Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and cyclosporine

cilomilast has been researched along with cyclosporine in 5 studies

Compound Research Comparison

Studies
(cilomilast)		Trials
(cilomilast)		Recent Studies (post-2010)
(cilomilast)		Studies
(cyclosporine)		Trials
(cyclosporine)		Recent Studies (post-2010) (cyclosporine)
16213423772170
162134230,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Funk, RH; Kasper, M; Kuss, H; Plötze, K; Roth-Eichhorn, S; Schade, I; Schüler, S1
Bäumer, W; Kietzmann, M1

Other Studies

5 other study(ies) available for cilomilast and cyclosporine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Benefit of phosphodiesterase 4 inhibitors as supplemental therapy after lung transplantation concerning their antiproliferative effects: an experimental study using a heterotopic rodent model.
    Transplantation, 2002, Aug-15, Volume: 74, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclosporine; Graft Survival; Immunosuppressive Agents; Lung Transplantation; Nitriles; Phosphodiesterase Inhibitors; Rats; Rats, Inbred BN; Rats, Inbred Lew; Rolipram; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous

2002
Effects of cyclosporin A and cilomilast on activated canine, murine and human keratinocytes.
    Veterinary dermatology, 2007, Volume: 18, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxylic Acids; Cell Proliferation; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclosporine; Dermatitis, Atopic; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Keratinocytes; Mice; Nitriles; Phosphodiesterase Inhibitors; Species Specificity

2007