Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and vardenafil

cilomilast has been researched along with vardenafil in 5 studies

Compound Research Comparison

Studies
(cilomilast)		Trials
(cilomilast)		Recent Studies (post-2010)
(cilomilast)		Studies
(vardenafil)		Trials
(vardenafil)		Recent Studies (post-2010) (vardenafil)
162134232020

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)vardenafil (IC50)
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)0.14
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.7801
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaHomo sapiens (human)0.0077
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)1.6334
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.817
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)0.57
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaHomo sapiens (human)0.0077
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0077
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)4.15
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaHomo sapiens (human)0.0077
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Homo sapiens (human)0.0077
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)0.265
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)1.3846
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)2.091
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)4.15
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)2.091
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)1.5801
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)1.9
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0077
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)0.265
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)1.34
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)1.3701
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)1.6601
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)1.4883

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY1
Hughes, RA; Manallack, DT; Thompson, PE1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1

Reviews

1 review(s) available for cilomilast and vardenafil

ArticleYear
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005

Other Studies

4 other study(ies) available for cilomilast and vardenafil

ArticleYear
Structural basis for the activity of drugs that inhibit phosphodiesterases.
    Structure (London, England : 1993), 2004, Volume: 12, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010