cidofovir anhydrous has been researched along with brivudine in 68 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 6 (8.82) | 18.2507 |
2000's | 24 (35.29) | 29.6817 |
2010's | 34 (50.00) | 24.3611 |
2020's | 4 (5.88) | 2.80 |
Authors | Studies |
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Andrei, G; Balzarini, J; Blache, Y; Chapat, JP; Chavignon, O; De Clercq, E; Debouzy, JC; Elhakmaoui, A; Essassi, EM; Gueiffier, A; Kerbal, A; Lhassani, M; Snoeck, R; Teulade, JC; Witvrouw, M | 1 |
Schneller, SW; Seley, KL; Wu, J | 1 |
Andrei, G; De Clercq, E; Froeyen, M; Hendrix, C; Herdewijn, P; Snoeck, R; Wang, J | 1 |
Andrei, G; De Clercq, E; Dimas, K; Foscolos, GB; Fytas, G; Kolocouris, A; Kolocouris, N; Pannecouque, C; Snoeck, R; Stamatiou, G; Witvrouw, M; Zoidis, G | 1 |
De Clercq, E; Garuti, L; Roberti, M | 1 |
Andrei, G; Balzarini, J; De Clercq, E; García-López, MT; Gerona-Navarro, G; González-Muñiz, R; Pérez de Vega, MJ; Snoeck, R | 1 |
De Clercq, E; Glapski, C; Guillerm, G; Muzard, M; Pilard, S | 1 |
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Krecmerová, M; Masojídková, M; Naesens, L; Neyts, J; Pískala, A; Snoeck, R | 1 |
Black, DH; Eberle, R; Focher, F; Gambino, JJ; Lossani, A; Maioli, A; Medveczky, M; Medveczky, P; Shugar, D; Spadari, S; Verri, A; Wright, GE | 1 |
Andrei, G; Balzarini, J; Cristofoli, WA; De Clercq, E; Knaus, EE; Snoeck, R; Wiebe, LI | 1 |
Balzarini, J; Clercq, ED; Kralj, M; Makuc, D; Mintas, M; Pavelić, K; Plavec, J; Prekupec, S; Raić-Malić, S; Suman, L | 1 |
De Clercq, E; Küçükgüzel, I; Küçükgüzel, SG; Rollas, S; Tatar, E | 1 |
Andrei, G; Balzarini, J; De Clercq, E; Gazivoda, T; Kralj, M; Mintas, M; Pavelić, K; Raić-Malić, S; Snoeck, R; Sokcević, M; Suman, L | 1 |
Andrei, G; De Clercq, E; Enguehard-Gueiffier, C; Gueiffier, A; Snoeck, R; Véron, JB | 1 |
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Krecmerová, M; Masojídková, M; Naesens, L; Neyts, J; Pohl, R; Snoeck, R | 1 |
Allouchi, H; Andrei, G; De Clercq, E; Enguehard-Gueiffier, C; Gueiffier, A; Snoeck, R; Véron, JB | 1 |
Balzarini, J; De Clercq, E; Judge, V; Kumar, P; Narang, R; Narasimhan, B; Sharma, D | 1 |
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E | 1 |
Andrei, G; Balzarini, J; Camarasa, MJ; De Castro, S; García-Aparicio, C; Snoeck, R; Velázquez, S | 1 |
Balzarini, J; Brancale, A; Cirilli, R; Coluccia, A; Giordano, C; La Regina, G; La Torre, F; Lavecchia, A; Maga, G; Novellino, E; Piscitelli, F; Samuele, A; Sansone, A; Silvestri, R; Zanoli, S | 1 |
Andrei, G; Bayrak, OF; De Clercq, E; Güniz Küçükgüzel, S; Karakuş, S; Küçükgüzel, I; Pannecouque, C; Sahin, F; Snoeck, R | 1 |
Andrei, G; De Clercq, E; Golankiewicz, B; Ostrowski, T; Snoeck, R | 1 |
Andrei, G; Balzarini, J; Baraka, MM; el-Sabbagh, OI; Ibrahim, SM; Pannecouque, C; Rashad, AA; Snoeck, R | 1 |
De Clercq, E; Ganguly, S; Kumar, KS; Veerasamy, R | 1 |
Andrei, G; Balzarini, J; Brehová, P; Cihlar, T; De Clercq, E; Dracínský, M; Holý, A; Hui, H; Krecmerová, M; Laflamme, G; Masojídková, M; Naesens, L; Neyts, J; Pohl, R; Pomeisl, K; Snoeck, R; Tichý, T | 1 |
Balzarini, J; De Clercq, E; Dewan, SK; Kumar, P; Narasimhan, B; Pannecouque, C; Yadav, S | 1 |
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
Agrofoglio, LA; Alexandre, JA; Andrei, G; Azzouzi, A; Balzarini, J; Broggi, J; Caillat, C; Deville-Bonne, D; El-Amri, C; Eriksson, S; Lin, J; Meyer, P; Pradère, U; Roy, V; Snoeck, R; Topalis, D | 1 |
Agrofoglio, LA; Andrei, G; Balzarini, J; Montagu, A; Roy, V; Snoeck, R | 1 |
Andrei, G; Balzarini, J; Dračínský, M; Holý, A; Krečmerová, M; Snoeck, R; Tichý, T | 1 |
Andrei, G; Balzarini, J; Karlsson, A; McGuigan, C; Persoons, L; Quintiliani, M; Snoeck, R; Solaroli, N | 1 |
Balzarini, J; Głowacka, IE; Piotrowska, DG | 1 |
Balzarini, J; Bharatam, PV; Chibale, K; Kaur, H; Little, S; Singh, K | 1 |
Agrofoglio, LA; Andrei, G; Balzarini, J; Roy, V; Sari, O; Snoeck, R | 1 |
Andrei, G; Balzarini, J; Dračínský, M; Krečmerová, M; Snoeck, R; Tichý, T | 1 |
Agrofoglio, LA; Andrei, G; Balzarini, J; Hamada, M; Montagu, A; Pradère, U; Roy, V; Sari, O; Snoeck, R | 1 |
Batta, G; Bereczki, I; Borbás, A; Fejes, Z; Herczegh, P; Kiss-Szikszai, A; Naesens, L; Ostorházi, E; Rőth, E; Rozgonyi, F; Sipos, A; Török, Z | 1 |
Balzarini, J; Chibale, K; Kaur, H; Singh, K | 1 |
Balzarini, J; Singh, K | 1 |
Andrei, G; Kokosza, K; Piotrowska, DG; Schols, D; Snoeck, R | 1 |
Andrei, G; Babkov, DA; Chizhov, AO; Khandazhinskaya, AL; Novikov, MS; Seley-Radtke, KL; Snoeck, R | 1 |
Andrei, G; Balzarini, J; Bertamino, A; Campiglia, P; Ciaglia, T; di Sarno, V; Gomez-Monterrey, IM; Musella, S; Novellino, E; Ostacolo, C; Sala, M; Scala, MC; Snoeck, R; Spensiero, A | 1 |
Huang, B; Kang, D; Liu, X; Naesens, L; Zhan, P; Zhang, H; Zhou, Z | 1 |
Andrei, G; Buckheit, RW; De Jonghe, S; Groaz, E; Hartman, T; Herdewijn, P; Kalkeri, R; Luo, M; Ptak, RG; Schols, D; Snoeck, R | 1 |
Andrei, G; Balzarini, J; Dračínský, M; Krečmerová, M; Pomeisl, K; Snoeck, R | 1 |
Andrei, G; De Jonghe, S; Herdewijn, P; Lescrinier, E; Plebanek, E; Snoeck, R | 1 |
Agrofoglio, LA; Andrei, G; Bessières, M; Chartier, A; Hervin, V; Lohier, JF; Roy, V; Snoeck, R | 1 |
Andrei, G; De Jonghe, S; Herdewijn, P; Liu, C; Snoeck, R; Srivastava, P; Wang, M | 1 |
Andrei, G; De Jonghe, S; Groaz, E; Herdewijn, P; Luo, M; Snoeck, R | 1 |
Andrei, G; Pertusati, F; Pileggi, E; Schols, D; Serpi, M; Snoeck, R | 1 |
Claessens, F; Dehaen, W; Helsen, C; Karypidou, K; Pannecouque, C; Persoons, L; Quevedo, MA; Ribone, SR | 1 |
Abdel-Moty, SG; Andrei, G; Hayallah, AM; Mohammed, AF; Simons, C; Snoeck, R | 1 |
Andrei, G; Cazin, I; Harej, A; Klobučar, M; Macan, AM; Pavelić, K; Pavelić, SK; Raić-Malić, S; Schols, D; Snoeck, R; Stepanić, V | 1 |
Balzarini, J; De Clercq, E; Karki, SS; Kulkarni, AA; Kumar, S; Veliyath, SK | 1 |
Andrei, G; Groaz, E; Herdewijn, P; Luo, M; Snoeck, R | 1 |
Andrei, G; De Jonghe, S; Groaz, E; Herdewijn, P; Snoeck, R; Zheng, Z | 1 |
Andrei, G; Aralov, AV; Belyaev, ES; Chistov, AA; Ishmukhametov, AA; Jegorov, AV; Korshun, VA; Kozlovskaya, LI; Matyugina, ES; Nikolaeva, YV; Osolodkin, DI; Shtro, AA; Snoeck, R; Volok, VP | 1 |
Andrei, G; D'Alonzo, D; De Fenza, M; Esposito, A; Guaragna, A; Snoeck, R; Talarico, G | 1 |
De Clercq, E; Maudgal, PC | 2 |
De Clercq, E | 1 |
De Clercq, E; Neyts, J | 1 |
De Clercq, E; Naesens, L | 1 |
Andrei, G; De Clercq, E; Snoeck, R | 1 |
Dediulescu, DF; Dediulescu, L | 1 |
Deinhardt, S; Sauerbrei, A; Wutzler, P; Zell, R | 1 |
Bohn, K; Hamprecht, K; Heim, A; Hoffmann, D; Hofmann, J; Jahn, G; Sauerbrei, A; Schnitzler, P; Weissbrich, B; Wutzler, P; Zell, R | 1 |
Andrei, G; Chen, X; Liu, NN; Schols, D; Snoeck, R; Wen, YN; Wu, QP; Xiang, YH; Zhang, QS; Zhang, ZF; Zhang, ZY | 1 |
3 review(s) available for cidofovir anhydrous and brivudine
Article | Year |
---|---|
Antivirals for the treatment of herpesvirus infections.
Topics: Acyclovir; Antiviral Agents; Belgium; Bromodeoxyuridine; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds | 1993 |
Recent developments in herpesvirus therapy.
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Clinical Trials as Topic; Cytosine; Famciclovir; Foscarnet; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valacyclovir; Valine | 2001 |
[Antiherpetic therapy].
Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Drug Combinations; Famciclovir; Foscarnet; Ganciclovir; Humans; Idoxuridine; Keratitis, Herpetic; Oligonucleotides; Ophthalmic Solutions; Organophosphonates; Treatment Outcome; Valacyclovir; Valine; Vidarabine | 2005 |
65 other study(ies) available for cidofovir anhydrous and brivudine
Article | Year |
---|---|
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Nucleosides; Pyridines; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured; Vero Cells | 1996 |
Carbocyclic oxetanocins lacking the C-3' methylene.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Cells, Cultured; Giant Cells; Guanine; Herpesvirus 1, Human; Herpesvirus 3, Human; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Viruses | 1997 |
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.
Topics: Animals; Antiviral Agents; Cyclohexanes; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Humans; Models, Molecular; Molecular Mimicry; Purine Nucleosides; Stereoisomerism; Structure-Activity Relationship | 2000 |
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
Topics: Bacteria; Cell Division; Cell Line; Formazans; Humans; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazolium Salts; Thiosemicarbazones; Tumor Cells, Cultured; Viruses | 2002 |
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Benzimidazoles; Cytomegalovirus; Drug Screening Assays, Antitumor; Herpesvirus 3, Human; Humans; Mice; Structure-Activity Relationship; T-Lymphocytes; Tumor Cells, Cultured; Viral Plaque Assay | 2002 |
From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
Topics: Alanine; Antiviral Agents; Azetidines; Cells, Cultured; Cytomegalovirus; Humans; Lactams; Protease Inhibitors; Structure-Activity Relationship | 2005 |
Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.
Topics: Adenosylhomocysteinase; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Deoxyadenosines; Herpesvirus 3, Human; Humans; Nucleosides; Stereoisomerism; Structure-Activity Relationship | 2006 |
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cidofovir; Cytosine; DNA Viruses; Humans; Mice; Organophosphonates; Retroviridae; RNA Viruses; Stereoisomerism; Structure-Activity Relationship; Triazines | 2007 |
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Topics: Acyclovir; Amino Acid Sequence; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxyuridine; Enzyme Inhibitors; Guanine; Herpesvirus 1, Cercopithecine; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphorylation; Substrate Specificity; Thymidine; Thymidine Kinase; Vero Cells | 2007 |
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
Topics: Alkynes; Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Deoxyuridine; Drug Screening Assays, Antitumor; Herpesvirus 3, Human; Humans; Mice; Simplexvirus; Stereoisomerism; Structure-Activity Relationship; Thymidine Kinase; Transfection; Uridine | 2007 |
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
Topics: Animals; Antiviral Agents; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Cytostatic Agents; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Positron-Emission Tomography; Pyrimidine Nucleosides; Pyrimidines; Structure-Activity Relationship | 2007 |
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
Topics: Animals; Antitubercular Agents; Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Thiourea; Triazoles | 2008 |
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Pyrimidines; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship | 2007 |
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).
Topics: Antiviral Agents; Cell Line; Cell Survival; Cytomegalovirus; Dose-Response Relationship, Drug; Herpesvirus 3, Human; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Stereoisomerism; Structure-Activity Relationship | 2007 |
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Topics: Antiviral Agents; Cell Line; Cytosine; DNA Viruses; Drug Resistance, Viral; Esters; Humans; Magnetic Resonance Spectroscopy; Prodrugs; Retroviridae; RNA Viruses; Stereoisomerism; Structure-Activity Relationship | 2007 |
Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.
Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Herpes Zoster; Herpesvirus 3, Human; Humans; Imidazoles; Lung; Molecular Structure; Pyridines; Structure-Activity Relationship | 2008 |
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Aspergillus niger; Bacillus subtilis; Candida albicans; Cells, Cultured; Chlorocebus aethiops; Drug Design; Escherichia coli; HeLa Cells; Herpesvirus 1, Human; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vero Cells | 2009 |
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship | 2009 |
4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cytomegalovirus; Herpesvirus 3, Human; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Naphthalenesulfonates; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Virus Replication | 2009 |
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Topics: Amino Acids; Animals; Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Cytostatic Agents; Drug Resistance, Viral; Enterovirus B, Human; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Lymphocytes; Mice; Models, Molecular; Molecular Conformation; Mutation; Protein Binding; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Sulfones; Virus Replication | 2009 |
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Sulfonamides; Thiourea; Viruses | 2009 |
Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.
Topics: Acyclovir; Antiviral Agents; Cell Line; Guanine; Herpesvirus 3, Human; Humans | 2009 |
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship; Thiazoles; Vero Cells; Viruses | 2009 |
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Topics: Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Quinazolines; Schiff Bases; Spectrophotometry, Infrared | 2010 |
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
Topics: Adenine; Antiviral Agents; Cell Proliferation; Cells, Cultured; Esters; Herpesviridae; Humans; Organophosphorus Compounds; Poxviridae; Prodrugs; RNA Viruses; Stereoisomerism; Structure-Activity Relationship; Virology | 2010 |
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
Topics: Animals; Anti-Infective Agents; Benzenesulfonates; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Dogs; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Quantitative Structure-Activity Relationship; Stereoisomerism; Structure-Activity Relationship; Vero Cells; Viruses | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
Topics: Antiviral Agents; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Herpesviridae; Humans; Ligands; Models, Molecular; Molecular Structure; Nucleoside-Phosphate Kinase; Organophosphonates; Prodrugs; Pyrimidine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase | 2011 |
Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Cells, Cultured; Chlorocebus aethiops; Cyclization; Deoxyuridine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Microbial Sensitivity Tests; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; T-Lymphocytes; Vero Cells; Viruses | 2011 |
New prodrugs of Adefovir and Cidofovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 2011 |
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Topics: Amides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Floxuridine; Hepacivirus; Humans; Mice; Microbial Sensitivity Tests; Molecular Conformation; Phosphoric Acids; Stereoisomerism; Structure-Activity Relationship; Virus Replication | 2011 |
Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
Topics: Animals; Antiviral Agents; Cell Line; Cytostatic Agents; Drug Design; Humans; Inhibitory Concentration 50; Mice; Nucleotides; Triazoles; Viruses | 2012 |
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; DNA; Dogs; Heme; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Protoporphyrins; Pyrimidines; Structure-Activity Relationship; Viruses | 2012 |
Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.
Topics: Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; Deoxyuridine; Humans; Inhibitory Concentration 50; Virus Replication; Viruses | 2012 |
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Topics: Animals; Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; DNA Viruses; Guanine; Humans; Hypoxanthine; Hypoxanthines; Nucleosides; Organophosphonates; Phosphorous Acids; Prodrugs; Structure-Activity Relationship | 2012 |
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; DNA Viruses; Dogs; Drug Design; Drug Discovery; HeLa Cells; Humans; Madin Darby Canine Kidney Cells; Organophosphonates; Prodrugs; Purine Nucleosides; RNA Viruses; Vero Cells; Viral Plaque Assay | 2012 |
Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
Topics: Anti-Bacterial Agents; Antiviral Agents; Cell Line; Cell Survival; Drug Resistance, Viral; Gram-Positive Bacteria; Herpesvirus 1, Human; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B virus; Isoindoles; Microbial Sensitivity Tests; o-Phthalaldehyde; Teicoplanin | 2012 |
Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
Topics: Antimalarials; Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; DNA; Heme; Humans; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship | 2013 |
Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
Topics: Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Dogs; Dose-Response Relationship, Drug; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship; Vero Cells; Viruses | 2013 |
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Topics: Acrylamides; Adenine; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Cycloaddition Reaction; Cytomegalovirus; Cytostatic Agents; Drug Design; Enterovirus; Humans; Isoxazoles; Naphthalimides; Nitrogen Oxides; Organophosphonates; Phlebovirus; Simplexvirus; Structure-Activity Relationship; Vaccinia virus | 2015 |
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.
Topics: Acetamides; Antiviral Agents; Cell Line; Cell Proliferation; Cytomegalovirus; DNA Viruses; Drug Evaluation, Preclinical; Herpesvirus 3, Human; Humans; RNA Viruses; Structure-Activity Relationship; Uracil; Virus Replication | 2015 |
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
Topics: Antiviral Agents; Cell Line; Cell Proliferation; Cells, Cultured; Drug Design; Herpesvirus 3, Human; Humans; Indoles; Molecular Structure; Virus Replication | 2016 |
First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach.
Topics: Adenoviridae; Antiviral Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line; Drug Discovery; Humans; Mass Spectrometry; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Quinazolines; Structure-Activity Relationship; Vaccinia virus | 2016 |
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistance, Viral; Drug Stability; Esters; Hepatitis B virus; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Nucleosides; Organophosphonates; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2017 |
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
Topics: Antiviral Agents; Cell Line; Cytomegalovirus; Herpesvirus 3, Human; Humans; Organophosphonates; Prodrugs; Pyrimidine Nucleosides; Simplexvirus | 2017 |
Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.
Topics: Antiviral Agents; Cell Line; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 3, Human; Humans; Nucleosides; Pyrazines; Varicella Zoster Virus Infection; Virus Replication | 2018 |
Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
Topics: Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Coronavirus 229E, Human; Dose-Response Relationship, Drug; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Structure-Activity Relationship | 2018 |
Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.
Topics: Antiviral Agents; Cyclopentanes; DNA Viruses; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Organophosphonates; Structure-Activity Relationship | 2018 |
Amidate Prodrugs of Cyclic 9-(
Topics: | 2018 |
Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
Topics: Antiviral Agents; Cell Line; DNA Viruses; Drug Stability; Humans; Nucleosides; Organophosphonates; Prodrugs; RNA Viruses; Structure-Activity Relationship | 2018 |
Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.
Topics: Antiviral Agents; Catalytic Domain; Cell Line, Tumor; Coronavirus; Coronavirus 3C Proteases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Protein Binding; Structure-Activity Relationship; Triazoles; Viral Proteins | 2018 |
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
Topics: Acyclovir; Antiviral Agents; Guanine; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Models, Molecular | 2019 |
Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Topics: Antineoplastic Agents; Antiviral Agents; Apoptosis; Ascorbic Acid; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Triazoles; Viruses | 2019 |
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
Topics: | 2013 |
Amidate Prodrugs of
Topics: | 2020 |
Influence of 4'-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2.
Topics: | 2021 |
Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; DNA Viruses; Dogs; Humans; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Oxazines; SARS-CoV-2; Structure-Activity Relationship; Vero Cells; Virus Replication | 2021 |
Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides.
Topics: Antiviral Agents; Biomimetics; Molecular Conformation; Nucleosides; Piperidines | 2022 |
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits.
Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase | 1991 |
(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Disease Models, Animal; Drug Administration Schedule; Female; Keratitis, Dendritic; Male; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Random Allocation; Simplexvirus; Thymidine Kinase | 1991 |
In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Chlorocebus aethiops; Cidofovir; Cytosine; Gammaherpesvirinae; Herpesviridae Infections; Mice; Mice, SCID; Organophosphonates; Organophosphorus Compounds; Vero Cells; Virus Replication | 1998 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Exodeoxyribonucleases; Foscarnet; Guanine; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Microbial Sensitivity Tests; Mutation, Missense; Organophosphonates; Oxidation-Reduction; Sequence Analysis, DNA; Staining and Labeling; Tetrazolium Salts; Thymidine Kinase; Viral Proteins | 2010 |
Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.
Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Bromodeoxyuridine; Child; Child, Preschool; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Female; Foscarnet; Genotype; Guanine; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Infant; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Thymidine Kinase; Viral Proteins | 2011 |
Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).
Topics: Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytomegalovirus; Cytosine; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Organophosphonates; Thymidine Kinase; Triazoles | 2017 |