ciguatoxins has been researched along with sulfoxide* in 1 studies
1 other study(ies) available for ciguatoxins and sulfoxide
Article | Year |
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Practical route to the left wing of CTX1B and total syntheses of CTX1B and 54-deoxyCTX1B.
Ciguatoxins, the principal causative agents of ciguatera seafood poisoning, are extremely large polycyclic ethers. We report herein a reliable route for constructing the left wing of CTX1B, which possesses the acid/base/oxidant-sensitive bisallylic ether moiety, by a 6-exo radical cyclization/ring-closing metathesis strategy. This new route enabled us to achieve the second-generation total synthesis of CTX1B and the first synthesis of 54-deoxyCTX1B. Topics: Ciguatoxins; Cyclization; Ethers; Free Radicals; Quantum Theory; Safrole; Stereoisomerism | 2015 |