cimetidine has been researched along with p-aminohippuric acid in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.50) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 20 (50.00) | 29.6817 |
| 2010's | 5 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Babbitt, PC; Chun, JK; Dresser, MJ; Giacomini, KM; Zhang, L | 1 |
| Inui, KI; Ito, T; Tanaka, K; Yano, I | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Jung, KY; Kim, DK; Narikawa, S; Sekine, T; Takeda, M; Tojo, A; Yoo, BS | 1 |
| Endou, H; Kusuhara, H; Nagata, Y; Sugiyama, Y | 1 |
| Endou, H; Kobayashi, Y; Ohshiro, N; Sasaki, T; Sekine, T; Shibusawa, A; Tokuyama, S; Yamamoto, T | 1 |
| Deguchi, T; Hosoya, K; Kang, YS; Mori, S; Ohtsuki, S; Takanaga, H; Terasaki, T | 1 |
| Bahn, A; Bakhiya, A; Burckhardt, G; Wolff, N | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Kobayashi, Y; Kohyama, N; Ohbayashi, M; Ohshiro, N; Tsuchiya, A; Yamamoto, T | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hirai, M; Hori, R; Kaneko, S; Katsura, T; Satoh, M; Takano, M; Yasuhara, M | 1 |
| Brändle, E; Greven, J | 1 |
| Hanano, M; Iga, T; Okudaira, N; Sawada, Y; Sugiyama, Y | 1 |
| Francalanza, G; Franco, C; Giachetti, A | 1 |
| Herbert, BH; Nelson, JA; Santos, G | 1 |
| Russo, J; Saffle, JR; Schentag, JJ; Smith, IL; Warden, GD; Watson, WA; Ziemniak, JA | 1 |
| Grantham, JJ | 1 |
| Cacini, W; Grund, VR; Keller, MB | 1 |
| McKinney, TD; Myers, P; Speeg, KV | 1 |
| Hashimoto, Y; Inui, K; Ito, T; Masuda, S; Yano, I | 1 |
| Hashimoto, Y; Inui, K; Ito, T; Yano, I | 1 |
| Dresser, MJ; Feng, B; Giacomini, KM; Johns, SJ; Shu, Y | 1 |
| Barrett, J; Cihlar, T; Hill, G; Ho, ES; Liu, B; Oo, C; Prior, K; Ward, P; Wiltshire, H | 1 |
| Feng, B; Giacomini, KM; Shu, Y | 1 |
| Inui, K; Ji, L; Masuda, S; Saito, H | 1 |
| Doi, Y; Hasegawa, T; Kitaichi, K; Matsushima, M; Morishita, Y; Takagi, K; Ueyama, J; Zhao, YL | 1 |
| Kikuchi, R; Kusuhara, H; Sugiyama, D; Sugiyama, Y | 1 |
| Cox, S; Evans, AM; Nation, RL; Wang, J | 1 |
| Hiramoto, K; Inui, K; Motohashi, H; Okuda, M; Uwai, Y | 1 |
| Braun, EJ; Dudas, PL; Pelis, RM; Renfro, JL | 1 |
| Abe, F; Hasegawa, T; Kato, M; Kimura, M; Kurono, S; Nadai, M; Saito, H; Yoshizumi, H | 1 |
| Briggs, JP; Eisner, C; Faulhaber-Walter, R; Leelahavanichkul, A; Levine, M; Mizel, D; Schnermann, J; Star, RA; Wang, Y; Yuen, PS | 1 |
3 review(s) available for cimetidine and p-aminohippuric acid
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Studies of organic anion and cation transport in isolated segments of proximal tubules.
Topics: Animals; Biological Transport; Cimetidine; Humans; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; p-Aminohippuric Acid; Rabbits; Uric Acid | 1982 |
1 trial(s) available for cimetidine and p-aminohippuric acid
| Article | Year |
|---|---|
The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Animals; Antiviral Agents; Biological Transport; CHO Cells; Cimetidine; Cricetinae; Cross-Over Studies; Drug Interactions; Female; Humans; Influenza, Human; Kidney; Male; Middle Aged; Neuraminidase; Organic Anion Transport Protein 1; Oseltamivir; p-Aminohippuric Acid; Probenecid; Prodrugs | 2002 |
36 other study(ies) available for cimetidine and p-aminohippuric acid
| Article | Year |
|---|---|
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; Kidney; Membrane Proteins; Molecular Sequence Data; Organic Cation Transporter 1; Protein Biosynthesis; Rats; RNA, Messenger; Tetraethylammonium Compounds; Xenopus laevis | 1997 |
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1.
Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Epithelial Cells; Epithelium; Fluoroquinolones; Humans; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Quinolones; Swine | 1997 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Characterization of ochratoxin A transport by human organic anion transporters.
Topics: Animals; Biological Transport; Cell Line; Humans; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Potassium | 2001 |
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
Topics: Animals; Choroid Plexus; Cimetidine; Enzyme Inhibitors; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Penicillins; Rats; Rats, Sprague-Dawley | 2002 |
Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice.
Topics: Amino Acid Sequence; Animals; Chromosome Mapping; Cloning, Molecular; Gene Expression Regulation; Mice; Molecular Sequence Data; Organic Anion Transporters, Sodium-Independent; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution | 2002 |
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
Topics: Animals; Blood-Brain Barrier; Cimetidine; Convulsants; Endothelium, Vascular; Enzyme Inhibitors; Homovanillic Acid; Indican; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Rats; Rats, Wistar; Transfection; Tritium; Xenopus laevis | 2003 |
Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux.
Topics: Animals; Base Sequence; Biological Transport; Citric Acid Cycle; Dicarboxylic Acid Transporters; Estrone; Humans; Molecular Sequence Data; Organic Anion Transporters, Sodium-Independent; RNA, Complementary; Uric Acid | 2003 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3.
Topics: Allopurinol; Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Kidney; Male; Mice; Oocytes; Organic Anion Transporters, Sodium-Independent; Substrate Specificity; Xenopus laevis | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Expression of renal organic cation transporter in Xenopus laevis oocytes.
Topics: Animals; Carrier Proteins; Cimetidine; Gene Expression; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Male; Mercuric Chloride; Oocytes; p-Aminohippuric Acid; Poly A; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Tetraethylammonium; Tetraethylammonium Compounds; Xenopus laevis | 1992 |
Transport of cimetidine across the basolateral membrane of rabbit kidney proximal tubules: interaction with organic anions.
Topics: Algorithms; Animals; Anions; Carbon Radioisotopes; Cell Membrane Permeability; Cimetidine; Female; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Rabbits; Tritium | 1992 |
Effect of procainamide on renal tubular transport of cimetidine in the isolated perfused rat kidney.
Topics: Albumins; Animals; Biological Transport; Blood Flow Velocity; Cimetidine; Creatinine; Kidney Cortex; Kidney Tubules; Male; p-Aminohippuric Acid; Perfusion; Procainamide; Rats; Rats, Inbred Strains | 1989 |
Mifentidine: evaluation of antiandrogen effects and kidney function studies.
Topics: Androgen Antagonists; Animals; Castration; Cimetidine; Creatinine; Dihydrotestosterone; Diuresis; Histamine H2 Antagonists; Imidazoles; Kidney; Kidney Function Tests; Male; Organ Size; p-Aminohippuric Acid; Potassium; Prostate; Rats; Rats, Inbred Strains; Seminal Vesicles; Sodium; Testosterone; Urea | 1985 |
Mechanisms for the renal secretion of cisplatin.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Cimetidine; Cisplatin; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred AKR; p-Aminohippuric Acid; Platinum; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds | 1984 |
Cimetidine kinetics during resuscitation from burn shock.
Topics: Adult; Burns; Cimetidine; Creatinine; Female; Humans; Kidney; Kinetics; Male; Metabolic Clearance Rate; p-Aminohippuric Acid; Resuscitation; Shock, Traumatic | 1984 |
Accumulation of cimetidine by kidney cortex slices.
Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1982 |
Cimetidine secretion by rabbit renal tubules in vitro.
Topics: Animals; Biological Transport; Chromatography, High Pressure Liquid; Cimetidine; Creatinine; Guanidines; In Vitro Techniques; Kidney Tubules; Kinetics; Ouabain; p-Aminohippuric Acid; Perfusion; Phlorhizin; Quinine; Rabbits; Tolazoline | 1981 |
Distribution characteristics of levofloxacin and grepafloxacin in rat kidney.
Topics: Animals; Anti-Infective Agents; Carbon Radioisotopes; Cimetidine; Dose-Response Relationship, Drug; Fluoroquinolones; In Vitro Techniques; Kidney Cortex; Kinetics; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Tissue Distribution | 1999 |
Transepithelial transport of levofloxacin in the isolated perfused rat kidney.
Topics: Animals; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biological Transport; Carbon Radioisotopes; Cimetidine; Coloring Agents; Enzyme Inhibitors; Epithelial Cells; Evans Blue; Fluoroquinolones; In Vitro Techniques; Inulin; Kidney; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Perfusion; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Urine | 2000 |
Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Sequence; Animals; Anions; Arginine; Biological Transport; Carrier Proteins; Cimetidine; Herbicides; Lysine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; p-Aminohippuric Acid; Rats; Recombinant Fusion Proteins; Xenopus laevis | 2001 |
Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cimetidine; Conserved Sequence; Estrone; Female; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Protein Biosynthesis; Protein Conformation; Rats; Recombinant Proteins; Sequence Alignment; Substrate Specificity; Transcription, Genetic; Xenopus laevis | 2002 |
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
Topics: Animals; Cimetidine; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Estradiol; Gonadal Steroid Hormones; Kidney Failure, Chronic; Male; Nephrectomy; Organic Cation Transport Proteins; Organic Cation Transporter 2; p-Aminohippuric Acid; Rats; Rats, Wistar; Testosterone | 2002 |
Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats.
Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Carnitine; Carrier Proteins; Central Nervous System Stimulants; Cimetidine; Dialysis Solutions; Gene Expression Regulation; Kidney; Male; Membrane Proteins; Metabolic Clearance Rate; Methamphetamine; Motor Activity; Myocardium; Organic Cation Transport Proteins; p-Aminohippuric Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium; Time Factors; Tissue Distribution | 2003 |
Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Capillaries; Cimetidine; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Male; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Pravastatin; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tritium | 2003 |
Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney.
Topics: Animals; Antiviral Agents; Cimetidine; Glomerular Filtration Rate; Guanosine; Male; Metabolic Clearance Rate; Nephrons; p-Aminohippuric Acid; Perfusion; Probenecid; Rats; Thioinosine; Tissue Distribution | 2004 |
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).
Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; Kidney; Kinetics; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; p-Aminohippuric Acid; Xenopus laevis | 2004 |
Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.
Topics: Animals; Biological Transport, Active; Bromcresol Green; Carbon Radioisotopes; Chickens; Cimetidine; Cytochalasins; DNA Primers; Electric Impedance; Epithelium; Estrone; Glutarates; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lithium; Membrane Potentials; Nocodazole; Organic Anion Transporters; Ouabain; p-Aminohippuric Acid; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uric Acid | 2005 |
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Topics: Animals; Cimetidine; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Organic Anion Transporters; Organic Cation Transport Proteins; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Substrate Specificity; Tetraethylammonium; Time Factors; Xanthines | 2007 |
Major contribution of tubular secretion to creatinine clearance in mice.
Topics: Animals; Cations; Cimetidine; Creatinine; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glomerular Filtration Rate; Inulin; Kidney; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; p-Aminohippuric Acid | 2010 |