Page last updated: 2024-09-04

cilomilast and theophylline

cilomilast has been researched along with theophylline in 11 studies

Compound Research Comparison

Studies
(cilomilast)
Trials
(cilomilast)
Recent Studies (post-2010)
(cilomilast)
Studies
(theophylline)
Trials
(theophylline)
Recent Studies (post-2010) (theophylline)
162134220,0761,6121,383

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)theophylline (IC50)
Adenosine receptor A1Bos taurus (cattle)2.43

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (72.73)29.6817
2010's2 (18.18)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Jabaris, SS; Kodimuthali, A; Pal, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
He, J; Ke, H; Peng, T; Qi, B; Shi, J1
Ezeamuzie, CI1
Devillier, P1
Vignola, AM1
Murdoch, RD; Schofield, JP; Webber, DM; Zussman, B1
Bitter-Suermann, S; Kanniess, F; Magnussen, H; Watz, H1
Ammit, AJ; Baehring, G; Kugel, MJ; Patel, BS1

Reviews

5 review(s) available for cilomilast and theophylline

ArticleYear
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive

2008
Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Development; Drug Discovery; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Conformation; Quinolones; Vomiting

2020
[Physiopathology of COPD: choosing the right therapeutic targets].
    Revue de pneumologie clinique, 2003, Volume: 59, Issue:2 Pt 2

    Topics: Adrenal Cortex Hormones; Aged; Albuterol; Animals; Bacterial Infections; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Therapy, Combination; Humans; Inflammation; Mucociliary Clearance; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Randomized Controlled Trials as Topic; Rats; Rolipram; Salmeterol Xinafoate; Smoking; Theophylline; Time Factors

2003
PDE4 inhibitors in COPD--a more selective approach to treatment.
    Respiratory medicine, 2004, Volume: 98, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rolipram; Theophylline; Treatment Outcome

2004
[Pharmacological treatment of COPD and future of anti-inflammatory therapy].
    Medizinische Klinik (Munich, Germany : 1983), 2006, Apr-15, Volume: 101, Issue:4

    Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Dyspnea; Expectorants; Forced Expiratory Volume; Forecasting; Humans; Inflammation; Infliximab; Lung; Macrolides; Nitriles; Phosphodiesterase Inhibitors; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Research; Respiratory Function Tests; Simvastatin; Smoking Cessation; Tetracycline; Theophylline; Tumor Necrosis Factor-alpha

2006

Trials

1 trial(s) available for cilomilast and theophylline

ArticleYear
Lack of pharmacokinetic interactions between cilomilast and theophylline or smoking in healthy volunteers.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aged; Area Under Curve; Bronchodilator Agents; Carboxylic Acids; Cross-Over Studies; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Heart; Humans; Male; Middle Aged; Nitriles; Phosphodiesterase Inhibitors; Smoking; Theophylline

2004

Other Studies

5 other study(ies) available for cilomilast and theophylline

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
    European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Albuterol; Benzamides; Cell Degranulation; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophil Peroxidase; Eosinophils; Histamine; Humans; Nitriles; Peroxidases; Phosphodiesterase Inhibitors; Pyridines; Rolipram; Superoxides; Theophylline

2001
Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect.
    Pulmonary pharmacology & therapeutics, 2017, Volume: 45

    Topics: Anti-Inflammatory Agents; Bronchi; Bronchodilator Agents; Cells, Cultured; Cyclic AMP; Cyclohexanecarboxylic Acids; Dual Specificity Phosphatase 1; Formoterol Fumarate; Humans; Inflammation; Interleukin-8; Myocytes, Smooth Muscle; Nitriles; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha

2017