ci 988 has been researched along with l 365260 in 34 studies
Studies (ci 988) | Trials (ci 988) | Recent Studies (post-2010) (ci 988) | Studies (l 365260) | Trials (l 365260) | Recent Studies (post-2010) (l 365260) |
---|---|---|---|---|---|
147 | 8 | 14 | 422 | 10 | 8 |
Protein | Taxonomy | ci 988 (IC50) | l 365260 (IC50) |
---|---|---|---|
5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0081 | |
5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0081 | |
Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | 0.4981 | |
Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | 0.039 | |
5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0081 | |
Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | 5 | |
Cholecystokinin receptor type A | Homo sapiens (human) | 0.1585 | |
Gastrin/cholecystokinin type B receptor | Homo sapiens (human) | 0.0079 | |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5 | |
Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | 0.044 | |
Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | 5 | |
Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | 5 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 31 (91.18) | 18.2507 |
2000's | 3 (8.82) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Horwell, DC; Hughes, J; Hunter, JC; Pritchard, MC; Richardson, RS; Roberts, E; Woodruff, GN | 1 |
Bellier, B; Danascimento, S; Ducos, B; Garbay, C; McCort-Tranchepain, I; Meudal, H; Noble, F; Roques, BP | 1 |
Capelli, AM; Carr, RA; Cassarà, P; Corsi, M; Curcuruto, O; Curotto, G; Dal Cin, M; Davalli, S; Donati, D; Feriani, A; Finch, H; Finizia, G; Gaviraghi, G; Marien, M; Pentassuglia, G; Polinelli, S; Ratti, E; Reggiani, A; Reggiani, AM; Tarzia, G; Tedesco, G; Tranquillini, ME; Trist, DG; Ursini, A; Van Amsterdam, FT | 1 |
Low, CM; Vinter, JG | 1 |
Branchereau, P; Champagnat, J; Denavit-Saubie, M; Roques, BP | 1 |
Crawley, JN | 1 |
Field, MJ; Hughes, J; Menzies, R; Oles, RJ; Singh, L; Vass, CA; Woodruff, GN | 1 |
Harding, M; Hayward, NJ; Hughes, J; Lloyd, SA; McKnight, AT; Woodruff, GN | 1 |
Field, MJ; Hughes, J; Lewis, AS; Singh, L; Woodruff, GN | 1 |
Chen, D; Ding, XQ; Håkanson, R | 1 |
Bickerdike, MJ; Dourish, CT; Fletcher, A; Marsden, CA | 1 |
Derrien, M; Ducos, B; Durieux, C; McCort-Tranchepain, I; Roques, BP | 1 |
Blanchard, JC; Böhme, GA; Lemaire, M; Piot, O; Roques, BP | 1 |
Akuzawa, S; Ito, H; Kamato, T; Katuyama, Y; Kobayashi, A; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M; Yuki, H | 1 |
Dickinson, CJ; Seva, C; Yamada, T | 1 |
Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
Blackmore, M; Doherty, E; Hirst, BH; Manning, JE | 1 |
Dickenson, A; Stanfa, L; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
Blommaert, A; Derrien, M; Durieux, C; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
Chapman, KL; Freedman, SB; Heald, A; Patel, S; Smith, AJ | 2 |
Boyle, SJ; McKnight, AT; Tang, KW; Woodruff, GN | 1 |
Blommaert, AG; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
Brotchi, J; Camby, I; Danguy, A; Kiss, R; Martinez, J; Pasteels, JL; Salmon, I | 1 |
Goudreau, N; Guillaume-Rousselet, N; Jagerschmidt, A; Maigret, B; Roques, BP; Vikland, ML | 1 |
Bado, A; Blommaert, AG; Böhme, A; Ducos, B; Garbay, C; Moizo, L; Roques, BP; Weng, JH | 1 |
Birkemo, LS; Ervin, GN; Johnson, MF; Mosher, JT | 1 |
Jenck, F; Martin, JR; Moreau, JL | 1 |
Bestervelt, LL; Dethloff, LA; Patmore, SJ; Tierney, BM; Zandee, JC | 1 |
Roques, BP; Valverde, O | 1 |
Alchepo, B; Attoub, S; Bado, A; Laigneau, JP; Lewin, MJ; Moizo, L | 1 |
Black, JW; Griffin, EP; Harper, EA; Shankley, NP | 1 |
Black, JW; Harper, EA; Shankley, NP | 1 |
Bradley, EL; Bright, CA; Kissin, I | 1 |
1 review(s) available for ci 988 and l 365260
Article | Year |
---|---|
Cholecystokinin and morphine analgesia: variations on a theme.
Topics: Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Humans; Indoles; Meglumine; Morphine; Phenylurea Compounds; Receptors, Cholecystokinin | 1994 |
33 other study(ies) available for ci 988 and l 365260
Article | Year |
---|---|
Rationally designed "dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Cholecystokinin; Gastrins; Indicators and Reagents; Male; Mice; Receptors, Cholecystokinin; Structure-Activity Relationship | 1991 |
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Topics: Adamantane; Animals; CHO Cells; Cricetinae; Dipeptides; Guinea Pigs; Kinetics; Magnetic Resonance Spectroscopy; Peptoids; Proline; Protein Conformation; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship; Substrate Specificity; Transfection | 1997 |
Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Callithrix; Cerebral Cortex; Crystallography, X-Ray; Guinea Pigs; HeLa Cells; Humans; In Vitro Techniques; Membranes; Mice; Models, Molecular; Pancreas; Radioligand Assay; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stereoisomerism; Structure-Activity Relationship | 2000 |
Rationalizing the activities of diverse cholecystokinin 2 receptor antagonists using molecular field points.
Topics: Animals; Benzoates; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cyclohexanes; Gastric Mucosa; Guinea Pigs; Heterocyclic Compounds, 2-Ring; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Least-Squares Analysis; Ligands; Linear Models; Models, Molecular; Pancreas; Phthalic Acids; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B | 2008 |
CCK modulates inhibitory synaptic transmission in the solitary complex through CCKB sites.
Topics: Animals; Benzodiazepinones; Bicuculline; Brain Stem; Cholecystokinin; Devazepide; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Indoles; Interneurons; Medulla Oblongata; Meglumine; Membrane Potentials; Microelectrodes; Phenylurea Compounds; Rats; Receptors, Cholecystokinin; Synapses; Synaptic Transmission; Vagus Nerve | 1992 |
Subtype-selective cholecystokinin receptor antagonists block cholecystokinin modulation of dopamine-mediated behaviors in the rat mesolimbic pathway.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Cholecystokinin; Darkness; Devazepide; Dopamine; Indoles; Injections, Intraperitoneal; Limbic System; Male; Meglumine; Microinjections; Motor Activity; Nucleus Accumbens; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Tegmentum Mesencephali | 1992 |
The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Carbolines; Central Nervous System Depressants; Cholecystokinin; Conflict, Psychological; Devazepide; Drug Interactions; Ethanol; Hypnotics and Sedatives; Indoles; Injections, Intraventricular; Male; Meglumine; Mice; Motor Activity; Pentagastrin; Pentobarbital; Pentylenetetrazole; Phenylurea Compounds; Postural Balance; Rats; Receptors, Cholecystokinin; Social Behavior | 1991 |
The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat.
Topics: Animals; Anti-Anxiety Agents; Atropine; Benzodiazepinones; Bethanechol Compounds; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Acid; Gastrins; Histamine; Indoles; Male; Meglumine; Omeprazole; Phenylurea Compounds; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
Topics: Animals; Anxiety; Benzodiazepinones; Cerebral Ventricles; Ceruletide; Chlordiazepoxide; Cholecystokinin; Devazepide; Indoles; Injections, Intraventricular; Male; Meglumine; Pentagastrin; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
Cholecystokinin-B receptor ligands of the dipeptoid series act as agonists on rat stomach histidine decarboxylase.
Topics: Animals; Benzodiazepinones; Devazepide; Enzyme Activation; Gastrins; Histidine Decarboxylase; Indoles; Ligands; Male; Meglumine; Phenethylamines; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Stomach | 1995 |
The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Devazepide; Diazepam; Indoles; Male; Maze Learning; Meglumine; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Rats; Receptors, Cholecystokinin; Selective Serotonin Reuptake Inhibitors; Zimeldine | 1994 |
Heterogeneity of CCK-B receptors involved in animal models of anxiety.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Cholecystokinin; Devazepide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Meglumine; Mice; Molecular Sequence Data; Pancreas; Peptide Fragments; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cholecystokinin | 1994 |
CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Cognition; Indoles; Male; Meglumine; Molecular Sequence Data; Peptide Fragments; Phenylurea Compounds; Pyrazoles; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide; Smell; Social Behavior | 1994 |
Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indoles; Male; Meglumine; Pentagastrin; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1994 |
Growth-promoting effects of glycine-extended progastrin.
Topics: Benzodiazepinones; Binding Sites; Cell Division; Gastrins; Humans; Indoles; Meglumine; Octreotide; Ornithine Decarboxylase; Phenylurea Compounds; Receptors, Cholecystokinin; Tumor Cells, Cultured | 1994 |
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
Topics: Adamantane; Analgesics; Animals; Benzodiazepinones; Dipeptides; Disulfides; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Nociceptors; Pain Measurement; Phenylalanine; Phenylurea Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Regression Analysis; Tail | 1994 |
Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.
Topics: Benzamides; Benzodiazepinones; Cell Division; Devazepide; Gastrins; Humans; Indoles; Kidney Neoplasms; Meglumine; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tumor Cells, Cultured; Wilms Tumor | 1994 |
CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration.
Topics: Animals; Antidepressive Agents; Benzodiazepinones; Blood-Brain Barrier; Brain; Cerebral Ventricles; Cholecystokinin; Electroshock; Indoles; Injections, Intraventricular; Meglumine; Mice; Motor Activity; Peptide Fragments; Phenylurea Compounds; Receptors, Cholecystokinin | 1994 |
Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Brain; Cerebral Ventricles; Indoles; Injections, Intraventricular; Inulin; Iodine Radioisotopes; Male; Meglumine; Mice; Mice, Inbred Strains; Phenylurea Compounds; Radioligand Assay; Receptors, Cholecystokinin; Tetrazoles | 1994 |
Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding.
Topics: Analysis of Variance; Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Guinea Pigs; Indoles; Injections, Intravenous; Injections, Intraventricular; Male; Meglumine; Mice; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Succinimides; Tetrazoles | 1994 |
Characterization of CCK receptors in a novel smooth muscle preparation from the guinea-pig stomach by use of the selective antagonists CI-988, L-365,260 and devazepide.
Topics: Animals; Benzodiazepinones; Carbachol; Cholecystokinin; Devazepide; Gastric Mucosa; Gastrins; Guinea Pigs; In Vitro Techniques; Indoles; Male; Meglumine; Muscle Contraction; Muscle, Smooth; Phenylurea Compounds; Receptors, Cholecystokinin; Stomach | 1993 |
Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist.
Topics: Analgesics; Animals; Benzodiazepinones; Disulfides; Drug Synergism; Drug Tolerance; Indoles; Male; Meglumine; Mice; Pain Measurement; Phenylalanine; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Time Factors | 1995 |
Influence of gastrin on human astrocytic tumor cell proliferation.
Topics: Amino Acid Sequence; Astrocytoma; Autoradiography; Benzodiazepinones; Brain Neoplasms; Cell Division; Cholecystokinin; Devazepide; Gastrins; Hormone Antagonists; Humans; Indoles; Meglumine; Molecular Sequence Data; Peptide Fragments; Phenylurea Compounds; Receptors, Cholecystokinin; Sincalide; Thymidine; Tritium; Tumor Cells, Cultured | 1996 |
His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity.
Topics: Animals; Arginine; Base Sequence; Benzodiazepinones; Cholecystokinin; Devazepide; Histidine; Indoles; Meglumine; Models, Molecular; Molecular Sequence Data; Phenylurea Compounds; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Tetragastrin | 1996 |
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Benzodiazepinones; CHO Cells; Cholecystokinin; Cricetinae; Dose-Response Relationship, Drug; Electrophysiology; Gastric Acid; Gastrointestinal Agents; Hippocampus; Indoles; Inositol Phosphates; Male; Meglumine; Molecular Sequence Data; Neurons; Neurotransmitter Agents; Oligopeptides; Pentagastrin; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship; Time Factors; Transfection | 1996 |
Several roles of CCKA and CCKB receptor subtypes in CCK-8-induced and LiCl-induced taste aversion conditioning.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Psychological; Devazepide; Dose-Response Relationship, Drug; Hormone Antagonists; Indoles; Lithium Chloride; Male; Meglumine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Taste | 1996 |
Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Caffeine; Clonazepam; Dose-Response Relationship, Drug; Indoles; Male; Meglumine; Phenylurea Compounds; Rats; Rats, Wistar | 1996 |
Gastric effects of the CCK-B/gastrin receptor ligand CI-988 in cynomolgus monkeys.
Topics: Animals; Benzodiazepinones; Gastric Acid; Gastric Mucosa; Indoles; Ligands; Macaca fascicularis; Meglumine; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Benzodiazepinones; Cholecystokinin; Conditioning, Classical; Devazepide; Indoles; Male; Meglumine; Morphine Dependence; Peptide Fragments; Phenylurea Compounds; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1998 |
YM022, a highly potent and selective CCKB antagonist inhibiting gastric acid secretion in the rat, the cat and isolated rabbit glands.
Topics: Aminopyrine; Animals; Benzodiazepines; Benzodiazepinones; Cats; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Acid; Gastric Fistula; Gastric Mucosa; Gastrins; Hormone Antagonists; Indoles; Male; Meglumine; Phenylurea Compounds; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Guinea Pigs; Hormone Antagonists; Indoleacetic Acids; Indoles; Iodine Radioisotopes; Male; Meglumine; Mice; Pancreas; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Succinimides; Thiazoles; Tritium | 1999 |
Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Hormone Antagonists; Indoles; Kinetics; Male; Meglumine; Membranes; Nootropic Agents; Pentagastrin; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Tritium | 1999 |
Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems.
Topics: Alfentanil; Analgesia; Analgesics, Opioid; Animals; Benzodiazepinones; Cholecystokinin; Dizocilpine Maleate; Drug Tolerance; Indoles; Infusions, Intravenous; Male; Meglumine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Threshold; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 2000 |