Page last updated: 2024-09-04

cilomilast and zardaverine

cilomilast has been researched along with zardaverine in 9 studies

Compound Research Comparison

Studies
(cilomilast)
Trials
(cilomilast)
Recent Studies (post-2010)
(cilomilast)
Studies
(zardaverine)
Trials
(zardaverine)
Recent Studies (post-2010) (zardaverine)
162134267222

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)zardaverine (IC50)
Chain A, Phosphodiesterase 4DHomo sapiens (human)0.16
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.39
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.764
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)0.764
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.764
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.21
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.8067
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.6691
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.6811
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)0.4912
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.94
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.94

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Hatzelmann, A; Sterk, GJ; Thibaut, U; Timmerman, H; Van der Laan, IJ; Van der Mey, M1
Bommelé, KM; Boss, H; Hatzelmann, A; Sterk, GJ; Timmerman, H; Van der Mey, M; Van Slingerland, M1
Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY1
Jabaris, SS; Kodimuthali, A; Pal, M1
Barlow, DJ; Ehrman, TM; Hylands, PJ1
Barreiro, EJ; Bourguignon, JJ; Cardozo, SV; Fraga, CA; Justiniano, H; Kümmerle, AE; Lopes, AB; Lugnier, C; Martins, MA; Romeiro, NC; Schmitt, M; Villa, P1
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R1
Bielska, M; Bruno, O; Bull, JA; Fossa, P; Giordanetto, F; Guariento, S; Iwanowa, X; Karawajczyk, A; Marchini, G1
He, J; Ke, H; Peng, T; Qi, B; Shi, J1

Reviews

2 review(s) available for cilomilast and zardaverine

ArticleYear
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive

2008
Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Development; Drug Discovery; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Conformation; Quinolones; Vomiting

2020

Other Studies

7 other study(ies) available for cilomilast and zardaverine

ArticleYear
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues.
    Journal of medicinal chemistry, 2001, Aug-02, Volume: 44, Issue:16

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Humans; In Vitro Techniques; Leukocytes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Phthalazines; Structure-Activity Relationship

2001
Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
    Journal of medicinal chemistry, 2003, May-08, Volume: 46, Issue:10

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Edema; Enzyme Inhibitors; Mice; Phthalazines; Pyridazines; Structure-Activity Relationship

2003
Structural basis for the activity of drugs that inhibit phosphodiesterases.
    Structure (London, England : 1993), 2004, Volume: 12, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary

2004
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

2010
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
    Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17

    Topics: Administration, Oral; Animals; Drug Design; Female; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Phosphodiesterase 4 Inhibitors; Pneumonia

2012
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship

2016
Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

    Topics: Azepines; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Design; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Molecular Structure; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2017