cimetidine has been researched along with aspirin in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 79 (61.24) | 18.7374 |
| 1990's | 17 (13.18) | 18.2507 |
| 2000's | 17 (13.18) | 29.6817 |
| 2010's | 16 (12.40) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Baskin, WN; Ivey, KJ; Krause, WJ; MacKercher, PA | 1 |
| Bommelaer, G; Guth, PH | 1 |
| Reus, VI | 1 |
| Bentch, HL; Harris, SC; Welch, RW | 1 |
| Grossman, MI; Kauffman, GL | 1 |
| Aures, D; Guth, PH; Paulsen, G | 1 |
| Levine, BA; Pruitt, BA; Sirinek, KR | 1 |
| Carmichael, HA; Nelson, LM; Russel, RI | 1 |
| Djahanguiri, B; Gerayesh-Nejad, S; Zarrindast, MR | 1 |
| Grossman, MI; Guth, PH; Kauffman, GL | 1 |
| Kurebayashi, Y; Tabuchi, Y | 1 |
| Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB | 1 |
| Bright, RM; DeNovo, RC; Jenkins, CC; Patton, CS; Rohrbach, BW | 1 |
| Dolan, PW; Malone, DG; Seebruch, JS; Verbsky, JW; Vikingsson, A | 1 |
| Burtin, C; Eschalier, A; Lavarenne, J; Tounissou, P | 1 |
| Borella, LE; DiJoseph, JF | 1 |
| Calzada, R; Dhar, R; Jaszewski, R | 1 |
| Friedman, H; Lanza, FL; Royer, GL; Schwartz, JH; Seckman, CE; Stubbs, CM | 1 |
| Bianchine, JR; Gerber, MC; Gerber, N; Tejwani, GA | 1 |
| Hernandez Avila, M; Jick, H; Perera, DR; Romieu, I; Spiegelman, DL; Walker, AM | 1 |
| Ageel, AM; Parmar, NS; Tariq, M | 1 |
| Hogan, DL; Isenberg, JI; Thomas, FJ | 1 |
| Bauer, RF; Bianchi, RG; Casler, J; Goldstin, B | 1 |
| Brooks, PM; Ellard, KT; Hills, LJ; Stiel, D | 1 |
| Katz, LB; Rosenthale, ME; Shriver, DA; Tobia, AJ | 1 |
| Gilbertson, SK; Kolbasa, KP; Lancaster, C; Olafsson, AS; Robert, A | 1 |
| Kimmey, MB; Silverstein, FE | 1 |
| Chapman, RC; Kimmey, MB; Saunders, DR; Silverstein, FE | 1 |
| Hogan, DL | 1 |
| Dimitrova, D; Ivancheva, E; Liochev, S; Russanov, E | 1 |
| Takeuchi, K; Tanaka, H; Ueki, S | 1 |
| Dveksler, G; Franchi, AM; Gimeno, AL; Gimeno, MF; Viggiano, M | 1 |
| Boulay, JP; Klausner, JS; Lipowitz, AJ | 1 |
| Frank, WO | 1 |
| Christensen, LA; Schmidt, EB | 1 |
| Jourdan, MH; Mason, RC; Rowe, PH | 1 |
| Lumachi, B; Scuri, R | 1 |
| Ariizumi, M; Egawa, K; Iwasaki, H; Kameda, H; Kawamura, T; Nozawa, H; Onizawa, N; Takayama, S; Torii, A | 1 |
| Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N | 1 |
| Carter, DC; Salim, AS; Utley, RJ | 1 |
| Hara, N; Okabe, S | 1 |
| Noguchi, M; Ohno, H; Takayanagi, N | 1 |
| Schubert, TT | 1 |
| Kolts, BE; Langfitt, M | 1 |
| Jefferys, DB; Keen, H; Strakosch, CR | 1 |
| Bennett, A; Clark-Wibberley, T; Stamford, IF; Wright, JE | 1 |
| Bunce, KT; Daly, MJ; Humphray, JM; Stables, R | 1 |
| Brittain, RT; Daly, MJ | 1 |
| Maeno, H; Takagi, T; Takeda, M; Yashima, Y | 1 |
| Del Soldato, P; Varin, L | 1 |
| Brittain, RT; Jack, D | 1 |
| Haga, K; Nakanishi, A; Osuga, K; Tsumagari, T | 1 |
| Greene, W | 1 |
| Bornman, PC; Gilinsky, NH; Girdwood, AH; Lucke, W; Marks, IN; Mee, AS; Tobias, P; Wright, JP | 1 |
| Best, R; Lewis, DA; Nasser, N | 1 |
| Parsons, ME; Pipkin, G; Price, CA | 1 |
| Havey, RJ | 1 |
| Dorsch, W; Hintschich, C; Neuhauser, J; Weber, J | 1 |
| Ishihara, Y; Kunimi, H; Okabe, S; Takeuchi, K | 1 |
| Aguwa, CN; Ramanujam, TR | 1 |
| Barnett, A; Chiu, PJ; Gerhart, C; Kaminski, J; Policelli, M | 1 |
| Nobuhara, Y; Takeuchi, K | 1 |
| Davis, JP; Field, SO; Lancaster, C; Nezamis, JE; Robert, A | 1 |
| Caspary, WF; Lembcke, B; Lembcke, C | 1 |
| Hennings, G; Parmar, NS | 1 |
| Cattaneo, AG; Caviezel, F; Corino, T; Mascherpa, M; Tell, A | 1 |
| Konishi, M; Miyazaki, M; Toda, N | 1 |
| Cairnie, AB; Leach, KE | 1 |
| Adams, MB; Hebert, LA; Kauffman, HM; Walczak, PM | 1 |
| D'Arcy, PF | 1 |
| Chiu, PJ; Derelanko, MJ; Long, JF; Steinberg, M | 1 |
| Thiers, B | 1 |
| West, GB | 1 |
| Oates, JA; Roberts, LJ; Turk, JW | 1 |
| Ivey, KJ; O'Laughlin, JC; Silvoso, GK | 1 |
| Ivey, KJ; O'Laughlin, JC; Silvoso, GR | 1 |
| Herbert, V; Massarrat, S; Veith, R | 1 |
| Azuumi, Y; Hotta, K; Ishihara, K; Ohara, S; Okabe, H | 1 |
| Ivey, KJ | 1 |
| Defilippi, CC; Espinoza, M; Gómez, E; Valenzuela, JE | 1 |
| Kather, H; Müller, P; Simon, B | 1 |
| Miyazaki, M; Toda, N | 1 |
| Ishizuka, Y; Kamisaki, T; Kawase, A; Kimura, I; Sato, M; Shimamura, H; Tanaka, Y; Tanimura, T; Terashima, K; Uenishi, K | 1 |
| Kinoshita, M; Noto, T; Tamaki, H | 1 |
| Ishizuka, Y; Kamisaki, T; Kawashima, M; Matsuda, M; Sato, M; Shimazaki, I; Terashima, K; Yaginuma, H | 1 |
| Barattini, P; Dayton, MT; Larsen, KR; Moore, JG | 1 |
| Ishizuka, Y; Kamisaki, T; Kawase, A; Sato, M; Shimamura, H; Tanaka, Y; Tanimura, T; Terashima, K | 1 |
| Burns, JC; Kashani, IA; Kligerman, M; Mason, W; Matsubara, T | 1 |
| Busch, U; Heinzel, G; Narjes, H; Nehmiz, G | 1 |
| Coffey, RJ; Greenson, JK; Meise, KS; Scheiman, JM | 1 |
| Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G | 1 |
| Dube, SN; Gupta, AK; Kaushik, MP; Kumar, D; Mazumder, PK | 1 |
| Akima, M; Katsuyama, I; Sakai, K | 1 |
| Al-shabanah, OA; Raza, M | 1 |
| Ayukawa, O; Kariyazono, H; Moriyama, Y; Nakamura, K; Shinkawa, T; Taira, A; Toyohira, H; Yamada, K; Yamaguchi, T; Yamashita, T; Yotsumoto, G | 1 |
| Goswami, SG; Patel, HM; Santani, DD | 1 |
| Caldwell, GG; Evangelisto, M; Jones, WW; Juzwin, SS; Masucci, JJ; Sasso, PP | 1 |
| Di Stasi, LC; Gonzalez, FG | 1 |
| Goswami, S; Paul, A; Santani, D; Sevak, R | 1 |
| Nogi, K; Onoda, Y; Taniguchi, H | 1 |
| Chen, IM; Cheng, CY; Lin, CH; Lin, MS; Lin, PR; Lin, YH; Tsai, MC | 1 |
| BLAUG, SM; RICH, AG | 1 |
| Yu, L; Zeng, S | 1 |
| Kaithwas, G; Majumdar, DK | 1 |
| Ansari, N; Bakhshi, IM; Bukhari, MH; Khalil, J; Qamar, S; Qamar, Z; Zahid, M | 1 |
| Amagase, K; Satoh, H; Takeuchi, K | 1 |
| Chi, YC; Chiang, CP; Lai, CL; Lee, SL; Lee, SP; Lee, YP; Yin, SJ | 1 |
| Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A | 1 |
8 review(s) available for cimetidine and aspirin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug interactions with cimetidine: an update.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Aspirin; Aziridines; Benzodiazepines; Benzoquinones; Cimetidine; Drug Interactions; Humans; Ibuprofen; Imipramine; Kinetics; Lidocaine; Liver Circulation; Pituitary Gland; Procaine; Xanthines | 1985 |
Gastric acid secretion and mucosal defense mechanisms with special reference to the role of cimetidine in critically ill patients.
Topics: Animals; Aspirin; Cimetidine; Gastric Acid; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Membrane Potentials | 1986 |
Update in treatment of peptic ulcer disease.
Topics: Adult; Aged; Alcohol Drinking; Aluminum; Antacids; Anti-Ulcer Agents; Aspirin; Bismuth; Cimetidine; Female; Humans; Male; Organometallic Compounds; Peptic Ulcer; Ranitidine; Recurrence; Smoking; Sucralfate; Vagotomy, Proximal Gastric | 1984 |
A review of the animal pharmacology of ranitidine--a new, selective histamine H2-antagonist.
Topics: Administration, Oral; Animals; Aspirin; Bethanechol Compounds; Cimetidine; Dogs; Furans; Gastric Acid; Gastric Mucosa; Guinea Pigs; Heart Atria; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Contraction; Prostate; Ranitidine; Rats; Stomach Ulcer | 1981 |
Histamine H2-antagonists--past, present and future.
Topics: Animals; Aspirin; Burimamide; Chemical Phenomena; Chemistry; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Guinea Pigs; Half-Life; Histamine H2 Antagonists; Humans; Imidazoles; Methylamines; Ranitidine; Rats; Stomach; Thiazoles; Triazoles | 1983 |
Drug interactions involving cimetidine--mechanisms, documentation, implications.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12 | 1984 |
Over-the-counter and iatrogenically induced psychoses: a review of the literature.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Aspirin; Cimetidine; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Humans; Illicit Drugs; Nonprescription Drugs; Parasympatholytics; Psychoses, Substance-Induced; Quinacrine | 1984 |
16 trial(s) available for cimetidine and aspirin
| Article | Year |
|---|---|
Protective effect of cimetidine on aspirin-induced gastric mucosal damage.
Topics: Adult; Aspirin; Cimetidine; Gastric Mucosa; Guanidines; Humans; Hydrogen-Ion Concentration; Male; Sodium Chloride; Stomach Diseases | 1977 |
Reduction of aspirin-induced gastrointestinal bleeding with cimetidine.
Topics: Arthritis; Aspirin; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Gastric Juice; Gastrointestinal Hemorrhage; Guanidines; Humans; Placebos | 1978 |
Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; Gastroscopy; Humans; Male; Middle Aged; Osteoarthritis; Prospective Studies; Stomach Ulcer; Tablets, Enteric-Coated | 1989 |
The effects of flurbiprofen, aspirin, cimetidine, and antacids on the gastric and duodenal mucosa of normal volunteers. An endoscopic and photographic study.
Topics: Adult; Antacids; Aspirin; Cimetidine; Duodenum; Endoscopy; Female; Flurbiprofen; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Male; Propionates; Time Factors | 1989 |
Cimetidine decreases aspirin-induced gastric mucosal damage in humans.
Topics: Adult; Aspirin; Cimetidine; Double-Blind Method; Female; Gastric Mucosa; Gastroscopy; Humans; Male; Middle Aged; Stomach Diseases | 1987 |
Protective effect of enprostil against aspirin-induced gastroduodenal mucosal injury in man. Comparison with cimetidine and sucralfate.
Topics: Adult; Aluminum; Aspirin; Cimetidine; Clinical Trials as Topic; Duodenum; Enprostil; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Intestinal Mucosa; Male; Prostaglandins E, Synthetic; Random Allocation; Sucralfate | 1986 |
Role of H2-receptor blockers in the prevention of gastric injury resulting from nonsteroidal anti-inflammatory agents.
Topics: Aspirin; Cimetidine; Double-Blind Method; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male | 1988 |
Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine.
Topics: Acute Disease; Adolescent; Adult; Aspirin; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Random Allocation; Stomach Diseases | 1987 |
Blockade of chlorpropamide alcohol flush by aspirin.
Topics: Aspirin; Blood Vessels; Body Temperature; Chlorpheniramine; Chlorpropamide; Cimetidine; Diabetes Mellitus; Double-Blind Method; Ethanol; Face; Guanidines; Humans; Skin | 1980 |
Ranitidine in the treatment of gastric ulceration.
Topics: Aged; Alcohol Drinking; Antacids; Anti-Ulcer Agents; Aspirin; Cimetidine; Clinical Trials as Topic; Female; Furans; Humans; Male; Middle Aged; Random Allocation; Ranitidine; Smoking; Stomach Ulcer; Time Factors | 1982 |
Platelet inhibitors in human renal homotransplantation: randomized comparison of aspirin versus dipyridamole.
Topics: Aspirin; Cimetidine; Cost-Benefit Analysis; Dipyridamole; Graft Rejection; Humans; Kidney Transplantation; Renal Artery Obstruction | 1980 |
Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin. A double-blind study with cimetidine and follow-up.
Topics: Antacids; Aspirin; Cimetidine; Double-Blind Method; Follow-Up Studies; Guanidines; Humans; Placebos; Prospective Studies; Rheumatic Heart Disease; Stomach Ulcer | 1982 |
Effect of low dose of cimetidine on gastric potentials difference and acetylsalicylic acid-induced change.
Topics: Adult; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; Guanidines; Humans; Membrane Potentials | 1981 |
Interaction of meloxicam with cimetidine, Maalox, or aspirin.
Topics: Administration, Oral; Adult; Aluminum Hydroxide; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Drug Combinations; Drug Interactions; Histamine H2 Antagonists; Humans; Magnesium Hydroxide; Male; Meloxicam; Middle Aged; Thiazines; Thiazoles | 1996 |
Transforming growth factor-alpha (TGF-alpha) levels in human proximal gastrointestinal epithelium. Effect of mucosal injury and acid inhibition.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy, Needle; Cimetidine; Duodenum; Gastric Acid; Gastric Mucosa; Humans; Intestinal Mucosa; Omeprazole; Peptic Ulcer; Pyloric Antrum; Radioimmunoassay; Transforming Growth Factor alpha | 1997 |
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Cross-Over Studies; Double-Blind Method; Duodenal Ulcer; Female; Fibroblast Growth Factor 2; Humans; Indomethacin; Male; Models, Biological; Recurrence; Stomach Ulcer | 1997 |
105 other study(ies) available for cimetidine and aspirin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Protection by histamine receptor antagonists and prostaglandin against gastric mucosal barrier disruption in the rat.
Topics: Administration, Topical; Animals; Aspirin; Cimetidine; Drug Combinations; Gastric Juice; Gastric Mucosa; Histamine H2 Antagonists; Injections, Intraperitoneal; Membrane Potentials; Potassium; Prostaglandins E, Synthetic; Pyrilamine; Rats; Sodium; Stomach Ulcer | 1979 |
Behavioral side effects of medical drugs.
Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Caffeine; Cimetidine; Contraceptives, Oral, Hormonal; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Levodopa; Male; Mental Disorders; Parasympatholytics; Placebos; Propranolol; Psychoses, Substance-Induced; Reserpine; Sympathomimetics; Thyroid Hormones | 1979 |
Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates.
Topics: Animals; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Juice; Gastric Mucosa; Guanidines; Male; Pepsin A; Prostaglandins E, Synthetic; Rats; Stomach Ulcer | 1978 |
Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine.
Topics: Animals; Aspirin; Cimetidine; Depression, Chemical; Gastric Juice; Guanidines; Hydrochloric Acid; Injections, Intraperitoneal; Injections, Subcutaneous; Pepsin A; Propantheline; Prostaglandins E; Rats; Stomach Ulcer | 1979 |
Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers.
Topics: Animals; Aspirin; Cimetidine; Disease Models, Animal; Female; Gastric Mucosa; Guanidines; Rats; Stomach Ulcer; Stress, Physiological; Taurocholic Acid | 1979 |
Cimetidine and prostaglandin: evidence for different modes of action on the rat gastric mucosa.
Topics: Animals; Aspirin; Cimetidine; Gastric Mucosa; Gastritis; Guanidines; Hydrochloric Acid; Male; Prostaglandins E, Synthetic; Rats | 1978 |
Effects of cold or restraint on incidence of gastric ulceration induced in rats by ulcerogenic drugs.
Topics: Animals; Aspirin; Cimetidine; Cold Temperature; Female; Histamine; Indomethacin; Male; Phenylbutazone; Rats; Restraint, Physical; Stomach Ulcer; Time Factors | 1978 |
Cimetidine and prostaglandin prevent damage to gastric mucosa.
Topics: Animals; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Guanidines; Hydrochloric Acid; Prostaglandins E, Synthetic; Rats; Stomach Ulcer | 1978 |
Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Immersion; Leukotriene Antagonists; Male; Mast Cells; Pylorus; Pyrimidines; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stomach Ulcer; Triazoles | 1992 |
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Azepines; Cimetidine; Dexamethasone; Edema; Male; Meclizine; Methysergide; Mice; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Triazoles | 1991 |
Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dog Diseases; Dogs; Double-Blind Method; Gastritis; Gastroscopy; Male; Omeprazole; Random Allocation; Stomach Ulcer | 1991 |
In vivo effects of nonsteroidal antiinflammatory drugs on rat skin and synovial mast cell-induced vasopermeability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capillary Permeability; Cimetidine; Diphenhydramine; Indomethacin; Ketoprofen; Male; Mast Cells; Rats; Rats, Inbred Strains; Skin; Synovial Membrane | 1991 |
Acute hemodynamic effects of an antitumoral agent: elliptinium. Involvement of histamine release.
Topics: Alkaloids; Animals; Antineoplastic Agents; Aspirin; Atropine; Blood Pressure; Cardiovascular Physiological Phenomena; Cimetidine; Coronary Circulation; Dogs; Ellipticines; Female; Heart Rate; Hemodynamics; Histamine Release; Male; Myocardial Contraction; Propranolol; Pyrilamine | 1986 |
Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester.
Topics: Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cyanoacrylates; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; In Vitro Techniques; Indomethacin; Male; Pentagastrin; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Psychological | 1989 |
Choice of non-steroidal anti-inflammatory drug in persons treated for dyspepsia.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; Dyspepsia; Female; Health Maintenance Organizations; Humans; Male; Peptic Ulcer | 1988 |
Gastric anti-ulcer and cytoprotective effect of selenium in rats.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dimaprit; Ethanol; Female; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; Reserpine; Selenious Acid; Selenium; Stomach Ulcer; Thiourea | 1988 |
Comparative mucosal protective properties of misoprostol, cimetidine, and sucralfate.
Topics: Alprostadil; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol; Rats; Stress, Physiological; Sucralfate; Taurocholic Acid | 1986 |
Selective gastric antilesion properties of rioprostil, a prostaglandin E1 analog, in rats and dogs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dogs; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid; Gastric Mucosa; Male; Prostaglandins E; Prostaglandins E, Synthetic; Ranitidine; Rats; Rats, Inbred Strains; Rioprostil | 1987 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal; Gastric Acid; Indomethacin; Injections, Subcutaneous; Male; Mesocricetus; Omeprazole; Peptic Ulcer Perforation; Prostaglandins E; Stomach Ulcer; Time Factors | 1988 |
Damage and protection of the human gastric mucosa. A multiparameter assessment.
Topics: Arbaprostil; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Gastroscopy; Humans; Hydrogen-Ion Concentration; Sodium; Taurocholic Acid | 1988 |
Phosphatidylcholine peroxidation induced by Cu(II) and some Cu(II) complexes.
Topics: Ascorbic Acid; Aspirin; Cimetidine; Copper; Glycine; Indomethacin; Lipid Peroxides; NAD; Oxidation-Reduction; Phosphatidylcholines | 1988 |
Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage.
Topics: 16,16-Dimethylprostaglandin E2; 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bicarbonates; Cimetidine; Dinoprostone; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Male; Membrane Potentials; Prostaglandins; Prostaglandins E; Rats; Taurocholic Acid | 1986 |
Is there a prostaglandin involvement in the positive inotropic action of histamine in isolated pregnant rat uterus, apparently mediated via H1-receptors activation?
Topics: Alprostadil; Animals; Aspirin; Chlorpheniramine; Cimetidine; Dinoprost; Dinoprostone; Female; Histamine; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Pyrilamine; Quinacrine; Rats; Receptors, Histamine; Receptors, Histamine H1; Stimulation, Chemical; Uterine Contraction | 1987 |
Effect of cimetidine on aspirin-induced gastric hemorrhage in dogs.
Topics: Animals; Aspirin; Cimetidine; Dogs; Feces; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hemoglobins; Male | 1986 |
Perforated peptic ulcer--a complication in acute salicylate intoxication.
Topics: Acute Disease; Acute Kidney Injury; Aspirin; Cimetidine; Female; Humans; Middle Aged; Peptic Ulcer Perforation; Renal Dialysis | 1987 |
Effect of cimetidine and omeprazole on aspirin and taurocholate-induced gastric mucosal damage.
Topics: Animals; Aspirin; Benzimidazoles; Cimetidine; Gastric Mucosa; Omeprazole; Rats; Taurocholic Acid | 1986 |
Hexaprazol antagonism to gastric electrical potential fall by acetylsalicylic acid in rat.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbenoxolone; Cimetidine; Electric Stimulation; Female; Membrane Potentials; Piperazines; Ranitidine; Rats; Rats, Inbred Strains; Stomach | 1985 |
[Histochemical examination of gastric covering and epithelial mucus in rats (the 2nd report). Effect of several anti-ulcer drugs on aspirin-induced mucosal damage].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzodiazepinones; Cimetidine; Dinoprostone; Gastric Mucosa; Male; Pirenzepine; Prostaglandins E; Rats; Rats, Inbred Strains | 1985 |
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cimetidine; Dogs; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Phenylpropionates; Pylorus; Rats; Rats, Inbred Strains; Regional Blood Flow; Serotonin; Stomach Ulcer; Stress, Physiological; Tranexamic Acid | 1985 |
Effect of cimetidine and omeprazole on aspirin- and taurocholate-induced gastric mucosal damage in the rat.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Omeprazole; Rats; Rats, Inbred Strains; Taurocholic Acid | 1985 |
[Effects of gefarnate on acute gastric lesions in rats].
Topics: Acute Disease; Animals; Aspirin; Cimetidine; Ethanol; Gefarnate; Male; Rats; Rats, Inbred Strains; Stomach Diseases; Taurocholic Acid; Terpenes | 1985 |
Effect of elcatonin on experimental gastric and duodenal ulcers.
Topics: Acetates; Acetic Acid; Actihaemyl; Animals; Anti-Ulcer Agents; Aspirin; Calcitonin; Cimetidine; Cysteamine; Dogs; Duodenal Ulcer; Humans; Immersion; Male; Rats; Rats, Inbred Strains; Reserpine; Secretin; Species Specificity; Stomach Ulcer; Stress, Psychological | 1985 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil | 1984 |
Aspirin-induced gastric mucosal damage in rats: cimetidine and deglycyrrhizinated liquorice together give greater protection than low doses of either drug alone.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Drug Interactions; Gastric Mucosa; Glycyrrhiza; Guanidines; Male; Plant Extracts; Plants, Medicinal; Rats; Time Factors | 1980 |
H2-receptor antagonists protect against aspirin-induced gastric lesions in the rat.
Topics: Animals; Aspirin; Cimetidine; Female; Furans; Gastric Mucosa; Histamine H2 Antagonists; Pyrilamine; Ranitidine; Rats; Stomach Ulcer | 1981 |
Effect of a new potent H2-blocker, 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2-sulfamoyl propionamidine (YM-11170), on gastric secretion, ulcer formation and weight of male accessory sex organs in rats.
Topics: Androgen Antagonists; Animals; Aspirin; Castration; Cimetidine; Famotidine; Gastric Juice; Gastric Mucosa; Genitalia, Male; Histamine H2 Antagonists; Male; Organ Size; Rats; Rats, Inbred Strains; Stomach Ulcer; Testosterone; Thiazoles | 1982 |
Studies of the factors that influence acetylsalicylic acid-induced gastric damage in stressed rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Female; Furans; Gastric Mucosa; Histamine H2 Antagonists; Humans; Prostaglandins; Ranitidine; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Psychological | 1983 |
Antiulcer activity of clotiazepam in rats.
Topics: Animals; Aspirin; Atropine; Azepines; Cimetidine; Female; Gastric Juice; Gastric Mucosa; Hexosamines; Male; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1984 |
The anti-ulcerogenic activity of the unripe plantain banana (Musa species).
Topics: Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Aspirin; Bucladesine; Cimetidine; Dinoprostone; DNA; Gastric Mucosa; Hexosamines; Male; N-Acetylneuraminic Acid; Plants, Medicinal; Prostaglandins E; Rats; Rats, Inbred Strains; Serotonin; Sialic Acids; Stomach Ulcer | 1984 |
Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid.
Topics: Animals; Aspirin; Biological Transport; Chromium Radioisotopes; Cimetidine; Drug Interactions; Electrolytes; Gastric Mucosa; Gastrointestinal Hemorrhage; Hydrogen-Ion Concentration; Infusions, Parenteral; Iodine Radioisotopes; Ischemia; Male; Potassium; Rats; Serum Albumin; Sodium; Time Factors | 1984 |
Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin.
Topics: Animals; Aspirin; Blood Platelets; Bronchi; Bronchial Provocation Tests; Chemical Phenomena; Chemistry; Cimetidine; Epoprostenol; Guinea Pigs; Histamine; Imidazoles; Male; Platelet Aggregation; Pyridines; Receptors, Histamine H1; Receptors, Histamine H2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats.
Topics: Animals; Aspirin; Chromones; Cimetidine; Gastric Juice; Histamine; Humans; Male; Mast Cells; Pylorus; Rats; Rats, Inbred Strains; Reserpine; Stomach Ulcer; Stress, Psychological | 1984 |
Antiulcer effects of trimipramine using various laboratory models.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dibenzazepines; Disease Models, Animal; Humans; Male; Rats; Reserpine; Stomach Ulcer; Stress, Psychological; Trimipramine | 1984 |
Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cysteamine; Drug Evaluation, Preclinical; Duodenal Ulcer; Ethanol; Gastric Mucosa; Imidazoles; Indomethacin; Male; Pyrazines; Rats; Reserpine; Stomach Ulcer; Stress, Physiological | 1984 |
Possible role of endogenous prostaglandins in alkaline response in rat gastric mucosa damaged by hypertonic NaCl.
Topics: Animals; Aspirin; Cimetidine; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Hydrogen-Ion Concentration; Hypertonic Solutions; Indomethacin; Male; Membrane Potentials; Prostaglandins; Prostaglandins E; Rats; Sodium Chloride | 1984 |
Distinction between antiulcer effect and cytoprotection.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Female; Gastric Acid; N-Methylscopolamine; Propantheline; Rats; Rats, Inbred Strains; Scopolamine Derivatives; Secretory Rate; Stomach Ulcer | 1984 |
[Transmural gastric potential difference (PD) and intragastric diurnal pH profile with proglumide].
Topics: Adult; Aspirin; Cimetidine; Circadian Rhythm; Double-Blind Method; Female; Gastric Acidity Determination; Gastric Mucosa; Glutamine; Humans; Male; Membrane Potentials; Proglumide | 1983 |
The effect of 3-methoxy-5,7,3',4'-tetrahydroxyflavan on the restraint induced gastric ulceration augmented by aspirin, a gastric mucosal barrier breaker.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Catechin; Cimetidine; Flavonoids; Gastric Mucosa; Male; Rats; Restraint, Physical; Stomach Ulcer | 1983 |
The effect of acetylsalicylic acid and diclofenac on stimulated growth hormone and prolactin secretion in humans.
Topics: Adolescent; Adult; Arginine; Aspirin; Cimetidine; Diclofenac; Female; Growth Hormone; Humans; Male; Metoclopramide; Middle Aged; Phenylacetates; Pituitary Function Tests; Prolactin; Prostaglandin Antagonists; Stimulation, Chemical | 1983 |
Involvement of endogenous prostaglandin I2 in the vascular action of histamine in dogs.
Topics: Animals; Aspirin; Blood Vessels; Chlorpheniramine; Cimetidine; Dogs; Epoprostenol; Female; Histamine; In Vitro Techniques; Indomethacin; Male; Platelet Aggregation; Prostaglandins; Tranylcypromine; Vasoconstriction; Vasodilation | 1982 |
Dexamethasone: a potent blocker for radiation-induced taste aversion in rats.
Topics: Animals; Aspirin; Avoidance Learning; Cimetidine; Conditioning, Classical; Dexamethasone; Dimethyl Sulfoxide; Domperidone; Dose-Response Relationship, Radiation; Gamma Rays; Haloperidol; Insulin; Male; Naloxone; Rats; Rats, Inbred Strains; Taste | 1982 |
Early reports on drug interactions.
Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine | 1983 |
Gastric antisecretory and cytoprotective activities of SCH 28080.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa; Histamine; Imidazoles; Indomethacin; Male; Membrane Potentials; Rats; Stomach Ulcer; Stress, Physiological | 1983 |
Therapeutic briefs. I.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Child; Cimetidine; Cyclophosphamide; Dipyridamole; Female; Humans; Infant; Isotretinoin; Pruritus; Skin Diseases; Tretinoin; Ultraviolet Therapy | 1980 |
Testing for drugs inhibiting the formation of gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cold Temperature; Copper; Indomethacin; Mucus; Organometallic Compounds; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Salicylates; Stomach Ulcer; Stress, Physiological | 1982 |
Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks.
Topics: Aspirin; Chlorpheniramine; Cimetidine; Epinephrine; Humans; Hypotension; Infusions, Parenteral; Prostaglandins D; Recurrence; Shock; Urticaria Pigmentosa | 1982 |
Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion.
Topics: Adolescent; Adult; Aged; Antacids; Arthritis, Rheumatoid; Aspirin; Cimetidine; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Stomach Ulcer; Time Factors | 1981 |
Efficacy of anti-ulcer drugs on the recovery of gastric mucosal glycoproteins with aspirin-induced gastric damage in rat.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Mucosa; Glycoproteins; Male; Rats; Rats, Inbred Strains; Tranexamic Acid | 1981 |
Drugs, gastritis, and peptic ulcer.
Topics: Acetaminophen; Animals; Aspirin; Bicarbonates; Cimetidine; Duodenitis; Gastric Acid; Gastric Mucosa; Gastritis; Humans; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Peptic Ulcer; Prostaglandins; Rats; Tablets, Enteric-Coated | 1981 |
[Relation between the rupture of the gastric mucous barrier and the pyloric sphincter of the dog. Protective role of cimetidine upon the effects of aspirin (author's transl)].
Topics: Animals; Aspirin; Cimetidine; Dogs; Drug Interactions; Gastric Mucosa; Guanidines; Pylorus | 1981 |
[Cytoprotection: a new principle in ulcer therapy?].
Topics: Aspirin; Carbenoxolone; Cimetidine; Gastric Mucosa; Humans; Indomethacin; Peptic Ulcer; Prostaglandins, Synthetic | 1980 |
Angiotensin-induced relaxation in isolated dog renal and cerebral arteries.
Topics: Aminophylline; Angiotensin II; Animals; Arteries; Aspirin; Atropine; Brain; Cimetidine; Cocaine; Depression, Chemical; Dogs; Female; Hexamethonium Compounds; In Vitro Techniques; Kidney; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ouabain; Propranolol; Prostaglandins F; Saralasin | 1981 |
Studies on antiulcer agents. II. Antiulcer properties of N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides inhibiting release of histamine from passively sensitized rat peritoneal mast cells.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cromolyn Sodium; Ethanol; Histamine H1 Antagonists; Histamine Release; Mast Cells; ortho-Aminobenzoates; Passive Cutaneous Anaphylaxis; Peritoneal Cavity; Pyrimidines; Rats; Stomach Ulcer; Tetrazoles | 1995 |
Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats.
Topics: Abietanes; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dinoprostone; Diterpenes; Drug Therapy, Combination; Gastric Mucosa; Hydrochloric Acid; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1995 |
Anti-ulcer effect of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid on experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Hydrochloric Acid; Male; p-Methoxy-N-methylphenethylamine; Pylorus; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Stomach Ulcer; Stress, Psychological; Tranexamic Acid | 1994 |
Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.
Topics: Animals; Aspirin; Bicarbonates; Cimetidine; Circadian Rhythm; Disease Models, Animal; Epoprostenol; Gastric Acid; Gastric Mucosa; Male; Pepsin A; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Ulcer | 1994 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Histamine; Indomethacin; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship | 1995 |
Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease.
Topics: Acute Disease; Aspirin; Child, Preschool; Cimetidine; Erythrocyte Transfusion; Female; gamma-Globulins; Gastrointestinal Hemorrhage; Humans; Male; Mucocutaneous Lymph Node Syndrome | 1996 |
Cardiovascular effects of an organophosphate toxin isolated from Ptychodiscus brevis.
Topics: Adrenergic alpha-Antagonists; Animals; Aspirin; Atropine; Cardiovascular System; Cholinesterase Inhibitors; Cimetidine; Dinoflagellida; Dose-Response Relationship, Drug; Drug Interactions; Ganglionic Blockers; Hexamethonium; Histamine H2 Antagonists; Humans; Male; Marine Toxins; Muscarinic Antagonists; Neostigmine; Organophosphorus Compounds; Platelet Aggregation Inhibitors; Potassium Channels; Prazosin; Rats; Rats, Wistar; Vasoconstriction | 1997 |
Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Acid; Gastric Mucosa; Glyburide; Hypoglycemic Agents; Immersion; Male; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Restraint, Physical; Stomach; Stomach Ulcer; Vasodilator Agents; Water | 1999 |
Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Mucosa; Male; Polyamines; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 1999 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Glyburide; Ligation; Male; Nicorandil; Proteins; Pylorus; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 2001 |
The use of on-line and off-line chromatographic extraction techniques coupled with mass spectrometry for support of in vivo and in vitro assays in drug discovery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antihypertensive Agents; Aspirin; Caco-2 Cells; Chromatography, Liquid; Cimetidine; Drug Evaluation, Preclinical; Gas Chromatography-Mass Spectrometry; Histamine H1 Antagonists; Humans; Hydrochlorothiazide; Pharmaceutical Preparations; Phosphodiesterase Inhibitors; Promethazine; Theophylline | 2001 |
Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Brazil; Cimetidine; Cucurbitaceae; Ethanol; Female; Flavonoids; Gastric Mucosa; Indomethacin; Male; Mice; Morphine; Motor Activity; Omeprazole; Phytotherapy; Plant Extracts; Rats; Stomach Ulcer; Tail; Toxicity Tests, Acute | 2002 |
Gastroprotective effect of beta3 adrenoreceptor agonists ZD 7114 and CGP 12177A in rats.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Female; Gastric Acid; Gastric Emptying; Gastric Mucosa; Gastrointestinal Motility; Ligation; Male; Pepsin A; Phenoxyacetates; Phenoxypropanolamines; Propanolamines; Pylorus; Rats; Rats, Wistar; Regional Blood Flow; Stomach Ulcer | 2002 |
Effects of the anti-ulcer agents ecabet sodium, cimetidine and sucralfate on acetylsalicylic acid-induced gastric mucosal damage deteriorated by renal failure in rats.
Topics: Abietanes; Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Blood Urea Nitrogen; Cimetidine; Disease Progression; Diterpenes; Gastric Mucosa; Kidney Function Tests; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sucralfate | 2002 |
A new isoquinolinone derivative with noble vasorelaxation activity.
Topics: Acetylcholine; Adrenergic Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Atropine; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Isoquinolines; Magnetic Resonance Spectroscopy; Male; Muscarinic Antagonists; Phenylephrine; Propranolol; Pyridines; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Yohimbine | 2003 |
INTERACTION BETWEEN POLY-N-VINYL-5-METHYL-2-OXAZOLIDINONE AND CERTAIN PHARMACEUTICALS IN AQUEOUS SOLUTION.
Topics: Aspirin; Barbiturates; Benzoates; Chemistry, Pharmaceutical; Cimetidine; Diphenhydramine; Drug Combinations; Ibuprofen; Indoles; Ketanserin; Macromolecular Substances; Methylprednisolone; Oxazoles; Oxazolidinones; Polymers; Research; Salicylic Acid; Sulfonamides; Xanthines | 1965 |
Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2.
Topics: Aspirin; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Cetirizine; Cimetidine; Diffusion; Dose-Response Relationship, Drug; Drug Interactions; Flunarizine; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Oxazolidinones; Permeability; Propranolol; Serotonin Receptor Agonists; Sodium-Hydrogen Exchangers; Tryptamines | 2007 |
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastric Mucosa; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Ileum; Indomethacin; Ligation; Linseed Oil; Misoprostol; Muscle Contraction; Promethazine; Pylorus; Rats; Rats, Wistar; Reserpine; Serotonin; Stomach Ulcer; Stress, Psychological | 2010 |
Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats.
Topics: Animals; Aspirin; Cimetidine; Honey; Humans; Male; Nigella sativa; Phytotherapy; Rats; Seeds; Stomach Ulcer | 2011 |
The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.
Topics: Administration, Oral; Animals; Aspirin; Cats; Cimetidine; Diet; Dietary Fiber; Disease Models, Animal; Eating; Female; Intestines; Male; Misoprostol; Peptic Ulcer; Stomach; Tablets, Enteric-Coated | 2013 |
Ethanol oxidation and the inhibition by drugs in human liver, stomach and small intestine: Quantitative assessment with numerical organ modeling of alcohol dehydrogenase isozymes.
Topics: Acetaminophen; Alcohol Dehydrogenase; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Genotype; Humans; Intestine, Small; Isoenzymes; Kinetics; Liver; Models, Biological; Oxidation-Reduction; Pharmaceutical Preparations; Salicylic Acid; Stomach; Substrate Specificity | 2016 |
Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cimetidine; Cytoprotection; Disease Models, Animal; Euphorbia; Gastric Mucosa; Malondialdehyde; Oxidative Stress; Plant Extracts; Rabbits; Stomach Ulcer | 2019 |