cimetidine and antipyrine

cimetidine has been researched along with antipyrine in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (63.51)	18.7374
1990's	5 (6.76)	18.2507
2000's	12 (16.22)	29.6817
2010's	10 (13.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Blake, JF; Curatolo, WJ; Lombardo, F	1
Artursson, P; Luthman, K; Norinder, U; Stenberg, P	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Atwood, JL; Breckenridge, AM; Mossman, S; Serlin, MJ; Sibeon, RG; Williams, JR; Willoughby, JM	1
Bianchetti, G; Desager, JP; Harvengt, C; Hulhoven, R	1
Rieth, H; Sauerbrey, N	1
Nakamura, K; Tanaka, E	1
Desager, JP; Harvengt, C; Horsmans, Y; Leclercq, V; Van Nieuwenhuyze, Y	1
Fribourg, HA; Heitmann, RN; McLaren, JB; Zanzalari, KP	1
Breimer, DD; Brugman, M; Schellens, JH; van der Wart, JH	1
Akamatsu, K; Hirabayashi, Y; Kanaoka, M; Masumoto, S; Nakanishi, K; Nishinobu, M; Ohta, Y; Okada, S; Sakaue, H; Sasaki, T	1
Dicke, JM; Henderson, GI; Johnson, RF; Kuehl, TJ; Schenker, S	1
Kuroiwa, Y; Misawa, S; Nakamura, K; Tanaka, E	1
Crewe, HK; Lennard, MS; Tucker, GT; Woods, HF	1
Larsson, H; Lorentzon, P; Wallmark, B	1
Back, DJ; Mönig, H; Ohnhaus, EE; Park, BK; Tjia, J	1
Eksymä, S; Gachalyi, B; Hämäläinen, A; Lahtela, JT; Sotaniemi, EA	1
Csillag, K; Gachályi, B; Káldor, A; Kocsis, F; Nagy, B; Vas, A	2
Døssing, M; Jørgensen, BG; Loft, S; Petersen, KT; Poulsen, HE; Sonne, J	1
Døssing, M; Loft, S; Pilsgaard, H; Poulsen, HE; Rasmussen, B; Sonne, J	1
Ching, MS; Date, NM; Hardy, KJ; Mihaly, GW; Morgan, DJ; Smallwood, RA	1
Desager, JP; Dumont, E; Harvengt, C	1
Adamska-Dyniewska, I; Chojnacki, J; Jabłkowski, M; Tkaczewski, W	1
Døssing, M; Loft, S; Pilsgaard, H; Poulsen, E; Sonne, J	1
Breckenridge, AM; Edwards, G; Mihaly, GW; Nicholl, DD; Ward, SA	1
Banditt, P; Kettner, W; Schröter, U; Walther, H	1
Breimer, DD; de Leede, LG; Kleinbloesem, CH; Teunissen, MW	1
Aarons, L; Adedoyin, A; Houston, JB	1
Bell, GD; Henry, DA; Kitchingman, G; Langman, MJ; Macdonald, IA	1
Henry, DA; Langman, MJ	1
Breen, KJ; Bury, R; Desmond, PV; Mashford, ML; Morphett, B; Shaw, RG; Westwood, B	1
Jones, DB; Smallwood, RA; Webster, LK	1
Dammann, HG; DeVries, JX; Koroknay, B; Müller, P; Simon, B; Staiger, C; Weber, E	1
Agnew, E; Brodie, MJ; Macphee, GJ; McColl, KE; Murray, T; Park, BK; Scobie, G; Thompson, GG	1
Hall, ST; Houston, JB; Rhodes, JC	1
de Vries, J; Staiger, C; Wang, NS; Weber, E	1
Døssing, M; Pilsgaard, H; Poulsen, HE; Rasmussen, B	1
Foote, SE; Paton, DM; Paxton, JW	1
Feely, J; Guy, E; Hockings, N; Pereira, L	1
Daneshmend, TK; Ene, MD; Parker, G; Roberts, CJ	1
Slusher, LB; Vesell, ES	1
Dammann, HG; Devries, JX; Korodnay, B; Müller, P; Simon, B; Staiger, C; Weber, E	1
Klotz, U; Reimann, I	1
Abernethy, DR; Divoll, M; Greenblatt, DJ; Shader, RI	1
Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Shader, RI	1
Bradbear, RA; Grice, J; O'Toole, J; Roberts, RK; Shepherd, RW	1
Grice, J; McGuffie, C; Petroff, V; Roberts, RK; Wood, L	1
Kaste, M; Neuvonen, PJ; Tokola, RA	1
Pelkonen, O; Puurunen, J; Sotaniemi, E	1
Bassily, M; Ghabrial, H; Morgan, DJ; Smallwood, RA	1
Janus, K; Suszycka, J	1
Berry, MN; Efthivoulou, MA	1
Bauman, JH; Fuentes, RJ	1
Ekblad, U; Heikkinen, T; Laine, K; Rahi, M; Rönnemaa, T; Tertti, K	1

Trials

9 trial(s) available for cimetidine and antipyrine

Article	Year
Cimetidine: interaction with oral anticoagulants in man. Lancet (London, England), 1979, Aug-18, Volume: 2, Issue:8138 Topics: Acenocoumarol; Administration, Oral; Adult; Aged; Antipyrine; Biological Availability; Cimetidine; Clinical Trials as Topic; Drug Synergism; Female; Guanidines; Half-Life; Humans; Male; Middle Aged; Phenindione; Prothrombin Time; Warfarin	1979
Effect of cimetidine on the pharmacodynamics, pharmacokinetics and biotransformation of a single oral dose of alpidem. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:12 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Antipyrine; Biotransformation; Cimetidine; Drug Interactions; Female; Humans; Imidazoles; Liver; Male; Mixed Function Oxygenases; Psychometrics; Pyridines	1990
[Interaction studies with fluconazole, a new triazole antifungal drug]. Wiener medizinische Wochenschrift (1946), 1989, Aug-31, Volume: 139, Issue:15-16 Topics: Adult; Antipyrine; Cimetidine; Clinical Trials as Topic; Contraceptives, Oral; Cyclosporins; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Male; Testosterone; Tolbutamide; Warfarin	1989
The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates. British journal of clinical pharmacology, 1989, Volume: 28, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Half-Life; Histamine H2 Antagonists; Humans; Indocyanine Green; Liver; Male; Pharmaceutical Preparations; Piperidines; Trimethadione	1989
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man. British journal of clinical pharmacology, 1986, Volume: 21, Issue:1 Topics: Adult; Antipyrine; Benzhydryl Compounds; Cimetidine; Enzyme Induction; Enzyme Inhibitors; Female; Glucose; Humans; Insulin; Kinetics; Male; Microsomes, Liver; Phenobarbital	1986
[The acetylator phenotype affects the antipyrine metabolism inhibiting action of cimetidine]. Orvosi hetilap, 1986, Jun-22, Volume: 127, Issue:25 Topics: Acetylation; Antipyrine; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Peptic Ulcer; Phenotype	1986
Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. British medical journal, 1980, Sep-20, Volume: 281, Issue:6243 Topics: Aminopyrine; Antipyrine; Cimetidine; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Microsomes, Liver; Ranitidine	1980
[Comparative study of the effect of famotidine and cimetidine on antipyrine pharmacokinetics in the human]. Arzneimittel-Forschung, 1984, Volume: 34, Issue:9 Topics: Adult; Antipyrine; Cimetidine; Famotidine; Female; Histamine H1 Antagonists; Humans; Kinetics; Male; Thiazoles	1984
[Effect of metronidazole on phenazone metabolism]. Arzneimittel-Forschung, 1984, Volume: 34, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Humans; Hydroxylation; Kinetics; Male; Metronidazole; Time Factors	1984

Other Studies

65 other study(ies) available for cimetidine and antipyrine

Article	Year
Computation of brain-blood partitioning of organic solutes via free energy calculations. Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24 Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics	1996
Experimental and computational screening models for the prediction of intestinal drug absorption. Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12 Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil	2001
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Influence of rifampicin, phenobarbital and cimetidine on mixed function monooxygenase in extensive and poor metabolizers of debrisoquine. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:12 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Debrisoquin; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Rifampin	1989
Effects of endophyte-infected fescue and cimetidine on respiration rates, rectal temperatures and hepatic mixed function oxidase activity as measured by hepatic antipyrine metabolism in sheep. Journal of animal science, 1989, Volume: 67, Issue:12 Topics: Alkaloids; Animal Feed; Animals; Antipyrine; Blood Flow Velocity; Body Temperature; Cimetidine; Female; Food Contamination; Liver; Mixed Function Oxygenases; Respiration; Sheep	1989
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Enzyme Induction; Female; Humans; Hydantoins; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Oxidation-Reduction; Phenobarbital; Smoking; Sparteine	1989
Effects of prolonged oral cimetidine, ranitidine, and famotidine therapy on antipyrine elimination. Clinical therapeutics, 1987, Volume: 9, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Antipyrine; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Ranitidine; Thiazoles	1987
A comparative evaluation of the transport of H2-receptor antagonists by the human and baboon placenta. The American journal of the medical sciences, 1988, Volume: 295, Issue:3 Topics: Adolescent; Adult; Animals; Antipyrine; Biological Transport; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Nizatidine; Papio; Perfusion; Placenta; Pregnancy; Ranitidine; Thiazoles	1988
The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats. Japanese journal of pharmacology, 1988, Volume: 46, Issue:1 Topics: Animals; Antipyrine; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Male; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Ranitidine; Rats; Rats, Inbred Strains; Sex Factors; Thiazoles	1988
Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs. Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16 Topics: Animals; Antipyrine; Cimetidine; Debrisoquin; Guanidines; Isoquinolines; Metoprolol; Microsomes, Liver; Ranitidine; Rats; Rats, Inbred Strains	1986
The mechanism of action of omeprazole--a survey of its inhibitory actions in vitro. Scandinavian journal of gastroenterology. Supplement, 1985, Volume: 108 Topics: Aminopyrine; Animals; Anti-Ulcer Agents; Antipyrine; Benzimidazoles; Bucladesine; Cimetidine; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; Male; Omeprazole; Parietal Cells, Gastric; Sodium-Potassium-Exchanging ATPase; Stomach; Swine	1985
Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide. European journal of clinical pharmacology, 1988, Volume: 34, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Female; Half-Life; Humans; Male; Oxidation-Reduction; Pharmaceutical Preparations; Primaquine; Sulfaphenazole; Tolbutamide	1988
Inhibition and induction of metronidazole and antipyrine metabolism. European journal of clinical pharmacology, 1987, Volume: 32, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Humans; Hydroxylation; Kinetics; Male; Metronidazole; Phenobarbital	1987
Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:4 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Female; Humans; Male; Phenobarbital	1987
Low clearance of cimetidine across the human placenta. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3 Topics: Antipyrine; Cimetidine; Female; Humans; Leucine; Maternal-Fetal Exchange; Mathematics; Metabolic Clearance Rate; Placenta; Pregnancy	1987
The urinary 6 beta-hydroxycortisol excretion in man on inducers and inhibitors of the hepatic mixed function oxidase. Pharmacology & therapeutics, 1987, Volume: 33, Issue:1 Topics: Antipyrine; Cimetidine; Enzyme Induction; Humans; Hydrocortisone; Liver; Mixed Function Oxygenases	1987
[Effect of combined therapy with cimetidine and (+)-cyanidanol-3 on the hepatic clearance of antipyrine]. Polskie Archiwum Medycyny Wewnetrznej, 1986, Volume: 75, Issue:3 Topics: Adolescent; Adult; Antipyrine; Catechin; Cimetidine; Drug Therapy, Combination; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Peptic Ulcer	1986
Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine. European journal of clinical pharmacology, 1987, Volume: 31, Issue:5 Topics: Acetylation; Adult; Antipyrine; Cimetidine; Edaravone; Female; Glucaric Acid; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Pharmacogenetics; Phenotype	1987
Inhibition of antipyrine elimination by disulfiram and cimetidine: the effect of concomitant administration. British journal of clinical pharmacology, 1986, Volume: 21, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Depression, Chemical; Disulfiram; Drug Interactions; Female; Humans; Liver; Male; Time Factors	1986
The effects of primaquine stereoisomers and metabolites on drug metabolism in the isolated perfused rat liver and in vitro rat liver microsomes. Biochemical pharmacology, 1985, Feb-01, Volume: 34, Issue:3 Topics: Animals; Antipyrine; Cimetidine; Depression, Chemical; Drug Interactions; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Perfusion; Primaquine; Rats; Rats, Inbred Strains; Stereoisomerism	1985
[Effect of histamine H2 receptor blockers on hepatic elimination of drugs]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1985, Feb-15, Volume: 40, Issue:4 Topics: Adult; Antipyrine; Cimetidine; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Peptic Ulcer	1985
Influence of cimetidine on steady state concentration and metabolite formation from antipyrine infused with a rectal osmotic mini pump. European journal of clinical pharmacology, 1985, Volume: 28, Issue:6 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Drug Interactions; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Perfusion; Rectum; Saliva	1985
High-performance liquid chromatographic method for the simultaneous determination of cimetidine and antipyrine in plasma. Journal of chromatography, 1985, Nov-29, Volume: 345, Issue:1 Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Cimetidine; Indicators and Reagents; Kinetics; Rats	1985
The effects of H2 receptor antagonists on hepatic drug metabolism. Scandinavian journal of gastroenterology. Supplement, 1981, Volume: 69 Topics: Adult; Aminopyrine; Antipyrine; Breath Tests; Cimetidine; Furans; Guanidines; Histamine H2 Antagonists; Humans; Liver; Middle Aged; Ranitidine; Structure-Activity Relationship	1981
Effects of cimetidine and ranitidine on hepatic drug metabolism. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Liver; Male; Mixed Function Oxygenases; Ranitidine; Theophylline	1982
How potent is the inhibition of drug metabolism by omeprazole? Lancet (London, England), 1984, Sep-29, Volume: 2, Issue:8405 Topics: Animals; Antipyrine; Benzimidazoles; Cimetidine; Drug Interactions; Half-Life; Humans; Liver; Omeprazole; Pharmaceutical Preparations; Rats	1984
Effects of cimetidine on carbamazepine auto- and hetero-induction in man. British journal of clinical pharmacology, 1984, Volume: 18, Issue:3 Topics: 5-Aminolevulinate Synthetase; Adult; Antipyrine; Carbamazepine; Cimetidine; Half-Life; Humans; Leukocytes; Male; Time Factors	1984
Inhibition of antipyrine metabolite formation in rats in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:9 Topics: Animals; Antipyrine; Benzoflavones; Cimetidine; Cytochrome P-450 Enzyme System; Male; Metyrapone; Proadifen; Rats; Rats, Inbred Strains	1984
Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. European journal of clinical pharmacology, 1983, Volume: 25, Issue:2 Topics: Adult; Aminopyrine; Antipyrine; Biotransformation; Breath Tests; Cimetidine; Female; Half-Life; Humans; Liver; Male; Phenobarbital	1983
No impairment of antipyrine elimination by the selective anticholinergic drug pirenzepine. Digestion, 1983, Volume: 27, Issue:1 Topics: Adult; Anti-Ulcer Agents; Antipyrine; Benzodiazepinones; Cimetidine; Drug Interactions; Half-Life; Humans; Liver; Male; Mixed Function Oxygenases; Parasympatholytics; Pirenzepine	1983
Factors affecting the response to inhibition of drug metabolism by cimetidine--dose response and sensitivity of elderly and induced subjects. British journal of clinical pharmacology, 1984, Volume: 17, Issue:1 Topics: Adult; Aged; Aging; Antipyrine; Cimetidine; Dose-Response Relationship, Drug; Female; Humans; Male; Random Allocation; Rifampin; Saliva	1984
Effects of chronic oral cimetidine on apparent liver blood flow and hepatic microsomal enzyme activity in man. Gut, 1984, Volume: 25, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Female; Humans; Indocyanine Green; Kinetics; Liver Circulation; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged	1984
Cimetidine-induced reduction in gastrointestinal absorption of antipyrine and rate constants for formation of its metabolites. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:5 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Humans; Intestinal Absorption; Kinetics; Male	1984
Comparative effects of famotidine and cimetidine on antipyrine kinetics in healthy volunteers. British journal of clinical pharmacology, 1984, Volume: 18, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Famotidine; Female; Humans; Kinetics; Male; Thiazoles	1984
Delayed clearance of diazepam due to cimetidine. The New England journal of medicine, 1980, May-01, Volume: 302, Issue:18 Topics: Adult; Antipyrine; Cimetidine; Diazepam; Drug Interactions; Drug Synergism; Female; Guanidines; Half-Life; Humans; Kinetics; Male; Nordazepam	1980
Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly. Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:11 Topics: Adult; Aged; Antipyrine; Cimetidine; Clorazepate Dipotassium; Guanidines; Humans; Metabolic Clearance Rate; Middle Aged; Nordazepam	1982
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3 Topics: Acetaminophen; Adult; Animals; Antipyrine; Biotransformation; Cimetidine; Diazepam; Guanidines; Humans; Kinetics; Lethal Dose 50; Lorazepam; Male; Mice; Oxidation-Reduction	1983
Cimetidine use in children with cystic fibrosis: inhibition of hepatic drug metabolism. The Journal of pediatrics, 1982, Volume: 100, Issue:2 Topics: Adolescent; Antipyrine; Child; Chromatography, High Pressure Liquid; Cimetidine; Guanidines; Humans; Liver; Saliva	1982
Cimetidine impairs the elimination of theophylline and antipyrine. Gastroenterology, 1981, Volume: 81, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Theophylline	1981
Cimetidine-phenytoin interaction: effect on serum phenytoin concentration and antipyrine test. European journal of clinical pharmacology, 1981, Volume: 21, Issue:3 Topics: Adult; Aged; Antipyrine; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Phenytoin; Prospective Studies	1981
Effect of cimetidine on microsomal drug metabolism in man. European journal of clinical pharmacology, 1980, Volume: 18, Issue:2 Topics: Adult; Antipyrine; Benzopyrene Hydroxylase; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Guanidines; Humans; In Vitro Techniques; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Pharmaceutical Preparations	1980
Determinants of placental drug transfer: studies in the isolated perfused human placenta. Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cimetidine; Diclofenac; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Models, Biological; Perfusion; Placenta; Pregnancy	1995
The effect of cimetidine on antipyrine metabolism in calves. Journal of veterinary pharmacology and therapeutics, 1997, Volume: 20, Issue:1 Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antipyrine; Cattle; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Edaravone; Female; Free Radical Scavengers; Histamine H2 Antagonists; Software	1997
Antipyrine and aminopyrine induce acetaldehyde accumulation from ethanol in isolated hepatocytes. Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:2 Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aminopyrine; Animals; Antipyrine; Cells, Cultured; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Ethanol; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Wistar	1997
Cimetidine impairs the elimination of theophylline and antipyrine. Gastroenterology, 1982, Volume: 82, Issue:3 Topics: Antipyrine; Biotransformation; Bronchodilator Agents; Cimetidine; Drug Interactions; Enzyme Inhibitors; Humans; Theophylline	1982
The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Jan-31, Volume: 39, Issue:1-3 Topics: Antipyrine; Biological Transport, Active; Cimetidine; Female; Humans; Maternal-Fetal Exchange; Metformin; Organic Cation Transport Proteins; Perfusion; Placenta; Pregnancy	2010