Page last updated: 2024-09-04

cilomilast and l-454,560

cilomilast has been researched along with l-454,560 in 2 studies

Compound Research Comparison

Studies (cilomilast)	Trials (cilomilast)	Recent Studies (post-2010) (cilomilast)	Studies (l-454,560)	Trials (l-454,560)	Recent Studies (post-2010) (l-454,560)
162	13	42	10	0	1

Protein Interaction Comparison

Protein	Taxonomy	l-454,560 (IC50)
Cytochrome P450 2C9	Homo sapiens (human)	0.4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	0.0011
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (human)	0.0037
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.001

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jabaris, SS; Kodimuthali, A; Pal, M	1
Abraham, WM; Claveau, D; Dias, R; Dubé, D; Gallant, M; Girard, Y; Goetghebeur, P; Huang, Z; Jones, T; Lacombe, P; Laliberte, F; Liu, S; Macdonald, D; Mancini, JA; Ng, K; Nicholson, DW; Otu, F; Styhler, A; Turner, MJ; Young, RN; Zhang, L	1

Reviews

1 review(s) available for cilomilast and l-454,560

Article	Year
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18 Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2008

Other Studies

1 other study(ies) available for cilomilast and l-454,560

Article	Year
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition. Biochemical pharmacology, 2007, Jun-15, Volume: 73, Issue:12 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Apoenzymes; Ascaris suum; Asthma; Benzamides; Bronchoconstriction; Carboxylic Acids; Cognition Disorders; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Interferon-gamma; Male; Molecular Structure; Nitriles; Ovalbumin; Polymerase Chain Reaction; Quinolines; Rats; Sensitivity and Specificity; Sheep	2007

Article

Year

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

Biochemical pharmacology, 2007, Jun-15, Volume: 73, Issue:12

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Apoenzymes; Ascaris suum; Asthma; Benzamides; Bronchoconstriction; Carboxylic Acids; Cognition Disorders; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Interferon-gamma; Male; Molecular Structure; Nitriles; Ovalbumin; Polymerase Chain Reaction; Quinolines; Rats; Sensitivity and Specificity; Sheep

2007