ci 988 has been researched along with morphine in 19 studies
| Studies (ci 988) | Trials (ci 988) | Recent Studies (post-2010) (ci 988) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 147 | 8 | 14 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | ci 988 (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (73.68) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hökfelt, T; Horwell, DC; Hughes, J; Wiesenfeld-Hallin, Z; Xu, XJ | 3 |
| Hoffmann, O; Wiesenfeld-Hallin, Z | 2 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Dickenson, A; Stanfa, L; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Hökfelt, T; Hughes, J; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Hökfelt, T; Hughes, J; Puke, MJ; Verge, VM; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Atwal, P; Field, MJ; Hunter, JC; Oles, RJ; Singh, L; Woodruff, GN | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Maldonado, R; Roques, BP; Smadja, C; Valverde, O | 1 |
| Broberger, C; Farkas-Szallasi, T; Hökfelt, T; Lundberg, JM; Szallasi, A; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Ardid, D; Boucher, M; Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Méen, M | 1 |
| Fournié-Zaluski, M; Hutcheson, DM; Maldonado, R; Pache, DM; Roques, BP; Sewell, RD; Subhan, F | 1 |
| Boucher, M; Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J | 1 |
| Benturquia, N; Canestrelli, C; Crete, D; Mas Nieto, M; Noble, F; Roques, BP; Wilson, J | 1 |
1 review(s) available for ci 988 and morphine
| Article | Year |
|---|---|
Cholecystokinin and morphine analgesia: variations on a theme.
Topics: Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Humans; Indoles; Meglumine; Morphine; Phenylurea Compounds; Receptors, Cholecystokinin | 1994 |
18 other study(ies) available for ci 988 and morphine
| Article | Year |
|---|---|
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Indoles; Injections, Intraperitoneal; Male; Meglumine; Morphine; Morphine Dependence; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1992 |
PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.
Topics: Analgesics; Animals; Cholecystokinin; Drug Synergism; Female; Galanin; Indoles; Injections, Spinal; Kinetics; Male; Meglumine; Morphine; Naloxone; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reflex; Sorbitol; Spinal Cord; Time Factors | 1990 |
Studies on the effect of systemic PD134308 (CAM 958) in spinal reflex and pain models with special reference to interaction with morphine and intrathecal galanin.
Topics: Analgesics; Animals; Drug Interactions; Female; Galanin; Indoles; Injections, Intravenous; Injections, Spinal; Male; Meglumine; Morphine; Naloxone; Pain; Peptides; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reflex; Spinal Cord | 1991 |
The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Indoles; Male; Meglumine; Morphine; Nociceptors; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cholecystokinin; Time Factors | 1994 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
The CCK-B antagonist CI988 enhances the reflex-depressive effect of morphine in axotomized rats.
Topics: Animals; Axons; Depression, Chemical; Drug Synergism; Electromyography; Female; Indoles; Meglumine; Morphine; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Reflex; Sciatic Nerve | 1994 |
Up-regulation of cholecystokinin in primary sensory neurons is associated with morphine insensitivity in experimental neuropathic pain in the rat.
Topics: Animals; Cholecystokinin; Ganglia, Spinal; Indoles; Male; Meglumine; Morphine; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; RNA, Messenger; Sciatic Nerve; Self Mutilation | 1993 |
Dextromethorphan potentiates morphine antinociception, but does not reverse tolerance in rats.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Dextromethorphan; Drug Synergism; Drug Tolerance; Hormone Antagonists; Indoles; Male; Meglumine; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley | 1996 |
The CCKB antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Enkephalins; Hormone Antagonists; Indoles; Male; Meglumine; Morphine; Pain Measurement; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1996 |
Effect of CCK receptor antagonists on the antinociceptive, reinforcing and gut motility properties of morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hormone Antagonists; Indoles; Male; Meglumine; Morphine; Pain Threshold; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cholecystokinin | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCKB receptor antagonist.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Indoles; Male; Meglumine; Morphine; Rats; Receptors, Cholecystokinin; Stress, Physiological; Time Factors | 1997 |
Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies.
Topics: Animals; Cholecystokinin; Decerebrate State; Diterpenes; Ganglia, Spinal; Hormone Antagonists; Indoles; Injections, Subcutaneous; Male; Meglumine; Morphine; Neurons; Neurotoxins; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Reflex; RNA, Messenger; Spinal Cord; Time Factors; Transcription, Genetic | 2000 |
Potentiation of morphine and clomipramine analgesia by cholecystokinin -B antagonist CI-988 in diabetic rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Clomipramine; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Male; Meglumine; Morphine; Nociceptors; Pain; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors | 2000 |
Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties.
Topics: Alanine; Analgesics; Animals; Anti-Anxiety Agents; Discrimination Learning; Discrimination, Psychological; Disulfides; Dose-Response Relationship, Drug; Indoles; Male; Meglumine; Morphine; Protease Inhibitors; Rats; Rats, Wistar | 2000 |
Spinal effect of the cholecystokinin-B receptor antagonist CI-988 on hyperalgesia, allodynia and morphine-induced analgesia in diabetic and mononeuropathic rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Drug Synergism; Hormone Antagonists; Hyperalgesia; Indoles; Injections, Intravenous; Injections, Spinal; Male; Meglumine; Morphine; Nervous System Diseases; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Touch | 2000 |
Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.
Topics: Analysis of Variance; Animals; Cholecystokinin; Conditioning, Psychological; Enkephalins; Hormone Antagonists; Indoles; Male; Meglumine; Morphine; Narcotics; Peptide Fragments; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Cholecystokinin; Reinforcement, Psychology | 2012 |