Page last updated: 2024-09-02

ci 988 and naloxone

ci 988 has been researched along with naloxone in 8 studies

Compound Research Comparison

Studies
(ci 988)
Trials
(ci 988)
Recent Studies (post-2010)
(ci 988)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
14781420,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyci 988 (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (87.50)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hökfelt, T; Horwell, DC; Hughes, J; Wiesenfeld-Hallin, Z; Xu, XJ3
Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP1
Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O1
Hökfelt, T; Hughes, J; Jing-Xia, H; Seiger, Å; Wiesenfeld-Hallin, Z; Xiao-Jun, X1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F1
Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP1

Other Studies

8 other study(ies) available for ci 988 and naloxone

ArticleYear
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat.
    British journal of pharmacology, 1992, Volume: 105, Issue:3

    Topics: Animals; Behavior, Animal; Drug Tolerance; Indoles; Injections, Intraperitoneal; Male; Meglumine; Morphine; Morphine Dependence; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1992
PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:18

    Topics: Analgesics; Animals; Cholecystokinin; Drug Synergism; Female; Galanin; Indoles; Injections, Spinal; Kinetics; Male; Meglumine; Morphine; Naloxone; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reflex; Sorbitol; Spinal Cord; Time Factors

1990
Studies on the effect of systemic PD134308 (CAM 958) in spinal reflex and pain models with special reference to interaction with morphine and intrathecal galanin.
    Neuropeptides, 1991, Volume: 19 Suppl

    Topics: Analgesics; Animals; Drug Interactions; Female; Galanin; Indoles; Injections, Intravenous; Injections, Spinal; Male; Meglumine; Morphine; Naloxone; Pain; Peptides; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reflex; Spinal Cord

1991
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
    British journal of pharmacology, 1995, Volume: 114, Issue:5

    Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss

1995
Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems.
    Pain, 1994, Volume: 56, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cholecystokinin; Chronic Disease; Diazepam; Endorphins; Female; Indoles; Meglumine; Naloxone; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Spinal Cord Injuries; Vocalization, Animal

1994
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1996
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
    British journal of pharmacology, 2001, Volume: 133, Issue:1

    Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss

2001