cimadronate and alendronate
cimadronate has been researched along with alendronate in 11 studies
Compound Research Comparison
| Studies (cimadronate) | Trials (cimadronate) | Recent Studies (post-2010) (cimadronate) | Studies (alendronate) | Trials (alendronate) | Recent Studies (post-2010) (alendronate) |
|---|---|---|---|---|---|
| 105 | 3 | 4 | 4,096 | 731 | 1,724 |
Protein Interaction Comparison
| Protein | Taxonomy | cimadronate (IC50) | alendronate (IC50) |
|---|---|---|---|
| Chain A, farnesyl pyrophosphate synthase | Trypanosoma cruzi | 147 | |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | 0.7523 |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Burzynska, A; Gómez, AO; González-Pacanowska, D; Kafarski, P; Mao, J; Meints, GA; Oldfield, E; Sanders, JM; Van Brussel, EM | 1 |
| Bruchhaus, I; Chan, JM; Croft, SL; Flessner, RM; Ghosh, S; Kemp, RG; Kendrick, H; Kobayashi, S; Lea, CR; Lewis, JC; Loftus, TC; Meints, GA; Nozaki, T; Oldfield, E; Tovian, ZS | 1 |
| Burzynska, A; Chan, JM; Colantino, A; Ghosh, S; Kafarski, P; Meints, G; Morita, CT; Oldfield, E; Raker, AM; Sanders, JM; Song, Y; Wang, H | 1 |
| Barnett, BL; Dunford, JE; Ebetino, FH; Kavanagh, KL; Kwaasi, AA; Oppermann, U; Rogers, MJ; Russell, RG | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Barbier, A; Baron, R; David, P; Nguyen, H | 1 |
| Azuma, Y; Chokki, M; Ito, M; Kiyoki, M; Ogino, Y; Ohta, T; Satomi, Y | 1 |
| Brown, RJ; Grove, JE; Watts, DJ | 1 |
| Endo, Y; Iwakura, Y; Motegi, K; Yamaguchi, K | 1 |
| Ito, Y; Kohri, K; Okada, A; Senzaki, H; Tozawa, K; Yasui, T | 1 |
| Imano, M; Itoh, T; Komai, M; Mukai, J; Nishida, S; Ogawa, N; Satou, T; Tsubaki, M | 1 |
Other Studies
11 other study(ies) available for cimadronate and alendronate
| Article | Year |
|---|---|
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.
Topics: Animals; Crystallography, X-Ray; Dimethylallyltranstransferase; Diphosphonates; Imidazoles; Leishmania major; Models, Molecular; Picolinic Acids; Pyridines; Quantitative Structure-Activity Relationship; Zoledronic Acid | 2003 |
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Cell Line; Cricetinae; Diphosphonates; Entamoeba histolytica; Entamoebiasis; Humans; In Vitro Techniques; Liver Abscess; Malaria; Mice; Mice, Inbred BALB C; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship | 2004 |
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Diphosphonates; Geranyltranstransferase; Humans; Leishmania major; Lymphocyte Activation; Models, Molecular; Quantitative Structure-Activity Relationship; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2004 |
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
Topics: Binding Sites; Diphosphonates; Enzyme Inhibitors; Geranyltranstransferase; Humans; Models, Molecular; Molecular Structure; Nitrogen; Stereoisomerism; Structure-Activity Relationship; Time Factors | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase.
Topics: Alendronate; Animals; Binding, Competitive; Bone Resorption; Cell Membrane Permeability; Chickens; Diphosphonates; Dose-Response Relationship, Drug; Ethylmaleimide; Etidronic Acid; Female; Hydrogen-Ion Concentration; Kidney; Lethal Dose 50; Osteoclasts; Proton-Translocating ATPases; Saccharomyces cerevisiae; Synaptic Vesicles | 1996 |
Comparison of cytotoxic effects of bisphosphonates in vitro and in vivo.
Topics: Alendronate; Animals; Calcium; Cell Membrane; Cell Survival; Creatine Kinase; Diphosphonates; Injections, Intravenous; Isoenzymes; Male; Osteoclasts; Rabbits; Rats; Rats, Sprague-Dawley; Trypan Blue | 1998 |
The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.
Topics: Alendronate; Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Base Sequence; Bone Resorption; Dictyostelium; Diphosphonates; DNA Primers; Etidronic Acid; Farnesyl-Diphosphate Farnesyltransferase; Geranyltranstransferase; Molecular Sequence Data; Risedronic Acid; RNA, Messenger; Sequence Homology, Amino Acid | 2000 |
Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice.
Topics: Alendronate; Animals; Diphosphonates; Drug Interactions; Escherichia coli; Histidine Decarboxylase; Ibandronic Acid; Inflammation; Interleukin-1; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Knockout; Prevotella intermedia | 2000 |
Alendronate inhibits urinary calcium microlith formation in a three-dimensional culture model.
Topics: Agar; Alendronate; Animals; Calcium Oxalate; Calcium Phosphates; Cell Culture Techniques; Cells, Cultured; Crystallization; Diphosphonates; Dogs; Kidney; Osteopontin; Sialoglycoproteins; Urinary Calculi | 2004 |
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
Topics: Alendronate; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Bone Density Conservation Agents; Cell Line, Tumor; Cell Nucleus; Cell Survival; Diphosphonates; Gene Expression Regulation, Neoplastic; Gene Silencing; Hematologic Neoplasms; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Prenylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; TOR Serine-Threonine Kinases | 2013 |