cilostamide has been researched along with carbostyril in 159 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (11.95) | 18.7374 |
| 1990's | 36 (22.64) | 18.2507 |
| 2000's | 51 (32.08) | 29.6817 |
| 2010's | 49 (30.82) | 24.3611 |
| 2020's | 4 (2.52) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, H; Hidaka, H; Hosokawa, T; Igawa, T; Kimura, Y; Kohri, H; Saitoh, Y | 1 |
| Yasunaga, K | 1 |
| Belfrage, P; Calvo, J; Manganiello, VC; Smith, CJ; Vasta, V | 1 |
| Belfrage, P; Fujita Yamaguchi, Y; Hockman, S; Kasuya, J; LeBon, TR; Manganiello, VC; Paxton, RJ | 1 |
| Deguchi, K; Komada, F; Morita, K; Nishikawa, M; Shirakawa, S | 1 |
| Dousa, TP; Lin, CT; McIntyre, SJ; Morgano, PG; Takeda, S | 1 |
| Coffey, AK; Dousa, TP; Homma, S; O'Sullivan, DJ; Valtin, H | 2 |
| Bode, DC; Brunton, LL; Kanter, JR | 1 |
| Crankshaw, D; Haslam, RJ; Maurice, DH | 1 |
| Fujita-Yamaguchi, Y; LeBon, TR; Xiong, LM | 1 |
| Haslam, RJ; Maurice, DH | 1 |
| Malik, KU; Williams, JL | 2 |
| Elks, ML; Manganiello, VC | 3 |
| Degerman, E; Elks, M; Manganiello, V | 1 |
| Breuiller, M; Cedrin, I; Ferre, F; Giovagrandi, Y; Leroy, MJ | 1 |
| Alvarez, R; Kenley, RA; Lin, LH; Venuti, MC; Visor, GC | 1 |
| Alvarez, R; Berks, AH; Bruno, JJ; Jones, GH; Prince, A; Venuti, MC | 1 |
| Belfrage, P; Degerman, E; Manganiello, VC; Newman, AH; Rice, KC | 1 |
| Beretz, A; Cazenave, JP; Corre, G; Lanza, F; Stierlé, A | 1 |
| Mori, H; Morita, S; Nakagawa, K; Shimizu, T; Yasuda, Y | 1 |
| Hidaka, H; Kimura, Y; Tanaka, T; Umekawa, H | 1 |
| Endoh, M; Satoh, K; Yamashita, S | 1 |
| Hidaka, H; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, S; Yamamoto, T | 1 |
| Beretz, A; Cazenave, JP; Lebec, A; Lugnier, C; Schoeffter, P; Stierlé, A; Stoclet, JC; Wermuth, CG | 1 |
| Hidaka, H; Lieberman, F; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, T | 1 |
| Kubo, M; Nakagawa, K; Shimizu, T | 1 |
| Moreno, S; Rossi, S; Tomes, C | 1 |
| Arauz, E; Fitzpatrick, DF; Krzanowski, JJ; Pan, X; Polson, JB | 1 |
| Downing, GJ; Poisner, AM | 1 |
| Kuo, SC; Yu, SM | 1 |
| Chini, CC; Chini, EN; Dousa, TP; Grande, JP; Matousovic, K | 1 |
| Malik, KU; Schwartz, DD; Williams, JL | 1 |
| Imai, A; Nashida, T; Shimomura, H | 1 |
| Downing, GJ; Poisner, AM; Poisner, R | 1 |
| Era, S; Izawa, T; Komabayashi, T; Suda, K; Tsuboi, M | 1 |
| Belfrage, P; Calvo, JC; Hockman, SC; Manganiello, VC; Taira, M | 1 |
| Kessler, T; Lugnier, C | 1 |
| Degerman, E; Leroy, MJ; Manganiello, VC; Meacci, E; Movsesian, MA; Murata, T; Taira, M; Wang, LH | 1 |
| Chun, SY; Conti, M; Hsueh, AJ; Tsafriri, A; Zhang, R | 1 |
| Chini, CC; Chini, EN; Dousa, TP; Grande, JP | 1 |
| DeGoey, SR; Dousa, MK; Dousa, TP; Moore, SB; Ploeger, NA | 1 |
| Dousa, TP; Grande, JP; Matousovic, K; Tsuboi, Y; Walker, H | 1 |
| Poduslo, JF; Walikonis, RS | 1 |
| Maurice, DH; Palmer, D; Tsoi, K | 1 |
| Carey, GB; Finnegan, RB | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| de Koster, BM; Elferink, JG; VanUffelen, BE | 1 |
| Hidaka, H; Inoue, Y; Kihara, Y; Kimura, Y; Koga, Y; Nishi, T; Okada, M; Tachibana, K; Tochizawa, S; Toga, K | 1 |
| Benelli, C; Clot, JP; Desbuquois, B; Fouque, F; Geoffroy, V; Lugnier, C; Nivet, V | 1 |
| Hara, S; Hisa, H; Satoh, S; Suzuki-Kusaba, M; Tanahashi, M; Yoshida, M | 1 |
| Carey, GB; Zacher, LA | 1 |
| Hidaka, H; Inoue, Y; Kimura, Y; Sudo, T; Tachibana, K; Tochizawa, S; Toga, K | 1 |
| Hidaka, H; Inoue, Y; Kimura, Y; Sudo, T; Tachibana, K; Tochizawa, S; Toga, K; Yoshida, Y | 1 |
| Manganiello, VC; Murata, T; Shimizu, K; Sugatani, T; Tagawa, T | 1 |
| Benelli, C; Desbuquois, B; Fouque, F; Geoffroy, V; Lugnier, C | 1 |
| Donzeau-Gouge, P; Fischmeister, R; Rücker-Martin, C; Vandecasteele, G; Verde, I | 1 |
| Beshay, E; Prud'homme, GJ | 1 |
| Greenberg, AG; Kraemer, FB; Xue, B; Zemel, MB | 1 |
| Conti, M; Richard, FJ; Tsafriri, A | 1 |
| Lee, R; Lerner, A; Moon, E; Near, R; Weintraub, L; Wolda, S | 1 |
| Absher, PM; Dunkerley, HA; Jimmo, SL; Maurice, DH; Netherton, SJ; Palmer, D; Raymond, DR; Russell, JC; Sage, EH; Tilley, DG; Vernon, RB | 1 |
| Armstrong, DT; Gilchrist, RB; Thomas, RE | 1 |
| Gupta, S; Huan, JN; Pal, R; Sahu, A; Zhao, AZ | 1 |
| Conti, M; DePaolo, LV; Jensen, JT; Schwinof, KM; Stouffer, RL; Zelinski-Wooten, MB | 1 |
| Shimomura, H; Shimooka, S; Tanaka, S | 1 |
| Kelly, C; Sawmiller, DR; Tarpey, SB; Thompson, WJ; Townsley, MI | 1 |
| Chung, C; MacNeil, DJ; Morin, NR; Patel, S; Scapin, G; Singh, SB; Tota, MR; Van der Ploeg, LH; Varnerin, JP | 1 |
| Dorigo, P; Floreani, M; Fossa, P; Menozzi, G; Mosti, L | 1 |
| Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM | 1 |
| Carey, GB; Zhang, X | 1 |
| Kawakami, Y; Nakamura, J; Okamura, N | 1 |
| Kojima, Y; Sakurai, H; Ueda, E; Yoshikawa, Y | 1 |
| Borini, A; Cecconi, S; Coticchio, G; Flamigni, C; Fleming, S; Grøndahl, C; Macchiarelli, G; Rossi, G | 1 |
| Maurice, DH; Netherton, SJ | 1 |
| Guéguen, L; Laforest, MF; Pouliot, E; Richard, FJ | 1 |
| Hersh, LB; Hockman, S; Ma, Z; Snow, EC; Wang, X | 1 |
| Hernández, J; Juan-Fita, MJ; Vargas, ML | 1 |
| Cortvrindt, R; Everaerdt, B; Nogueira, D; Smitz, J | 1 |
| Hiramoto, K; Manganiello, VC; Murata, T; Nakagawa, T; Shimizu, K; Sugiyama, T; Tagawa, T | 1 |
| Hernandez, J; Kaumann, AJ; Vargas, ML | 1 |
| Edens, NK; Reaves, LA; Wang, H | 1 |
| Côté, N; Guillemette, C; Richard, FJ; Sasseville, M | 1 |
| Christ, T; Engel, A; Kaumann, AJ; Ravens, U | 1 |
| De Sutter, P; Dhont, M; Gerris, J; Nogueira, D; Van der Elst, J; Vanhoutte, L | 1 |
| Kaumann, A; Molenaar, P; Semmler, AB | 1 |
| Carter, RL; Maurice, DH; Raymond, DR; Wilson, LS | 1 |
| Galindo-Tovar, A; Kaumann, AJ | 1 |
| De Sutter, P; Dhont, M; Gerris, J; Nogueira, D; Vanhoutte, L | 1 |
| Ke, PQ; Liang, XY; Ren, Z; Shen, HW; Shu, YM; Wang, NN; Yao, SZ; Zeng, HT; Zhuang, GL | 1 |
| Abi-Gerges, A; Conti, M; Fischmeister, R; Lechêne, P; Leroy, J; Mazet, JL; Nikolaev, VO; Richter, W; Vandecasteele, G | 1 |
| Chen, HY; Chian, RC; Jee, BC | 1 |
| Adderley, S; Bowles, EA; Hanson, MS; Sprague, RS; Sridharan, M; Stephenson, AH | 1 |
| Galindo-Tovar, A; Kaumann, AJ; Vargas, ML | 2 |
| Christ, T; Galindo-Tovar, A; Kaumann, AJ; Ravens, U; Thoms, M | 1 |
| Escudero, E; Galindo-Tovar, A; Kaumann, AJ; Vargas, ML | 1 |
| Fujii, K; Goto, K; Iida, M; Kansui, Y; Matsumura, K; Oniki, H | 1 |
| Nogueira, D; Vanhoutte, L | 1 |
| De Sutter, P; Dumortier, F; Nogueira, D; Vanhoutte, L | 1 |
| Bakavoli, M; Hosseini, A; Mansouri, SM; Nick, RS; Parsaee, H; Saberi, MR; Sadeghian, H; Seyedi, SM | 1 |
| Hayashi, H; Sudo, T | 1 |
| Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A | 1 |
| Justiniano, H; Keravis, T; Lugnier, C; Maarouf, S; Sabra, R; Tahseldar-Roumieh, R | 1 |
| Aronsen, JM; Hougen, K; Levy, FO; Moltzau, LR; Nguyen, CH; Osnes, JB; Qvigstad, E; Sjaastad, I; Skomedal, T | 1 |
| Barouch, LA; Kass, DA; Lee, DI; Solaro, RJ; Takimoto, E; Tocchetti, CG; Vahebi, S | 1 |
| Sahu, A | 1 |
| Albuz, FK; Armstrong, DT; Gilchrist, RB; Lane, M; Sasseville, M; Thompson, JG | 1 |
| Hashimoto, K; Ishima, T | 1 |
| Arnoletti, E; Baragli, A; Ghè, C; Ghigo, E; Granata, R; Muccioli, G | 1 |
| Bäckdahl, L; Beck, S; Bushell, A; Feng, G; Francis, RS; Nadig, SN; Schiopu, A; Whatcott, A; Wood, KJ | 1 |
| Franciosi, F; Lodde, V; Luciano, AM; Modina, SC | 1 |
| Calvert, AE; Chen, B; Meng, X; Nelin, LD | 1 |
| Fernández-Galilea, M; Martinez, JA; Moreno-Aliaga, MJ; Pérez-Matute, P; Prieto-Hontoria, PL | 1 |
| Gilchrist, RB; Kelly, JM; Rose, RD; Sutton-McDowall, ML; Thompson, JG | 1 |
| Afzal, F; Aronsen, JM; Hussain, RI; Krobert, KA; Levy, FO; Osnes, JB; Sjaastad, I; Skomedal, T | 1 |
| Das, D; Khan, PP; Maitra, S | 1 |
| Forouzanfar, M; Gharibi, Sh; Hajian, M; Hosseini, SM; Nasr-Esfahani, MH; Ostadhosseini, S | 1 |
| Ahmad, F; Chen, X; Chung, YW; Degerman, E; Gavrilova, O; Guirguis, E; Hockman, S; Liu, S; Manganiello, V; Niu, G; Raghavachari, N; Yang, Y; Yu, ZX | 1 |
| Albertini, DF; Dieci, C; Franciosi, F; Galli, C; Lagutina, I; Lazzari, G; Lodde, V; Luciano, AM; Modina, SC; Tessaro, I | 1 |
| Dwinell, MB; Hauser, AD; Roy, I; Williams, CL; Wilson, JM; Zimmerman, NP | 1 |
| Blanchard, E; Conti, M; Finkbeiner, WE; Gruenert, DC; Lao, A; Mika, D; Namkung, W; Richter, W; Scheitrum, C; Verkman, AS; Xie, M; Zlock, L | 1 |
| Christ, T; Haase, H; Matschke, K; Ravens, U; Rozmaritsa, N; Stasch, JP; Van Wagoner, DR | 1 |
| Baulain, U; Diederich, M; Großfeld, R; Heinzmann, J; Herrmann, D; Lucas-Hahn, A; Niemann, H; Timmermann, B; Ulloa, SM | 1 |
| Chang, Y; Fischmeister, R; Ji, G; Leblais, V; Liu, Q; Wei, B; Zhai, K | 1 |
| de Seigneux, S; Derouette, JP; Dizin, E; Féraille, E; Hasler, U; Martin, PY; Roth, I; Szanto, I | 1 |
| Andersen, GØ; Ata, SH; Dahl, CP; Levy, FO; Orstavik, O; Osnes, JB; Qvigstad, E; Riise, J; Skomedal, T | 1 |
| Balligand, JL; Gorelik, J; Götz, KR; Kuhn, M; Lehnart, SE; Nikolaev, VO; Perera, RK; Sprenger, JU; Steinbrecher, JH | 1 |
| Berk, E; Christ, T; Engel, A; Galindo-Tovar, A; Gillette, KT; Kaumann, AJ; Molenaar, P; Ravens, U | 1 |
| Tan, W; Thomas, P | 1 |
| Belacel-Ouari, M; Domergue-Dupont, V; Fischmeister, R; Hubert, F; Joubert, F; Leblais, V; Manoury, B; Mateo, P; Zhai, K | 1 |
| Albertini, DF; Coticchio, G; Dal Canto, M; Fadini, R; Franciosi, F; Lodde, V; Luciano, AM; Modina, SC; Renzini, MM; Tessaro, I | 1 |
| Ahmady, A; Bedaiwy, M; Farghaly, T; Hussein, M; Khalifa, E; Mostafa, S | 1 |
| Ahmad, F; Backx, PH; Bae, DH; Brantner, CA; Chen, Y; Chung, YW; Daniels, MP; Esfahani, SG; Gucek, M; Hockman, SC; Lagranha, C; Lee, BS; Manganiello, VC; Murphy, E; Polidovitch, N; Rhee, DK; Sun, J; Tong, G; Wu, J | 1 |
| Alinejad, B; Ghorbani, A; Sadeghian, H; Shafiee-Nick, R | 1 |
| Dode, MA; Guimarães, AL; Kussano, NR; Pereira, SA | 1 |
| Corradini, E; Heck, AJ; Klaasse, G; Leurs, U; Martin, NI; Scholten, A | 1 |
| Azari-Dolatabad, N; Hajian, M; Hosseini, SM; Nasr-Esfahani, MH; Ostadhosseini, S; Rahmani, HR | 1 |
| Anamthathmakula, P; Sahu, A; Sahu, M | 1 |
| Elahi, F; Hyun, SH; Lee, E; Lee, H; Lee, J; Lee, ST; Lee, Y; Park, B; Park, CK | 1 |
| Li, QY; Lou, J; Lu, KH; Lu, SS; Lu, YQ; Yang, XG | 1 |
| Cayé-Thomasen, P; Degerman, E; Eliasson, L; In 't Zandt, R; Magnusson, M; Pålbrink, A | 1 |
| Caixeta, FM; Dode, MA; Guimarães, AL; Leme, LO; Netto, SB; Pivato, I; Sousa, RV; Sprícigo, JF | 1 |
| Elahi, F; Hyun, SH; Lee, E; Lee, H; Lee, J; Lee, ST | 1 |
| Ake-Villanueva, JR; Centurion-Castro, F; Cuello, C; Gil, MA; Martinez, CA; Martinez, EA; Maside, C; Nohalez, A; Parrilla, I; Roca, J | 1 |
| Botigelli, RC; Castro, FC; Del Collado, M; Fernandes, H; Leal, CLV; Schwarz, KL; Zaffalon, FG | 1 |
| Pang, Y; Thomas, P | 1 |
| Gosens, R; Halayko, AJ; Han, B; Kistemaker, LEM; Nikolaev, VO; Poppinga, WJ; Ringnalda, L; Schmidt, M; Zuo, H | 1 |
| Alam, MH; Lee, J; Miyano, T | 1 |
| Choi, DS; García, AJ; Javeed, N; Jia, YF; Matveyenko, AV; Oyelere, AK; Pithadia, DJ; Raji, IO; Shin, CH; Tapadar, S; Weaver, JD; Xu, J | 1 |
| Alves, BG; Correia, HHV; Figueiredo, JR; Mielgo, CM; Paes, VM; Rodrigues, APR; Silva, JRV; Vieira, LA; Wheeler, MB | 1 |
| Brown, M; Chansaenroj, A; Doriguzzi, N; Nagashima, J; Songsasen, N; Thongkittidilok, C | 1 |
| Colleoni, S; Corbani, D; Franciosi, F; Galli, C; Lazzari, G; Lodde, V; Luciano, AM; Tessaro, I | 1 |
| Chaube, SK; Gupta, A | 1 |
| Gergs, U; Laufs, U; Neumann, J; Voss, R; Werner, C | 1 |
| McKie, GL; Medak, KD; Seguin, I; Shamshoum, H; Wright, DC | 1 |
1 review(s) available for cilostamide and carbostyril
| Article | Year |
|---|---|
Causes of the urinary concentrating defect in mice with nephrogenic diabetes insipidus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Water; Cyclic AMP; Diabetes Insipidus; Kidney Concentrating Ability; Mice; Permeability; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram; Vasopressins | 1990 |
158 other study(ies) available for cilostamide and carbostyril
| Article | Year |
|---|---|
Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Cyclic AMP; In Vitro Techniques; Platelet Aggregation; Quinolines; Quinolones; Rabbits | 1979 |
[Inhibition of platelet aggregation by platelet inhibitory agents and its relation to their clinical effects].
Topics: Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Humans; Phthalazines; Platelet Aggregation; Pyridazines; Quinolines; Quinolones; Sulfinpyrazone; Thrombosis | 1979 |
Insulin and isoproterenol induce phosphorylation of the particulate cyclic GMP-inhibited, low Km cyclic AMP phosphodiesterase (cGI PDE) in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipose Tissue; Animals; Blotting, Western; Cell Differentiation; Cross Reactions; Insulin; Isoproterenol; Mice; Phosphorylation; Protein Kinases; Quinolones | 1992 |
Purification and characterization of guanosine 3',5'-monophosphate-inhibited low K(m) adenosine 3',5'-monophosphate phosphodiesterase from human placental cytosolic fractions.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Blotting, Western; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cyclic GMP; Cytosol; Electrophoresis, Polyacrylamide Gel; Female; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Placenta; Platelet Aggregation Inhibitors; Pregnancy; Quinolones | 1992 |
Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Blood Platelets; Calcium; Carbazoles; Cyclic AMP; Humans; Indoles; Phosphorylation; Platelet Aggregation Inhibitors; Protein Kinases; Pyrroles; Quinolones; Thromboxane A2 | 1992 |
High activity of low-Michaelis-Menten constant 3', 5'-cyclic adenosine monophosphate-phosphodiesterase isozymes in renal inner medulla of mice with hereditary nephrogenic diabetes insipidus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Calmodulin; Diabetes Insipidus; Isoenzymes; Kidney Medulla; Kinetics; Mice; Mice, Inbred CBA; Pyrrolidinones; Quinolones; Rolipram | 1991 |
Induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane; Cyclic AMP; Diabetes Insipidus; Freeze Fracturing; Isoenzymes; Kidney Diseases; Mice; Mice, Mutant Strains; Microscopy, Electron; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram | 1991 |
Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic GMP; Heart Ventricles; Isoenzymes; Kinetics; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Inbred Strains; Rolipram; Substrate Specificity | 1991 |
Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle.
Topics: Adenylyl Cyclases; Animals; Aorta; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Isoproterenol; Male; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Quinolones; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Characterization of human placental cytosolic adenosine 3',5'-monophosphate phosphodiesterase by inhibitors and insulin treatment.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cytosol; Female; Humans; Hydrolysis; Insulin; Placenta; Pregnancy; Quinolones; Subcellular Fractions | 1990 |
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
Topics: Adenosine; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Enzyme Activation; Ferricyanides; Hemoglobins; In Vitro Techniques; Kinetics; Molsidomine; Nitroprusside; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolones; Rabbits; Radioimmunoassay; Vasodilator Agents | 1990 |
Forskolin stimulates prostaglandin synthesis in rabbit heart by a mechanism that requires calcium and is independent of cyclic AMP.
Topics: 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Diltiazem; Epoprostenol; Heart; In Vitro Techniques; Myocardium; Phenylisopropyladenosine; Phosphoric Diester Hydrolases; Prostaglandins; Quinolones; Rabbits; Stimulation, Chemical | 1990 |
A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Azo Compounds; Cell Differentiation; Cell Line; Dexamethasone; Glycerolphosphate Dehydrogenase; Insulin; Lipid Metabolism; Mice; Phenylisopropyladenosine; Quinolines; Quinolones; Solubility; Theophylline; Time Factors | 1985 |
Selective inhibitors of specific phosphodiesterases in intact adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cattle; Cells, Cultured; Cyclic GMP; Dexamethasone; Insulin; Kinetics; Liver; Mice; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolines; Quinolones; Rats; Structure-Activity Relationship | 1988 |
Inhibitory modulation by cAMP of isoproterenol-induced prostacyclin synthesis in rabbit heart.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclase Inhibitors; Animals; Blood Pressure; Colforsin; Cyclic AMP; Epoprostenol; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardium; Phenylisopropyladenosine; Platelet Aggregation Inhibitors; Quinolones; Rabbits; Thionucleotides | 1989 |
Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Dose-Response Relationship, Drug; Female; Humans; Pregnancy; Pyrrolidinones; Quinolones; Rolipram; Uterine Contraction; Valerates | 1989 |
Electrochemical evaluation of the interaction between ascorbic acid and the cardiotonic drug RS-82856.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Ascorbic Acid; Cardiotonic Agents; Drug Interactions; Electrochemistry; Platelet Aggregation Inhibitors; Quinazolines; Quinolones; Solutions | 1987 |
Antilipolytic action of insulin: role of cAMP phosphodiesterase activation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Enzyme Activation; Insulin; Isoproterenol; Lipolysis; Quinolines; Quinolones; Rats | 1985 |
Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Platelets; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Myocardium; Quinazolines; Quinolines; Quinolones; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship | 1987 |
Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; In Vitro Techniques; Insulin; Kinetics; Male; Molecular Weight; Quinolines; Quinolones; Rats; Rats, Inbred Strains | 1987 |
Cyclic nucleotide phosphodiesterase inhibitors prevent aggregation of human platelets by raising cyclic AMP and reducing cytoplasmic free calcium mobilization.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Alprostadil; Aminoquinolines; Blood Platelets; Calcium; Cyclic AMP; Cytoplasm; Humans; Isoquinolines; Phthalazines; Platelet Aggregation; Quercetin; Quinazolines; Quinolines; Quinolones; Tetrahydroisoquinolines | 1987 |
The metabolism of cilostamide in the rat in vitro and in vivo.
Topics: Animals; Carbon Radioisotopes; Feces; Hydroxylation; In Vitro Techniques; Liver; Male; Quinolines; Quinolones; Rats; Rats, Inbred Strains | 1985 |
Purification of cyclic adenosine monophosphate phosphodiesterase from human platelets using new-inhibitor Sepharose chromatography.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Chromatography, Affinity; Chromatography, Agarose; Chromatography, Gel; Humans; Kinetics; Platelet Aggregation; Quinolines; Quinolones | 1984 |
Inhibition of cyclic AMP phosphodiesterase activity and myocardial contractility: effects of cilostamide, a novel PDE inhibitor, and methylsiobutylxanthine on rabbit and canine ventricular muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Dogs; Female; Heart Rate; Isoproterenol; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Quinolines; Quinolones; Rabbits; Theophylline | 1980 |
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Dipyridamole; Hydrolysis; Kinetics; Liver; Papaverine; Quinolines; Quinolones; Theophylline | 1983 |
Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Kinetics; Lipolysis; Mice; Phosphodiesterase Inhibitors; Quinolines; Quinolones | 1984 |
Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Blood Platelets; Cattle; Humans; In Vitro Techniques; Lactams; Muscle, Smooth, Vascular; Organ Specificity; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Substrate Specificity | 1983 |
Selective inhibition of two soluble adenosine cyclic 3',5'-phosphate phosphodiesterases partially purified from calf liver.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Cyclic GMP; Kinetics; Liver; Quinolines; Quinolones; Solubility | 1984 |
[Coupled column chromatography using hydrophilic gel permeation column to clean up biological fluid].
Topics: Animals; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Gels; Quinolines; Quinolones; Rats; Specimen Handling | 1983 |
Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Etazolate; In Vitro Techniques; Mucor; Myocardium; Phosphodiesterase Inhibitors; Quinolones; Rats; Signal Transduction | 1993 |
Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isozyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cell Line; Drug Synergism; Isoenzymes; Models, Chemical; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Quinolones; Rats; Rolipram; Thymidine | 1994 |
Stimulation of placental prorenin secretion by selective inhibition of cyclic nucleotide phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Chorionic Gonadotropin; Culture Media; Culture Techniques; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Precursors; Humans; Placenta; Protein Kinases; Pyridazines; Quinolones; Renin | 1995 |
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.
Topics: Aldehyde Reductase; Animals; Aorta; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Guanylate Cyclase; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Platelet Aggregation Inhibitors; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram | 1995 |
Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Glomerular Mesangium; Isoenzymes; Male; Platelet-Derived Growth Factor; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Thymidine | 1995 |
Contribution of calcium to isoproterenol-stimulated lipolysis in the isolated perfused rabbit heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channel Blockers; Cyclic AMP; Diltiazem; Gallic Acid; Glycerol; Heart; In Vitro Techniques; Isoproterenol; Lipolysis; Male; Myocardium; Quinolones; Rabbits | 1993 |
Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Calmodulin; Chromatography, Agarose; Cyclic GMP; Enzyme Activation; Isoenzymes; Kinetics; Male; Milrinone; Molecular Weight; Parotid Gland; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram | 1995 |
Phosphodiesterase inhibitors have differential effects on placental versus decidual prorenin release.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Chorion; Culture Media; Decidua; Enzyme Precursors; Extraembryonic Membranes; Female; Humans; In Vitro Techniques; Phosphodiesterase Inhibitors; Placenta; Platelet Aggregation Inhibitors; Pregnancy; Quinolones; Renin | 1994 |
Effect of insulin on adipocyte lipolysis in exercise-trained rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Adrenergic beta-Antagonists; Animals; Binding, Competitive; In Vitro Techniques; Insulin; Lipolysis; Male; Norepinephrine; Physical Conditioning, Animal; Propanolamines; Quinolones; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 1993 |
Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; Cloning, Molecular; Consensus Sequence; Cyclic GMP; DNA; Humans; Molecular Sequence Data; Nucleic Acid Hybridization; Phosphorylation; Quinolones; Rats; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sequence Homology | 1993 |
Rolipram increases cyclic GMP content in L-arginine-treated cultured bovine aortic endothelial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Aorta; Arginine; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Exonucleases; Indomethacin; Nitric Oxide; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Rolipram | 1995 |
Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Base Sequence; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA Primers; DNA, Complementary; Fibroblasts; Gene Library; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Quinolones; Rats; Recombinant Proteins; Spodoptera; Transfection | 1996 |
Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors.
Topics: Animals; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Cyclic AMP; Female; Gene Expression Regulation, Developmental; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rolipram | 1996 |
Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bucladesine; Cell Compartmentation; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Glomerular Mesangium; Kinetics; Mitosis; NADPH Oxidases; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rats; Rolipram; Signal Transduction; Superoxides; Xanthines | 1997 |
Antagonists of cyclic nucleotide phosphodiesterase (PDE) isozymes PDE 3 and PDE 4 suppress lymphoblastic response to HLA class II alloantigens: a potential novel approach to preventing allograft rejection?
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Graft Rejection; Histocompatibility Antigens Class II; Humans; Lymphocyte Culture Test, Mixed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rolipram | 1997 |
Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Division; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Down-Regulation; Folic Acid; Isoenzymes; Kidney Tubules; Male; Phosphodiesterase Inhibitors; Proliferating Cell Nuclear Antigen; Pyrrolidinones; Quinazolines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Tetrazoles | 1997 |
Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation, Enzymologic; Male; Myelin Sheath; Nerve Crush; Nerve Regeneration; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Rolipram; S100 Proteins; Sciatic Nerve; Time Factors; Transcription, Genetic; Xanthines | 1998 |
Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Aorta; Becaplermin; Cell Movement; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Humans; Kinetics; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Quinolones; Rats; Recombinant Proteins | 1998 |
Characterization of cyclic AMP efflux from swine adipocytes in vitro.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Antimycin A; Cells, Cultured; Colforsin; Cyclic AMP; Isoproterenol; Probenecid; Quinolones; Swine; Swine, Miniature; Xanthines | 1998 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
Interaction of cyclic GMP and cyclic AMP during neutrophil migration: involvement of phosphodiesterase type III.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Movement; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Milrinone; Neutrophils; Phosphodiesterase Inhibitors; Pyridones; Quinolones; Thionucleotides | 1998 |
2(1H)-quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities.
Topics: Animals; Arteriosclerosis; Cilostazol; Hyperplasia; Platelet Aggregation Inhibitors; Quinolines; Quinolones; Rabbits; Tetrazoles; Thrombosis; Urea | 1998 |
Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endosomes; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Liver; Male; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Quinolones; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Effects of rolipram and cilostamide on renal functions and cyclic AMP release in anesthetized dogs.
Topics: Anesthesia, General; Animals; Blood Pressure; Cyclic AMP; Diuresis; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Indomethacin; Kidney; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinolones; Renal Circulation; Rolipram; Sodium; Vascular Resistance | 1999 |
Cyclic AMP metabolism by swine adipocyte microsomal and plasma membranes.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Adipocytes; Animals; Biomarkers; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Intracellular Membranes; Kinetics; Membrane Proteins; Microsomes; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Isoforms; Purinergic P1 Receptor Antagonists; Quinolones; Second Messenger Systems; Swine; Xanthines | 1999 |
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Humans; Isoenzymes; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinolines; Quinolones; Recombinant Proteins; Semicarbazides; Urea | 2000 |
Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double-injury model.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Catheterization; Cell Count; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Disease Models, Animal; Hyperplasia; Male; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Proliferating Cell Nuclear Antigen; Quinolones; Rats; Rats, Sprague-Dawley; Time Factors; Tunica Intima | 2000 |
Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Division; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Phosphodiesterase Inhibitors; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Submandibular Gland Neoplasms; Tumor Cells, Cultured | 2001 |
Characterization of an in vivo hormonally regulated phosphodiesterase 3 (PDE3) associated with a liver Golgi-endosomal fraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Endosomes; Gene Expression Regulation, Enzymologic; Glucagon; Golgi Apparatus; Growth Hormone; Hormones; Insulin; Isoenzymes; Liver; Male; Obesity; Phosphodiesterase Inhibitors; Pyridazines; Quinolones; Rats; Rats, Zucker; Subcellular Fractions | 2001 |
Cyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Aged; Aged, 80 and over; Calcium Channels, L-Type; Child; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Heart Atria; Humans; Middle Aged; Muscle Fibers, Skeletal; Myocardium; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolones; Stimulation, Chemical | 2001 |
Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Culture Techniques; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Islets of Langerhans; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pentoxifylline; Phosphodiesterase Inhibitors; Quinolones; RNA, Messenger; Rolipram; Tumor Cells, Cultured | 2001 |
Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Androstadienes; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Insulin; Isoproterenol; Lipolysis; Phosphodiesterase Inhibitors; Phosphorylation; Potassium Chloride; Quinolones; Sterol Esterase; Wortmannin; Xanthines | 2001 |
Role of phosphodiesterase type 3A in rat oocyte maturation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Chorionic Gonadotropin; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Immunosorbent Techniques; Meiosis; Oocytes; Ovarian Follicle; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Sprague-Dawley | 2001 |
Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; Blotting, Northern; Blotting, Western; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Isoenzymes; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Protein Isoforms; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Time Factors; Up-Regulation | 2002 |
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cell Membrane; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Diabetes Mellitus, Type 2; Hydrolysis; Muscle, Smooth, Vascular; Obesity; Phenotype; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Mutant Strains | 2002 |
Differential effects of specific phosphodiesterase isoenzyme inhibitors on bovine oocyte meiotic maturation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cattle; Cell Culture Techniques; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Granulosa Cells; Isoenzymes; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Sensitivity and Specificity | 2002 |
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Weight; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA; DNA-Binding Proteins; Electrodes, Implanted; Enzyme Activation; Enzyme Inhibitors; Feeding Behavior; Hypothalamus; Injections, Intraventricular; Janus Kinase 2; Leptin; Male; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinolones; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Trans-Activators | 2002 |
Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Feasibility Studies; Female; Macaca mulatta; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Rolipram; Thiophenes | 2002 |
Changes in phosphodiesterase activity in the developing rat submandibular gland.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blotting, Western; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Quinolones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Submandibular Gland | 2002 |
Phosphodiesterase 3 activity is reduced in dog lung following pacing-induced heart failure.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Capillaries; Capillary Permeability; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Heart Failure; Hydrolysis; Lung; Pacemaker, Artificial; Phosphodiesterase Inhibitors; Pulmonary Circulation; Quinolones; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
The role of tryptophan 1072 in human PDE3B inhibitor binding.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; COS Cells; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Escherichia coli; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Phosphodiesterase Inhibitors; Protein Binding; Quinolones; Sequence Alignment; Tryptophan | 2003 |
Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Cardiotonic Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Humans; Milrinone; Models, Molecular; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridones; Quinolones | 2003 |
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.
Topics: Androstadienes; Animals; Chromones; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insulin Resistance; Leptin; Lipid Metabolism; Liver; Male; Morpholines; Obesity; Oxygen Consumption; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinolones; Rats; Rats, Wistar; Serine; Time Factors; Triglycerides; Wortmannin | 2004 |
Plasma membrane-bound cyclic AMP phosphodiesterase activity in 3T3-L1 adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3-L1 Cells; Adipocytes; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Dose-Response Relationship, Drug; Kinetics; Membrane Proteins; Mice; Phosphodiesterase Inhibitors; Protein Isoforms; Quinolones | 2004 |
Augmentation of lipolysis in adipocytes from fed rats, but not from starved rats, by inhibition of rolipram-sensitive phosphodiesterase 4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Chromones; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Lipolysis; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolones; Rats; Rolipram; Starvation | 2004 |
The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes.
Topics: Adipocytes; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Fatty Acids, Nonesterified; Insulin; Male; Maltose; Organometallic Compounds; Picolinic Acids; Quinolones; Rats; Rats, Wistar; Sulfates; Threonine; Wortmannin; Zinc | 2004 |
Mouse oocyte meiotic resumption and polar body extrusion in vitro are differentially influenced by FSH, epidermal growth factor and meiosis-activating sterol.
Topics: Animals; Bucladesine; Cell Differentiation; Cells, Cultured; Cholestenes; Coculture Techniques; Epidermal Growth Factor; Female; Follicle Stimulating Hormone; Hypoxanthine; Meiosis; Mice; Oocytes; Ovarian Follicle; Quinolones | 2004 |
Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Aorta; Cell Movement; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Humans; Kinetics; Microcirculation; Neovascularization, Physiologic; Phosphoric Diester Hydrolases; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Umbilical Veins | 2005 |
Fundamental significance of specific phosphodiesterases in the control of spontaneous meiotic resumption in porcine oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Combinations; Female; Gonadotropins, Equine; Meiosis; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Sus scrofa | 2005 |
Subcellular localization of nardilysin during mouse oocyte maturation.
Topics: Active Transport, Cell Nucleus; Animals; Female; In Vitro Techniques; Meiosis; Metalloendopeptidases; Mice; Microscopy, Fluorescence; Oocytes; Quinolones; Subcellular Fractions; Tubulin | 2005 |
The phosphodiesterase 3 inhibitor cilostamide enhances inotropic responses to glucagon but not to dobutamine in rat ventricular myocardium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dobutamine; Dose-Response Relationship, Drug; Drug Synergism; Exonucleases; Female; Glucagon; Heart Ventricles; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase I; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Quinolones; Rats; Rats, Sprague-Dawley; Ventricular Function; Xanthines | 2005 |
Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Follicular Phase; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microscopy, Fluorescence; Oocytes; Oogenesis; Ovarian Follicle; Ovulation; Quinolones; Thiophenes; Time Factors | 2005 |
Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Gene Expression; Male; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Submandibular Gland | 2006 |
Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-1 Receptor Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Norepinephrine; Propanolamines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Ventricular Function | 2006 |
Ginseng extract inhibits lipolysis in rat adipocytes in vitro by activating phosphodiesterase 4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Fatty Acids, Nonesterified; Glycerol; Insulin; Lipolysis; Male; Panax; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinolones; Rats; Rats, Sprague-Dawley | 2006 |
New insight into the role of phosphodiesterase 3A in porcine oocyte maturation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Nucleus; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Meiosis; Okadaic Acid; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Time Factors | 2006 |
Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Aged; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Epinephrine; Female; Heart Atria; Humans; Hydrolysis; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Myocardium; Norepinephrine; Phosphodiesterase Inhibitors; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram | 2006 |
Nuclear and cytoplasmic maturation of in vitro matured human oocytes after temporary nuclear arrest by phosphodiesterase 3-inhibitor.
Topics: Cell Nucleus; Cells, Cultured; Chromatin; Cytoplasm; Embryonic Development; Female; Humans; Meiosis; Oocytes; Ovulation Induction; Phosphodiesterase Inhibitors; Quinolones; Spindle Apparatus | 2007 |
The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Aged; Animals; Atrial Appendage; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Female; Humans; Isometric Contraction; Isoproterenol; Male; Middle Aged; Norepinephrine; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Rolipram; Signal Transduction | 2007 |
Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Cell Adhesion; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activators; Guanine Nucleotide Exchange Factors; Humans; Multiprotein Complexes; Peptide Fragments; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Protein Structure, Tertiary; Quinolones; Signal Transduction; Transfection | 2007 |
Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Female; Heart Atria; Heart Rate; Heart Ventricles; Imidazoles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Sinoatrial Node; Tachycardia, Sinus; Tachycardia, Ventricular | 2008 |
Effect of temporary nuclear arrest by phosphodiesterase 3-inhibitor on morphological and functional aspects of in vitro matured mouse oocytes.
Topics: Aneuploidy; Animals; Cell Nucleus; Embryonic Development; Female; Fertilization in Vitro; In Vitro Techniques; Kinetics; Meiosis; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oocytes; Oogenesis; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Quinolones | 2008 |
Effects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytes.
Topics: Adenylyl Cyclases; Adult; Cells, Cultured; Colforsin; Drug Synergism; Embryonic Development; Female; Gap Junctions; Humans; Meiosis; Oocytes; Phosphodiesterase Inhibitors; Quinolones | 2008 |
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Animals; Biosensing Techniques; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide-Gated Cation Channels; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescence Resonance Energy Transfer; Guanine Nucleotide Exchange Factors; Heart Ventricles; Isoproterenol; Kinetics; Male; Membrane Potentials; Microscopy, Fluorescence; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Quinolones; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Sarcolemma; Signal Transduction; Transfection | 2008 |
Effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent mouse embryo development.
Topics: Animals; Blastocyst; Embryonic Development; Female; Fertilization; Gonadotropins, Equine; Meiosis; Mice; Mice, Inbred Strains; Oocytes; Phosphodiesterase Inhibitors; Pregnancy; Quinolones | 2009 |
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP.
Topics: Adult; Aged; Animals; Blotting, Western; Cilostazol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Erythrocyte Membrane; Female; Humans; Iloprost; Male; Middle Aged; Milrinone; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Rabbits; Tetrazoles; Up-Regulation | 2008 |
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Arrhythmia, Sinus; Atrial Function, Left; Atrial Function, Right; Bradycardia; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Partial Agonism; Female; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Propanolamines; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Stimulation, Chemical; Tachycardia | 2009 |
Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart.
Topics: Animals; Atrial Function; Calcium Channels, L-Type; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Cardiac; Norepinephrine; Patch-Clamp Techniques; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Ventricular Function | 2009 |
Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.
Topics: Age Factors; Animals; Animals, Newborn; Arrhythmia, Sinus; Atrial Function; Calcium Channels, L-Type; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Receptors, Serotonin, 5-HT4; Rolipram; Serotonin; Species Specificity; Swine; Ventricular Function | 2009 |
Cilostamide produces hyperpolarization associated with K(ATP) channel activation, but does not augment endothelium-derived hyperpolarization in rat mesenteric arteries.
Topics: Animals; Biological Factors; Endothelium, Vascular; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Mesenteric Arteries; Potassium Channels; Quinolones; Rats; Rats, Wistar; Vasodilation | 2009 |
Use of phosphodiesterase type 3 inhibitor to improve IVM outcome: experimental set up matters.
Topics: Animals; Embryonic Development; Fertilization in Vitro; Mice; Oocytes; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Quinolones | 2009 |
Assessment of a new in vitro maturation system for mouse and human cumulus-enclosed oocytes: three-dimensional prematuration culture in the presence of a phosphodiesterase 3-inhibitor.
Topics: Animals; Cell Culture Techniques; Cells, Cultured; Collagen; Culture Media; Cumulus Cells; Embryonic Development; Female; Humans; Mice; Oocytes; Phosphodiesterase Inhibitors; Pregnancy; Quinolones | 2009 |
Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Amrinone; Animals; Atrial Function; Cardiotonic Agents; Catalytic Domain; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Design; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Quinolines; Quinolones; Rats; Rats, Wistar; Sequence Alignment | 2009 |
Effects of the cAMP-elevating agents cilostamide, cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets.
Topics: Animals; Binding Sites; Blood Platelets; Cilostazol; Colforsin; Collagen; Cyclic AMP; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; In Vitro Techniques; Isoquinolines; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Rats; Rats, Sprague-Dawley; Serine; Sulfonamides; Tetrazoles | 2009 |
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve Stenosis; Cardiomegaly; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Male; Myocardial Contraction; Myocytes, Cardiac; Organ Size; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Wistar; Second Messenger Systems | 2009 |
PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Bile Ducts; Cyclic Nucleotide Phosphodiesterases, Type 3; Isoenzymes; Kidney; Kidney Cortex; Ligation; Liver Cirrhosis; Mesenteric Arteries; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Sprague-Dawley | 2009 |
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition.
Topics: Animals; Apoptosis; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Failure; Male; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Signal Transduction | 2010 |
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.
Topics: Animals; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Piperazines; Purines; Quinolones; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Signal Transduction; Sildenafil Citrate; Sulfones; Triazines; Troponin I | 2010 |
Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4.
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epinephrine; Heart Atria; Heart Ventricles; In Vitro Techniques; Norepinephrine; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram; Sinoatrial Node; Swine; Tachycardia | 2010 |
A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Gene Expression; Hypothalamus; Leptin; Male; Models, Neurological; Neurons; Neurotensin; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Pro-Opiomelanocortin; Quinolones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2010 |
Simulated physiological oocyte maturation (SPOM): a novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Cell Communication; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Culture Media, Serum-Free; Cumulus Cells; Cyclic AMP; Embryo Implantation; Embryo, Mammalian; Embryonic Development; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gap Junctions; Mice; Oocytes; Oogenesis; Pregnancy; Pregnancy Outcome; Quinolones | 2010 |
Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.
Topics: Animals; Cilostazol; Drug Synergism; Inositol 1,4,5-Trisphosphate Receptors; JNK Mitogen-Activated Protein Kinases; Milrinone; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurites; PC12 Cells; Peptide Elongation Factor 1; Phosphatidylinositol 3-Kinases; Phosphodiesterase 3 Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; raf Kinases; ras Proteins; Rats; Receptor, trkA; Signal Transduction; Tetrazoles | 2011 |
Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
Topics: Acylation; Adipocytes; Adrenergic beta-Agonists; Animals; Benzimidazoles; Blotting, Western; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Interactions; Ghrelin; Glycerol; Intra-Abdominal Fat; Isoproterenol; Lipolysis; Male; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Quinoxalines; Rats; Rats, Wistar; Thiazolidinediones | 2011 |
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Forkhead Transcription Factors; Graft Rejection; Methylation; Mice; Quinolones; T-Lymphocytes, Regulatory | 2011 |
Gap junction-mediated communications regulate chromatin remodeling during bovine oocyte growth and differentiation through cAMP-dependent mechanism(s).
Topics: Animals; Cattle; Chromatin Assembly and Disassembly; Cyclic AMP; Female; Gap Junctions; Meiosis; Oocytes; Oogenesis; Phosphodiesterase Inhibitors; Quinolones | 2011 |
Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Arginase; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Induction; Humans; Myocytes, Smooth Muscle; Phosphodiesterase 3 Inhibitors; Pulmonary Artery; Quinolones; Signal Transduction | 2012 |
Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anthracenes; Carrier Proteins; Chromones; Isoquinolines; JNK Mitogen-Activated Protein Kinases; Lipase; Lipolysis; Mice; Morpholines; Perilipin-1; Phosphoproteins; Phosphorylation; Quinolones; Ribonucleotides; Sterol Esterase; Sulfonamides; Thioctic Acid | 2012 |
Regulation of sheep oocyte maturation using cAMP modulators.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Embryo, Mammalian; Embryonic Development; Female; Follicle Stimulating Hormone; In Vitro Oocyte Maturation Techniques; Oocytes; Oogenesis; Osmolar Concentration; Phosphodiesterase Inhibitors; Quality Control; Quinolones; Sheep | 2013 |
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbachol; Cardiotonic Agents; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Failure; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Muscarinic Agonists; Myocardial Contraction; Myocardial Infarction; Pertussis Toxin; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats; Rats, Wistar; Rolipram; Ventricular Pressure | 2013 |
Participation of PI3-kinase/Akt signalling in insulin stimulation of p34cdc2 activation in zebrafish oocyte: phosphodiesterase 3 as a potential downstream target.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Chromones; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Developmental; Hydroxyprogesterones; Insulin; Isoenzymes; Meiosis; Morpholines; Oocytes; Phosphatidylinositol 3-Kinase; Phosphodiesterase 3 Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolones; Recombinant Proteins; Signal Transduction; Wortmannin; Zebrafish | 2013 |
Effect of phosphodiesterase type 3 inhibitor on nuclear maturation and in vitro development of ovine oocytes.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cumulus Cells; Drug Evaluation, Preclinical; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Oocytes; Oogenesis; Phosphodiesterase 3 Inhibitors; Polar Bodies; Quinolones; Sheep, Domestic | 2013 |
A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice.
Topics: Adipogenesis; Adipose Tissue, Brown; Adipose Tissue, White; Adrenergic beta-3 Receptor Agonists; Adult Stem Cells; Animals; Biomarkers; Crosses, Genetic; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclooxygenase 2; Dioxoles; Enzyme Induction; Epididymis; Gene Expression Profiling; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Phosphodiesterase Inhibitors; Quinolones | 2013 |
The effect of cilostamide on gap junction communication dynamics, chromatin remodeling, and competence acquisition in pig oocytes following parthenogenetic activation and nuclear transfer.
Topics: Animals; Cell Communication; Cells, Cultured; Chromatin Assembly and Disassembly; Cumulus Cells; Dose-Response Relationship, Drug; Female; Gap Junctions; Meiosis; Nuclear Transfer Techniques; Oocytes; Oogenesis; Parthenogenesis; Quinolones; Swine | 2013 |
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Pyridines; Quinolones; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Vasodilator Agents | 2015 |
Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
Topics: Amiloride; Cells, Cultured; Chlorides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Humans; Immunoprecipitation; Quinolones; Respiratory Mucosa; Rolipram | 2014 |
Attenuated response of L-type calcium current to nitric oxide in atrial fibrillation.
Topics: Atrial Fibrillation; Calcium; Calcium Channels, L-Type; Cyclic AMP; Cyclic GMP; Humans; Myocardium; Nitric Oxide; Patch-Clamp Techniques; Phosphodiesterase 3 Inhibitors; Quinolones | 2014 |
Effects of different oocyte retrieval and in vitro maturation systems on bovine embryo development and quality.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Colforsin; Culture Media; DNA Methylation; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Male; Oocyte Retrieval; Quinolones | 2015 |
Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms.
Topics: Animals; Calcium; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Ions; Male; Muscle Cells; Muscle Contraction; Peptides; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Protein Isoforms; Quinolones; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Urinary Bladder | 2014 |
NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aquaporin 2; Arginine Vasopressin; Blotting, Western; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Kidney Tubules, Collecting; Mice; NADPH Oxidase 4; NADPH Oxidases; Quinolones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Rolipram; Signal Transduction | 2014 |
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Pyridazines; Quinolines; Quinolones; Rats, Wistar; Rolipram; Simendan; Thiadiazines | 2014 |
Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.
Topics: Animals; Biosensing Techniques; Cyclic AMP; Cyclic GMP; Fluorescence Resonance Energy Transfer; Mice; Mice, Transgenic; Models, Animal; Myocytes, Cardiac; Phosphodiesterase 3 Inhibitors; Quinolones | 2014 |
Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium.
Topics: Adrenergic beta-Antagonists; Adult; Carbazoles; Carvedilol; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epinephrine; Female; Heart Failure; Heart Transplantation; Humans; Male; Middle Aged; Norepinephrine; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Propanolamines; Quinolones; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Rolipram | 2014 |
Activation of the Pi3k/Akt pathway and modulation of phosphodiesterase activity via membrane progestin receptor-alpha (mPRalpha) regulate progestin-initiated sperm hypermotility in Atlantic croaker.
Topics: Androstadienes; Animals; Azepines; Blotting, Western; Chromones; Enzyme Activation; Male; Morpholines; Perciformes; Phosphatidylinositol 3-Kinases; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-akt; Quinolones; Receptors, Progesterone; Rolipram; Signal Transduction; Sperm Motility; Spermatozoa; Wortmannin | 2014 |
Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
Topics: Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dinoprost; Endothelium, Vascular; Gene Expression; Heart Failure; In Vitro Techniques; Isoproterenol; Male; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Rats, Wistar; RNA, Messenger; Vasoconstriction | 2014 |
Natriuretic peptide precursor C delays meiotic resumption and sustains gap junction-mediated communication in bovine cumulus-enclosed oocytes.
Topics: Abattoirs; Animals; Blastocyst; Cattle; Cell Communication; Chromatin; Cumulus Cells; Ectogenesis; Embryo Culture Techniques; Female; Fertilization in Vitro; Gap Junctions; In Vitro Oocyte Maturation Techniques; Meiotic Prophase I; Natriuretic Peptide, C-Type; Oocysts; Oogenesis; Phosphodiesterase 3 Inhibitors; Protein Precursors; Quinolones | 2014 |
The effect of temporary meiotic attenuation on the in vitro maturation outcome of bovine oocytes.
Topics: Animals; Blastocyst; Cattle; Cells, Cultured; Colforsin; Culture Media; Female; Fertilization in Vitro; Follicle Stimulating Hormone; In Vitro Oocyte Maturation Techniques; Luteinizing Hormone; Male; Meiosis; Oocytes; Purines; Quinolones; Roscovitine; Time Factors | 2015 |
Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.
Topics: Animals; Caveolin 3; Connexin 43; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Mice; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphodiesterase Inhibitors; Quinolones | 2015 |
Metabolic effects of newly synthesized phosphodiesterase-3 inhibitor 6-[4-(4-methylpiperidin-1-yl)-4-oxobutoxy]-4-methylquinolin-2(1H)-one on rat adipocytes.
Topics: Adipocytes; Adipogenesis; Animals; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Lipolysis; Male; Phosphodiesterase 3 Inhibitors; Piperidines; Quinolones; Rats; Rats, Wistar | 2015 |
The effect of pre-maturation culture using phosphodiesterase type 3 inhibitor and insulin, transferrin and selenium on nuclear and cytoplasmic maturation of bovine oocytes.
Topics: Animals; Blastocyst; Cattle; Cell Nucleus; Cell Survival; Cells, Cultured; Cumulus Cells; Cytoplasm; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Insulin; Male; Meiosis; Oocytes; Phosphodiesterase 3 Inhibitors; Quinolones; Selenium; Time Factors; Transferrin | 2016 |
Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach.
Topics: 1-Methyl-3-isobutylxanthine; 14-3-3 Proteins; Cyclic Nucleotide Phosphodiesterases, Type 3; HeLa Cells; Humans; Papaverine; Phosphodiesterase Inhibitors; Protein Binding; Protein Interaction Maps; Protein Phosphatase 2; Proteomics; Quinolones | 2015 |
Effects of cilostamide and/or forskolin on the meiotic resumption and development competence of growing ovine oocytes selected by brilliant cresyl blue staining.
Topics: Animals; Colforsin; Embryonic Development; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Oxazines; Quinolones; Sheep | 2016 |
Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice.
Topics: Animals; Body Weight; Cyclic Nucleotide Phosphodiesterases, Type 3; Eating; Gene Expression; Hypothalamus; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Phosphorylation; Pro-Opiomelanocortin; Proto-Oncogene Proteins c-akt; Quinolones; Signal Transduction; STAT3 Transcription Factor; Weight Loss | 2017 |
Cilostamide and forskolin treatment during pre-IVM improves preimplantation development of cloned embryos by influencing meiotic progression and gap junction communication in pigs.
Topics: Adjuvants, Immunologic; Animals; Blastocyst; Bucladesine; Colforsin; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryo Transfer; Female; Gap Junctions; In Vitro Oocyte Maturation Techniques; Meiosis; Phosphodiesterase Inhibitors; Quinolones; Swine | 2016 |
Effect of the meiotic inhibitor cilostamide on resumption of meiosis and cytoskeletal distribution in buffalo oocytes.
Topics: Actin Cytoskeleton; Animals; Buffaloes; Cell Cycle Checkpoints; Cells, Cultured; Cytoskeleton; Female; Meiosis; Microtubules; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Time Factors | 2016 |
Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.
Topics: Animals; Endolymphatic Hydrops; Female; Humans; Magnetic Resonance Imaging; Mice, Inbred CBA; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolones; Rolipram; Saccule and Utricle; Sildenafil Citrate | 2017 |
Meiotic arrest as an alternative to increase the production of bovine embryos by somatic cell nuclear transfer.
Topics: Animals; Cattle; Cloning, Organism; Cyclic Nucleotide Phosphodiesterases, Type 3; Embryo Culture Techniques; Embryo, Mammalian; Female; Meiosis; Natriuretic Peptide, C-Type; Nuclear Transfer Techniques; Oocytes; Parthenogenesis; Phosphodiesterase 3 Inhibitors; Quinolones | 2017 |
Supplement of cilostamide in growth medium improves oocyte maturation and developmental competence of embryos derived from small antral follicles in pigs.
Topics: Animals; Colforsin; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Oocytes; Ovarian Follicle; Quinolones; Swine | 2017 |
Effects of meiotic inhibitors and gonadotrophins on porcine oocytes in vitro maturation, fertilization and development.
Topics: Animals; Blastocyst; Bucladesine; Cycloheximide; Embryonic Development; Female; Fertilization; Fertilization in Vitro; Gonadotropins; In Vitro Oocyte Maturation Techniques; Male; Oocytes; Quinolones; Swine | 2017 |
Influence of nitric oxide and phosphodiesterases during in vitro maturation of bovine oocytes on meiotic resumption and embryo production.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blastocyst; Cattle; Cyclic AMP; Cyclic GMP; Dipyridamole; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Male; Meiosis; Nitric Oxide; Nitric Oxide Donors; Oocytes; Phosphodiesterase Inhibitors; Quinolones; S-Nitroso-N-Acetylpenicillamine; Sildenafil Citrate | 2017 |
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper).
Topics: Animals; Cell Cycle Checkpoints; Estrogens; Female; Gene Expression Regulation; Meiosis; Natriuretic Peptide, C-Type; Oocytes; Oogenesis; Ovarian Follicle; Phosphodiesterase Inhibitors; Quinolones; Receptors, Atrial Natriuretic Factor; Receptors, G-Protein-Coupled; RNA, Messenger; Rolipram; Signal Transduction; Zebrafish; Zebrafish Proteins | 2018 |
Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.
Topics: Animals; Biosensing Techniques; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Epithelial Cells; Fluorescence Resonance Energy Transfer; Humans; Mice, Transgenic; Myocytes, Smooth Muscle; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Quinolones; Respiratory System; Rolipram; Smoke; Tobacco Products; Up-Regulation | 2018 |
Inhibition of PDE3A sustains meiotic arrest and gap junction of bovine growing oocytes in in vitro growth culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cell Communication; Cell Cycle Checkpoints; Cumulus Cells; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Gap Junctions; In Vitro Oocyte Maturation Techniques; Meiosis; Milrinone; Oocytes; Phosphodiesterase 3 Inhibitors; Quinolones | 2018 |
Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.
Topics: Animals; Cell Proliferation; Cinnamates; Humans; I-kappa B Kinase; Insulin-Secreting Cells; Protein Serine-Threonine Kinases; Quinolones; Rats, Inbred Lew; Regeneration; Zebrafish | 2018 |
Cilostamide affects in a concentration and exposure time-dependent manner the viability and the kinetics of in vitro maturation of caprine and bovine oocytes.
Topics: Animals; Cattle; Female; Goats; In Vitro Oocyte Maturation Techniques; Kinetics; Meiosis; Oocytes; Quinolones | 2019 |
Cilostamide and forskolin maintain gap junction function of incubated dog follicles.
Topics: Animals; Cells, Cultured; Colforsin; Dogs; Female; Gap Junctions; Meiosis; Oocytes; Oogenesis; Ovarian Follicle; Quinolones | 2020 |
A prematuration approach to equine IVM: considering cumulus morphology, seasonality, follicle of origin, gap junction coupling and large-scale chromatin configuration in the germinal vesicle.
Topics: Animals; Cell Communication; Cell Size; Cells, Cultured; Chromatin; Cumulus Cells; Embryo Culture Techniques; Embryonic Development; Female; Gap Junctions; Horses; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Ovarian Follicle; Quinolones; Seasons; Specimen Handling | 2019 |
Cilostamide and rolipram prevent spontaneous meiotic resumption from diplotene arrest in rat oocytes cultured in vitro.
Topics: Actins; Animals; Cells, Cultured; Cumulus Cells; Cyclic AMP; Dose-Response Relationship, Drug; Drug Combinations; Female; Gap Junctions; Gene Expression Regulation; In Vitro Techniques; Kinetics; Meiosis; Meiotic Prophase I; Oocytes; Ovary; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolones; Rats; Rolipram | 2020 |
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H
Topics: Adenine; Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Heart Atria; Heart Rate; Histamine; Humans; Male; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors; Quinolones; Receptors, Histamine H2; Rolipram | 2021 |
The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued bycilostamide.
Topics: Adipose Tissue; Animals; Blood Glucose; Dioxoles; Fatty Acids; Hypoglycemic Agents; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Phosphodiesterase Inhibitors; Quinolones; Thermogenesis; Uncoupling Protein 1 | 2022 |