Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and cdp 840

cilomilast has been researched along with cdp 840 in 6 studies

Compound Research Comparison

Studies
(cilomilast)		Trials
(cilomilast)		Recent Studies (post-2010)
(cilomilast)		Studies
(cdp 840)		Trials
(cdp 840)		Recent Studies (post-2010) (cdp 840)
16213421803

Protein Interaction Comparison

ProteinTaxonomycilomilast (IC50)cdp 840 (IC50)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)0.7675
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.1028
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)0.1032
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.1029

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andresen, CJ; Cheng, JB; Cohan, VL; Decker, C; DiCapua, FM; Duplantier, AJ; Johnson, KL; Kraus, KG; Turner, CR; UmLand, JP; Watson, JW; Wester, RT; Williams, AS; Williams, JA1
Blouin, M; Brideau, C; Chan, CC; Chauret, N; Ducharme, Y; Girard, M; Girard, Y; Guay, D; Hamel, P; Huang, Z; Jones, TR; Laliberté, F; Masson, P; McAuliffe, M; Piechuta, H; Silva, J; Young, RN1
Boss, H; Hatzelmann, A; Sterk, GJ; Timmerman, H; Van der Laan, IJ; Van der Mey, M1
Boss, H; Couwenberg, D; Goubitz, K; Hatzelmann, A; Schenk, H; Sterk, GJ; Timmerman, H; Van der Mey, M1
Blouin, M; Brideau, C; Chauret, N; Ducharme, Y; Frenette, R; Friesen, RW; Girard, Y; Hamel, P; Jones, TR; Laliberté, F; Li, C; Masson, P; McAuliffe, M1
Jabaris, SS; Kodimuthali, A; Pal, M1

Reviews

1 review(s) available for cilomilast and cdp 840

ArticleYear
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive

2008

Other Studies

5 other study(ies) available for cilomilast and cdp 840

ArticleYear
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
    Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13

    Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line; Cyclic AMP; Cytokines; Dihydropyridines; Drug Evaluation, Preclinical; Eosinophils; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Macaca fascicularis; Molecular Conformation; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyrrolidinones; Rolipram; Structure-Activity Relationship

1998
Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.
    Bioorganic & medicinal chemistry letters, 2002, Jun-03, Volume: 12, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Bronchoconstriction; Cell Line, Transformed; Cyclic Nucleotide Phosphodiesterases, Type 4; Emetics; Ferrets; Guinea Pigs; Half-Life; Humans; Inhibitory Concentration 50; Ovalbumin; Phosphodiesterase Inhibitors; Pyridines; Rats; Recombinant Fusion Proteins; Saimiri; Sheep; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2002
Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones.
    Journal of medicinal chemistry, 2002, Jun-06, Volume: 45, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adamantane; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheptanes; Edema; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Luminescent Measurements; Mice; Phthalazines; Reactive Oxygen Species; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2002
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.
    Journal of medicinal chemistry, 2002, Jun-06, Volume: 45, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adamantane; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 4; Edema; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Mice; Molecular Conformation; Neutrophils; Phthalazines; Stereoisomerism; Structure-Activity Relationship

2002
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.
    Bioorganic & medicinal chemistry letters, 2002, Oct-21, Volume: 12, Issue:20

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkylation; Animals; Biological Availability; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Half-Life; Humans; Indicators and Reagents; Phosphodiesterase Inhibitors; Pyridines; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2002