cimetidine and coumarin

cimetidine has been researched along with coumarin in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19907 (35.00)18.7374
1990's6 (30.00)18.2507
2000's2 (10.00)29.6817
2010's5 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Butler, K; Fried, A; Marshall, ME1
Fentem, JH; Fry, JR1
Hennig, FW; Herrmann, R; Manegold, C; Matthiessen, W; Maurer, B1
Amato, R; Dexeus, FH; Dozier, N; Fitz, K; Logothetis, CJ; Reuben, JM; Sella, A1
Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C1
Davenport, Y; Tseng, A; Venook, AP1
Cibull, M; Eichhorn, T; Jennings, CD; Marshall, ME; Rhoades, J; Riley, LK; Thompson, J1
Butler, K; Cantrell, J; Harvey, J; Macdonald, J; Marshall, ME; Mendelsohn, L1
Ernstoff, MS; Kirkwood, JM1
Butler, K; Cantrell, J; Macdonald, JS; Marshall, ME; Mendelsohn, L; Riley, L; Taylor, R; Wiseman, C1
Langvad, E; Pedersen, L; Rose, C1
Bueschen, A; Butler, K; Edmonds, K; Markiewicz, M; Marshall, ME; Mohler, JL; Ryles, M; Urban, D; Weiss, L; Williams, B1
Flamm, J; Ludwig, H; Micksche, M; Sagaster, P1

Reviews

1 review(s) available for cimetidine and coumarin

ArticleYear
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin.
    Journal of cancer research and clinical oncology, 1994, Volume: 120 Suppl

    Topics: Adult; Aged; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Cimetidine; Coumarins; Drug Therapy, Combination; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Survival Analysis; Treatment Outcome; Umbelliferones

1994

Trials

3 trial(s) available for cimetidine and coumarin

ArticleYear
Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies.
    Molecular biotherapy, 1991, Volume: 3, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Radiography

1991
Phase II trial of coumarin and cimetidine in advanced renal cell carcinoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1990, Volume: 1, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Pleural Neoplasms; Survival Rate

1990
Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Female; Humans; Interferon alpha-2; Interferon-alpha; Kidney Neoplasms; Male; Middle Aged; Prospective Studies; Recombinant Proteins

1995

Other Studies

16 other study(ies) available for cimetidine and coumarin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes.
    Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7

    Topics: Animals; Cimetidine; Coumarins; Drug Interactions; Gerbillinae; Humans; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones

1991
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Kidney Neoplasms; Lymphocyte Activation; Male; Middle Aged; Remission Induction; T-Lymphocytes, Regulatory

1990
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Female; Humans; Male; Melanoma; Middle Aged; Pilot Projects

1989
Activity of coumarin and cimetidine in metastatic renal cell carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:3

    Topics: Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Drug Therapy, Combination; Humans; Kidney Neoplasms

1989
Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies.
    Journal of biological response modifiers, 1989, Volume: 8, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coumarins; Female; Humans; Killer Cells, Natural; Lymphocytes; Male; Middle Aged; Monocytes; Neoplasms

1989
Treatment of non-small cell lung cancer with coumarin and cimetidine.
    Cancer treatment reports, 1987, Volume: 71, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged

1987
Coumarin plus cimetidine: yet another angle for therapy of renal cell carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Humans; Kidney Neoplasms; Pilot Projects

1987
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Nephrectomy; Pilot Projects; Remission Induction

1987
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study.
    Cancer immunology, immunotherapy : CII, 1987, Volume: 24, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Skin Neoplasms

1987