cimetidine and lidocaine

cimetidine has been researched along with lidocaine in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (44.78)	18.7374
1990's	6 (8.96)	18.2507
2000's	18 (26.87)	29.6817
2010's	13 (19.40)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Grönneberg, R; Hägermark, O; Strandberg, K	1
Alzamora, F; Cunha-Melo, JR; Freire-Maia, L; Gonzaga, HM	1
Daifotis, Z; Danou, K; Kaniaris, P; Karayannacos, P; Sabatakaki, A	1
Kishikawa, K; Miyashita, K; Namiki, A; Saitoh, K	1
Bar-Meir, S; Bruck, R; Krepel, Z	1
Collier, PS; Flynn, RJ; Howard, PJ; Moore, J	2
Bianchine, JR; Gerber, MC; Gerber, N; Tejwani, GA	1
Heath, CA; Johnson, RF; Roberts, RK; Schenker, S; Speeg, KV	1
Kapil, RP; Lalonde, RL; Mattern, AL; North, DS	1
Cheek, DB; Dailey, PA; Healy, K; Hughes, SC; Rosen, MA; Shnider, SM	1
Itho, H; Kawamata, Y; Koyama, C; Nishigaki, R; Shibasaki, S; Ueno, F; Umemura, K	1
Curry, SH; Gotz, VP; Lopez, LM; Mehta, JL; Parish, RC	1
Kim, KC; Tasch, MD	1
Cross, R; Foster, J; Patterson, JH; Powell, JR; Wargin, W	1
Bauman, JL; Berk, SI; Douglas, JB; Gal, P; McCue, JD; Powell, JR	1
Bentley, JB; Fukui, T; Gandolfi, AJ; Glass, SJ; Jackson, JE; Plachetka, JR	1
Abernethy, DR; Schwartz, JB; Todd, EL	1
Wood, JR	1
Greene, WL; Levinson, MJ; Self, TH	1
Sedman, AJ	1
Greene, W	1
Feely, J	1
Bauer, LA; Blouin, RA; Edwards, WA; Randolph, FP	1
Frank, WO; Humphries, TJ; Myerson, RM; Peace, KE; Seaman, JJ	1
Birkett, DJ; Foenander, T; Lillywhite, K; Miners, JO; Wanwimolruk, S; Wing, LM	1
Karmen, A; Keren, G; Knapp, AB; Levitt, B; Maguire, W; Miura, DS; Somberg, JC	1
D'Arcy, PF	1
Powell, JR	1
DiGregorio, GJ; Fruncillo, RJ; Soll, A	1
Feely, J; McAllister, CB; Wilkinson, GR; Wood, AJ	1
Loi, CM; Schmucker, DL; Vestal, RE; Wei, X	1
Borzone, S; Caglieris, S; Ghia, M; Giannini, E; Mattioli, F; Mereto, E; Risso, D; Testa, R	1
Chichester, C; McKindley, DS; Raymond, R	1
Hashiguchi, M; Kasanuki, H; Rikihisa, T; Shiga, T; Urae, A	1
Arase, S; Miyaoka, Y; Skrebova, N; Takiwaki, H	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Honda, K; Inomata, S; Nakamura, T; Tanaka, E	1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI; Usui, T	1

Reviews

5 review(s) available for cimetidine and lidocaine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions with cimetidine: an update. Pharmacology & therapeutics, 1985, Volume: 27, Issue:3 Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Aspirin; Aziridines; Benzodiazepines; Benzoquinones; Cimetidine; Drug Interactions; Humans; Ibuprofen; Imipramine; Kinetics; Lidocaine; Liver Circulation; Pituitary Gland; Procaine; Xanthines	1985
Cimetidine-drug interactions. The American journal of medicine, 1984, Volume: 76, Issue:1 Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Chlormethiazole; Cimetidine; Drug Interactions; Humans; Ketoconazole; Kidney; Lidocaine; Morphine; Penicillins; Theophylline	1984
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
Interaction of cimetidine with other drugs. Southern medical journal, 1983, Volume: 76, Issue:6 Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin	1983

Trials

9 trial(s) available for cimetidine and lidocaine

Article	Year
[Famotidine does not modify the plasma levels of lidocaine for spinal anesthesia. A comparative study of famotidine and cimetidine]. Cahiers d'anesthesiologie, 1992, Volume: 40, Issue:5 Topics: Aged; Anesthesia, Spinal; Cimetidine; Depression, Chemical; Famotidine; Gastric Acid; Humans; Lidocaine; Male	1992
Effects of famotidine and cimetidine on plasma levels of epidurally administered lignocaine. Anaesthesia, 1990, Volume: 45, Issue:9 Topics: Anesthesia, Epidural; Cimetidine; Famotidine; Female; Humans; Lidocaine; Male; Middle Aged; Pneumonia, Aspiration; Preanesthetic Medication; Time Factors	1990
Single dose oral H2-antagonists do not affect plasma lidocaine levels in the parturient. Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:7 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Drug Interactions; Female; Fetal Blood; Humans; Lidocaine; Pregnancy; Randomized Controlled Trials as Topic; Ranitidine	1989
Effect of intravenous cimetidine on lignocaine disposition during extradural caesarean section. Anaesthesia, 1989, Volume: 44, Issue:9 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Humans; Injections, Intravenous; Lidocaine; Pregnancy; Random Allocation	1989
The effect of histamine-2 receptor antagonists on tocainide pharmacokinetics. Journal of clinical pharmacology, 1988, Volume: 28, Issue:7 Topics: Adult; Anti-Arrhythmia Agents; Cimetidine; Drug Interactions; Female; Half-Life; Histamine H2 Antagonists; Humans; Lidocaine; Male; Middle Aged; Ranitidine; Tocainide	1988
Effect of duration of lidocaine infusion and route of cimetidine administration on lidocaine pharmacokinetics. Clinical pharmacy, 1986, Volume: 5, Issue:12 Topics: Adult; Cimetidine; Dealkylation; Drug Interactions; Humans; Infusions, Intravenous; Kinetics; Lidocaine; Male	1986
Effects of histamine-2 receptor blockade on lidocaine kinetics. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:5 Topics: Administration, Oral; Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Cimetidine; Double-Blind Method; Drug Interactions; Half-Life; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Orosomucoid; Ranitidine	1985
Increased toxicity and reduced clearance of lidocaine by cimetidine. Annals of internal medicine, 1982, Volume: 96, Issue:5 Topics: Adult; Blood Proteins; Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Male; Metabolic Clearance Rate; Protein Binding	1982
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Enzyme Inhibitors; Humans; Kidney; Lidocaine; Male; Probenecid; Reference Values; Uricosuric Agents	2000

Other Studies

53 other study(ies) available for cimetidine and lidocaine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Effects of histamine receptor antagonists on histamine-induced responses in human skin. Acta dermato-venereologica, 1979, Volume: 59, Issue:4 Topics: Adult; Axons; Cimetidine; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Injections, Intradermal; Lidocaine; Metiamide; Pyrilamine; Reflex; Skin	1979
Gastric secretion induced by scorpion toxin. Toxicon : official journal of the International Society on Toxinology, 1979, Volume: 17, Issue:3 Topics: Animals; Anura; Atropine; Cimetidine; Gastric Juice; Lidocaine; Rats; Scorpion Venoms; Stimulation, Chemical; Vagotomy	1979
Cimetidine and omeprazole have different effects on hepatic extraction of lidocaine in rats. Gastroenterology, 1990, Volume: 99, Issue:3 Topics: Animals; Cimetidine; Indocyanine Green; Lidocaine; Liver; Male; Omeprazole; Rats; Rats, Inbred Strains	1990
Effect of H2-receptor antagonists on steady-state extraction of indocyanine green and lidocaine by the perfused rat liver. The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:2 Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Indocyanine Green; Lidocaine; Liver; Male; Oxygen Consumption; Perfusion; Ranitidine; Rats; Rats, Inbred Strains	1986
Effect of cimetidine and ranitidine on lidocaine concentrations during epidural anesthesia for cesarean section. Anesthesiology, 1988, Volume: 69, Issue:6 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Fetal Blood; Humans; Lidocaine; Pregnancy; Ranitidine	1988
Effects of cimetidine on lidocaine distribution in rats. Journal of pharmacobio-dynamics, 1988, Volume: 11, Issue:12 Topics: Animals; Blood Proteins; Cimetidine; Drug Interactions; Erythrocytes; Hydrogen-Ion Concentration; In Vitro Techniques; Lidocaine; Male; Mathematics; Protein Binding; Rats; Rats, Inbred Strains; Tissue Distribution	1988
Serum lidocaine concentrations following application to the oropharynx: effects of cimetidine. Therapeutic drug monitoring, 1987, Volume: 9, Issue:3 Topics: Administration, Topical; Adult; Cimetidine; Drug Interactions; Humans; Lidocaine; Oropharynx; Orosomucoid	1987
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. Anesthesia and analgesia, 1986, Volume: 65, Issue:8 Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Lidocaine; Mice; Procaine; Ranitidine; Seizures	1986
The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction. International journal of cardiology, 1987, Volume: 14, Issue:1 Topics: Administration, Oral; Aged; Cimetidine; Drug Interactions; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Ventricular Fibrillation	1987
Lack of interaction between verapamil and cimetidine. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3 Topics: Administration, Oral; Adult; Biological Availability; Blood Proteins; Chromatography, Gas; Cimetidine; Drug Administration Schedule; Drug Interactions; Electrocardiography; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Random Allocation; Verapamil	1985
H2 receptor antagonists: cimetidine and ranitidine. British medical journal (Clinical research ed.), 1983, Apr-30, Volume: 286, Issue:6375 Topics: Cimetidine; Drug Interactions; Furans; Guanidines; Histamine H2 Antagonists; Humans; Lidocaine; Propranolol; Ranitidine	1983
Cimetidine drug interactions. The Journal of family practice, 1983, Volume: 16, Issue:6 Topics: Adrenergic beta-Antagonists; Analgesics, Opioid; Anti-Arrhythmia Agents; Anticonvulsants; Benzodiazepines; Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Peptic Ulcer; Warfarin	1983
Cimetidine-induced decrease in lidocaine metabolism. American heart journal, 1984, Volume: 108, Issue:2 Topics: Adult; Cimetidine; Drug Interactions; Humans; Kinetics; Lidocaine; Liver; Liver Circulation; Male	1984
Lidocaine-cimetidine interaction. Annals of internal medicine, 1983, Volume: 99, Issue:3 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Research Design	1983
Lidocaine disposition--sex differences and effects of cimetidine. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Cimetidine; Drug Interactions; Female; Humans; Injections, Intravenous; Lidocaine; Male; Protein Binding; Sex Factors; Smoking	1984
The cimetidine-lidocaine interaction. Annals of internal medicine, 1983, Volume: 98, Issue:2 Topics: Cimetidine; Diphenhydramine; Drug Interactions; Female; Guanidines; Humans; Lidocaine; Male; Middle Aged	1983
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Cimetidine and lidocaine. Annals of internal medicine, 1983, Volume: 99, Issue:2 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine	1983
Effect of cimetidine on the pharmacokinetics of quinidine and lidocaine in the rat. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:7 Topics: Animals; Cimetidine; Drug Interactions; Guanidines; Kinetics; Lidocaine; Male; Quinidine; Rats; Rats, Inbred Strains	1983
Lidocaine-cimetidine interaction can be toxic. JAMA, 1982, Jun-18, Volume: 247, Issue:23 Topics: Arrhythmias, Cardiac; Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Peptic Ulcer	1982
Characterization of the independent and combined effects of two inhibitors on oxidative drug metabolism in rat liver microsomes. Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11 Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Kinetics; Lidocaine; Male; Mexiletine; Microsomes, Liver; Rats; Rats, Sprague-Dawley	1995
Effects of reduced glutathione and n-acetylcysteine on lidocaine metabolism in cimetidine treated rats. Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:2 Topics: Acetylcysteine; Anesthetics, Local; Animals; Cimetidine; Drug Interactions; Fluorescence Polarization Immunoassay; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Injections, Intraperitoneal; Lidocaine; Rats; Rats, Sprague-Dawley; Time Factors	1998
Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver. Shock (Augusta, Ga.), 1999, Volume: 12, Issue:6 Topics: Anesthetics, Local; Animals; Cimetidine; Coloring Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Inhibitors; Indocyanine Green; Isoenzymes; Lidocaine; Liver; Male; Metabolic Clearance Rate; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Shock, Septic	1999
Localized heat urticaria: a clinical study using laser Doppler flowmetry. Journal of dermatological science, 2001, Volume: 26, Issue:2 Topics: Administration, Topical; Aged; Cimetidine; Diphenhydramine; Female; Histamine; Histamine H1 Antagonists; Hot Temperature; Humans; Laser-Doppler Flowmetry; Lidocaine; Male; Middle Aged; Phenothiazines; Skin; Time Factors; Urticaria	2001
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide	2006
Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Benzamides; Cations; Cell Line; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Isoquinolines; Lidocaine; Metformin; Organic Cation Transport Proteins; Procainamide; Quinidine; Rats	2008