cilomilast has been researched along with ci 1044 in 5 studies
| Studies (cilomilast) | Trials (cilomilast) | Recent Studies (post-2010) (cilomilast) | Studies (ci 1044) | Trials (ci 1044) | Recent Studies (post-2010) (ci 1044) |
|---|---|---|---|---|---|
| 162 | 13 | 42 | 14 | 1 | 4 |
| Protein | Taxonomy | cilomilast (IC50) | ci 1044 (IC50) |
|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | 1.7 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | 1.7 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | 1.7 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | 0.27 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | 1.7 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | 0.27 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | 0.27 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | 0.27 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Auclair, E; Avenel, N; Bertin, B; Bigot, C; Burnouf, C; Calvet, A; Chan, K; Doherty, AM; Durand, C; Fasquelle, V; Féru, F; Gilbertsen, R; Jacobelli, H; Kebsi, A; Lallier, E; Maignel, J; Martin, B; Milano, S; Ouagued, M; Pascal, Y; Pruniaux, MP; Puaud, J; Rocher, MN; Terrasse, C; Wrigglesworth, R | 1 |
| Jabaris, SS; Kodimuthali, A; Pal, M | 1 |
| Astier, A; Bertrand, C; Jacob, C; Lagente, V; Martin-Chouly, CA; Pruniaux, MP | 1 |
| Belleguic, C; Bertrand, C; Brinchault, G; Depincé, A; Lagente, V; Leportier-Comoy, C; Martin-Chouly, CA; Ouagued, M; Pruniaux, MP | 1 |
| Bertin, B; Bertrand, CP; Bouget, A; Burnouf, C; Doherty, AM; Dubuit, JP; Julien-Larose, C; Lagente, V; Leportier, C; Martin, B; Moreau, F; Ouaged, M; Pruniaux, MP; Rocher, MN | 1 |
1 review(s) available for cilomilast and ci 1044
| Article | Year |
|---|---|
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive | 2008 |
1 trial(s) available for cilomilast and ci 1044
| Article | Year |
|---|---|
The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Azepines; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dexamethasone; Dose-Response Relationship, Drug; Female; France; Humans; Male; Middle Aged; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Polysaccharides, Bacterial; Pulmonary Disease, Chronic Obstructive; Rolipram; Tumor Necrosis Factor-alpha | 2005 |
3 other study(ies) available for cilomilast and ci 1044
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Azepines; Binding, Competitive; Brain; Bronchoalveolar Lavage; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Eosinophils; Ferrets; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Isoenzymes; Male; Monocytes; Niacinamide; Ovalbumin; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Trachea; Tumor Necrosis Factor-alpha; Vomiting | 2000 |
Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Azepines; Blotting, Western; Bronchodilator Agents; Carboxylic Acids; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Fibroblasts; Humans; Isoenzymes; Lung; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Metalloproteases; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2004 |
Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways.
Topics: Administration, Oral; Animals; Azepines; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Male; Niacinamide; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Rats; Rats, Inbred BN; Rolipram; Tumor Necrosis Factor-alpha | 2010 |