H2-receptor antagonist, on monochloramine-induced gastric lesions in rats: role of capsaicin-sensitive sensory neurons.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Chloramines; Cimetidine; Gastric Mucosa; Histamine H2 Antagonists; Ischemia; Membrane Potentials; Neurons, Afferent; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stomach; Stomach Ulcer | 1999 |
Drug interaction studies with repaglinide: repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics.
Topics: Adolescent; Adult; Carbamates; Cimetidine; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Mixed Function Oxygenases; Piperidines; Theophylline | 2000 |
Long-lasting binding of IT-066 to human histamine H2 receptor.
Topics: Animals; Anti-Ulcer Agents; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Famotidine; Fixatives; Formaldehyde; Histamine H2 Antagonists; Piperidines; Polymers; Protein Binding; Pyridines; Ranitidine; Receptors, Histamine H2 | 2000 |
Drug interactions and donepezil.
Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines | 2000 |
Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the submucous plexus of guinea-pig small intestine.
Topics: Animals; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Intestine, Small; Male; Methylhistamines; Norepinephrine; Phentolamine; Piperidines; Receptors, Histamine H3; Submucous Plexus; Synaptic Transmission | 2000 |
Thioperamide and cimetidine modulate acetylcholine release from the amygdala of freely moving rats.
Topics: Acetylcholine; Amygdala; Animals; Cimetidine; Histamine Antagonists; Histamine H2 Antagonists; Male; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H3 | 2000 |
Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain.
Topics: Animals; Autoradiography; Brain; Cimetidine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Agonists; Histamine Antagonists; Imidazoles; Kinetics; Male; Methylhistamines; Piperidines; Pyrilamine; Radioligand Assay; Receptors, Histamine H3; Sulfur Radioisotopes; Thiourea; Tritium; Zebrafish | 2000 |
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles | 2000 |
Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice.
Topics: Animals; Anxiety; Cimetidine; Disease Models, Animal; Histamine Antagonists; Histamine Release; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; p-Methoxy-N-methylphenethylamine; Piperidines; Pyrilamine | 2000 |
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.
Topics: Acetylcholine; Amiloride; Cimetidine; Corticosterone; DNA, Antisense; Dose-Response Relationship, Drug; Female; Guanidine; Humans; In Vitro Techniques; Norepinephrine; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Piperidines; Placenta; Pregnancy; Procaine; Quinine; Time Factors; Verapamil | 2001 |
Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Cells, Cultured; Cimetidine; GTP-Binding Protein alpha Subunits, Gs; Guanidine; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Histamine Agonists; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Conformation; Protein Isoforms; Ranitidine; Receptors, Histamine H2; Sequence Homology, Amino Acid; Species Specificity; Structure-Activity Relationship; Sulfur Radioisotopes; Tritium | 2001 |
Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; Cimetidine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Granulation Tissue; Histamine; Histamine Antagonists; Immunohistochemistry; Indoles; Indomethacin; Inflammation; Isoquinolines; Lymphokines; Macrophages, Peritoneal; Male; Maleimides; Naphthalenes; Neovascularization, Pathologic; Piperidines; Protein Kinase C; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H2; RNA, Messenger; Specific Pathogen-Free Organisms; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Potent and long-lasting action of lafutidine on the human histamine H(2) receptor.
Topics: Acetamides; Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Humans; Piperidines; Pyridines; Receptors, Histamine H2; Transfection | 2001 |
Effects of N-alpha-methyl-histamine on human H(2) receptors expressed in CHO cells.
Topics: Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Famotidine; Female; Histamine Agonists; Histamine Antagonists; Histamine H2 Antagonists; Methylhistamines; Ovary; Piperidines; Receptors, Histamine H2; Receptors, Histamine H3 | 2002 |
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
Topics: Analgesics; Animals; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Ventricles; Cimetidine; Dronabinol; Endocannabinoids; Hot Temperature; Injections, Intraventricular; Male; Mice; Pain; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2002 |
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Cloning, Molecular; Corticosterone; Dose-Response Relationship, Drug; Gene Expression; Genetic Vectors; Humans; Imidazoles; Kinetics; Mice; Norepinephrine; Organic Cation Transport Proteins; Papaverine; Piperidines; Quinolines; Rats; Thiourea; Transfection; Tritium | 2002 |
Evidence for the involvement of a macrophage-derived chemotactic mediator in the neutrophil recruitment induced by staphylococcal enterotoxin B in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Capsaicin; Chemotaxis, Leukocyte; Cimetidine; Dexamethasone; Diterpenes; Enterotoxins; Enzyme Inhibitors; Ginkgolides; Hydroxamic Acids; Indomethacin; Interleukin-8; Lactones; Macrophages, Peritoneal; Male; Mice; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar | 2002 |
Functional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi.
Topics: Animals; Bronchi; Cattle; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H2 Antagonists; Muscle Relaxation; Muscle, Smooth; Piperidines; Receptors, Histamine H2; Receptors, Histamine H3; Respiratory Mucosa; Trachea | 2003 |
Histaminergic modulation of the intact respiratory network of adult mice.
Topics: Animals; Cimetidine; Histamine; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Hypoxia; Medulla Oblongata; Mice; Mice, Inbred C57BL; Nerve Net; Neurons; Phrenic Nerve; Piperidines; Pons; Pyrilamine; Receptors, Histamine H3; Respiratory System | 2003 |
Lafutidine vs cimetidine to decrease gastric fluid acidity and volume in children.
Topics: Acetamides; Adolescent; Anesthesia, General; Child; Child, Preschool; Cimetidine; Gastric Acid; Gastric Acidity Determination; Gastric Juice; Histamine H2 Antagonists; Humans; Piperidines; Pneumonia, Aspiration; Pyridines | 2003 |
Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo.
Topics: Animals; Bone Marrow Cells; Carrageenan; Cimetidine; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Leukotriene B4; Mast Cells; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Piperidines; Pleurisy; Pyrilamine; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Zymosan | 2003 |
Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cimetidine; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Piperidines; Xenograft Model Antitumor Assays | 2003 |
Estimation of pK(a) values using microchip capillary electrophoresis and indirect fluorescence detection.
Topics: Aniline Compounds; Chemical Phenomena; Chemistry, Physical; Cimetidine; Electrophoresis, Microchip; Ethosuximide; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Piperidines; Prilocaine; Procaine; Pyridines; Ranitidine; Reproducibility of Results; Rhodamines; Sulfanilamide; Sulfanilamides; Uracil | 2005 |
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles | 2005 |
Histamine regulates growth of malignant melanoma implants via H2 receptors in mice.
Topics: Administration, Oral; Animals; Cell Line, Tumor; Cell Proliferation; Cimetidine; Dose-Response Relationship, Drug; Gene Expression; Histamine; Histamine Agents; Histamine H2 Antagonists; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Piperidines; Receptors, Histamine H2; RNA, Messenger | 2005 |
Histamine-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue cultures.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Kinetics; Male; Oxytocin; Piperidines; Pituitary Gland, Posterior; Pyrilamine; Rats; Tissue Culture Techniques; Vasopressins | 2006 |
Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cell Line; Cimetidine; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Injections, Intraventricular; Male; Pain Measurement; Pain Threshold; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Rimonabant; Sulfur Isotopes | 2006 |
Identification of zebrafish histamine H1, H2 and H3 receptors and effects of histaminergic ligands on behavior.
Topics: Animals; Behavior, Animal; Cimetidine; Histamine Agonists; Histamine Antagonists; Imidazoles; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Zebrafish | 2007 |
Improgan-induced hypothermia: a role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature.
Topics: Analgesics; Animals; Body Temperature; Cimetidine; Imidazoles; Male; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sulfides | 2007 |
Significance of cannabinoid CB1 receptors in improgan antinociception.
Topics: Analgesics; Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Prophylactic effect of lafutidine against the adverse reaction induced in rat stomach by repeated administration of 5-fluorouracil.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Cimetidine; Dinoprostone; Drug Interactions; Fluorouracil; Gastric Mucosa; Hydrochloric Acid; Male; Membrane Potentials; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach; Stomach Ulcer; Taurocholic Acid | 2007 |
Specific cerebral heat shock proteins and histamine receptor cross-talking mechanisms promote distinct lead-dependent neurotoxic responses in teleosts.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Brain; Brain Chemistry; Cimetidine; Fishes; Fluoresceins; Fluorescent Dyes; Heat-Shock Proteins; Histamine H2 Antagonists; Histamine H3 Antagonists; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; In Situ Hybridization; Injections, Intraperitoneal; Lead Poisoning, Nervous System; Molecular Sequence Data; Organic Chemicals; Piperidines; Receptor Cross-Talk; Receptors, Histamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Benzylamines; Brain; Chlorpheniramine; Cimetidine; Exploratory Behavior; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine H3 Antagonists; Male; Motor Activity; Norepinephrine; Piperidines; Rats; Rats, Wistar; Sympathomimetics | 2008 |
Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Brain Stem; Cannabinoid Receptor Modulators; Cimetidine; Male; Microinjections; Morpholines; Naphthalenes; Neural Pathways; Nociceptors; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Piperidines; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rhombencephalon; Rimonabant | 2009 |
Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model.
Topics: Animals; Cell Count; Cimetidine; Cyclophosphamide; Cyclosporine; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Ear Auricle; Eosinophil Peroxidase; Eosinophils; Gene Expression; Histamine; Histamine Antagonists; Immunoglobulin E; Interferon-gamma; Interleukin-4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Picryl Chloride; Piperidines; Pyrilamine; Tetradecanoylphorbol Acetate; Thymic Stromal Lymphopoietin | 2009 |
Characterization of histamine-induced relaxation in pre-contracted rat aorta.
Topics: Animals; Aorta; Cimetidine; Ethylenediamines; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine H3 Antagonists; Male; Muscle Relaxation; Piperidines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Histamine | 2009 |
Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine.
Topics: Acetamides; Animals; Cimetidine; Female; Gastric Acid; Gastric Emptying; Gastric Mucosa; Histamine H2 Antagonists; Hydrochloric Acid; Hydrogen-Ion Concentration; Models, Animal; Neurons, Afferent; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Solitary Nucleus; Stomach; Time Factors | 2009 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Intestinal Secretions; Male; Mecamylamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neural Inhibition; Neurogenic Bowel; Neurokinin-1 Receptor Antagonists; Nicotinic Antagonists; Piperidines; Propane; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Histamine H2; Receptors, Neurokinin-1; Reflex; Theophylline; Xanthines | 2009 |
Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats.
Topics: Analgesia; Animals; Benzothiazoles; Cholestasis; Cimetidine; Dimaprit; Disease Models, Animal; Histamine H2 Antagonists; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Perception; Phenoxypropanolamines; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H2; Rotarod Performance Test | 2011 |
A single LC-tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma.
Topics: Acetamides; Calibration; Chromatography, Liquid; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; Piperidines; Pyridines; Ranitidine; Reproducibility of Results; Tandem Mass Spectrometry; Therapeutic Equivalency | 2009 |
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Capsaicin; Cimetidine; Disease Models, Animal; Enterobacteriaceae; Famotidine; Histamine H2 Antagonists; Intestinal Mucosa; Intestine, Small; Male; Mucin-2; Nitric Oxide Synthase Type II; Omeprazole; Peptic Ulcer; Peroxidase; Phenylpropionates; Piperidines; Proton Pump Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensory Receptor Cells | 2010 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mucus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptic Ulcer; Piperidines; Prostaglandins; Rats; Rats, Sprague-Dawley | 2010 |
Histamine is a modulator of metamorphic competence in Strongylocentrotus purpuratus (Echinodermata: Echinoidea).
Topics: Animals; Apoptosis; Chlorpheniramine; Cimetidine; Ectoderm; Gene Expression Regulation, Developmental; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine H3 Antagonists; Histidine Decarboxylase; Larva; Metamorphosis, Biological; Methylhistidines; Organ Specificity; Piperidines; Receptors, Histamine H1; Strongylocentrotus purpuratus | 2012 |
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.
Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium | 2013 |
Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives.
Topics: Animals; Cimetidine; Guanidines; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Piperidines; Pyrilamine | 2013 |
TCTP from
Topics: Animals; Biomarkers, Tumor; Cimetidine; Cromolyn Sodium; Dose-Response Relationship, Drug; Hypersensitivity; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Mast Cells; Mice; Phosphoric Diester Hydrolases; Piperidines; Promethazine; Rabbits; Rats; Skin Diseases; Spider Venoms; Tumor Cells, Cultured; Tumor Protein, Translationally-Controlled 1 | 2019 |