cimetidine has been researched along with clonidine in 88 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 31 (35.23) | 18.7374 |
1990's | 17 (19.32) | 18.2507 |
2000's | 19 (21.59) | 29.6817 |
2010's | 20 (22.73) | 24.3611 |
2020's | 1 (1.14) | 2.80 |
Authors | Studies |
---|---|
Brown, TH; Ganellin, CR; Griffiths, R; Jones, M; Mitchell, RC; Rana, KK; Saunders, D; Smith, IR; Sore, NE; Young, RC | 1 |
Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L | 1 |
Giacomini, KM; Schaner, ME; Zhang, L | 1 |
Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X | 1 |
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
Topliss, JG; Yoshida, F | 1 |
Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X | 1 |
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM | 1 |
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM | 1 |
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E | 1 |
Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R | 1 |
Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E | 1 |
Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW | 1 |
Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E | 1 |
Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW | 1 |
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S | 1 |
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW | 1 |
Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
Bugajski, J; Zacny, E | 1 |
McCulloch, MW; Medgett, IC | 1 |
Andersson, RG; Colldahl, H; Lindgren, BR | 1 |
Duckworth, JW; Lance, JW; Lord, GD; Mylecharane, EJ; Spira, PJ | 1 |
Gołembiowska-Nikitin, K; Pilc, A; Vetulani, J | 1 |
Vogt, M | 1 |
Wikberg, J | 1 |
Ganapathy, V; Leibach, FH; Mahesh, VB; Nair, CN; Ramamoorthy, S; Tiruppathi, C | 1 |
Bhandare, PN; D'Souza, RS; Dhume, VG | 1 |
Cragoe, EJ; Ganapathy, V; Kulanthaivel, P; Leibach, FH; Mahesh, VB | 1 |
Andersson, RG; Grundström, N; Lindgren, BR | 1 |
Holcslaw, TL; Lassiter, D | 1 |
Kitzen, JM; Lucchesi, BR; Söhngen, W; Ventura, A; Winbury, MM | 1 |
Leggieri, E; Lorini, M; Miadonna, A; Parravicini, P; Tedeschi, A; Zanussi, C | 1 |
Aroskar, VA; Dadkar, NK; Dohadwalla, AN; Gupte, RD | 1 |
Couse, NF; Yeo, CJ; Zinner, MJ | 1 |
Kawasaki, H; Takasaki, K | 1 |
Devoe, LD; Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB | 1 |
Leff, P; Trist, DG | 1 |
Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB; Nair, CN | 1 |
Ghignone, M; Orko, R; Pouttu, J; Rosenberg, PH | 1 |
Chiba, S; Nakane, T | 1 |
Clark, BG; Vestal, RE | 1 |
Frisk-Holmberg, M | 1 |
Sanchez-Chapula, J | 2 |
Robinson, BV | 1 |
Beeley, L | 1 |
Bugajski, J; Zacny, E; Zdebska, A | 1 |
Brown, MJ; Dollery, CT; FitzGerald, G; Watkins, J; Zamboulis, C | 1 |
Slotkin, TA; Subramanian, N | 1 |
Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K | 1 |
Rountree, CB; Wilkin, JK | 1 |
Padan, E; Pinner, E; Schuldiner, S | 1 |
Orlowski, J; Shull, GE; Yu, FH | 1 |
Ganapathy, V; Reinach, P; Torres-Zamorano, V | 1 |
Hamilton, JR; MacLeod, RJ | 1 |
Ally, A | 2 |
Casavola, V; Di Sole, F; Guerra, L; Perlino, E; Reshkin, SJ; Ronco, PM; Valenti, G | 1 |
Brunette, MG; Claveau, D; Leclerc, M; Pellerin, I | 1 |
Chow, CW | 1 |
Alli, HA; Angle, JM; Black, ED; Donowitz, M; Madara, JL; Tse, CM; Turner, JR; Uchwat, FA; Ward, J | 1 |
Hough, LB; Leurs, R; Menge, WM; Nalwalk, JW; Svokos, K; Timmerman, H | 1 |
Ho, JW; Leung, YK | 1 |
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E | 1 |
Honda, K; Inomata, S; Nakamura, T; Tanaka, E | 1 |
3 review(s) available for cimetidine and clonidine
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug-induced sexual dysfunction and infertility.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine; Clonidine; Cytotoxins; Diuretics; Ejaculation; Erectile Dysfunction; Ethanol; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Ketoconazole; Libido; Male; Methyldopa; Middle Aged; Narcotics; Orgasm; Parasympatholytics; Penis; Phenothiazines; Propranolol; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Sulfasalazine | 1984 |
Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.
Topics: Adenosine Triphosphate; Amiloride; Animals; Cimetidine; Clonidine; Epithelial Cells; Guanidines; Ion Transport; Kidney; Phosphorylation; Protein Isoforms; Sodium-Hydrogen Exchangers; Sulfones | 1999 |
2 trial(s) available for cimetidine and clonidine
Article | Year |
---|---|
Effect of clonidine on haemodynamic responses to endotracheal intubation and on gastric acidity.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Clonidine; Diazepam; Female; Gastric Acid; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Male; Middle Aged; Preanesthetic Medication; Random Allocation | 1987 |
Absence of opiate and histamine H2 receptor-mediated effects of clonidine.
Topics: Adult; Cimetidine; Clonidine; Epinephrine; Humans; Male; Naloxone; Norepinephrine; Receptors, Histamine; Receptors, Histamine H2; Receptors, Opioid | 1980 |
83 other study(ies) available for cimetidine and clonidine
Article | Year |
---|---|
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists.
Topics: Algorithms; Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry, Physical; Clonidine; Guinea Pigs; Histamine H2 Antagonists; Imipramine; Pyrilamine; Structure-Activity Relationship | 1988 |
Cloning and functional expression of a human liver organic cation transporter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis | 1997 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine | 2011 |
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding | 2012 |
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding | 2014 |
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies | 2014 |
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins | 2014 |
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship | 2014 |
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2015 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship | 2016 |
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2016 |
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries | 2017 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine | 2019 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate | 2022 |
Effect of histamine H2-receptor antagonist, cimetidine, on hypothermia induced by an alpha-adrenergic agonist, clonidine, in the rat [proceedings].
Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Cimetidine; Clonidine; Drug Interactions; Guanidines; Phentolamine; Rats | 1979 |
Effects of clonidine, guanfacine and three imidazolidine derivatives related to clonidine on blood pressure, heart rate and gastric acid secretion in the anaesthetized rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cimetidine; Clonidine; Female; Gastric Juice; Guanidines; Heart Rate; Histamine; Hydrogen-Ion Concentration; Imidazoles; Male; Phenylacetates; Rats | 1979 |
Inhibitory effects of imidazolines on histamine liberation from human leukocytes and on tracheal smooth muscle tone.
Topics: Animals; Cattle; Cimetidine; Clemastine; Clonidine; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Humans; Imidazoles; Leukocytes; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Phentolamine; Phenylephrine; Propranolol; Tolazoline | 1978 |
Evaluation of drugs applicable to treatment of migraine in the cranial circulation of the monkey.
Topics: Acetylcholine; Animals; Bradykinin; Cerebrovascular Circulation; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Ergotamine; Haplorhini; Histamine; Macaca; Methysergide; Metiamide; Migraine Disorders; Norepinephrine; Pizotyline; Prostaglandins; Serotonin | 1978 |
Negligible binding of 3H-clonidine to histamine H2 receptor.
Topics: Animals; Brain; Cimetidine; Clonidine; Male; Methylhistamines; Metiamide; Rats; Receptors, Histamine; Receptors, Histamine H2 | 1979 |
Histamine H2-receptors in the brain and sleep produced by clonidine.
Topics: Animals; Brain; Chickens; Cimetidine; Clonidine; Male; Metiamide; Receptors, Histamine; Receptors, Histamine H2; Sleep | 1977 |
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta.
Topics: Animals; Aorta, Thoracic; Cimetidine; Clonidine; Dibenzylchlorethamine; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Oxymetazoline; Parasympathetic Nervous System; Phenoxybenzamine; Phentolamine; Phenylephrine; Rabbits; Receptors, Adrenergic; Tolazoline | 1978 |
Relative sensitivity to inhibition by cimetidine and clonidine differentiates between the two types of Na(+)-H+ exchangers in cultured cells.
Topics: Animals; Carrier Proteins; Cell Line; Choriocarcinoma; Cimetidine; Clonidine; HeLa Cells; Humans; Opossums; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured | 1991 |
Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
Topics: Animals; Cimetidine; Clonidine; Drug Synergism; Ethanol; Male; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Receptors, Opioid; Stomach Ulcer | 1990 |
The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane.
Topics: Amiloride; Animals; Carrier Proteins; Cell Membrane; Cell-Free System; Cimetidine; Clonidine; Harmaline; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Cortex; Microvilli; Placenta; Rabbits; Sodium; Sodium-Hydrogen Exchangers | 1990 |
Comparison of the effects of clonidine and guanfacine on the histamine liberation from human mast cells and basophils and on the human bronchial smooth muscle activity.
Topics: Adrenergic alpha-Agonists; Basophils; Bronchi; Carbachol; Cimetidine; Clonidine; Electric Stimulation; Guanfacine; Guanidines; Histamine Release; Humans; In Vitro Techniques; Lung; Mast Cells; Muscle Contraction; Muscle, Smooth; Phenylacetates | 1987 |
Evidence for presynaptic inhibitory histamine (H2) receptors in the rat hindquarter vasculature.
Topics: Animals; Blood Vessels; Cimetidine; Clonidine; Electric Stimulation; Hindlimb; Histamine; Imidazoles; Impromidine; Male; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Neurotransmitter; Sympathetic Nervous System; Vasodilation | 1987 |
The mechanism for the clonidine-induced coronary artery dilatation in the canine heart.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Blood Platelets; Blood Pressure; Cimetidine; Clonidine; Coronary Circulation; Coronary Vessels; Dogs; Histamine; In Vitro Techniques; Male; Perfusion; Receptors, Purinergic; Serotonin; Vasodilator Agents | 1988 |
Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes.
Topics: Adrenergic alpha-Agonists; Adult; Antibodies, Anti-Idiotypic; Basophils; Calcimycin; Calcium; Cimetidine; Clonidine; Female; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine | 1989 |
The interaction of cimetidine with various antihypertensive agents in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cimetidine; Clonidine; Guanethidine; Injections, Intraventricular; Male; Minoxidil; Pentolinium Tartrate; Rats; Rats, Inbred SHR; Time Factors | 1985 |
Discrimination between alpha 1- and alpha 2-adrenergic receptors in the isolated perfused ileum.
Topics: Adrenergic alpha-Agonists; Animals; Cimetidine; Clonidine; Ileum; Intestinal Absorption; Norepinephrine; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha; Vascular Resistance | 1988 |
Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats.
Topics: Animals; Azepines; Blood Pressure; Brain; Cimetidine; Clonidine; Hydroxydopamines; Injections, Intraventricular; Ketanserin; Male; Methoxamine; Oxidopamine; Piperidines; Prazosin; Procaine; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
Interaction of clonidine with human placental Na+ -H+ exchanger.
Topics: Amiloride; Carrier Proteins; Cimetidine; Clonidine; Female; Humans; In Vitro Techniques; Kinetics; Microvilli; Placenta; Pregnancy; Sodium; Sodium-Hydrogen Exchangers | 1986 |
Quantification of H2-agonism by clonidine and dimaprit in an adenylate cyclase assay.
Topics: Adenylyl Cyclases; Animals; Cimetidine; Clonidine; Dimaprit; Guinea Pigs; Histamine; In Vitro Techniques; Myocardium; Receptors, Histamine; Receptors, Histamine H2; Thiourea | 1985 |
Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta.
Topics: Carrier Proteins; Cations, Monovalent; Cimetidine; Clonidine; Female; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Membrane Proteins; Microvilli; Placenta; Pregnancy; Sodium | 1988 |
Possible involvement of histamine H2-receptors in the vasodilator effect of clonidine on isolated and perfused canine coronary arteries.
Topics: Animals; Chlorpheniramine; Cimetidine; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Perfusion; Receptors, Histamine H2; Vasodilation | 1986 |
Adverse drug reactions in the elderly: case studies.
Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol | 1984 |
Evidence for a histamine H2-receptor involvement in clonidine's antihypertensive effects during multiple dosing.
Topics: Animals; Antihypertensive Agents; Cimetidine; Clonidine; Histamine H2 Antagonists; Rats; Receptors, Histamine; Receptors, Histamine H2 | 1980 |
Multiple effects of putative alpha-adrenoceptor agonists on the electrical and mechanical activity of guinea-pig papillary muscle.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Receptors, Histamine H2 | 1981 |
Histamine receptor agonists and antagonists on granulocyte adherence.
Topics: Cimetidine; Clonidine; Granulocytes; Histamine; Histamine Antagonists; Humans; Pyrilamine | 1982 |
The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat.
Topics: Animals; Body Temperature; Cimetidine; Clonidine; Drug Interactions; Injections, Intraperitoneal; Injections, Intraventricular; Male; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Histamine; Receptors, Histamine H2; Time Factors | 1980 |
Solubilization of a [3H]cimetidine binding site from rat brains. A clonidine-sensitive H-2 receptor subtype?
Topics: Animals; Brain; Cimetidine; Clonidine; Copper; Female; Guanidines; Imidazoles; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Histamine; Receptors, Histamine H2 | 1981 |
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Acid; Male; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
Blockade of carcinoid flush with cimetidine and clonidine.
Topics: Adult; Chlorpheniramine; Cimetidine; Clonidine; Drug Therapy, Combination; Female; Guanidines; Humans; Malignant Carcinoid Syndrome | 1982 |
Differential effects of histamine on left and righ guinea-pig atria.
Topics: Action Potentials; Animals; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Functional Laterality; Guinea Pigs; Heart Atria; Histamine; In Vitro Techniques; Myocardial Contraction | 1981 |
Amiloride and harmaline are potent inhibitors of NhaB, a Na+/H+ antiporter from Escherichia coli.
Topics: Amiloride; Bacterial Proteins; Biological Transport; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Escherichia coli; Harmaline; Proteolipids; Sodium; Sodium-Hydrogen Exchangers | 1995 |
Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.
Topics: Amiloride; Animals; Biological Transport, Active; Carrier Proteins; CHO Cells; Cimetidine; Clone Cells; Clonidine; Cricetinae; Harmaline; Hydrogen-Ion Concentration; Kinetics; Rats; Sodium; Sodium-Hydrogen Exchangers | 1993 |
Characterization and subtype identification of the Na(+)-H+ exchanger in bovine corneal epithelium.
Topics: Amiloride; Animals; Binding, Competitive; Carrier Proteins; Cattle; Cell Membrane; Cimetidine; Clonidine; Cornea; Epithelium; Hydrogen-Ion Concentration; Sodium; Sodium-Hydrogen Exchangers; Temperature | 1993 |
Activation of Na+/H+ exchange is required for regulatory volume decrease after modest "physiological" volume increases in jejunal villus epithelial cells.
Topics: Alkalies; Amiloride; Ammonium Chloride; Animals; Biological Transport; Cell Size; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Guinea Pigs; Hydrogen-Ion Concentration; Jejunum; Male; Protons; Sodium | 1996 |
Cardiovascular effects of central administration of clonidine in conscious cats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Behavior, Animal; Benzofurans; Blood Pressure; Cardiovascular System; Cats; Cimetidine; Clonidine; Coloring Agents; Consciousness; Dose-Response Relationship, Drug; Evans Blue; Female; Heart Rate; Histamine H2 Antagonists; Imidazoles; Injections, Intraventricular; Yohimbine | 1997 |
Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.
Topics: Amiloride; Animals; Base Sequence; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Clonidine; DNA Primers; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Collecting; Kinetics; Polymerase Chain Reaction; Protein Kinases; Rabbits; Sodium-Hydrogen Exchangers; Sulfones | 1998 |
Characterization of the Na+/H+ exchanger in the luminal membrane of the distal nephron.
Topics: Amiloride; Animals; Biological Transport; Bucladesine; Cell Membrane; Cimetidine; Clonidine; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Nephrons; Rabbits; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1998 |
Cardiovascular effects of intravenous administration of clonidine in conscious cats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Histamine H2 Antagonists; Injections, Intravenous; Injections, Intraventricular; Yohimbine | 1998 |
Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.
Topics: Acids; Alkalies; Amiloride; Animals; Anti-Ulcer Agents; Antihypertensive Agents; Biological Transport; Caco-2 Cells; Cimetidine; Clonidine; Cytoplasm; Diuretics; Electric Impedance; Electrophysiology; Epithelial Cells; Glucose; Guanidines; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Methacrylates; Microvilli; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tight Junctions | 2000 |
A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cimetidine; Clonidine; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Yohimbine | 2001 |
Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes.
Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Atropine; Carcinogens; Cimetidine; Clonidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hypoglycemic Agents; Male; Microsomes, Liver; Muscarinic Antagonists; Nitrosamines; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tolbutamide; Vitamins | 2001 |
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal | 2005 |
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Topics: Amides; Anesthetics, Local; Bupivacaine; Cells, Cultured; Cimetidine; Clonidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Lidocaine; Microsomes, Liver; Midazolam; Premedication; Ropivacaine; Thiamylal; Vecuronium Bromide | 2006 |