Compounds > cimetidine

cimetidine and metyrapone

cimetidine has been researched along with metyrapone in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (25.00)	18.7374
1990's	3 (25.00)	18.2507
2000's	2 (16.67)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Pratim Roy, P; Roy, K	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bennett, BM; McDonald, BJ; St James, MJ	1
Birkett, DJ; Lelo, A; Miners, JO	1
Kairaluoma, M; Pasanen, M; Pelkonen, O; Sotaniemi, EA; Taskinen, T	1
Hall, ST; Houston, JB; Rhodes, JC	1
Margolis, S; Schwartz, MA	1
Bland, TJ; Robertson, IG	1

Reviews

1 review(s) available for cimetidine and metyrapone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

11 other study(ies) available for cimetidine and metyrapone

Article	Year
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Hepatic cytochrome P-450-mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2 Topics: Animals; Aorta; Cimetidine; Cytochrome P-450 Enzyme System; Enzyme Activation; Guanylate Cyclase; Male; Metyrapone; Microsomes, Liver; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Ranitidine; Rats; Rats, Inbred Strains	1992
Mechanism of formation of 6-amino-5-(N-methylformylamino)-1-methyluracil and 3,7-dimethyluric acid from theobromine in the rat in vitro: involvement of cytochrome P-450 and a cellular thiol. Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:8 Topics: Acetylcysteine; Animals; Cimetidine; Cysteine; Cytochrome P-450 Enzyme System; Dithiothreitol; Glutathione; Kinetics; Male; Metyrapone; Microsomes, Liver; Pyridines; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Theobromine; Uracil; Uric Acid	1990
Inhibitor panel studies of human hepatic and placental cytochrome P-450-associated monooxygenase activities. Pharmacology & toxicology, 1988, Volume: 62, Issue:5 Topics: Aminoglutethimide; Animals; Benzoflavones; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Enzyme Inhibitors; Female; Furans; Humans; Isoenzymes; Liver; Male; Metyrapone; Oxidoreductases; Placenta; Pregnancy; Rats; Rats, Inbred Strains	1988
Inhibition of antipyrine metabolite formation in rats in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:9 Topics: Animals; Antipyrine; Benzoflavones; Cimetidine; Cytochrome P-450 Enzyme System; Male; Metyrapone; Proadifen; Rats; Rats, Inbred Strains	1984
Effects of drugs and sterols on cholesterol 7 alpha-hydroxylase activity in rat liver microsomes. Journal of lipid research, 1983, Volume: 24, Issue:1 Topics: Aminoglutethimide; Animals; Ascorbic Acid; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Cimetidine; Kinetics; Male; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rats, Inbred Strains; Steroid Hydroxylases; Sterols	1983
Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10 Topics: Acridines; Acridones; Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cimetidine; Cytosol; Kinetics; Liver; Male; Methimazole; Metyrapone; Microsomes, Liver; NAD; Proadifen; Rats; Rats, Wistar	1993