Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and rp 73401

cilomilast has been researched along with rp 73401 in 14 studies

Compound Research Comparison

Studies
(cilomilast)		Trials
(cilomilast)		Recent Studies (post-2010)
(cilomilast)		Studies
(rp 73401)		Trials
(rp 73401)		Recent Studies (post-2010) (rp 73401)
162134292023

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)rp 73401 (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.78
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)2.78
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.78
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)0.001
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)0.0027
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)2.78
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.5166
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)0.0035
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.5363
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)2.78
Endothelin-1 receptorSus scrofa (pig)0.001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)2.78
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)2.78
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)2.78

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's8 (57.14)29.6817
2010's3 (21.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Andresen, CJ; Cheng, JB; Cohan, VL; Decker, C; DiCapua, FM; Duplantier, AJ; Johnson, KL; Kraus, KG; Turner, CR; UmLand, JP; Watson, JW; Wester, RT; Williams, AS; Williams, JA1
Ferlenga, P; Marchini, F; Morazzoni, G; Napoletano, M; Norcini, G; Pellacini, F; Pradella, L1
Fattori, R; Ferlenga, P; Marchini, F; Morazzoni, G; Napoletano, M; Norcini, G; Pellacini, F; Pradella, L1
Alonso, JM; Andrés, JI; Boeckx, G; Cools, M; de Chaffoy, D; De Clerck, F; Deroose, F; Díaz, A; Diels, G; Fernández, J; Freyne, EJ; Iturrino, L; Martínez, P; Matesanz, E; Megens, A; Peeters, D; Petit, D; Somers, M; Stoppie, P; Van Wauwe, J1
Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY1
Bachert, EL; Cheng, JB; Cohan, VL; Duplantier, AJ; Jenkinson, TH; Kraus, KG; McKechney, MW; Pillar, JD; Watson, JW1
Barlow, DJ; Ehrman, TM; Hylands, PJ1
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R1
He, J; Ke, H; Peng, T; Qi, B; Shi, J1
Au, BT; Collins, PD; Teixeira, MM; Williams, TJ1
Ezeamuzie, CI1
Dai, YR; Xia, XD; Xu, ZJ1
Beume, R; Bundschuh, DS; Marx, D; Wohlsen, A; Wollin, L1
Barg, M; Geerts, A; Quednau, R; Tersteegen, A; Wunder, F1

Reviews

2 review(s) available for cilomilast and rp 73401

ArticleYear
Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Development; Drug Discovery; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Conformation; Quinolones; Vomiting

2020
[Phosphosdiesterase 4 inhibitors in the treatment of pulmonary diseases].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2004, Volume: 27, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Asthma; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Lung Diseases; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyridines

2004

Other Studies

12 other study(ies) available for cilomilast and rp 73401

ArticleYear
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
    Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13

    Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line; Cyclic AMP; Cytokines; Dihydropyridines; Drug Evaluation, Preclinical; Eosinophils; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Macaca fascicularis; Molecular Conformation; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyrrolidinones; Rolipram; Structure-Activity Relationship

1998
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
    Bioorganic & medicinal chemistry letters, 2001, Jan-08, Volume: 11, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzamides; Biological Availability; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Guinea Pigs; Humans; Inhibitory Concentration 50; Molecular Structure; Monocytes; Neutrophils; Phthalazines; Protein Binding; Pyridines; Rolipram; Tumor Necrosis Factor-alpha

2001
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.
    Bioorganic & medicinal chemistry letters, 2002, Jan-07, Volume: 12, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Binding Sites; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen Bonding; Neutrophils; Phosphodiesterase Inhibitors; Phthalazines; Rolipram; Structure-Activity Relationship

2002
Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.
    Bioorganic & medicinal chemistry letters, 2002, Feb-25, Volume: 12, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Topical; Animals; Anti-Inflammatory Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Ear Diseases; Enzyme Inhibitors; Humans; Imidazoles; Inflammation; Inhibitory Concentration 50; Rats; Structure-Activity Relationship

2002
Structural basis for the activity of drugs that inhibit phosphodiesterases.
    Structure (London, England : 1993), 2004, Volume: 12, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary

2004
SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.
    Journal of medicinal chemistry, 2007, Jan-25, Volume: 50, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Biological Availability; Cyclic Nucleotide Phosphodiesterases, Type 4; Dogs; Eosinophils; Female; Ferrets; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Isoenzymes; Male; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Rats; Recombinant Proteins; Structure-Activity Relationship; Triazoles; Vomiting

2007
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

2010
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship

2016
Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol.
    British journal of pharmacology, 1998, Volume: 123, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Albuterol; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Drug Synergism; Humans; Interleukin-8; Neutrophils; Nitriles; Phosphodiesterase Inhibitors; Prostaglandins; Pyridines; Pyrrolidinones; Rolipram; Zymosan

1998
Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
    European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Albuterol; Benzamides; Cell Degranulation; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophil Peroxidase; Eosinophils; Histamine; Humans; Nitriles; Peroxidases; Phosphodiesterase Inhibitors; Pyridines; Rolipram; Superoxides; Theophylline

2001
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Aminopyridines; Animals; Benzamides; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Immunization; Male; Neutrophils; Nitriles; Ovalbumin; Phosphodiesterase Inhibitors; Pneumonia; Pyridines; Rats; Respiratory Hypersensitivity; Rolipram; Serotonin; Treatment Outcome; Tumor Necrosis Factor-alpha

2006
Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter cell lines.
    Molecular pharmaceutics, 2013, Oct-07, Volume: 10, Issue:10

    Topics: Aminopyridines; Animals; Benzamides; CHO Cells; Cricetulus; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide-Gated Cation Channels; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Models, Biological; Nitriles; Phosphodiesterase 4 Inhibitors; Pyridines; Receptors, Adrenergic, beta-1; Reverse Transcriptase Polymerase Chain Reaction

2013