Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and dinoprostone

cilomilast has been researched along with dinoprostone in 5 studies

Compound Research Comparison

Studies
(cilomilast)		Trials
(cilomilast)		Recent Studies (post-2010)
(cilomilast)		Studies
(dinoprostone)		Trials
(dinoprostone)		Recent Studies (post-2010) (dinoprostone)
162134229,1051,3466,357

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)dinoprostone (IC50)
Prostaglandin E2 receptor EP1 subtypeHomo sapiens (human)0.0155
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)0.0031
Prostaglandin E2 receptor EP4 subtypeRattus norvegicus (Norway rat)0.0021
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)0.002
Prostaglandin E2 receptor EP2 subtypeHomo sapiens (human)0.0087
Prostacyclin receptorHomo sapiens (human)0.26
Prostaglandin E2 receptor EP2 subtypeRattus norvegicus (Norway rat)0.0052

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ammit, AJ; Amrani, Y; Hay, DW; Hoffman, RK; Lazaar, AL; Panettieri, RA; Penn, RB; Torphy, TJ1
Ezeamuzie, CI1
Abe, S; Barnette, MS; Cieslinski, L; Fang, Q; Kobayashi, T; Kohyama, T; Liu, X; Rennard, SI; Wen, FQ1
Bäumer, W; Kietzmann, M1
Fang, Q; Liu, X; Ma, Y; Michalski, J; Rennard, SI; Wang, J1

Other Studies

5 other study(ies) available for cilomilast and dinoprostone

ArticleYear
Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Cells, Cultured; Chemokine CCL5; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Humans; Interleukin-6; Muscle, Smooth; NF-kappa B; Nitriles; Phosphodiesterase Inhibitors; RNA, Messenger; Time Factors; Trachea; Transcription, Genetic; Tumor Necrosis Factor-alpha

2000
Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
    European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Albuterol; Benzamides; Cell Degranulation; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophil Peroxidase; Eosinophils; Histamine; Humans; Nitriles; Peroxidases; Phosphodiesterase Inhibitors; Pyridines; Rolipram; Superoxides; Theophylline

2001
Cytokines modulate cilomilast response in lung fibroblasts.
    Clinical immunology (Orlando, Fla.), 2004, Volume: 111, Issue:3

    Topics: Bronchodilator Agents; Carboxylic Acids; Cell Movement; Cells, Cultured; Collagen; Cyclohexanecarboxylic Acids; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Fetus; Fibroblasts; Humans; Interleukin-1; Interleukin-4; Lung; Nitriles; Recombinant Proteins

2004
Effects of cyclosporin A and cilomilast on activated canine, murine and human keratinocytes.
    Veterinary dermatology, 2007, Volume: 18, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxylic Acids; Cell Proliferation; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclosporine; Dermatitis, Atopic; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Keratinocytes; Mice; Nitriles; Phosphodiesterase Inhibitors; Species Specificity

2007
PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Fibroblasts; Gels; Gene Expression Regulation; Humans; Indomethacin; Lung; Nitriles; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Salmeterol Xinafoate; Up-Regulation

2013