Page last updated: 2024-09-04

cilomilast and niacinamide

cilomilast has been researched along with niacinamide in 3 studies

Compound Research Comparison

Studies (cilomilast)	Trials (cilomilast)	Recent Studies (post-2010) (cilomilast)	Studies (niacinamide)	Trials (niacinamide)	Recent Studies (post-2010) (niacinamide)
162	13	42	13,381	1,097	5,797

Protein Interaction Comparison

Protein	Taxonomy	niacinamide (IC50)
Chain A, NAD-dependent deacetylase	Thermotoga maritima	1000
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	3.3
NAD-dependent protein deacetylase sirtuin-2	Homo sapiens (human)	2.9
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)	8.1

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Astier, A; Bertrand, C; Jacob, C; Lagente, V; Martin-Chouly, CA; Pruniaux, MP	1
Belleguic, C; Bertrand, C; Brinchault, G; Depincé, A; Lagente, V; Leportier-Comoy, C; Martin-Chouly, CA; Ouagued, M; Pruniaux, MP	1
Bertin, B; Bertrand, CP; Bouget, A; Burnouf, C; Doherty, AM; Dubuit, JP; Julien-Larose, C; Lagente, V; Leportier, C; Martin, B; Moreau, F; Ouaged, M; Pruniaux, MP; Rocher, MN	1

Trials

1 trial(s) available for cilomilast and niacinamide

Article	Year
The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients. Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Azepines; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dexamethasone; Dose-Response Relationship, Drug; Female; France; Humans; Male; Middle Aged; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Polysaccharides, Bacterial; Pulmonary Disease, Chronic Obstructive; Rolipram; Tumor Necrosis Factor-alpha	2005

Article

Year

The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients.

Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:1

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Azepines; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dexamethasone; Dose-Response Relationship, Drug; Female; France; Humans; Male; Middle Aged; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Polysaccharides, Bacterial; Pulmonary Disease, Chronic Obstructive; Rolipram; Tumor Necrosis Factor-alpha

2005

Other Studies

2 other study(ies) available for cilomilast and niacinamide

Article	Year
Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors. Life sciences, 2004, Jul-02, Volume: 75, Issue:7 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Azepines; Blotting, Western; Bronchodilator Agents; Carboxylic Acids; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Fibroblasts; Humans; Isoenzymes; Lung; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Metalloproteases; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha	2004
Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways. Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:1 Topics: Administration, Oral; Animals; Azepines; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Male; Niacinamide; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Rats; Rats, Inbred BN; Rolipram; Tumor Necrosis Factor-alpha	2010

Article

Year

Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors.

Life sciences, 2004, Jul-02, Volume: 75, Issue:7

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Azepines; Blotting, Western; Bronchodilator Agents; Carboxylic Acids; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Fibroblasts; Humans; Isoenzymes; Lung; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Metalloproteases; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2004

Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways.

Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:1

Topics: Administration, Oral; Animals; Azepines; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Male; Niacinamide; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Rats; Rats, Inbred BN; Rolipram; Tumor Necrosis Factor-alpha

2010