Page last updated: 2024-09-04

cilomilast and sb 203580

cilomilast has been researched along with sb 203580 in 2 studies

Compound Research Comparison

Studies (cilomilast)	Trials (cilomilast)	Recent Studies (post-2010) (cilomilast)	Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)
162	13	42	3,489	4	1,137

Protein Interaction Comparison

Protein	Taxonomy	sb 203580 (IC50)
Citron Rho-interacting kinase	Homo sapiens (human)	1
Cyclin-G-associated kinase	Homo sapiens (human)	0.4133
Mitogen-activated protein kinase 13	Homo sapiens (human)	0.2329
Mitogen-activated protein kinase 2	Pneumocystis carinii	0.105
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	1.0359
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	0.7575
Cytochrome P450 1A2	Homo sapiens (human)	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	3.45
Neutrophil elastase	Homo sapiens (human)	0.025
Cytochrome P450 3A4	Homo sapiens (human)	0.062
Cytochrome P450 2D6	Homo sapiens (human)	2
Tyrosinase	Mus musculus (house mouse)	0.034
Cholesteryl ester transfer protein	Homo sapiens (human)	0.04
Cytochrome P450 2C9	Homo sapiens (human)	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	5
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	1
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	0.36
Prostaglandin G/H synthase 1	Homo sapiens (human)	2
Thromboxane-A synthase	Homo sapiens (human)	0.494
Adenosine receptor A2a	Homo sapiens (human)	6.068
Ephrin type-B receptor 2	Homo sapiens (human)	7.8
Adenosine receptor A1	Homo sapiens (human)	2.95
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.01
Delta-type opioid receptor	Mus musculus (house mouse)	0.02
Cytochrome P450 2C19	Homo sapiens (human)	0.8
TGF-beta receptor type-1	Homo sapiens (human)	6
Mitogen-activated protein kinase 9	Homo sapiens (human)	0.9517
Mitogen-activated protein kinase 14	Mus musculus (house mouse)	0.056
Casein kinase I isoform delta	Homo sapiens (human)	0.4147
Casein kinase I isoform epsilon	Homo sapiens (human)	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	0.2329
Mitogen-activated protein kinase 10	Homo sapiens (human)	0.6933
Mitogen-activated protein kinase 1	Rattus norvegicus (Norway rat)	0.048
Myotonin-protein kinase	Homo sapiens (human)	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	0.2646
Mitogen-activated protein kinase 14	Homo sapiens (human)	0.39
P2X purinoceptor 7	Homo sapiens (human)	5
Serine/threonine-protein kinase 36	Homo sapiens (human)	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	1
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	1

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barlow, DJ; Ehrman, TM; Hylands, PJ	1
Allen, JM; Bertrand, C; Jacob, C; Lagente, V; Szilagyi, C	1

Other Studies

2 other study(ies) available for cilomilast and sb 203580

Article	Year
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship	2010
Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism. British journal of pharmacology, 2004, Volume: 143, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; CREB-Binding Protein; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Superoxides; Trans-Activators	2004

Article

Year

In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.

Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

2010

Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.

British journal of pharmacology, 2004, Volume: 143, Issue:2

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; CREB-Binding Protein; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Superoxides; Trans-Activators

2004