cimetidine and clonidine

cimetidine has been researched along with clonidine in 88 studies

Research

Studies (88)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (35.23)	18.7374
1990's	17 (19.32)	18.2507
2000's	19 (21.59)	29.6817
2010's	20 (22.73)	24.3611
2020's	1 (1.14)	2.80

Authors

Authors	Studies
Brown, TH; Ganellin, CR; Griffiths, R; Jones, M; Mitchell, RC; Rana, KK; Saunders, D; Smith, IR; Sore, NE; Young, RC	1
Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L	1
Giacomini, KM; Schaner, ME; Zhang, L	1
Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X	1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Topliss, JG; Yoshida, F	1
Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM	1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E	1
Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R	1
Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E	1
Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW	1
Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E	1
Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW	1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S	1
Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S	1
Bugajski, J; Zacny, E	1
McCulloch, MW; Medgett, IC	1
Andersson, RG; Colldahl, H; Lindgren, BR	1
Duckworth, JW; Lance, JW; Lord, GD; Mylecharane, EJ; Spira, PJ	1
Gołembiowska-Nikitin, K; Pilc, A; Vetulani, J	1
Vogt, M	1
Wikberg, J	1
Ganapathy, V; Leibach, FH; Mahesh, VB; Nair, CN; Ramamoorthy, S; Tiruppathi, C	1
Bhandare, PN; D'Souza, RS; Dhume, VG	1
Cragoe, EJ; Ganapathy, V; Kulanthaivel, P; Leibach, FH; Mahesh, VB	1
Andersson, RG; Grundström, N; Lindgren, BR	1
Holcslaw, TL; Lassiter, D	1
Kitzen, JM; Lucchesi, BR; Söhngen, W; Ventura, A; Winbury, MM	1
Leggieri, E; Lorini, M; Miadonna, A; Parravicini, P; Tedeschi, A; Zanussi, C	1
Aroskar, VA; Dadkar, NK; Dohadwalla, AN; Gupte, RD	1
Couse, NF; Yeo, CJ; Zinner, MJ	1
Kawasaki, H; Takasaki, K	1
Devoe, LD; Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB	1
Leff, P; Trist, DG	1
Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB; Nair, CN	1
Ghignone, M; Orko, R; Pouttu, J; Rosenberg, PH	1
Chiba, S; Nakane, T	1
Clark, BG; Vestal, RE	1
Frisk-Holmberg, M	1
Sanchez-Chapula, J	2
Robinson, BV	1
Beeley, L	1
Bugajski, J; Zacny, E; Zdebska, A	1
Brown, MJ; Dollery, CT; FitzGerald, G; Watkins, J; Zamboulis, C	1
Slotkin, TA; Subramanian, N	1
Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K	1
Rountree, CB; Wilkin, JK	1
Padan, E; Pinner, E; Schuldiner, S	1
Orlowski, J; Shull, GE; Yu, FH	1
Ganapathy, V; Reinach, P; Torres-Zamorano, V	1
Hamilton, JR; MacLeod, RJ	1
Ally, A	2
Casavola, V; Di Sole, F; Guerra, L; Perlino, E; Reshkin, SJ; Ronco, PM; Valenti, G	1
Brunette, MG; Claveau, D; Leclerc, M; Pellerin, I	1
Chow, CW	1
Alli, HA; Angle, JM; Black, ED; Donowitz, M; Madara, JL; Tse, CM; Turner, JR; Uchwat, FA; Ward, J	1
Hough, LB; Leurs, R; Menge, WM; Nalwalk, JW; Svokos, K; Timmerman, H	1
Ho, JW; Leung, YK	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Honda, K; Inomata, S; Nakamura, T; Tanaka, E	1

Reviews

3 review(s) available for cimetidine and clonidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced sexual dysfunction and infertility. Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine; Clonidine; Cytotoxins; Diuretics; Ejaculation; Erectile Dysfunction; Ethanol; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Ketoconazole; Libido; Male; Methyldopa; Middle Aged; Narcotics; Orgasm; Parasympatholytics; Penis; Phenothiazines; Propranolol; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Sulfasalazine	1984
Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. Clinical and investigative medicine. Medecine clinique et experimentale, 1999, Volume: 22, Issue:5 Topics: Adenosine Triphosphate; Amiloride; Animals; Cimetidine; Clonidine; Epithelial Cells; Guanidines; Ion Transport; Kidney; Phosphorylation; Protein Isoforms; Sodium-Hydrogen Exchangers; Sulfones	1999

Trials

2 trial(s) available for cimetidine and clonidine

Article	Year
Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity. Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Clonidine; Diazepam; Female; Gastric Acid; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Male; Middle Aged; Preanesthetic Medication; Random Allocation	1987
Absence of opiate and histamine H2 receptor-mediated effects of clonidine. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:5 Topics: Adult; Cimetidine; Clonidine; Epinephrine; Humans; Male; Naloxone; Norepinephrine; Receptors, Histamine; Receptors, Histamine H2; Receptors, Opioid	1980

Other Studies

83 other study(ies) available for cimetidine and clonidine

Article	Year
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Algorithms; Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry, Physical; Clonidine; Guinea Pigs; Histamine H2 Antagonists; Imipramine; Pyrilamine; Structure-Activity Relationship	1988
Cloning and functional expression of a human liver organic cation transporter. Molecular pharmacology, 1997, Volume: 51, Issue:6 Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis	1997
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection	1998
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2 Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis	1999
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium	1999
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine	2011
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. European journal of medicinal chemistry, 2014, Feb-12, Volume: 73 Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding	2014
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies. European journal of medicinal chemistry, 2014, Sep-12, Volume: 84 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies	2014
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19 Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins	2014
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & medicinal chemistry letters, 2014, Dec-01, Volume: 24, Issue:23 Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship	2014
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. European journal of medicinal chemistry, 2015, Nov-13, Volume: 105 Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi	2015
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors. Bioorganic & medicinal chemistry, 2016, 10-15, Volume: 24, Issue:20 Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship	2016
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic & medicinal chemistry, 2016, 11-01, Volume: 24, Issue:21 Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2016
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured	2016
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine	2019
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. European journal of medicinal chemistry, 2022, Jun-05, Volume: 236 Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate	2022
Effect of histamine H2-receptor antagonist, cimetidine, on hypothermia induced by an alpha-adrenergic agonist, clonidine, in the rat [proceedings]. Agents and actions, 1979, Volume: 9, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Cimetidine; Clonidine; Drug Interactions; Guanidines; Phentolamine; Rats	1979
Effects of clonidine, guanfacine and three imidazolidine derivatives related to clonidine on blood pressure, heart rate and gastric acid secretion in the anaesthetized rat. Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 240, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cimetidine; Clonidine; Female; Gastric Juice; Guanidines; Heart Rate; Histamine; Hydrogen-Ion Concentration; Imidazoles; Male; Phenylacetates; Rats	1979
Inhibitory effects of imidazolines on histamine liberation from human leukocytes and on tracheal smooth muscle tone. Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:5 Topics: Animals; Cattle; Cimetidine; Clemastine; Clonidine; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Humans; Imidazoles; Leukocytes; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Phentolamine; Phenylephrine; Propranolol; Tolazoline	1978
Evaluation of drugs applicable to treatment of migraine in the cranial circulation of the monkey. Research and clinical studies in headache, 1978, Volume: 6 Topics: Acetylcholine; Animals; Bradykinin; Cerebrovascular Circulation; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Ergotamine; Haplorhini; Histamine; Macaca; Methysergide; Metiamide; Migraine Disorders; Norepinephrine; Pizotyline; Prostaglandins; Serotonin	1978
Negligible binding of 3H-clonidine to histamine H2 receptor. European journal of pharmacology, 1979, Volume: 56, Issue:1-2 Topics: Animals; Brain; Cimetidine; Clonidine; Male; Methylhistamines; Metiamide; Rats; Receptors, Histamine; Receptors, Histamine H2	1979
Histamine H2-receptors in the brain and sleep produced by clonidine. British journal of pharmacology, 1977, Volume: 61, Issue:3 Topics: Animals; Brain; Chickens; Cimetidine; Clonidine; Male; Metiamide; Receptors, Histamine; Receptors, Histamine H2; Sleep	1977
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta. Acta physiologica Scandinavica, 1978, Volume: 103, Issue:3 Topics: Animals; Aorta, Thoracic; Cimetidine; Clonidine; Dibenzylchlorethamine; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Oxymetazoline; Parasympathetic Nervous System; Phenoxybenzamine; Phentolamine; Phenylephrine; Rabbits; Receptors, Adrenergic; Tolazoline	1978
Relative sensitivity to inhibition by cimetidine and clonidine differentiates between the two types of Na(+)-H+ exchangers in cultured cells. The Biochemical journal, 1991, Dec-01, Volume: 280 ( Pt 2) Topics: Animals; Carrier Proteins; Cell Line; Choriocarcinoma; Cimetidine; Clonidine; HeLa Cells; Humans; Opossums; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured	1991
Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action. Indian journal of physiology and pharmacology, 1990, Volume: 34, Issue:4 Topics: Animals; Cimetidine; Clonidine; Drug Synergism; Ethanol; Male; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Receptors, Opioid; Stomach Ulcer	1990
The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane. The Journal of biological chemistry, 1990, Jan-25, Volume: 265, Issue:3 Topics: Amiloride; Animals; Carrier Proteins; Cell Membrane; Cell-Free System; Cimetidine; Clonidine; Harmaline; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Cortex; Microvilli; Placenta; Rabbits; Sodium; Sodium-Hydrogen Exchangers	1990
Comparison of the effects of clonidine and guanfacine on the histamine liberation from human mast cells and basophils and on the human bronchial smooth muscle activity. Arzneimittel-Forschung, 1987, Volume: 37, Issue:5 Topics: Adrenergic alpha-Agonists; Basophils; Bronchi; Carbachol; Cimetidine; Clonidine; Electric Stimulation; Guanfacine; Guanidines; Histamine Release; Humans; In Vitro Techniques; Lung; Mast Cells; Muscle Contraction; Muscle, Smooth; Phenylacetates	1987
Evidence for presynaptic inhibitory histamine (H2) receptors in the rat hindquarter vasculature. Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:6 Topics: Animals; Blood Vessels; Cimetidine; Clonidine; Electric Stimulation; Hindlimb; Histamine; Imidazoles; Impromidine; Male; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Neurotransmitter; Sympathetic Nervous System; Vasodilation	1987
The mechanism for the clonidine-induced coronary artery dilatation in the canine heart. Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:6 Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Blood Platelets; Blood Pressure; Cimetidine; Clonidine; Coronary Circulation; Coronary Vessels; Dogs; Histamine; In Vitro Techniques; Male; Perfusion; Receptors, Purinergic; Serotonin; Vasodilator Agents	1988
Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes. International journal of immunopharmacology, 1989, Volume: 11, Issue:5 Topics: Adrenergic alpha-Agonists; Adult; Antibodies, Anti-Idiotypic; Basophils; Calcimycin; Calcium; Cimetidine; Clonidine; Female; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine	1989
The interaction of cimetidine with various antihypertensive agents in the spontaneously hypertensive rat. The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:5 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cimetidine; Clonidine; Guanethidine; Injections, Intraventricular; Male; Minoxidil; Pentolinium Tartrate; Rats; Rats, Inbred SHR; Time Factors	1985
Discrimination between alpha 1- and alpha 2-adrenergic receptors in the isolated perfused ileum. Surgery, 1988, Volume: 104, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Cimetidine; Clonidine; Ileum; Intestinal Absorption; Norepinephrine; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha; Vascular Resistance	1988
Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Animals; Azepines; Blood Pressure; Brain; Cimetidine; Clonidine; Hydroxydopamines; Injections, Intraventricular; Ketanserin; Male; Methoxamine; Oxidopamine; Piperidines; Prazosin; Procaine; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine	1986
Interaction of clonidine with human placental Na+ -H+ exchanger. Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22 Topics: Amiloride; Carrier Proteins; Cimetidine; Clonidine; Female; Humans; In Vitro Techniques; Kinetics; Microvilli; Placenta; Pregnancy; Sodium; Sodium-Hydrogen Exchangers	1986
Quantification of H2-agonism by clonidine and dimaprit in an adenylate cyclase assay. Agents and actions, 1985, Volume: 16, Issue:3-4 Topics: Adenylyl Cyclases; Animals; Cimetidine; Clonidine; Dimaprit; Guinea Pigs; Histamine; In Vitro Techniques; Myocardium; Receptors, Histamine; Receptors, Histamine H2; Thiourea	1985
Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta. The Journal of biological chemistry, 1988, Apr-05, Volume: 263, Issue:10 Topics: Carrier Proteins; Cations, Monovalent; Cimetidine; Clonidine; Female; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Membrane Proteins; Microvilli; Placenta; Pregnancy; Sodium	1988
Possible involvement of histamine H2-receptors in the vasodilator effect of clonidine on isolated and perfused canine coronary arteries. European journal of pharmacology, 1986, Dec-16, Volume: 132, Issue:2-3 Topics: Animals; Chlorpheniramine; Cimetidine; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Perfusion; Receptors, Histamine H2; Vasodilation	1986
Adverse drug reactions in the elderly: case studies. Geriatrics, 1984, Volume: 39, Issue:12 Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol	1984
Evidence for a histamine H2-receptor involvement in clonidine's antihypertensive effects during multiple dosing. Acta physiologica Scandinavica, 1980, Volume: 108, Issue:2 Topics: Animals; Antihypertensive Agents; Cimetidine; Clonidine; Histamine H2 Antagonists; Rats; Receptors, Histamine; Receptors, Histamine H2	1980
Multiple effects of putative alpha-adrenoceptor agonists on the electrical and mechanical activity of guinea-pig papillary muscle. Naunyn-Schmiedeberg's archives of pharmacology, 1981, Volume: 316, Issue:2 Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Receptors, Histamine H2	1981
Histamine receptor agonists and antagonists on granulocyte adherence. The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:7 Topics: Cimetidine; Clonidine; Granulocytes; Histamine; Histamine Antagonists; Humans; Pyrilamine	1982
The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology, 1980, Volume: 19, Issue:1 Topics: Animals; Body Temperature; Cimetidine; Clonidine; Drug Interactions; Injections, Intraperitoneal; Injections, Intraventricular; Male; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Histamine; Receptors, Histamine H2; Time Factors	1980
Solubilization of a [3H]cimetidine binding site from rat brains. A clonidine-sensitive H-2 receptor subtype? Molecular pharmacology, 1981, Volume: 20, Issue:2 Topics: Animals; Brain; Cimetidine; Clonidine; Copper; Female; Guanidines; Imidazoles; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Histamine; Receptors, Histamine H2	1981
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 82, Issue:4 Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Acid; Male; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Stomach Ulcer	1983
Blockade of carcinoid flush with cimetidine and clonidine. Archives of dermatology, 1982, Volume: 118, Issue:2 Topics: Adult; Chlorpheniramine; Cimetidine; Clonidine; Drug Therapy, Combination; Female; Guanidines; Humans; Malignant Carcinoid Syndrome	1982
Differential effects of histamine on left and righ guinea-pig atria. European journal of pharmacology, 1981, Sep-11, Volume: 74, Issue:2-3 Topics: Action Potentials; Animals; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Functional Laterality; Guinea Pigs; Heart Atria; Histamine; In Vitro Techniques; Myocardial Contraction	1981
Amiloride and harmaline are potent inhibitors of NhaB, a Na+/H+ antiporter from Escherichia coli. FEBS letters, 1995, May-22, Volume: 365, Issue:1 Topics: Amiloride; Bacterial Proteins; Biological Transport; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Escherichia coli; Harmaline; Proteolipids; Sodium; Sodium-Hydrogen Exchangers	1995
Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. The Journal of biological chemistry, 1993, Dec-05, Volume: 268, Issue:34 Topics: Amiloride; Animals; Biological Transport, Active; Carrier Proteins; CHO Cells; Cimetidine; Clone Cells; Clonidine; Cricetinae; Harmaline; Hydrogen-Ion Concentration; Kinetics; Rats; Sodium; Sodium-Hydrogen Exchangers	1993
Characterization and subtype identification of the Na(+)-H+ exchanger in bovine corneal epithelium. Current eye research, 1993, Volume: 12, Issue:1 Topics: Amiloride; Animals; Binding, Competitive; Carrier Proteins; Cattle; Cell Membrane; Cimetidine; Clonidine; Cornea; Epithelium; Hydrogen-Ion Concentration; Sodium; Sodium-Hydrogen Exchangers; Temperature	1993
Activation of Na+/H+ exchange is required for regulatory volume decrease after modest "physiological" volume increases in jejunal villus epithelial cells. The Journal of biological chemistry, 1996, Sep-20, Volume: 271, Issue:38 Topics: Alkalies; Amiloride; Ammonium Chloride; Animals; Biological Transport; Cell Size; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Guinea Pigs; Hydrogen-Ion Concentration; Jejunum; Male; Protons; Sodium	1996
Cardiovascular effects of central administration of clonidine in conscious cats. Brain research, 1997, Jul-04, Volume: 761, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Behavior, Animal; Benzofurans; Blood Pressure; Cardiovascular System; Cats; Cimetidine; Clonidine; Coloring Agents; Consciousness; Dose-Response Relationship, Drug; Evans Blue; Female; Heart Rate; Histamine H2 Antagonists; Imidazoles; Injections, Intraventricular; Yohimbine	1997
Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells. Kidney international, 1998, Volume: 53, Issue:5 Topics: Amiloride; Animals; Base Sequence; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Clonidine; DNA Primers; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Collecting; Kinetics; Polymerase Chain Reaction; Protein Kinases; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	1998
Characterization of the Na+/H+ exchanger in the luminal membrane of the distal nephron. The Journal of membrane biology, 1998, Oct-01, Volume: 165, Issue:3 Topics: Amiloride; Animals; Biological Transport; Bucladesine; Cell Membrane; Cimetidine; Clonidine; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Nephrons; Rabbits; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate	1998
Cardiovascular effects of intravenous administration of clonidine in conscious cats. Brain research, 1998, Nov-09, Volume: 810, Issue:1-2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Histamine H2 Antagonists; Injections, Intravenous; Injections, Intraventricular; Yohimbine	1998
Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: Acids; Alkalies; Amiloride; Animals; Anti-Ulcer Agents; Antihypertensive Agents; Biological Transport; Caco-2 Cells; Cimetidine; Clonidine; Cytoplasm; Diuretics; Electric Impedance; Electrophysiology; Epithelial Cells; Glucose; Guanidines; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Methacrylates; Microvilli; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tight Junctions	2000
A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic. Brain research, 2001, Dec-27, Volume: 923, Issue:1-2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cimetidine; Clonidine; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Yohimbine	2001
Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes. Archives of physiology and biochemistry, 2001, Volume: 109, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Atropine; Carcinogens; Cimetidine; Clonidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hypoglycemic Agents; Male; Microsomes, Liver; Muscarinic Antagonists; Nitrosamines; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tolbutamide; Vitamins	2001
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide	2006