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cidofovir anhydrous and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

cidofovir anhydrous has been researched along with cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (40.00)	18.2507
2000's	6 (40.00)	29.6817
2010's	3 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cihlar, T; Ho, ES	1
Andrei, G; De Clercq, E; Holy, A; Krecmerová, M; Lebeau, I; Snoeck, R	1
Andrei, G; Crance, JM; De Clercq, E; De Vos, R; Duraffour, S; Garin, D; Holy, A; Krecmerová, M; Snoeck, R; van Den Oord, J	1
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Krecmerová, M; Masojídková, M; Naesens, L; Neyts, J; Pohl, R; Snoeck, R	1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E	1
Borysko, K; Breitenbach, J; Drach, JC; Hilfinger, J; Kashemirov, BA; Kijek, P; Kim, JS; McKenna, CE; Mitchell, S; Peterson, LW	1
Borysko, KZ; Breitenbach, JM; Collins, M; Drach, JC; Hilfinger, JM; Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Serpi, M; Zakharova, VM	1
Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R	1
Barkhimer, DB; Bischofberger, N; Chen, MS; Cundy, KC; Hitchcock, MJ; Kent, KM; Lacy, SA; Lee, WA; Li, ZH; Mendel, DB	1
Cundy, KC; Hitchcock, MJ; Lee, WA; Lynch, G; Shaw, JP	1
Bidgood, AM; Cundy, KC; Griffin, L; Lee, WA; Lynch, G; Shaw, JP	1
Barditch-Crovo, P; Cundy, KC; Jaffe, HS; Lietman, PS; Petty, BG; Redpath, M; Ruby, A	1
Lee, WA; Oliyai, R; Visor, GC; Yuan, LC	1
Bailey, KW; Sidwell, RW; Smee, DF	1
Andrei, G; Coen, N; Duraffour, S; Krecmerová, M; Naesens, L; Snoeck, R; Van den Oord, J	1

Trials

1 trial(s) available for cidofovir anhydrous and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

Article	Year
Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Administration, Oral; Adult; Anti-HIV Agents; Biological Availability; Cidofovir; Cytosine; Female; HIV Infections; Humans; Injections, Intravenous; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs	1999

Article

Year

Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.

Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2

Topics: Administration, Oral; Adult; Anti-HIV Agents; Biological Availability; Cidofovir; Cytosine; Female; HIV Infections; Humans; Injections, Intravenous; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs

1999

Other Studies

14 other study(ies) available for cidofovir anhydrous and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

Article	Year
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Analytical biochemistry, 2000, Jul-15, Volume: 283, Issue:1 Topics: Animals; Anion Transport Proteins; Anions; Arylsulfonates; Boron Compounds; Carrier Proteins; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescein; Fluoresceins; Fluorescent Dyes; Glutarates; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Spectrometry, Fluorescence; Time Factors; Transfection	2000
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Animals; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Mice; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Polyomavirus; Pyrimidine Nucleosides; Pyrimidines; Simian virus 40	2007
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Male; Mice; Microscopy, Electron, Transmission; Nucleosides; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Swiss 3T3 Cells; Virus Replication	2007
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23 Topics: Antiviral Agents; Cell Line; Cytosine; DNA Viruses; Drug Resistance, Viral; Esters; Humans; Magnetic Resonance Spectroscopy; Prodrugs; Retroviridae; RNA Viruses; Stereoisomerism; Structure-Activity Relationship	2007
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship	2009
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir. Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13 Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Molecular Structure; Organophosphonates; Peptides; Prodrugs; Rats; Serine; Valine	2011
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies. Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16 Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cidofovir; Cowpox virus; Cytomegalovirus; Cytosine; Fibroblasts; Herpesvirus 1, Human; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Structure; Organophosphonates; Prodrugs; Rats; Tyrosine; Vaccinia virus	2011
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclovir; Humans; Microbial Sensitivity Tests; Nucleic Acid Hybridization; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay	1991
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10 Topics: Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Drug Stability; Female; Humans; Male; Mice; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley	1994
Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits. Current eye research, 1996, Volume: 15, Issue:5 Topics: AIDS-Related Opportunistic Infections; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Eye; Half-Life; Humans; Injections; Kidney; Male; Organophosphonates; Organophosphorus Compounds; Rabbits; Retina; Tissue Distribution; Vitreous Body	1996
Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:7 Topics: Administration, Cutaneous; Animals; Antiviral Agents; Biological Availability; Carbon Radioisotopes; Cidofovir; Cytosine; Female; Injections, Intravenous; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution; Virus Diseases	1996
Enhanced chemical stability of the intracellular prodrug, 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir. International journal of pharmaceutics, 1999, Mar-15, Volume: 179, Issue:2 Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Stability; Hydrolysis; Kinetics; Organophosphonates; Organophosphorus Compounds; Prodrugs; Solubility	1999
Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice. Chemotherapy, 2003, Volume: 49, Issue:3 Topics: Administration, Intranasal; Animals; Antiviral Agents; Cidofovir; Cowpox; Cytosine; Female; Infusions, Parenteral; Liver; Lung Diseases; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Vaccinia	2003
Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells. Journal of virology, 2013, Volume: 87, Issue:22 Topics: Animals; Antiviral Agents; Apoptosis; Blotting, Western; Cells, Cultured; Cidofovir; Cyclic AMP; Cytosine; Gammaherpesvirinae; Herpesviridae Infections; Humans; Kidney; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; NIH 3T3 Cells; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tumor Virus Infections; Virus Activation; Virus Replication	2013