Compounds > cilostamide

cilostamide and rolipram

cilostamide has been researched along with rolipram in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.08)18.7374
1990's16 (32.65)18.2507
2000's16 (32.65)29.6817
2010's12 (24.49)24.3611
2020's3 (6.12)2.80

Authors

AuthorsStudies
Bristol, JA; Cain, MH; Weishaar, RE1
Barbosa, J; Barrish, JC; Brown, B; Dodd, JH; Donaldson, K; Guo, J; Huynh, T; Kiener, PA; Leftheris, K; Pitts, WJ; Poss, MA; Roberge, JY; Starling, GC; Vaccaro, W; Watson, A1
Hughes, RA; Manallack, DT; Thompson, PE1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H1
Bankala, R; Doss, HM; Kapavarapu, RK; Kulkarni, P; Kumar, JS; Mathew, JE; Medishetti, R; Mudgal, J; Pal, M; Parsa, KVL; Ramarao, EVVS; Rasool, M; Shenoy, GG; Sunke, R; Thirupataiah, B1
Dousa, TP; Lin, CT; McIntyre, SJ; Morgano, PG; Takeda, S1
Coffey, AK; Dousa, TP; Homma, S; O'Sullivan, DJ; Valtin, H2
Bode, DC; Brunton, LL; Kanter, JR1
Breuiller, M; Cedrin, I; Ferre, F; Giovagrandi, Y; Leroy, MJ1
Arauz, E; Fitzpatrick, DF; Krzanowski, JJ; Pan, X; Polson, JB1
Kuo, SC; Yu, SM1
Chini, CC; Chini, EN; Dousa, TP; Grande, JP; Matousovic, K1
Imai, A; Nashida, T; Shimomura, H1
Kessler, T; Lugnier, C1
Chun, SY; Conti, M; Hsueh, AJ; Tsafriri, A; Zhang, R1
Chini, CC; Chini, EN; Dousa, TP; Grande, JP1
DeGoey, SR; Dousa, MK; Dousa, TP; Moore, SB; Ploeger, NA1
Dousa, TP; Grande, JP; Matousovic, K; Tsuboi, Y; Walker, H1
Poduslo, JF; Walikonis, RS1
Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A1
Hara, S; Hisa, H; Satoh, S; Suzuki-Kusaba, M; Tanahashi, M; Yoshida, M1
Manganiello, VC; Murata, T; Shimizu, K; Sugatani, T; Tagawa, T1
Beshay, E; Prud'homme, GJ1
Lee, R; Lerner, A; Moon, E; Near, R; Weintraub, L; Wolda, S1
Conti, M; DePaolo, LV; Jensen, JT; Schwinof, KM; Stouffer, RL; Zelinski-Wooten, MB1
Shimomura, H; Shimooka, S; Tanaka, S1
Kawakami, Y; Nakamura, J; Okamura, N1
Hernandez, J; Kaumann, AJ; Vargas, ML1
Christ, T; Engel, A; Kaumann, AJ; Ravens, U1
Kaumann, A; Molenaar, P; Semmler, AB1
Galindo-Tovar, A; Kaumann, AJ1
Galindo-Tovar, A; Kaumann, AJ; Vargas, ML2
Christ, T; Galindo-Tovar, A; Kaumann, AJ; Ravens, U; Thoms, M1
Escudero, E; Galindo-Tovar, A; Kaumann, AJ; Vargas, ML1
Afzal, F; Aronsen, JM; Hussain, RI; Krobert, KA; Levy, FO; Osnes, JB; Sjaastad, I; Skomedal, T1
Blanchard, E; Conti, M; Finkbeiner, WE; Gruenert, DC; Lao, A; Mika, D; Namkung, W; Richter, W; Scheitrum, C; Verkman, AS; Xie, M; Zlock, L1
de Seigneux, S; Derouette, JP; Dizin, E; Féraille, E; Hasler, U; Martin, PY; Roth, I; Szanto, I1
Andersen, GØ; Ata, SH; Dahl, CP; Levy, FO; Orstavik, O; Osnes, JB; Qvigstad, E; Riise, J; Skomedal, T1
Berk, E; Christ, T; Engel, A; Galindo-Tovar, A; Gillette, KT; Kaumann, AJ; Molenaar, P; Ravens, U1
Tan, W; Thomas, P1
Cayé-Thomasen, P; Degerman, E; Eliasson, L; In 't Zandt, R; Magnusson, M; Pålbrink, A1
Pang, Y; Thomas, P1
Gosens, R; Halayko, AJ; Han, B; Kistemaker, LEM; Nikolaev, VO; Poppinga, WJ; Ringnalda, L; Schmidt, M; Zuo, H1
Chaube, SK; Gupta, A1
Gergs, U; Laufs, U; Neumann, J; Voss, R; Werner, C1
Bang, S; Cha, D; Cho, J; Choi, K; Fang, X; Kang, H; Lee, S; Qamar, AY; Saadeldin, IM; Seo, C; Shim, J; Tanga, BM1

Reviews

3 review(s) available for cilostamide and rolipram

ArticleYear
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity

1985
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005
Causes of the urinary concentrating defect in mice with nephrogenic diabetes insipidus.
    Physiologia Bohemoslovaca, 1990, Volume: 39, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Water; Cyclic AMP; Diabetes Insipidus; Kidney Concentrating Ability; Mice; Permeability; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram; Vasopressins

1990

Other Studies

46 other study(ies) available for cilostamide and rolipram

ArticleYear
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
    Bioorganic & medicinal chemistry letters, 2004, Jun-07, Volume: 14, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Binding Sites; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 7; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Purines; Structure-Activity Relationship; T-Lymphocytes

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
    The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15

    Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi

2012
InCl
    European journal of medicinal chemistry, 2019, Jul-15, Volume: 174

    Topics: Animals; Arthritis; Cyclic Nucleotide Phosphodiesterases, Type 4; Encephalomyelitis, Autoimmune, Experimental; Freund's Adjuvant; Indium; Indoles; Molecular Structure; Multiple Sclerosis; Oligodendrocyte-Myelin Glycoprotein; Phosphodiesterase 4 Inhibitors; Quinoxalines; Rats; Structure-Activity Relationship; Zebrafish; Zebrafish Proteins

2019
High activity of low-Michaelis-Menten constant 3', 5'-cyclic adenosine monophosphate-phosphodiesterase isozymes in renal inner medulla of mice with hereditary nephrogenic diabetes insipidus.
    Endocrinology, 1991, Volume: 129, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Calmodulin; Diabetes Insipidus; Isoenzymes; Kidney Medulla; Kinetics; Mice; Mice, Inbred CBA; Pyrrolidinones; Quinolones; Rolipram

1991
Induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus.
    The American journal of physiology, 1991, Volume: 261, Issue:4 Pt 2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane; Cyclic AMP; Diabetes Insipidus; Freeze Fracturing; Isoenzymes; Kidney Diseases; Mice; Mice, Mutant Strains; Microscopy, Electron; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram

1991
Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue.
    Circulation research, 1991, Volume: 68, Issue:4

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic GMP; Heart Ventricles; Isoenzymes; Kinetics; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Rolipram; Substrate Specificity

1991
Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term.
    Biochemical pharmacology, 1989, Jan-01, Volume: 38, Issue:1

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Dose-Response Relationship, Drug; Female; Humans; Pregnancy; Pyrrolidinones; Quinolones; Rolipram; Uterine Contraction; Valerates

1989
Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isozyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells.
    Biochemical pharmacology, 1994, Aug-17, Volume: 48, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cell Line; Drug Synergism; Isoenzymes; Models, Chemical; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Quinolones; Rats; Rolipram; Thymidine

1994
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.
    British journal of pharmacology, 1995, Volume: 114, Issue:8

    Topics: Aldehyde Reductase; Animals; Aorta; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Guanylate Cyclase; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Platelet Aggregation Inhibitors; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram

1995
Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Glomerular Mesangium; Isoenzymes; Male; Platelet-Derived Growth Factor; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Thymidine

1995
Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland.
    Archives of oral biology, 1995, Volume: 40, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calmodulin; Chromatography, Agarose; Cyclic GMP; Enzyme Activation; Isoenzymes; Kinetics; Male; Milrinone; Molecular Weight; Parotid Gland; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram

1995
Rolipram increases cyclic GMP content in L-arginine-treated cultured bovine aortic endothelial cells.
    European journal of pharmacology, 1995, Jul-18, Volume: 290, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Aorta; Arginine; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Exonucleases; Indomethacin; Nitric Oxide; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram

1995
Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors.
    Developmental biology, 1996, Sep-15, Volume: 178, Issue:2

    Topics: Animals; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Cyclic AMP; Female; Gene Expression Regulation, Developmental; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rolipram

1996
Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis.
    The Journal of biological chemistry, 1997, Apr-11, Volume: 272, Issue:15

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bucladesine; Cell Compartmentation; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Glomerular Mesangium; Kinetics; Mitosis; NADPH Oxidases; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rats; Rolipram; Signal Transduction; Superoxides; Xanthines

1997
Antagonists of cyclic nucleotide phosphodiesterase (PDE) isozymes PDE 3 and PDE 4 suppress lymphoblastic response to HLA class II alloantigens: a potential novel approach to preventing allograft rejection?
    Clinical nephrology, 1997, Volume: 47, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Graft Rejection; Histocompatibility Antigens Class II; Humans; Lymphocyte Culture Test, Mixed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rolipram

1997
Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid.
    The Journal of laboratory and clinical medicine, 1997, Volume: 130, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Division; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Down-Regulation; Folic Acid; Isoenzymes; Kidney Tubules; Male; Phosphodiesterase Inhibitors; Proliferating Cell Nuclear Antigen; Pyrrolidinones; Quinazolines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Tetrazoles

1997
Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries.
    The Journal of biological chemistry, 1998, Apr-10, Volume: 273, Issue:15

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation, Enzymologic; Male; Myelin Sheath; Nerve Crush; Nerve Regeneration; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Rolipram; S100 Proteins; Sciatic Nerve; Time Factors; Transcription, Genetic; Xanthines

1998
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
    The Journal of clinical investigation, 1998, Aug-01, Volume: 102, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes

1998
Effects of rolipram and cilostamide on renal functions and cyclic AMP release in anesthetized dogs.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Anesthesia, General; Animals; Blood Pressure; Cyclic AMP; Diuresis; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Indomethacin; Kidney; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Renal Circulation; Rolipram; Sodium; Vascular Resistance

1999
Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
    Anti-cancer drugs, 2001, Volume: 12, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Division; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Phosphodiesterase Inhibitors; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Submandibular Gland Neoplasms; Tumor Cells, Cultured

2001
Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production.
    Laboratory investigation; a journal of technical methods and pathology, 2001, Volume: 81, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Culture Techniques; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Islets of Langerhans; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pentoxifylline; Phosphodiesterase Inhibitors; Quinolones; RNA, Messenger; Rolipram; Tumor Cells, Cultured

2001
Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; Blotting, Northern; Blotting, Western; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Isoenzymes; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Protein Isoforms; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Time Factors; Up-Regulation

2002
Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro.
    Human reproduction (Oxford, England), 2002, Volume: 17, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Feasibility Studies; Female; Macaca mulatta; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Rolipram; Thiophenes

2002
Changes in phosphodiesterase activity in the developing rat submandibular gland.
    Archives of oral biology, 2002, Volume: 47, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blotting, Western; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Quinolones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Submandibular Gland

2002
Augmentation of lipolysis in adipocytes from fed rats, but not from starved rats, by inhibition of rolipram-sensitive phosphodiesterase 4.
    Archives of biochemistry and biophysics, 2004, May-01, Volume: 425, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Chromones; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Lipolysis; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolones; Rats; Rolipram; Starvation

2004
Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle.
    British journal of pharmacology, 2006, Volume: 147, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-1 Receptor Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Norepinephrine; Propanolamines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Ventricular Function

2006
Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 374, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Aged; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Epinephrine; Female; Heart Atria; Humans; Hydrolysis; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Myocardium; Norepinephrine; Phosphodiesterase Inhibitors; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram

2006
The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Aged; Animals; Atrial Appendage; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Female; Humans; Isometric Contraction; Isoproterenol; Male; Middle Aged; Norepinephrine; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Rolipram; Signal Transduction

2007
Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Female; Heart Atria; Heart Rate; Heart Ventricles; Imidazoles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Sinoatrial Node; Tachycardia, Sinus; Tachycardia, Ventricular

2008
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:4

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Arrhythmia, Sinus; Atrial Function, Left; Atrial Function, Right; Bradycardia; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Partial Agonism; Female; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Tachycardia

2009
Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart.
    British journal of pharmacology, 2009, Volume: 156, Issue:1

    Topics: Animals; Atrial Function; Calcium Channels, L-Type; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Cardiac; Norepinephrine; Patch-Clamp Techniques; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Ventricular Function

2009
Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.
    British journal of pharmacology, 2009, Volume: 156, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Arrhythmia, Sinus; Atrial Function; Calcium Channels, L-Type; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Receptors, Serotonin, 5-HT4; Rolipram; Serotonin; Species Specificity; Swine; Ventricular Function

2009
Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4.
    European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3

    Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epinephrine; Heart Atria; Heart Ventricles; In Vitro Techniques; Norepinephrine; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Sinoatrial Node; Swine; Tachycardia

2010
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
    Journal of molecular and cellular cardiology, 2013, Volume: 56

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbachol; Cardiotonic Agents; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Failure; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Muscarinic Agonists; Myocardial Contraction; Myocardial Infarction; Pertussis Toxin; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats; Rats, Wistar; Rolipram; Ventricular Pressure

2013
Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014, Volume: 28, Issue:2

    Topics: Amiloride; Cells, Cultured; Chlorides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Humans; Immunoprecipitation; Quinolones; Respiratory Mucosa; Rolipram

2014
NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Aquaporin 2; Arginine Vasopressin; Blotting, Western; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Kidney Tubules, Collecting; Mice; NADPH Oxidase 4; NADPH Oxidases; Quinolones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Rolipram; Signal Transduction

2014
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
    British journal of pharmacology, 2014, Volume: 171, Issue:23

    Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Pyridazines; Quinolines; Quinolones; Rats, Wistar; Rolipram; Simendan; Thiadiazines

2014
Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:7

    Topics: Adrenergic beta-Antagonists; Adult; Carbazoles; Carvedilol; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epinephrine; Female; Heart Failure; Heart Transplantation; Humans; Male; Middle Aged; Norepinephrine; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram

2014
Activation of the Pi3k/Akt pathway and modulation of phosphodiesterase activity via membrane progestin receptor-alpha (mPRalpha) regulate progestin-initiated sperm hypermotility in Atlantic croaker.
    Biology of reproduction, 2014, Volume: 90, Issue:5

    Topics: Androstadienes; Animals; Azepines; Blotting, Western; Chromones; Enzyme Activation; Male; Morpholines; Perciformes; Phosphatidylinositol 3-Kinases; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-akt; Quinolones; Receptors, Progesterone; Rolipram; Signal Transduction; Sperm Motility; Spermatozoa; Wortmannin

2014
Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.
    Acta oto-laryngologica, 2017, Volume: 137, Issue:1

    Topics: Animals; Endolymphatic Hydrops; Female; Humans; Magnetic Resonance Imaging; Mice, Inbred CBA; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolones; Rolipram; Saccule and Utricle; Sildenafil Citrate

2017
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper).
    General and comparative endocrinology, 2018, 09-01, Volume: 265

    Topics: Animals; Cell Cycle Checkpoints; Estrogens; Female; Gene Expression Regulation; Meiosis; Natriuretic Peptide, C-Type; Oocytes; Oogenesis; Ovarian Follicle; Phosphodiesterase Inhibitors; Quinolones; Receptors, Atrial Natriuretic Factor; Receptors, G-Protein-Coupled; RNA, Messenger; Rolipram; Signal Transduction; Zebrafish; Zebrafish Proteins

2018
Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.
    British journal of pharmacology, 2018, Volume: 175, Issue:14

    Topics: Animals; Biosensing Techniques; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epithelial Cells; Fluorescence Resonance Energy Transfer; Humans; Mice, Transgenic; Myocytes, Smooth Muscle; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Respiratory System; Rolipram; Smoke; Tobacco Products; Up-Regulation

2018
Cilostamide and rolipram prevent spontaneous meiotic resumption from diplotene arrest in rat oocytes cultured in vitro.
    European journal of pharmacology, 2020, Jul-05, Volume: 878

    Topics: Actins; Animals; Cells, Cultured; Cumulus Cells; Cyclic AMP; Dose-Response Relationship, Drug; Drug Combinations; Female; Gap Junctions; Gene Expression Regulation; In Vitro Techniques; Kinetics; Meiosis; Meiotic Prophase I; Oocytes; Ovary; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolones; Rats; Rolipram

2020
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:6

    Topics: Adenine; Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Heart Atria; Heart Rate; Histamine; Humans; Male; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors; Quinolones; Receptors, Histamine H2; Rolipram

2021
The combination of rolipram and cilostamide improved the developmental competence of cloned porcine embryos.
    Scientific reports, 2023, 04-07, Volume: 13, Issue:1

    Topics: Animals; Blastocyst; Embryonic Development; Glutathione; In Vitro Oocyte Maturation Techniques; Oocytes; Reactive Oxygen Species; Rolipram; Swine

2023