Page last updated: 2024-09-02

ci 988 and diazepam

ci 988 has been researched along with diazepam in 7 studies

Compound Research Comparison

Studies
(ci 988)
Trials
(ci 988)
Recent Studies (post-2010)
(ci 988)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
14781418,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomyci 988 (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Field, MJ; Hughes, J; Singh, L; Vass, CA; Woodruff, GN1
Costall, B; Domeney, AM; Hughes, J; Kelly, ME; Naylor, RJ; Woodruff, GN1
Bickerdike, MJ; Dourish, CT; Fletcher, A; Marsden, CA1
Dooley, DJ; Klamt, I1
Hökfelt, T; Hughes, J; Jing-Xia, H; Seiger, Å; Wiesenfeld-Hallin, Z; Xiao-Jun, X1
Costall, B; Naylor, RJ1
Lawrence, AJ; Lodge, DJ1

Other Studies

7 other study(ies) available for ci 988 and diazepam

ArticleYear
The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988.
    British journal of pharmacology, 1992, Volume: 105, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Drug Administration Schedule; Indoles; Light; Male; Meglumine; Mice; Mice, Inbred Strains; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1992
Anxiolytic effects of CCK-B antagonists.
    Neuropeptides, 1991, Volume: 19 Suppl

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Callitrichinae; Diazepam; Indoles; Meglumine; Mice; Rats; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1991
The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze.
    European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Devazepide; Diazepam; Indoles; Male; Maze Learning; Meglumine; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Rats; Receptors, Cholecystokinin; Selective Serotonin Reuptake Inhibitors; Zimeldine

1994
Differential profile of the CCKB receptor antagonist CI-988 and diazepam in the four-plate test.
    Psychopharmacology, 1993, Volume: 112, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Electroshock; Exploratory Behavior; Flumazenil; Indoles; Male; Meglumine; Mice; Ondansetron; Receptors, Cholecystokinin

1993
Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems.
    Pain, 1994, Volume: 56, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cholecystokinin; Chronic Disease; Diazepam; Endorphins; Female; Indoles; Meglumine; Naloxone; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Spinal Cord Injuries; Vocalization, Animal

1994
The influence of 5-HT2 and 5-HT4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Animals; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Darkness; Devazepide; Diazepam; Drug Antagonism; Fenclonine; Indoles; Light; Losartan; Male; Meglumine; Mice; Organophosphorus Compounds; Proline; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Ritanserin; Serotonin Antagonists; Sulfonamides

1997
The neurochemical effects of anxiolytic drugs are dependent on rearing conditions in Fawn-Hooded rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Indoles; Male; Meglumine; Rats; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Dopamine D2; RNA, Messenger; Social Isolation; Tyrosine 3-Monooxygenase

2003