ciglitazone has been researched along with thiazoles in 135 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (20.00) | 18.7374 |
| 1990's | 22 (16.30) | 18.2507 |
| 2000's | 83 (61.48) | 29.6817 |
| 2010's | 3 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gill, AM; Powell, JG; Sampson, BM; Yen, TT | 1 |
| Dietrich, A; Harrison, MC; Hohman, TC; McCaleb, M; Millen, J; Sredy, J; Sullivan, D; Woolson, SA; Wrobel, J | 1 |
| Cheeseman, RS; Christos, TE; Kees, KL; McCaleb, ML; Patt, WC; Prozialeck, DH; Smith, TM; Steiner, KE | 1 |
| Alessi, TR; Bagli, JF; Dolak, TM; Ellinboe, JW; Guzzo, F; McCaleb, ML; Nguyen, TT; Tomer, JD | 1 |
| Gill, AM; Yen, TT | 1 |
| Jirkovsky, I; McCaleb, ML; Nowicki, JW; Zask, A | 1 |
| Ikeda, H; Kawamatsu, Y; Meguro, K; Momose, Y; Sohda, T; Sugiyama, Y | 1 |
| Belin, D; Bruzzone, R; Trimble, ER | 1 |
| Caro, JF; Ittoop, O; Sinha, MK | 1 |
| Chisholm, DJ; James, DE; Jenkins, AB; Kraegen, EW; Storlien, LH | 1 |
| Lien, EL; Steiner, KE | 1 |
| Chang, AY; Wyse, BM | 1 |
| Diani, AR; Sawada, GA; Wyse, BM | 1 |
| Colca, JR; Connell, CL; Diani, AR; Fletcher-McGruder, BL; Jodelis, KS; Palazuk, BJ; Sawada, G; Wyse, BM | 1 |
| Kern, HF; Rausch, U; Trimble, ER | 1 |
| Fujita, T; Taketomi, S; Yokono, K | 1 |
| Antwi, D; Bray, GA; Chan, TM; Fukushima, M; Shargill, NS; Tatoyan, A | 1 |
| Mercer, SW; Trayhurn, P | 1 |
| Rothwell, NJ; Stock, MJ; Tedstone, AE | 1 |
| Arch, JR; Thurlby, PL; Wilson, S | 1 |
| Chang, AY; Diani, AR; Gilchrist, BJ; Hearron, AE; Jodelis, K; Peterson, T; Sawada, G; Wyse, BM | 1 |
| Bachmann, W; Häring, HU; Kirsch, DM | 1 |
| Iwasaki, M; Kobayashi, M; Maegawa, H; Ohgaku, S; Shigeta, Y; Watanabe, N | 1 |
| Fujita, T; Iwatsuka, H; Kawamatsu, Y; Sohda, T; Sugiyama, Y; Suzuoki, Z; Taketomi, S | 1 |
| Chang, AY; Diani, AR; Gilchrist, BJ; Peterson, T; Wyse, BM | 1 |
| Chang, AY; Gilchrist, BJ; Wyse, BM | 2 |
| Chang, AY; Diani, AR; Gilchrist, BJ; Hearron, AE; Peterson, T; Sawada, GA; Wyse, BM | 1 |
| Kawamatsu, Y; Meguro, K; Sohda, T | 1 |
| Kawamatsu, Y; Mizuno, K; Sohda, T | 1 |
| Fujita, T; Sugiyama, Y; Tanayama, S; Torii, H; Yoshida, K | 1 |
| Tanayama, S; Torii, H; Tsukamoto, T; Yoshida, K | 1 |
| Cox, JW; Pullen, RH | 1 |
| Fujita, T; Imamiya, E; Kawamatsu, Y; Mizuno, K; Sohda, T; Sugiyama, Y | 1 |
| Benson, S; Feuerstein, BG; Hyun, WC; Kurtz, TW; Pershadsingh, HA; Szollosi, J | 1 |
| Kliewer, SA; Lehmann, JM; Lenhard, JM; Morris, DC; Patel, I; Willson, TM | 1 |
| Umeda, F | 1 |
| Lambe, KG; Tugwood, JD | 1 |
| Clark, DA; Genereux, PE; Gibbs, EM; Hulin, B; Lewis, DM; Newton, LS | 1 |
| Connell, J; Petrie, J; Small, M | 1 |
| Benson, SC; Kurtz, TW; Morikang, E; Pershadsingh, HA | 1 |
| Bucher, NL; Farmer, SR; Morrison, RF; Wu, Z; Xie, Y | 1 |
| Akatsuka, H; Arakawa, K; Homma, K; Iijima, I; Inamasu, M; Kawanami, S; Matsumoto, M; Okumura, K; Ozeki, M; Saiga, Y; Watanabe, A; Yasuda, K | 1 |
| Goldammer, T; Kanitz, W; Löhrke, B; Pöhland, R; Shahi, SK; Viergutz, T; Walzel, H; Wollenhaupt, K | 1 |
| Dandine, M; Dauzats, M; Daviaud, D; Langin, D; Saulnier-Blache, JS; Viguerie-Bascands, N | 1 |
| Gerritsen, ME; Kowalski, J; Xin, X; Yang, S | 1 |
| Gebicke-Haerter, PJ; Kakimura, J; Kitamura, Y; Matsuoka, Y; Nomura, Y; Taniguchi, T | 1 |
| Combs, CK; Doller, C; Fitch, MT; Landreth, GE; Silver, J | 1 |
| Kniss, DA; Li, HM; Liu, L; Sabourin, CL; Seewaldt, V; Smith, PJ; Yee, LD | 1 |
| Casini, A; Ceni, E; Crabb, D; Galli, A; Price, D; Salzano, R; Surrenti, C | 1 |
| Bishop-Bailey, D; Clark, RB; Estrada-Hernandez, T; Hla, T; Padula, SJ; Puddington, L | 1 |
| Dietl, G; Krüger, B; Löhrke, B; Renne, U; Schmidt, P; Shahi, SK | 1 |
| Kuzuya, T | 1 |
| Ikeda, H; Murase, K; Sugiyama, Y | 1 |
| Demer, LL; Jackson, SM | 1 |
| Loitsch, SM; Stein, J; Wächtershäuser, A | 1 |
| Black, PM; Brown, EM; Chattopadhyay, N; Godbole, MM; Heese, O; Singh, DP; Sinohara, T | 1 |
| Chiang, HT; Ho, LL; Li, HF; Wu, SN | 1 |
| Cho, D; Chung, SW; Kang, BY; Kim, SH; Kim, TS; Pak, YK; Trinchieri, G | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, RM; Vázquez, M | 1 |
| Aleo, MD; Avery, MJ; Beierschmitt, WP; Drupa, CA; Fortner, JH; Kaplan, AH; Navetta, KA; Shepard, RM; Walsh, CM | 1 |
| Cao, HJ; Kaur, K; Padilla, J; Phipps, RP; Smith, TJ | 1 |
| Brüne, B; Von Knethen A, A | 1 |
| Kagechika, H; Kawashima, S; Sato, M; Tanaka, K; Yajima, Y | 1 |
| Dixon, C; Hilbelink, T; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Gunawan, I; Malamas, MS; McCaleb, M; Mihan, B; Sredy, J; Sullivan, D | 1 |
| Harris, SG; Phipps, RP | 1 |
| Conrad, DJ; Dai, X; Luu, B; Wang, AC | 1 |
| Albajar, M; Galetto, R; Polanco, JI; Rodríguez-Rey, JC; Zakin, MM | 1 |
| Hupfeld, CJ; Weiss, RH | 1 |
| Bláha, L; Hofmanová, J; Kozubík, A; Minksová, K; Soucek, K; Stika, J; Vondrácek, J | 1 |
| Frucht, H; Yang, WL | 1 |
| Kang, K; Pariza, MW | 1 |
| Dulak, J; Huk, I; Jozkowicz, A; Nanobashvili, J; Nigisch, A; Prager, M; Weigel, G; Winter, B | 1 |
| Levine, L | 1 |
| Berry, E; Gilmour, R; Helliwell, R; Keelan, J; Marvin, K; Mitchell, M; Nijmeijer, B; Sato, T | 1 |
| Coffey, MJ; Hayes, MM; King, SR; Lane, BR; Markovitz, DM | 1 |
| Marra, F; Pastacaldi, S | 1 |
| Archer, DC; Cunard, R; DiCampli, D; Glass, CK; Kahn, DA; Kelly, CJ; Ricote, M | 1 |
| Brüne, B; Fischer, B; von Knethen, A | 1 |
| Dixon, C; Doseff, AI; Hilbelink, T; Kotur, M; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Chang, TH; Szabo, E | 1 |
| Bright, JJ; Natarajan, C | 1 |
| Dembinska-Kiec, A; Dulak, J; Jozkowicz, A; Piatkowska, E; Placha, W | 1 |
| Breyer, B; Cheng, H; Feng, T; Haydon, RC; He, TC; Ishikawa, A; Jiang, W; Montag, A; Peabody, T; Simon, MA; Zhou, L | 1 |
| Baik, EJ; Kim, EJ; Kwon, KJ; Lee, SH; Moon, CH; Park, JY | 1 |
| Dessouroux, A; Lennon, AM; Pierre, M; Ramaugé, M | 1 |
| Blaschke, F; Bungenstock, A; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Stawowy, P | 1 |
| Feinstein, D; Grommes, C; Heneka, MT; Klockgether, T; Koenigsknecht, J; Kraus, JA; Landreth, G; Schlegel, U; Zander, T | 1 |
| Frauwirth, KA; Lazar, MA; Rangwala, SM; Thompson, CB; Wang, YL | 1 |
| Chi, KH; Chio, CC; Huang, WC; Lin, WW; Wu, HM | 1 |
| Chatterjee, PK; Cuzzocrea, S; Hattori, Y; McDonald, MC; Mota-Filipe, H; Pisano, B; Thiemermann, C; Wayman, NS | 1 |
| Miyazaki, Y; Tachibana, H; Yamada, K | 1 |
| Büchele, B; Jendrach, M; Schüle, A; Simmet, T; Syrovets, T | 1 |
| Battarbee, H; Coates, G; Nissim, I; Welbourne, T | 1 |
| Cho, H; Tai, HH | 2 |
| Fujimura, Y; Tachibana, H; Yamada, K | 1 |
| Chan, UP; Chen, GG; Ip, PC; Lau, WY; Lee, JF; Wang, SH | 1 |
| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Cammarota, S; Chiariotti, L; Fusco, A; Iuliano, R; Kroll, T; Le Pera, I; Martelli, ML; Monaco, C; Sama', I; Santoro, M | 1 |
| Hansen, M; Maisch, B; Rupp, H; Wahl, R | 1 |
| Bungenstock, A; Czupalla, C; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Nürnberg, B; Spencer-Hänsch, C; Stawowy, P | 1 |
| Fujita, T; Ikeda, H; Kawamatsu, Y; Meguro, K; Sohda, T | 1 |
| Jensen, BA; Mann, KK; Ryu, HY; Schlezinger, JJ; Sherr, DH | 1 |
| Corbett, L; Knox, AJ; Nie, M; Pang, L | 1 |
| Calnek, DS; Hart, CM; Mazzella, L; Roman, J; Roser, S | 1 |
| Aruna, B; Ehtesham, NZ; Ghosh, S; Mukhopadhyay, S; Singh, AK | 1 |
| Belvisi, MG; Bishop-Bailey, D; Mitchell, JA; Patel, HJ; Yacoub, MH | 1 |
| Brune, K; Hinz, B; Pahl, A | 1 |
| Chen, YE; Fu, M; Lin, Y; Mao, Z; Zhang, J; Zhu, X | 1 |
| Kehrer, JP; Tong, Z; Wu, X | 1 |
| Burghardt, R; Qin, C; Safe, S; Smith, R; Stewart, J; Wormke, M | 1 |
| Han, S; Huang, RP; Sidell, N; Wanichkul, T | 1 |
| Chao, VA; Hornung, D; Taylor, RN; Vigne, JL; Wallwiener, D | 1 |
| Slomiany, A; Slomiany, BL | 1 |
| Ethridge, RT; Evers, BM; Hashimoto, K | 1 |
| Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL | 1 |
| Brüne, B; Tautenhahn, A; von Knethen, A | 1 |
| Bradbury, J; Clinton, SK; Guo, Y; Seewaldt, VL; Suster, S; Yee, LD | 1 |
| Holman, NA; May, FJ; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Smith, SA | 1 |
| Burgermeister, E; Liscovitch, M; Tencer, L | 1 |
| Dawson, MI; James, SY; Kolluri, SK; Lin, F; Zhang, XK | 1 |
| Dai, J; Remick, DG; Wang, X; Zeng, X | 1 |
| Auwerx, J; Capron, M; Dombrowicz, D; Honda, K; Loyens, M; Papin, JP; Staels, B; Woerly, G | 1 |
| Fu, J; Gaetani, S; Lin, E; Oveisi, F; Piomelli, D | 1 |
| Knight, B; Olynyk, JK; Yeap, BB; Yeoh, GC | 1 |
| Cabot, PJ; Davis, B; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Venkata, NG | 1 |
| Brunskill, NJ; Chana, RS | 1 |
| Futagami, M; Mizunuma, H; Shigeto, T; Xin, B; Yokoyama, Y | 1 |
| Elias, PM; Feingold, KR; Jiang, YJ; Kim, P; Lu, B; Paragh, G; Schmitz, G | 1 |
| Guo, SW; Wu, Y | 1 |
| Baron, DM; Hudec, X; Kaindl, U; Koneczny, I; König, JS; Marian, B; Röhrl, C | 1 |
| Buono, C; Busch, S; Chibout, SD; Cruz, E; Gurnani, M; McLean, LA; Moulin, P; Patel, P; Pognan, F; Reising, A; Sampath, S; Shangari, N; Wolf, A | 1 |
| Caballero, J; Fuentes, E; Muñoz-Gutiérrez, C; Palomo, I; Sepúlveda, C | 1 |
6 review(s) available for ciglitazone and thiazoles
| Article | Year |
|---|---|
Hypoglycaemic agents which do not release insulin.
Topics: Animals; Fatty Acids; Humans; Hypoglycemic Agents; Insulin; Somatostatin; Thiazoles; Thiazolidinediones | 1987 |
Potential role of thiazolidinediones in older diabetic patients.
Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Japan; Mice; Pioglitazone; Randomized Controlled Trials as Topic; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Mice; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Mechanisms of thiazolidinedione derivatives for hypoglycemic and insulin sensitizing effects].
Topics: Animals; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2000 |
[Thiazolidinediones and PPARgamma system in repair of liver damage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arteriosclerosis; Chromans; Diabetes Mellitus, Type 2; Eicosanoids; Fatty Acids; Forecasting; Humans; Hypoglycemic Agents; In Vitro Techniques; Inflammation; Liver Cirrhosis; Neoplasms; Obesity; Receptors, Cytoplasmic and Nuclear; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
[Discovery and development of a new insulin sensitizing agent, pioglitazone].
Topics: Animals; Clinical Trials as Topic; Clofibrate; Diabetes Mellitus; Diabetes Mellitus, Experimental; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Mice; Pioglitazone; Thiazoles; Thiazolidinediones | 2002 |
129 other study(ies) available for ciglitazone and thiazoles
| Article | Year |
|---|---|
Ciglitazone prevents and reverses dexamethasone-induced hyperglycemia in female viable yellow mice.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Corticosterone; Dexamethasone; Dose-Response Relationship, Drug; Female; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Thiazoles; Thiazolidinediones | 1992 |
Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Glyceraldehyde; Hypoglycemic Agents; Indoles; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Rats; Structure-Activity Relationship; Succinimides; Thiazoles; Thiazolidinediones | 1992 |
Perfluorocarbon-based antidiabetic agents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fluorocarbons; Hypoglycemic Agents; Insulin; Mice; Mice, Obese; Molecular Structure; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1992 |
Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Rats; Rats, Zucker; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1992 |
Effects of ciglitazone on endogenous plasma islet amyloid polypeptide and insulin sensitivity in obese-diabetic viable yellow mice.
Topics: Amyloid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Mice; Mice, Obese; Reference Values; Thiazoles; Thiazolidinediones; Triglycerides | 1991 |
Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Lactates; Male; Mice; Naphthalenes; Rats; Rats, Zucker; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1990 |
Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones.
Topics: Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Mice, Obese; Pioglitazone; Pyridines; Thiazoles; Thiazolidinediones; Triglycerides | 1990 |
Insulin resistance is accompanied by impairment of amylase-gene expression in the exocrine pancreas of the obese Zucker rat.
Topics: Amylases; Animals; Female; Gene Expression Regulation; Glucose; Insulin Resistance; Obesity; Pancreas; Protein Biosynthesis; Rats; Rats, Mutant Strains; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones | 1986 |
Glyburide but not ciglitazone enhances insulin action in the liver independent of insulin receptor kinase activation.
Topics: Animals; Cells, Cultured; Drug Synergism; Glyburide; Hypoglycemic Agents; Insulin; Kinetics; Liver; Macromolecular Substances; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones | 1989 |
A potent in vivo effect of ciglitazone on muscle insulin resistance induced by high fat feeding of rats.
Topics: Animals; Blood Glucose; Deoxyglucose; Dietary Fats; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscles; Phosphorylation; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidinediones | 1989 |
The hypoglycemic effect of ciglitazone in obese, hyperglycemic animal models.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Blood Glucose; Disease Models, Animal; Glycolysis; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Mitochondria; Obesity; Oxygen Consumption; Receptor, Insulin; Thiazoles; Thiazolidinediones | 1988 |
A review of the effects of ciglitazone on the pancreatic islets of obese, hyperglycemic mice.
Topics: Animals; Hyperglycemia; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mice; Mice, Obese; Obesity; Thiazoles; Thiazolidinediones | 1988 |
Ciglitazone, a hypoglycemic agent: early effects on the pancreatic islets of ob/ob mice.
Topics: Animals; Blood Glucose; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Thiazoles; Thiazolidinediones | 1988 |
Changes in individual rates of pancreatic enzyme and isoenzyme biosynthesis in the obese Zucker rat.
Topics: Amino Acids; Animals; Blood Glucose; Eating; Insulin; Isoelectric Focusing; Isoenzymes; Kinetics; Obesity; Pancreas; Proteins; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones | 1987 |
Insulin receptor and postbinding defects in KK mouse adipocytes and improvement by ciglitazone.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Carbon Radioisotopes; Cells, Cultured; Diabetes Mellitus, Experimental; Glucose; Glycolysis; Hypoglycemic Agents; Insulin Resistance; Kinetics; Male; Methylglucosides; Methylglycosides; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptor, Insulin; Thiazoles; Thiazolidinediones; Tritium | 1988 |
Effect of ciglitazone on glucose uptake and insulin sensitivity in skeletal muscle of the obese (ob/ob) mouse: distinct insulin and glucocorticoid effects.
Topics: Adrenal Cortex; Animals; Deoxyglucose; Glucocorticoids; Gluconeogenesis; Glucose; Hypoglycemic Agents; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Muscles; Thiazoles; Thiazolidinediones | 1986 |
Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice.
Topics: Adipose Tissue, Brown; Animals; Cold Temperature; Guanosine Diphosphate; Insulin; Insulin Resistance; Lipids; Male; Mice; Mice, Obese; Mitochondria; Thiazoles; Thiazolidinediones | 1986 |
Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Body Weight; Eating; Energy Metabolism; Male; Oxygen Consumption; Propranolol; Purine Nucleotides; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidinediones | 1987 |
Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Calorimetry; Energy Metabolism; Female; Guanosine Diphosphate; Hypoglycemic Agents; Mice; Thiazoles; Thiazolidinediones | 1987 |
Ciglitazone, a new hypoglycemic agent. 5. Effect on renal lesions in C57BL/KsJ-db/db mice.
Topics: Animals; Blood Glucose; Diabetic Nephropathies; Drug Evaluation, Preclinical; Glomerular Mesangium; Glycogen; Histocytochemistry; Hypoglycemic Agents; Immunoglobulin G; Immunoglobulin M; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Thiazoles; Thiazolidinediones | 1986 |
Ciglitazone reverses cAMP-induced post-insulin receptor resistance in rat adipocytes in vitro.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Cyclic AMP; Insulin; Insulin Resistance; Isoproterenol; Male; Methylglucosides; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones | 1984 |
A new potentiator of insulin action. Post-receptor activation in vitro.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Blood Glucose; Body Weight; Deoxyglucose; Diabetes Mellitus, Experimental; Drug Synergism; Glucose; Glycolysis; Insulin; Kinetics; Obesity; Rats; Rats, Inbred Strains; Receptor, Insulin; Thiazoles; Thiazolidinediones | 1983 |
Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Mice; Mice, Obese; Obesity; Phospholipids; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidinediones; Triglycerides | 1983 |
Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucagon; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Rats; Thiazoles; Thiazolidinediones; Triglycerides | 1983 |
Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Thiazoles; Thiazolidinediones | 1983 |
Ciglitazone, a new hypoglycaemic agent. 4. Effect on pancreatic islets of C57BL/6J-ob/ob and C57BL/KsJ-db/db mice.
Topics: Animals; Blood Glucose; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microscopy, Electron; Thiazoles; Thiazolidinediones | 1984 |
Studies on antidiabetic agents. IV. Synthesis and activity of the metabolites of 5-[4-(1-methylcyclohexylmethoxy)benzyl]-2,4-thiazolidinedione (ciglitazone).
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry; Hypoglycemic Agents; Hypolipidemic Agents; Mice; Mice, Obese; Thiazoles; Thiazolidinediones; Triglycerides | 1984 |
Studies on antidiabetic agents. VI. Asymmetric transformation of (+/-)-5-[4-(1-methylcyclohexylmethoxy)benzyl]-2,4- thiazolidinedione(ciglitazone) with optically active 1-phenylethylamines.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Hypoglycemic Agents; Mice; Mice, Obese; Phenethylamines; Stereoisomerism; Thiazoles; Thiazolidinediones | 1984 |
Ciglitazone, a new hypoglycaemic agent. 3. Effect on glucose disposal and gluconeogenesis in vivo in C57BL/6J-ob/ob and -+/? mice.
Topics: Animals; Blood Glucose; Gluconeogenesis; Glucose; Glycogen; Hypoglycemic Agents; Kinetics; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Proteins; Thiazoles; Thiazolidinediones | 1983 |
Rat-plasma metabolites of ciglitazone, a new antidiabetic agent.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Feeding Behavior; Female; Gas Chromatography-Mass Spectrometry; Hydroxylation; Hypoglycemic Agents; Male; Mice; Mice, Obese; Rats; Rats, Inbred Strains; Stereoisomerism; Thiazoles; Thiazolidinediones | 1984 |
Disposition in rats and dogs of ciglitazone, a new antidiabetic agent.
Topics: Administration, Oral; Animals; Bile; Blood Proteins; Dogs; Erythrocytes; Feces; Female; Hypoglycemic Agents; Male; Maternal-Fetal Exchange; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidinediones; Tissue Distribution | 1984 |
Isomodal column switching high-performance liquid chromatographic technique for the analysis of ciglitazone and its metabolites in human serum.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Isomerism; Male; Reference Standards; Thiazoles; Thiazolidinediones | 1984 |
Studies on antidiabetic agents. II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives.
Topics: Animals; Hypoglycemic Agents; Male; Mice; Mice, Obese; Thiazoles; Thiazolidinediones | 1982 |
Effects of ciglitazone on blood pressure and intracellular calcium metabolism.
Topics: Animals; Blood Pressure; Calcium; Female; Insulin; Intracellular Membranes; Obesity; Platelet-Derived Growth Factor; Rats; Rats, Zucker; Signal Transduction; Thiazoles; Thiazolidinediones; Tumor Cells, Cultured | 1993 |
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Topics: Adipocytes; Animals; Binding, Competitive; Cell Differentiation; Cells, Cultured; Fibroblasts; Hypoglycemic Agents; Ligands; Mice; Microbodies; Prostaglandin D2; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 1995 |
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.
Topics: Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Benzopyrans; Chromans; DNA, Complementary; Fatty Acids; Humans; Mice; Molecular Sequence Data; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1996 |
Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.
Topics: 3T3 Cells; Adipocytes; Animals; Benzofurans; Carboxylic Acids; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Mice; Mice, Mutant Strains; Mice, Obese; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1996 |
"Glitazones", a prospect for non-insulin-dependent diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Effects of thiazolidinediones on growth and differentiation of human aorta and coronary myocytes.
Topics: Aorta; Cell Division; Cells, Cultured; Chromans; Coronary Vessels; Humans; Hypoglycemic Agents; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.
Topics: 3T3 Cells; Adaptor Protein Complex 2; Adaptor Protein Complex alpha Subunits; Adaptor Proteins, Vesicular Transport; Adipocytes; Animals; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Complement Factor D; Dexamethasone; DNA-Binding Proteins; Gene Expression; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Ligands; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA, Messenger; Serine Endopeptidases; Thiazoles; Thiazolidinediones; Transcription Factors | 1998 |
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Topics: Animals; Benzopyrans; Benzoxazoles; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Male; Mice; Obesity; Pioglitazone; Rosiglitazone; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells.
Topics: Analysis of Variance; Animals; Aurintricarboxylic Acid; Cattle; Cell Cycle; Dose-Response Relationship, Drug; Female; Flow Cytometry; Granulosa Cells; Hypoglycemic Agents; Luteal Cells; Luteinizing Hormone; Microscopy, Fluorescence; Progesterone; Prostaglandin D2; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, LH; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors | 1998 |
Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes.
Topics: Adipocytes; Adipose Tissue; Adult; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Ion Channels; Leptin; Membrane Transport Proteins; Middle Aged; Mitochondrial Proteins; Palmitates; Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha; Uncoupling Protein 2 | 1999 |
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cornea; Eicosanoids; Endothelium, Vascular; Gene Expression Regulation; Humans; Ligands; Neovascularization, Physiologic; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cells, Cultured; Dinoprostone; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Interferon-gamma; Lipopolysaccharides; Neuroglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 1999 |
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Brain Injuries; Cell Movement; Cells, Cultured; Cerebral Cortex; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Indomethacin; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Microscopy, Video; Neurites; Neuroglia; Neurons; Proteoglycans; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Zymosan | 1999 |
Peroxisome proliferator-activated receptor gamma activation in human breast cancer.
Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Female; Genes, Reporter; Humans; Hypoglycemic Agents; Prostaglandins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Proteins; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1999 |
Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Gene Expression; Gene Expression Regulation; Humans; Liver; Platelet-Derived Growth Factor; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection | 2000 |
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses.
Topics: Adjuvants, Immunologic; Animals; Binding Sites, Antibody; CD3 Complex; Clone Cells; Female; Immune Sera; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microbodies; Nuclear Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Spleen; T-Lymphocytes, Helper-Inducer; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Thiazolidinedione-induced activation of the transcription factor peroxisome proliferator-activated receptor gamma in cells adjacent to the murine skeletal muscle: implications for fibroblast functions.
Topics: Adipocytes; Animals; Blotting, Western; Cell Separation; DNA, Complementary; Down-Regulation; Fatty Acids; Fibroblasts; Flow Cytometry; Glucose; Homeostasis; Hypoglycemic Agents; Immunohistochemistry; Macrophages; Male; Mice; Mice, Obese; Muscle, Skeletal; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2000 |
Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts.
Topics: Animals; Bone Density; Cell Differentiation; Cells, Cultured; Humans; Mice; Osteoblasts; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2000 |
PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate.
Topics: Alkaline Phosphatase; Blotting, Western; Butyrates; Caco-2 Cells; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Pentanoic Acids; Propionates; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substrate Specificity; Thiazoles; Thiazolidinediones; Transcription Factors; Up-Regulation | 2000 |
Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis.
Topics: Apoptosis; Astrocytes; Caspase 3; Caspases; Cell Survival; DNA Fragmentation; Gene Expression; Humans; Hypoglycemic Agents; Peroxisomes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Regulation of Ca(2+)-activated K+ currents by ciglitazone in rat pituitary GH3 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Hypoglycemic Agents; Membrane Potentials; Pituitary Gland; Potassium Channels; Rats; Thiazoles; Thiazolidinediones; Tumor Cells, Cultured | 2000 |
Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Female; Gene Expression Regulation; HeLa Cells; Humans; Hypoglycemic Agents; Interleukin-12; Lipopolysaccharides; Lipoproteins, LDL; Macrophages; Mice; Mice, Inbred DBA; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Spleen; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection | 2000 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Topics: Acyl-CoA Dehydrogenase; Animals; Atorvastatin; Bezafibrate; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Cholesterol; Chromans; Down-Regulation; Fatty Acid Desaturases; Heptanoic Acids; Hypoglycemic Agents; Ion Channels; Ligands; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscles; Oleic Acid; Peroxisome Proliferators; Proteins; Pyrimidines; Pyrroles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triazenes; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2000 |
The use of explant lens culture to assess cataractogenic potential.
Topics: Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Benzopyrans; Biotransformation; Cataract; Drug-Related Side Effects and Adverse Reactions; Glutathione; Lens, Crystalline; Lipoxygenase Inhibitors; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Toxicity Tests; Xenobiotics | 2000 |
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Lineage; Cells, Cultured; Chromans; Dinoprost; Hypoglycemic Agents; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Escherichia coli; Genes, Reporter; Humans; Hypoglycemic Agents; Interferon-gamma; Lipopolysaccharides; Luciferases; Macrophages; Mice; Microbodies; Monocytes; NG-Nitroarginine Methyl Ester; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Respiratory Burst; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2001 |
Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists.
Topics: Adipocytes; Aminobenzoates; Animals; Benzazepines; Benzoates; Bexarotene; Cell Differentiation; Cell Line; Dibenzazepines; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2001 |
A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.
Topics: Cells, Cultured; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Humans; Hypoglycemic Agents; Immunologic Factors; JNK Mitogen-Activated Protein Kinases; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Prostaglandins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Obese; Oxadiazoles; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2001 |
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Topics: Animals; Antigen Presentation; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chromans; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ionomycin; Ligands; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation.
Topics: Adjuvants, Immunologic; Cytokines; Down-Regulation; Humans; Inflammation Mediators; Interleukin-4; Interleukin-8; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region.
Topics: Animals; Apolipoproteins E; Astrocytoma; Base Sequence; Binding Sites; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Line; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Glioblastoma; Introns; Luciferases; Macrophages; Microbodies; Molecular Sequence Data; Protein Biosynthesis; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27.
Topics: Animals; Becaplermin; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Suppressor Proteins | 2001 |
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
Topics: Apoptosis; Arachidonic Acid; Caspase 3; Caspases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; HL-60 Cells; Humans; Indomethacin; Isoenzymes; Masoprocol; Membrane Proteins; Peroxisome Proliferators; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Tumor Necrosis Factor-alpha | 2001 |
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA Fragmentation; Down-Regulation; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Genes, cdc; HT29 Cells; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Antioxidants; Hypoglycemic Agents; Leptin; Linoleic Acid; Male; Masoprocol; Mice; Mice, Inbred ICR; Thiazoles; Thiazolidinediones | 2001 |
Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner.
Topics: Cell Line; Cell Survival; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Humans; Interleukin-8; Ligands; NF-kappa B; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Up-Regulation | 2001 |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Kinetics; Liver; Prostaglandin D2; Prostaglandins A; Pyrazoles; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells.
Topics: Amino Acid Chloromethyl Ketones; Amnion; Apoptosis; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Hypoglycemic Agents; Immunologic Factors; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors | 2001 |
Peroxisome proliferator-activated receptor gamma agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects.
Topics: Cell Line; Cells, Cultured; Dactinomycin; Dose-Response Relationship, Drug; HeLa Cells; HIV-1; Humans; Hypoglycemic Agents; Macrophages; Plasmids; Promoter Regions, Genetic; Prostaglandins A; Protein Synthesis Inhibitors; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA-Directed DNA Polymerase; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; U937 Cells | 2002 |
Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Topics: Adjuvants, Immunologic; Animals; Concanavalin A; Cytokines; Female; Interleukin-4; Ligands; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microbodies; Promoter Regions, Genetic; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, IgE; RNA, Messenger; Spleen; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Up-Regulation | 2002 |
Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Linoleic Acids; Linoleic Acids, Conjugated; Lipoproteins, LDL; Macrophage Activation; Macrophages; Mice; Monocytes; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Respiratory Burst; Thiazoles; Thiazolidinediones; Transcription Factors; U937 Cells | 2002 |
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Death; Cell Division; Cells, Cultured; Chromans; Chromones; Enzyme Inhibitors; Glomerular Mesangium; Humans; Morpholines; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung.
Topics: Adenocarcinoma; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Gelsolin; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Ligands; Lung Neoplasms; Phenylbutyrates; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2002 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Immunologic Factors; Interleukin-12; Janus Kinase 2; Kinetics; Lymphocyte Activation; Macrophages; Mice; Microglia; Myelin Basic Protein; Prostaglandin D2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Spinal Cord; Th1 Cells; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages.
Topics: Animals; Antineoplastic Agents; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Hypoglycemic Agents; Interleukin-1; Ligands; Lipopolysaccharides; Lymphokines; Macrophages; Mice; Muscle, Smooth; Promoter Regions, Genetic; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Osteosarcoma; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Neoplasm; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Tretinoin; Troglitazone; Tumor Cells, Cultured | 2002 |
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Topics: Animals; Cell Culture Techniques; Cell Death; Chromans; Clofibrate; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Escherichia coli; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred ICR; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxisome Proliferators; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenat
Topics: Adipocytes; Animals; Astrocytes; Cells, Cultured; Enzyme Activation; MAP Kinase Signaling System; Prostaglandin D2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
PPAR activators inhibit endothelial cell migration by targeting Akt.
Topics: Apoptosis; Blotting, Western; Cell Movement; Cells, Cultured; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fenofibrate; Flavonoids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipid Metabolism; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2002 |
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cadherins; Carrier Proteins; Cell Division; Cell Survival; DNA Fragmentation; Drug Evaluation, Preclinical; Glioma; Humans; Nuclear Proteins; Oligonucleotides, Antisense; Prostaglandin D2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2002 |
Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Humans; Hypoglycemic Agents; Interleukin-3; Lymphocyte Activation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondria; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Rosiglitazone; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Up-Regulation | 2002 |
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
Topics: Animals; Benzophenones; Cell Line; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Peroxisomes; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostaglandin D2; Protein Kinase C; Proto-Oncogene Proteins c-raf; ras Proteins; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Superoxides; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine CCL2; Clofibrate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ligands; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Pioglitazone; Prostaglandin D2; Prostaglandins A; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39.
Topics: B-Lymphocytes; Cell Line; Germ Cells; Humans; Immunoglobulin E; Immunoglobulin Heavy Chains; Interleukin-4; Ligands; Phosphorylation; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; STAT6 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors | 2002 |
Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity.
Topics: Chemotaxis, Leukocyte; Fibrinolysin; Humans; Inflammation; Interleukin-1; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2002 |
Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
Topics: Acidosis; Alanine Transaminase; Animals; Cell Line; Chromans; Epithelial Cells; Glutamine; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kidney; L-Lactate Dehydrogenase; Nitrogen; Nitrogen Isotopes; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Topics: Drug Evaluation, Preclinical; Enzyme Inhibitors; Hydroxyprostaglandin Dehydrogenases; Imipramine; Kinetics; NAD; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2002 |
Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.
Topics: Basophils; Flow Cytometry; Histamine Release; Humans; Ligands; Mast Cells; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, IgE; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2002 |
Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer.
Topics: Apoptosis; Cell Division; Cell Survival; Colon; Colonic Neoplasms; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; HT29 Cells; Humans; Hypoglycemic Agents; Immunoenzyme Techniques; Immunologic Factors; Ligands; NF-kappa B; Promoter Regions, Genetic; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
Topics: Apoptosis; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; DNA Mutational Analysis; Gene Expression; Humans; Mutation; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thiazoles; Thiazolidinediones; Thyroid Gland; Thyroid Neoplasms; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Characterization of sucrose-induced changes in cardiac phenotype.
Topics: Animals; Calcium; Dietary Sucrose; Heart; Hypoglycemic Agents; Imidazoles; Insulin; Myosin Heavy Chains; Phenotype; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Sympatholytics; Thiazoles; Thiazolidinediones; Ventricular Myosins | 2002 |
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
Topics: Androstadienes; Cell Line; Cell Movement; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Leptin; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins; Wortmannin | 2002 |
Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Hydroxyprostaglandin Dehydrogenases; Inhibitory Concentration 50; Isoenzymes; Kinetics; Membrane Proteins; NAD; Placenta; Prostaglandin-Endoperoxide Synthases; Thiazoles; Thiazolidinediones | 2002 |
Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Line, Transformed; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Peroxisome Proliferators; Peroxisomes; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Lung; Membrane Proteins; Muscle, Smooth; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Response Elements; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells.
Topics: Animals; Aorta; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Humans; Immunologic Factors; Ligands; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin D2; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Umbilical Veins | 2003 |
The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; DNA; Exons; Genes; Hormones, Ectopic; Humans; Intercellular Signaling Peptides and Proteins; Introns; Luciferases; Mice; Molecular Sequence Data; Nerve Growth Factor; Protein Binding; Proteins; Recombinant Fusion Proteins; Resistin; Sequence Analysis, DNA; Thiazoles; Thiazolidinediones; Transfection | 2003 |
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cell Division; Cells, Cultured; Dexamethasone; DNA Fragmentation; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Interleukin-1; Ligands; Male; Middle Aged; Muscle, Smooth; Peroxisomes; Prostaglandin D2; Protein Isoforms; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Trachea; Transcription Factors | 2003 |
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Topics: Cyclooxygenase 2; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunologic Factors; In Vitro Techniques; Inflammation; Interleukin-1; Interleukin-6; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2003 |
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Topics: Anilides; Aorta; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hypoglycemic Agents; Inhibitor of Differentiation Protein 2; Muscle, Smooth, Vascular; Oxazoles; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine | 2003 |
Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
Topics: Acute-Phase Proteins; Animals; Apoptosis; Carcinogens; Caspase 3; Caspases; Gene Expression Regulation; Indoles; Lipocalin-2; Lipocalins; Lipoxygenase Inhibitors; Mice; Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Thiazoles; Thiazolidinediones | 2003 |
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cyclin D1; Cysteine Endopeptidases; Down-Regulation; Estrogen Receptor alpha; G1 Phase; Humans; Multienzyme Complexes; Prostaglandin D2; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; RNA, Messenger; S Phase; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitin | 2003 |
Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells.
Topics: Benzophenones; Colony-Stimulating Factors; Cytokines; Endometrium; Epithelial Cells; Female; Humans; Interleukin-6; Ligands; Phenylacetates; Prostaglandin D2; Protein Array Analysis; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2003 |
Thiazolidinedione inhibition of peritoneal inflammation.
Topics: Animals; Chemokine CCL5; Disease Models, Animal; Endometriosis; Female; Interleukin-1; Leukocyte Count; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Peritonitis; Peroxisome Proliferators; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Thioglycolates; Tumor Necrosis Factor-alpha | 2003 |
Suppression of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by peroxisome proliferator-activated receptor gamma activation.
Topics: Animals; Apoptosis; Cyclooxygenase 2; Gastric Mucosa; Gastritis; Helicobacter pylori; Inflammation; Isoenzymes; Ligands; Lipopolysaccharides; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells.
Topics: 3T3 Cells; Adenocarcinoma; alpha Catenin; Animals; Antineoplastic Agents; Apoptosis; beta Catenin; Cadherins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Collagen; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Cytoskeletal Proteins; Drug Combinations; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Laminin; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Pancreatic Neoplasms; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligands; Prostaglandin D2; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Uterine Neoplasms | 2003 |
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Topics: Apoptosis; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Humans; Hydrazines; Jurkat Cells; Lymphocyte Activation; Lymphopenia; Nitrogen Oxides; Phytohemagglutinins; Promoter Regions, Genetic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells.
Topics: Apoptosis; Breast; Cell Cycle; Cell Division; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Hypoglycemic Agents; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Gene Expression Regulation; Ligands; Neurons; Prostaglandin D2; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.
Topics: Apoptosis; Benzoates; Breast Neoplasms; Cell Division; Female; Gene Expression Regulation, Neoplastic; Humans; Ligands; Lung Neoplasms; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoids; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation.
Topics: Anilides; Animals; Asthma; Chemotaxis; Disease Models, Animal; DNA-Binding Proteins; Down-Regulation; Eosinophils; GATA3 Transcription Factor; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Mice, Knockout; Rats; Receptors, Cytoplasmic and Nuclear; Respiratory Hypersensitivity; Rosiglitazone; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors | 2003 |
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Topics: Animals; Body Weight; Butyrates; CD36 Antigens; Cholesterol; Coenzyme A Ligases; Eating; Endocannabinoids; Fatty Acid-Binding Proteins; Hepatocytes; Hyperlipidemias; Ion Channels; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Obesity; Oleic Acids; Phenylurea Compounds; PPAR alpha; Pyrimidines; Rats; Rats, Inbred WF; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Triglycerides; Uncoupling Protein 2 | 2005 |
Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Ethionine; Liver; Male; Mice; Mice, Inbred C57BL; PPAR alpha; PPAR gamma; Receptors, Cytoplasmic and Nuclear; Stem Cells; Thiazoles; Thiazolidinediones | 2005 |
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Topics: Breast Neoplasms; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Female; Humans; Phenylurea Compounds; Phthalic Acids; Plasticizers; PPAR alpha; PPAR gamma; PPAR-beta; Statistics, Nonparametric; Thiazoles; Thiazolidinediones; Transfection | 2006 |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.
Topics: Albumins; Anilides; Animals; Cells, Cultured; Cholesterol; Chromans; Farnesol; Kidney Tubules, Proximal; Ligands; Mevalonic Acid; Opossums; Polyisoprenyl Phosphates; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Troglitazone | 2006 |
Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers.
Topics: Animals; Apoptosis; Ascites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Humans; Immunohistochemistry; Intramolecular Oxidoreductases; Meloxicam; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Peritoneal Neoplasms; PPAR gamma; Prostaglandin-E Synthases; Survival Analysis; Thiazines; Thiazoles; Thiazolidinediones; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
Topics: ATP-Binding Cassette Transporters; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermis; Gene Expression Regulation; Humans; Keratinocytes; Liver X Receptors; Orphan Nuclear Receptors; Permeability; Peroxisome Proliferator-Activated Receptors; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones | 2008 |
Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells.
Topics: Cell Division; Cell Line; Endometrium; Estradiol; Female; Humans; Nicotinic Acids; PPAR gamma; Progesterone; Retinoid X Receptors; Stromal Cells; Tetrahydronaphthalenes; Tetrazolium Salts; Thiazoles; Thiazolidinediones | 2009 |
Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenase 2; Humans; Peroxisome Proliferator-Activated Receptors; PPAR delta; PPAR gamma; PPAR-beta; RNA, Messenger; Thiazoles; Thiazolidinediones; Vascular Endothelial Growth Factor A | 2011 |
The use of rat lens explant cultures to study the mechanism of drug-induced cataractogenesis.
Topics: Acetates; Animals; Cataract; Cell Survival; Eye Proteins; Gene Expression Profiling; Gene Expression Regulation; Lens, Crystalline; Male; Oligonucleotide Array Sequence Analysis; Oxidative Stress; PPAR delta; Rats; Rats, Wistar; RNA, Messenger; Thiazoles; Thiazolidinediones; Tissue Culture Techniques | 2012 |
Study of the interactions between Edaglitazone and Ciglitazone with PPARγ and their antiplatelet profile.
Topics: Binding Sites; Blood Platelets; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; PPAR gamma; Protein Binding; Thiazoles; Thiazolidinediones | 2017 |